Trental

Trental is a drug that belongs to the pharmacological group of angioprotective medicines.

Promotes normalization of circulatory processes, improves microcirculation, as well as cellular respiration, positively influences the rheological characteristics of the blood. Trental is indicated in the fight against frostbite, trophic disorders, circulatory disorders in the brain area, as well as the vascular ocular membrane.

This drug promotes early recovery after a stroke. Normalizes the patient's condition in ischemic and post-thrombotic syndrome.

Clinical and pharmacological group

A drug that improves microcirculation. Angioprotector.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much is Trental in pharmacies? The average price is at the level of600 rubles.

Composition and form of release

Trental is available in the following forms:

tablets, covered with enteric film coating, 100 mg: biconvex, round, white (10 pcs. in blisters, in a cardboard bundle of six blisters);
tablets of prolonged action (Trental 400), 400 mg: biconvex, oblong, white, engraved with ATA on one side (10 pcs. in blisters, in a cardboard bundle 2 blisters);
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Concentrate for solution for infusion: colorless, almost transparent (5 ml in ampoules, in a cardboard bundle 5 ampoules).

Composition per 1 tablet, coated with enteric film coating:

active substance: pentoxifylline - 100 mg;
auxiliary components: starch, silicon dioxide colloid, talc, magnesium stearate, lactose;
film shell: macrogol 8000, methacrylic acid copolymer, titanium dioxide, sodium hydroxide, talc.

Composition for 1 tablet of prolonged action, film-coated:

active substance: pentoxifylline - 400 mg;
auxiliary components: hydroxyethylcellulose, magnesium stearate, povidone, talc;
film shell: macrogol 6000, hydroxypropylmethylcellulose, titanium dioxide, benzyl alcohol, talc.

Composition per 1 ml of concentrate for solution for infusion:

active substance: pentoxifylline - 20 mg;
auxiliary components: water for injection, sodium chloride.

pharmachologic effect

The active substance of the drug reduces the ability of platelets to stick together, thereby improving blood circulation in small vessels. In addition, Trental reduces the protein content of fibrinogen, which significantly affects the viscosity of the blood and improves the state of the cellular membranes of red blood cells, increasing their resistance to deformation.

There is also a general relaxing effect of the drug on the vascular wall, which allows to reduce resistance and increase the amount of blood arriving to the organs. Also, the drug improves the functional state of the central nervous system. Trental has no effect on the heart rate.

The therapeutic effect is achieved an hour after taking the drug in the form of tablets. Its neutralization occurs in the liver, excretion through the kidneys. Decomposition products also have a curative effect and have a similar effect.

Indications for use

What are these tablets from? Trental has the following indications:

Raynaud's disease and other angio-neuropathies;
pathology of peripheral circulation;
gangrene, trophic ulcers and frostbites;
pathology of respiratory organs with obstruction;
discirculatory encephalopathy, ischemic stroke and encephalopathy of atherosclerotic origin;
insufficiency of blood circulation in the vessels of the retina and in the region of the inner ear;
pathology of sexual function associated with circulatory failure.

Contraindications

The use of tablets Trental 100 mg is contraindicated in certain pathological and physiological conditions of the patient's body, which include:

Increased blood pressure (arterial hypertension), which is difficult to treat with drugs.
Hypersensitivity to any chemical compounds of methylxanthine derivatives.
Hypersensitivity to any of the components of the drug.
Volumetric bleeding of various localizations in the body.
Acute myocardial infarction (death of the heart muscle).
Extensive hemorrhages localized in the retina of the eye.
Severe violations of the rhythm of contractions of the heart (arrhythmia).
Hemorrhages in the tissue structures of the brain.
Pregnancy at any time of the current, lactation (breastfeeding).

With caution this drug is used in patients with concomitant increase in blood pressure, which is amenable to drug control, a pronounced impairment of the functional liver and kidney conditions, chronic insufficiency of the contractile function of the heart, a violation of hemostasis (coagulating blood system), which is accompanied by an increased tendency to bleeding, including against the background of the use of drugs of the pharmacological group, indirect anticoagulants, as well as after surgical interventions carried out in the recent past.

Before prescribing the drug, the doctor must be sure that there are no contraindications.

Intended use for pregnancy and lactation

The drug is not recommended for use in pregnancy, tk. not enough data.

Pentoxifylline penetrates into breast milk in small amounts. If it is necessary to use the drug during lactation, breastfeeding should be stopped (given the lack of experience in the application).

Dosage and route of administration

As indicated in the instructions for use, Trental is taken internally. Tablets should be swallowed whole, washed down with sufficient water, during or immediately after meals.

The dose is set by the doctor in accordance with the individual characteristics of the patient.

The average dose of the drug for oral administration is 100 mg (1 tab.) 3 times / day, followed by a slow increase in the dose to 200 mg (2 tablets) 2-3 times / day. The maximum single dose is 400 mg. The maximum daily dose is 1200 mg.

In patients with impaired renal function (QC less than 30 ml / min), the dose can be reduced to 100-200 mg (1-2 tablets) / day.

Dose reduction, taking into account individual tolerance, is necessary in patients with severe impairment of liver function.

Treatment can be initiated in small doses in patients with low blood pressure, as well as in patients at risk because of possible reduction of blood pressure (patients with severe forms of ischemic heart disease or with hemodynamically significant stenoses of cerebral vessels). In these cases, the dose can be increased only gradually.

Side effects

The use of high doses of Trental or an IV infusion exceeding the recommended infusion rate can cause the following side effects on the part of organs and systems:

sensory organs: scotoma, visual impairment;
nervous system: dizziness, headache, convulsions, sleep disorders, anxiety;
digestive system: anorexia, xerostomia, intestinal atony;
Cardiovascular system: arrhythmia, tachycardia, cardialgia, decreased blood pressure, progression of angina pectoris;
hypersensitivity reactions: skin hyperemia, itching, urticaria, anaphylactic shock, angioedema;
skin and subcutaneous fatty tissue: swelling, hyperemia of the skin of the face, increased fragility of the nails, tides of blood to the face and to the upper chest;
system of hemostasis and hematopoiesis: thrombocytopenia, leukopenia, pancytopenia, bleeding (from the mucous membranes, vessels of the skin, intestines, stomach), hypofibrinogenemia.

Very rarely there were cases of intrahepatic cholestasis, an increase in the activity of liver enzymes, and the emergence of aseptic meningitis.

Receiving tablets Trental can cause a sensation of pressure and overfilling in the stomach, nausea, vomiting and diarrhea from the digestive system.

Overdose

It is manifested by tonic-clonic convulsions, agitation, drowsiness, tachycardia, syncope, a decrease in the level of blood pressure, dizziness, weakness, vomiting "coffee grounds" and other signs of gastrointestinal bleeding. Emergency gastric lavage, introduction of enterobrots, activated charcoal, and post-dandruff therapy are required.

special instructions

Before you start using the drug, read the special instructions:

Treatment should be carried out under the control of blood pressure.
Smoking can reduce the therapeutic effectiveness of the drug.
The safety and efficacy of pentoxifylline in children have not been adequately studied.
When appointing the drug Trental, simultaneously with anticoagulants, it is necessary to monitor the parameters of the blood coagulation system.
Patients who have recently undergone surgery need regular monitoring of hemoglobin and hematocrit.
In patients with low and unstable BP, the dose of pentoxifylline should be reduced.
In elderly patients, a reduction in the dose of the drug may be required (increased bioavailability and a decrease in the rate of excretion of pentoxifylline).
In patients with diabetes mellitus, who take hypoglycemic drugs, the administration of the drug in high doses can cause expressed hypoglycemia (correction of doses of hypoglycemic agents and conduction of glycemic control may be required).

Considering possible side effects (for example, dizziness), care should be taken when driving vehicles and engaging in potentially hazardous activities.

Interaction with other drugs

Trental can potentiate the effect of antihypertensive drugs.

Against the background of the use of pentoxifylline parenterally in high doses, it is possible to increase the hypoglycemic action of insulin in patients with diabetes mellitus.

In combination with ketorolac, the risk of bleeding and / or an increase in prothrombin time is increased; with meloxicam - increased risk of bleeding; with sympatholytic, ganglioblokatorami and vasodilators - it is possible to lower blood pressure; with heparin, fibrinolytic drugs - strengthening anticoagulant action.

Cimetidine increases the concentration of pentoxifylline in the blood plasma and increases the risk of side effects.

Reviews

We offer you to read reviews of people who used the drug Trental:

Anton. Took on the instructions of the doctor with a seasonal illness of hypothermia of the extremities, as a result of which there was a strong swelling of the hands and feet, itching and ulcers. Nothing helped, the torment lasted until on the street the temperature rose to plus. As soon as Trental began to use it, I felt the relief immediately. The drug not only removes unpleasant symptoms, it acts on the cause of the disease. I suspect that all this is due to thick blood, and "Trental" it "liquefies."
Vladislav. And I almost lost sleep ((After about a week of reception, insomnia began and some unpleasant sensations accompanied by anxiety or nervousness. I almost did not sleep for quite some time. Then he became thoughtful and decided to stop taking trental. The next night I slept well, as usual, and all subsequent days too. After that, I do not take the drug and everything with sleep is good.
Oksana. Pretty good drug. Accepted it, when there was a problem with the sensitivity of both hands and feet, and specifically the numbness of the fingertips, feet, palms. Trental helps if taken long enough and in conjunction with other drugs. But, in comparison with analogues, which are no worse, it is quite an expensive medicine.

The doctors' comments confirm that this is an effective drug and it really improves microcirculation, is used in diabetes. You can use Trental IV and in tablets of 100 and 400 mg of the active ingredient. Side effects are frequent. Increases fluidity of blood from the solution and tablets Trental, which may cause a bleeding in the eyes, so before using it is better to consult an oculist.

Analogues

Trental analogues are preparations (list):

Agapurin.
Arbiflex.
Vazonite.
Pentylin.
Pentohexal.
Pentomere.
Radomine.
Pentoxifylline.
Latren.
Trenpental.
Flexitale.
Pentamon.
Ralofect.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Use the product after the expiration of the recommended shelf life of the manufacturer is dangerous. It is important to observe and storage conditions, that is, store the medicine in a dark cool place, protected from penetration of sunlight and dampness.

The tablet form of Trental is stored for no more than 4 years, and the solution for intravenous administration is no more than 5 years.