Pyridoxine - what is this vitamin?

Pyridoxine is a vitamin B6, clothed in a tablet or injection form.

Strictly speaking, vitamin B6 is represented by three different vitamers, which pass one into another - pyridoxine, pyridoxal and pyridoxamine, but only one of them, pyridoxine, is used as a medicinal preparation.

Although by and large this is not so important: in any case, when passing through the liver, all vitamers pyridoxine are converted into pyridoxal, which, in turn, is phosphorylated to form pyridoxal phosphate.

Clinical and pharmacological group

Vitamin B6.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much does Pyridoxine cost in pharmacies? The average price is at the level of50 rubles.

Form of issue and composition

Dosage forms of pyridoxine:

• Solution for injection (1 or 2 ml each in an ampoule, in a contoured cell pack 5 ampoules, in a cardboard bundle 1 or 2 packs complete with a knife ampoule, in a contour cell packing 10 ampoules, in a cardboard bundle 1 or 2 packs complete with a knife ampoule; in a cardboard box 10 ampoules complete with a knife ampoule).
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• Tablets: flat-cylindrical, white, with a risk and chamfer, a slight marble is possible (50 pcs. Each). in a bank of light-protective glass or in a polymer bank, in a cardboard bundle of 1 bank; 50 pieces each. in a polymer bottle, in a cardboard bundle 1 bottle, it is also possible to release polymer cans and vials without packs; 10 pieces each. in a planar cell package, in a cardboard bundle of 1, 2, 3, 4 or 5 packages; 10 pieces each. in contour non-cellular packages, placed in a group package).

Active substance: pyridoxine hydrochloride - 10 mg in 1 tablet; 10 or 50 mg in 1 ml of the solution.

An additional substance in the solution is water for injection.

Pharmacological effect

Pyridoxine normalizes the functioning of the central and peripheral nervous system, participates in the exchange of aminocarboxylic acids: glutamine, tryptophan, methionine and others. Vitamin b6 promotes normal lipid metabolism.

The use of pyridoxine will help start the metabolic processes of the body by converting the active substance into pyridoxal-6-phosphate. This compound is a coenzyme substance that activates the enzymes necessary for the normal metabolism of amino acids and lipids.

Indications for use

Pyridoxine in tabletsapply for the treatment and prevention of hypo- and avitaminosis B6.

As part of complex therapy Pyridoxine is recommended for use in the following diseases:

1. Lesions of the nervous system (Meniere's syndrome, neuralgia);
2. Toxicosis of pregnant women (sideroblastic, microcytic and hypochromic anemia);
3. Hepatitis in acute and chronic form.
4. Seborrheic and non-seborrheic dermatitis, shingles, neurodermatites, psoriasis, exudative diathesis and other dermatological diseases.

Injectionuse for the prevention and treatment of hypo- and avitaminosis B6 (long-term infectious diseases, malnutrition, syndrome malabsorption, enteritis, diarrhea, sprue, prolonged stress, condition after removal of the stomach and large areas of the intestine, hemodialysis).

As part of combination therapy, the agent is used to treat congenital pyridoxine-dependent convulsive syndrome in newborns.

Also, tablets and injectable solutions are recommended for use in combination with isoniazid and other anti-tuberculosis drugs to prevent or reduce the toxic manifestations of the latter (the onset of seizures).

Contraindications

The presence of hypersensitivity to the components of the drug is a contraindication to the use of pyridoxine.

In patients with peptic ulcer of the stomach and duodenal ulcer and ischemic heart disease, caution should be exercised when prescribing the drug.

Use in pregnancy and lactation

In spite of the fact that vitamin B6 is necessary for women during pregnancy and lactation, use of Pyridoxine in this situation is possible only according to the doctor's prescription.

Dosage and route of administration

The instructions for use indicate thatPYRIDOXIN Tabletstaken inside after eating. They are not chewed and washed down with enough water. The average dosage of the drug for the treatment of vitamin B6 deficiency in adults is 80 mg 4 times a day, for the prevention of hypovitaminosis - 40 mg per day.

For a comprehensive treatment of various pathologies, the physician selects the dose of the drug individually.

Pyridoxine injections: instructions for use

A solution for injections is also used to treat and prevent vitamin deficiency or hypovitaminosis of vitamin B6. Additionally, water for injection is used. In pharmacies, the drug is sold strictly by prescription. Enter the solution intramuscularly, subcutaneously or intravenously. Adults and children are given a daily dose individually, depending on the severity of the condition.

The daily need of a child is up to 20 mg. Adults are recommended at 100 mg / day, but you can prescribe up to 600 mg / day (convulsive syndrome), up to 25 days.

Side effects

The use of both dosage forms of the preparation, in accordance with the annotation, in rare cases can be accompanied by: allergic reactions (skin rash, urticaria), increased acidity of the stomach, abdominal pain, a feeling of compression of the limbs, as well as a decrease in lactation.

Overdose

Data on the overdose of tablets Pyridoxine to date, no.

special instructions

With caution apply for peptic ulcer of the stomach and duodenum, IHD.

With severe liver damage, pyridoxine in high doses can cause deterioration of its function.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. With simultaneous use, potentiates the action of diuretics.
2. When combined with levodopa, the effects of levodopa are reduced or completely inhibited.
3. With simultaneous use with hormonal contraceptives, an increase in the concentration of pyridoxine in the blood plasma is possible.
4. With simultaneous use with isonicotinhydrazide, penicillamine, cycloserine, a decrease in the effectiveness of pyridoxine is possible.
5. With simultaneous use with phenytoin, phenobarbital, the concentrations in the blood plasma of phenytoin and phenobarbital may decrease.
6. The physiological function of vitamins B1 and B6 is the potentiation of the action of each other, manifested in a positive effect on the nervous, muscular and cardiovascular systems.

Reviews

We picked up some reviews of people who used vitamin B6 Pyridoxine:

1. David. I was given this vitamin in connection with numbness and tingling in the legs and hands. I went through two courses of treatment. Since the first was not all normalized. Numbness and tingling went away gradually. True, the second course had a small rash on his neck. I do not know if it was a side effect of pyridoxine. But he helped me.
2. Lisa. Vitamin B6 was prescribed for anemia along with iron preparations. Analyzes were not made special beforehand. And such treatment with a finger into the sky hit the spot, hemoglobin rose. After the course of treatment with vitamin and iron was no longer lowered.
3. Angela. I tried to take a group of vitamins at the same time in tablets, it seemed to me more effective and convenient, but there was no effect and the expected result. I decided to try each group separately. She started with B6, felt relief, pains diminished. Since I have a disease of the nervous system, permanent neuritis and neuralgia, I have to go through a mandatory course once a year, but it's not at all difficult, and even more so that I myself learned to stab. The pains have decreased much, but the main thing is to prevent an exacerbation, otherwise you will have to undergo a complete course, and it is enough to pierce it for prevention.

Analogues

Structural analogs for the active substance:

• Pyridoxine bufus;
• Pyridoxine Vial;
• Pyridoxine hydrochloride.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Pyridoxine should be stored, according to the annotation, in a sheltered from sunlight, a cool and dry place. Shelf life - 36 months.

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