Flavamed is a drug that is prescribed for cough with hard-to-separate sputum. The drug acts in two ways: dilutes the mucus and creates conditions for its rapid evacuation from the respiratory tract.
The main active substance of the drug is ambroxol. It stimulates the function of the secretory glands of bronchial epithelium, accelerates the production of biologically active substances that lining the inner surface of the alveoli. The substance dilutes sputum and increases it in volume, stabilizes the chemical composition of the exudate in accordance with physiological norms.
By activating special enzymes, ambroxol reduces the viscosity of mucus. Stimulates the work of cilia of ciliated epithelium.
Clinical and pharmacological group
Mucolytic and expectorant drug.
Terms of sale from pharmacies
Can buywithout a doctor's prescription.
Price
How much does Flavamed cost in pharmacies? The average price is at the level of150 rubles.
.Composition and form of release
Medicinal forms of the Flavamed release:
- tablets: white or almost white with a yellowish tinge, plane-parallel, round, with one-sided risk and bevelled edges (10 pcs. in blisters, in a cardboard bundle of 1, 2 or 5 blisters);
- solution for ingestion: transparent, brownish or colorless, has a crimson smell (in dark glass bottles of 60, 100 or 200 ml, in a cardboard bundle 1 bottle complete with a measuring spoon).
Composition of Flavamed:
- In one tablet of the drug contains 30 mg of ambroxol hydrochloride + excipients (corn starch, croscarmellose sodium, lactose monohydrate, microcrystalline cellulose, povidone, stearate magnesium).
- Syrup Flavamed contains active ingredient 15 ml per 5 ml, excipients (purified water, glycerol 85%, hydroxyethylcellulose, raspberry flavor, benzoic acid, sorbitol 70%).
Pharmacological effect
The drug belongs to the group of drugs with mucolytic action. The main active substance is ambroxol, refers to substituted benzylamines, an active metabolite of bromhexine. The structure of ambroxol as an active substance contains a hydroxyl group, while the methyl group is absent, in contrast to bromhexine.
The administration of the drug Flavamed is aimed at stimulating sputum discharge, provided there is a moist cough. The mechanism of action is mainly associated with an increase in the activity of ciliated epithelium and wave-like contractions of respiratory bronchioles, while characterized by a slight increase in the secretion of bronchial glands and a decrease in the viscosity of sputum, due to an increase in the proportion of the serous component in secretion bronchi. Due to the effect on the separately located in the single-layer ciliate epithelium bronchioles, Clara cells and alveolocytes, the drug stimulates the effect on the surfactant system. Ambroxol has the ability to increase the permeability of the vascular barrier of the broncho-pulmonary system. So the drug has mucolytic and secretory effects.
After taking the drug, its active substance is almost completely adsorbed. The maximum concentration is achieved in 1-3 hours. After the first pass through the human liver, the bioavailability of ambroxol when administered orally decreases by one-third. The active substance of the preparation is 85% capable of binding to plasma proteins. Ambroxol is able to penetrate the blood-brain barrier, through the placenta and, accordingly, into the breast milk, so this should be taken into account when prescribing for pregnant women, and for women in the period lactation.
Metabolites Ambroxol formed in the liver, are excreted by the kidneys about 90%. The remaining 10% is displayed unchanged. When an overdose of the drug, hemodialysis and forced diuresis are ineffective due to a high degree binding to blood plasma proteins of the drug, and also because the drug slowly passes from tissues to blood.
When taking the drug during severe violations of the kidneys, it is possible to accumulate its metabolites. In cases of severe liver disease, the rate of clearance of the body from the drug is reduced by 20-40%.
Indications for use
The main direction of using the drug according to the instructions are respiratory diseases. These include:
- bronchitis;
- pneumonia;
- bronchial asthma;
- bronchiectatic disease;
- chronic obstructive pulmonary disease;
- respiratory distress syndrome in newborns or premature infants;
- acute, chronic diseases of the respiratory tract, accompanied by a violation of sputum transport.
Contraindications
Contraindications are:
- Hypersensitivity;
- Children under 6 years;
- Pregnancy 1 trimester;
- Intolerance to fructose.
It is also indicated that with caution the drug is used in such patients who have a history of:
- Disturbance of bronchial motility;
- Formation of secret in large quantities;
- Syndrome of motionless cilia;
- Renal and hepatic insufficiency;
- Peptic ulcer of the gastrointestinal tract;
- Pregnancy 2-3 trimesters;
- Age to 2 years for solution.
Application in pregnancy and lactation
- I trimester of pregnancy - therapy is contraindicated;
- II-III trimesters and the period of breastfeeding - the drug may be administered with caution.
Dosage and route of administration
As indicated in the instructions for use Flavamed take after meals: tablets - without chewing and drinking with a sufficient amount of liquid, a solution - using a measuring spoon. Duration of application is determined individually, depending on the indications and course of the disease.
- Adults and children over 12 years of age within the first 2-3 days are prescribed 3 times / day for 30 mg (1 table. or 2 measured. spoon (10 ml) solution, which corresponds to 90 mg ambroxol hydrochloride / day, then - 2 times / day to 30 mg (1 tab. or 2 measured. spoons), (corresponding to 60 mg of ambroxol hydrochloride / day. If necessary, to increase the therapeutic effect, you can appoint 60 mg (2 tablets). or 4 measured. spoon (20 ml) solution) 2 times / day (corresponding to 120 mg ambroxol hydrochloride / day).
- Children aged 6 to 12 years: 2-3 times / day for 15 mg (1/2 table. or 1 metric. spoon solution), which corresponds to 30-45 mg ambroxol hydrochloride / day.
- Children aged 2 to 6 years, the drug is prescribed only in the form of a solution 3 times / day in 1/2 measure. spoon (2.5 ml), which corresponds to 22.5 mg of ambroxol hydrochloride / day.
- Children under 2 years: 2 times / day on a 1/2-liter spoon (2.5 ml) solution, which corresponds to 15 mg ambroksola hydrochloride / day.
With renal failure or severe liver damage, you should increase the interval between doses or reduce the dose.
Without the appointment of a doctor, Flavamed should not be taken more than 4-5 days.
Adverse Reactions
Side effects were manifested as:
- Allergic reactions of cutaneous and respiratory type;
- Diarrhea, dry mouth, constipation, nausea, vomiting and pain in the stomach;
- Exanthema;
- Weakness and headache;
- Dysuria;
- Toxic epidermal necrolysis;
- Syndrome Stevens-Johnson.
The most frequent among the side symptoms were skin manifestations in the form of itching, hives and swelling. The very manifestation of symptoms appeared only in some people prone to allergic reactions,
Overdose
The main symptoms: vomiting, short restlessness, nausea, diarrhea; in case of taking the drug in significantly exceeding the recommended doses (above 25 mg / kg per day) - drooling, lowering of arterial pressure.
Therapy: the intake of fat-containing products, artificial vomiting, gastric lavage in the first 1-2 hours after receiving Flavamed, symptomatic treatment.
special instructions
In severe renal failure, it is necessary to take into account the possibility of cumulation of metabolites of ambroxolol formed in the liver.
To maintain the secretolytic action of ambroxol during the period of taking the drug, it is necessary to ensure the intake of liquid in the body in sufficient quantities.
When prescribing the drug for patients with diabetes mellitus, it should be borne in mind that in 5 ml of the solution (1 met. spoon) contains 1.75 g of sorbitol, which corresponds to 0.15 XE.
Compatibility with other drugs
Increases the penetration into the bronchial secret of amoxicillin, cefuroxime, erythromycin and doxycycline.
With combined use of ambroxol and antitussive drugs that suppress the cough reflex, due to the weakening of the cough reflex, there can be a danger of congestion in the bronchi.
Reviews
We offer you to read reviews of people who used Flavamed:
- Lydia. Three years in the morning there was a raw cough, like that of smokers, (I never smoked). What I did not drink from the drugs and what I did not use: the photon and the heating and grinding did not help anything. But Flavamed (pills) helped. Until now, I do not know what a cough is.
- Arseny. I started taking Flavamed tablets when I realized that the cough was caused not just by a cold, but by a serious illness. I did not want to go to the doctor, so I bought them at the nearest pharmacy. It turned out that I'm allergic to one of the components of the composition, so the pills made the complication. I will not take any more money that I have assigned myself.
- Alina. Very worthy cough remedy. It is not surprising, because the active substance ambroksol. Always very carefully check the composition of the medicine. To me the preparation very well helps or assists, if a cough dry and difficultly leaves a sputum. Literally a couple of days (a day or two) and there comes a relief. Also I continue to take, when the cough became "wet the secret is secreted quickly. I recommend unequivocally. The undoubted advantage is that "Flavamed" is released in the form of syrup, which is convenient for treating bronchitis in children. I gave the child - I liked it. The syrup has a pleasant taste and smell.
Analogues
Replace the drug can with mucolytic or expectorant effect on the basis of the same or another active ingredient. Analogues of the medicine:
- Lazolvan - pastilles, solution for inhalation, tablets and syrup based on ambroxol;
- Mukolvan - a solution and tablets with mucolytic action;
- Ambroben - capsules, tablets, syrup and solution based on the same active ingredient;
- Mucosol - a solution for infusions, syrup and capsules containing carbocysteine;
- Lazoleks - solution for inhalation and oral drops containing ambroxol;
- Ambrospray is an oral solution with the same active substance;
- Fljuditik - syrup for children and adults based on carbocysteine;
- Pectolvan - strawberry syrup containing carbocysteine, ambroxol hydrochloride.
Before buying an analogue, consult your doctor.
Shelf life and storage conditions
Store at temperatures up to 25 ° C. Keep away from children.
Shelf life:
- tablets - 2 years;
- solution - 3 years.
After opening the package, the solution can be taken for 6 months.
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