Livedoks tablets (150 and 300 mg): instructions for use

Livedoksa - hepatoprotector, which has immunomodulating and choleretic effect on the human body. In addition, the drug serves to normalize lipids and cholesterol levels in the blood.

This drug can accelerate the process of solubility of cholesterol in bile and promotes the excretion of gallstones and prevents their re-education. But also the immunomodulating effect of the drug is observed.

Ursodeoxycholic acid, getting into the body, suppresses the expression of human leukocyte antigens, which are found on the membranes of the hepatic cells and normalizes the immune properties lymphocytes.

Clinical and pharmacological group

Hepatoprotector with choleretic and cholelitholytic action.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much does Livedovs cost? The average price in pharmacies is at the level of300 rubles.

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Form of issue and composition

Livedoksa is available in the form of tablets: round, biconcave, film-coated brown-red color, with a risk on one side; on the break - the core of white color (10 pcs. in blisters, in a cardboard bundle of 1, 5 or 10 blisters).

• The active substance is ursodeoxycholic acid: 150 mg or 300 mg in 1 tablet.
• Auxiliary components: sodium carboxymethyl starch, silicon dioxide colloid, magnesium stearate, cellulose microcrystalline, povidone K-30, talc purified, sodium lauryl sulfate, starch, lactose.

Composition of the membrane: hypromellose (E5 premium), titanium dioxide, macrogol 6000, iron dyes oxide yellow and iron oxide red.

Pharmacological effect

Livevox has a pronounced choleretic and cholelitholytic effect, as well as immunomodulating, lipid-lowering and hypocholesterolemic effects. The active component of the drug, ursodeoxycholic acid, has the ability to stabilize the cell membranes of hepatocytes and cholangiocytes, thereby providing a direct cytoprotective effect.

Livedovox reduces the content of potentially toxic bile acids and slows down the process of cell death caused by them, and also stimulates the excretion of toxic acids through the intestine. In addition, the drug reduces the absorption of cholesterol in the intestine, lowers the saturation of bile with cholesterol and increases its solubility in bile. As a result, cholesterol gallstones dissolve.

As the data from clinical studies indicate, the drug is an effective preventive agent that prevents the development of varicose veins of the esophagus. In patients with cystic fibrosis, primary biliary cirrhosis and alcoholic steatohepatitis, the drug slows the progression of these diseases.

Indications for use

Liverax is indicated for use in cholelithiasis, cholangitis, hepatitis, autoimmune disorders, toxic liver damage, reflux gastritis and esophagitis, acute inflammatory processes in biliary tract.

Positive feedback Livedoksa received as an effective drug for the dissolution of cholesterol stones in the gallbladder, as well as for the treatment of liver and gallbladder pathologies.

Contraindications

It is not recommended to use Livevox in patients suffering from:

• gallstones;
• a dysfunctional gallbladder;
• cirrhosis of the liver in the stage of decompensation;
• increased individual sensitivity to its components;
• marked violations of the kidneys, liver and pancreas;
• intolerance to lactose, deficiency of lactase, malabsorption of glucose-galactose;
• acute inflammatory diseases of the gallbladder, intestines and bile ducts.

Also, the drug is banned in children under 3 years. With caution Livevox is prescribed to small patients 3-4 years, as it is difficult for them to swallow tablets.

Use in pregnancy and lactation

The use of ursodeoxycholic acid in pregnancy is possible only if the expected benefit for the mother exceeds potential risk for the fetus (adequate strictly controlled studies of the use of ursodeoxycholic acid in pregnant women are not was conducted).

Data on the isolation of ursodeoxycholic acid with breast milk are currently not available. If it is necessary to use ursodeoxycholic acid during lactation, the question of stopping breastfeeding should be solved.

Dosage and route of administration

The instructions for use indicate: Livedoks tablets are taken orally, without chewing, with enough water. A tablet can be divided in half.

1. To dissolve cholesterol gallstones, the average daily dose of Livedovox is 10 mg / kg (up to 12-15 mg / kg). The drug is taken in the evening, before going to bed. The course of treatment is 6-12 months.
2. For the prevention of repeated formation of stones, it is recommended to take the drug for several months after the dissolution of the stones.
3. Symptomatic therapy of primary biliary cirrhosis: the average daily dose is 10-15 mg / kg (up to 20 mg / kg, if necessary) from 6 months to several years. The drug is taken with food, squeezed with enough liquid.
4. With biliary reflux gastritis and reflux-esophagitis, the dose is 10 mg / kg / day - 1 time / day before bedtime. The course of treatment - from 10-14 days to 6 months, if necessary - up to 2 years.
5. With chronic hepatitis of various genesis (toxic, medicinal, etc.), primary non-alcoholic steatohepatitis, alcoholic liver disease, the average daily dose is 10-15 mg / kg body weight in 2-3 reception. The duration of therapy is 6-12 months or more.
6. In primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis), the average daily dose is 12-15 mg / kg (if necessary - up to 20-30 mg / kg / day) in 2-3 divided doses. The duration of therapy is from 6 months to several years.
7. With dyskinesia of bile ducts, the average daily dose is 10 mg / kg in 2 divided doses for 2 weeks to 2 months. If necessary, the course of treatment is recommended to be repeated.

The dose for children is determined individually at the rate of 10-20 mg / kg per day.

Calculation of the daily amount of Livedovenx tablets as a function of the patient's weight with a dose of 10 mg / kg per day (for Livedox 150 mg / Livedox 300 mg):

• 34-50 kg - 3 tablets /, tables;
• 51-65 kg - 4 tablets / 2 tables;
• 66-85 kg - 5 tablets /, tables;
• 86-100 kg - 6 table / 3 table;
• & g; 00 kg - 7 table / 4 table.

Calculation of the daily amount of Livedovox tablets, depending on the weight of the patient, when administering a dose of 15 mg / kg per day (for Livedoks 150 mg / Livedoksa 300 mg):

• 34-50 kg - 5 tablets / 2 tables;
• 51-65 kg - 6 tablets / 3 tablets;
• 66-85 kg - 7 tablets /, tables;
• 86-100 kg - 8 tablets /, tables;
• & g; 00 kg - 9 table / 6 table.

Calculation of the daily amount of Livedovox tablets 300 mg, depending on the weight of the patient with a dose of 20 mg / kg:

• 34-50 kg - 3 tablets;
• 51-65 kg - 4 tablets;
• 66-85 kg - 5 tablets;
• 86-100 kg - 6 tablets;
• & g; 00 kg - 7 tablets.

Calculation of the daily amount of LIVELEKS tablets 300 mg, depending on the weight of the patient with a dose of 30 mg / kg:

• 34-50 kg - 5 tablets;
• 51-65 kg - 6 tablets;
• 66-85 kg - 7 tablets;
• 86-100 kg - 8 tablets;
• & g; 00 kg - 9 tablets.

Side effects

Taking Livedoks tablets in some cases leads to undesirable effects associated with the digestive system. These include:

1. Nausea;
2. Diarrhea;
3. Enlargement of gallstones;
4. Sharp pain in the abdomen; increased activity of hepatocytes and improvement of liver enzymes.

During treatment of biliary cirrhosis, there is sometimes a disruption in the functioning of the liver, which occurs due to a sharp discontinuation of the drug.

Overdose

Cases of Ledewax tablets overdose have not been recorded to date.

special instructions

Before you start using the drug, read the special instructions:

1. When the drug is used to dissolve gallstones, it is necessary to monitor the activity of hepatic transaminases, alkaline phosphatase, gamma-glutamyltransferase and bilirubin concentration. If there are still high rates, you should stop taking the medication.
2. To dissolve stones with Liverax, it was necessary that their size not exceed 15-20 mm, they were purely cholesteric, they filled the gallbladder no more than half, and the bile ducts completely retained their function.
3. When after 6-12 months of taking the drug there was no partial dissolution of the stones, it is unlikely that further treatment will be effective.
4. Detection during an ultrasound of a non-invasive gallbladder is an indication that there has not been a complete dissolution of the stones, and the drug should be discontinued.
5. The drug should be canceled in cases of violation of the contractility of the gallbladder, calcification of gallstones or frequent biliary colic attacks.

In the first 3 months of therapy, Lidewoksoy should perform cholecystography every 28 days, in the future - once every 3 months. During the first year of treatment every six months, it is necessary to monitor the effectiveness of therapy through ultrasound (ultrasound). The drug should be taken at least 3 months after the complete dissolution of the stones, To facilitate the dissolution of remains of stones, the dimensions of which are too small for their detection.

Drug Interactions

Do not use the drug simultaneously with antacids containing aluminum and ion exchange resins, because these drugs can disrupt the absorption of ursodeoxycholic acid.
With the simultaneous use of lipid-lowering drugs, estrogens, neomycin or gestagens (oral contraceptives) increase the saturation of bile with cholesterol and may reduce the ability of ursodeoxycholic acid to dissolve cholesterol bile concrements.

Ursodeoxycholic acid can increase the absorption of cyclosporine from the intestine, which requires monitoring the concentration of cyclosporine in the blood, and if necessary - correcting its mode dosing.

Reviews

We picked up some responses from people who took the drug Livevox:

1. Marina. Her husband discovered the first signs of cirrhosis. It was no surprise - he often drank a lot. This caused him to quit alcohol abuse and begin treatment. For the past year he has been drinking Livedoks tablets. While all indicators slowly but surely move to normal, but the process of fibrosis is difficult to stop. At least a year will have to be treated with a medication.
2. Svetlana. It was just torture martyrs, when I dissolve the campus in the bile with the help of linguax. Lazar did not take them, so I had to drink tablets, and after them I felt sick all the time, unrelenting, did not depend, I did not eat, and this completely disgusts me. So me all 4 months and protoshnilo, a little crazy did not come down. And then somehow everything stopped and it turned out that the stones had dissipated!
3. Vladimir. Livedoksu advised me a young doctor, and said, forget about all the drugs and buy it. You know, the price was happy, and put in doubt, but after just a couple months of taking the drug, I advise it to everyone who has liver problems and for prevention also recommend.

Analogues

The analogues of Livevox are Urdoksa, Ursoliv, Holudexan and Exhole. These drugs have similar pharmacological properties and have an effective choleretic effect.

Hepatoprotectors Urdoksa and Holudeksan, in addition to reducing the cytotoxic effect of bile acids, have an immunomodulatory effect.

Before using analogues, consult your doctor.

Ursofalk or Livedovx

Ursofa or Ursofalk is a popular analogue of Livevox with the same active component. It improves circulation in the liver and kidneys, has choleretic properties, is released in capsules 250 mg and suspension for oral administration. The latter is relevant for use in children. The difference is also the increased price of Ursofalk, but in general the drugs do not differ in effect.

Livedoksa or Ursosan

Both drugs have the same active substance, so they are considered interchangeable. Differences consist in the form of release: Ursosan is capsules of 150 mg, Livedoksa - cheap tablets of 150 or 300 mg. Unlike the drug in question, Ursosan has a mild choleretic effect, so it is used in conjunction with enzymes Pankeratin or Mezim.

Storage conditions and shelf life

The shelf life of Livedoks tablets is 2 years from the date of their manufacture. The drug should be stored in a dark, dry place inaccessible to children at an air temperature of not more than + 25ºC.

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