Dexamethasone injections: instruction

Dexamethasone, injections

Other dosage forms: ophthalmic ointment, tablets.

Ampoules "Dexamethasone" produces several manufacturers, in addition, there are synonyms:

• Decadron;
• Dexaven;
• Dexazone;
• Dexamed;
• Dexafar;
• Dexon.

More corticosteroids >>

Price

The average price online * 197 p. (pack of 25 ampoules)

Where can I buy:

Instructions for use

"Dexamethasone" is a drug that is used as an anti-inflammatory drug, and also stops attacks of allergy and skin itching. The medicine belongs to the group of glucocorticoids, therefore it is used only for the prescribing of the attending physician.

Description and properties

"Dexamethasone" is a hormonal remedy of a wide spectrum of action. The preparation has the following properties:

• effectively removes inflammation;
• eliminates allergic reactions;
• has anti-shock effect;
• normalizes the water balance;
• participates in the synthesis of glycogen;
• supports glucose homeostasis;
• helps to adjust the exchange of sodium and potassium;
• shows immunosuppressive activity;
• removes itching (on the skin and mucous membranes).

The main component of the drug is dexamethasone, which powerfully affects the epicenter of the lesion, allowing you to quickly cope with even the inflammatory processes of high intensity.

"Dexamethasone" for injections is available as a solution in ampoules of 1 and 2 ml (25 ampoules per pack).

The therapeutic effect is:

• at intravenous introduction - instantly (within 5-15 minutes);
• when administered intramuscularly - after 8 hours.

The drug has a long-term effect, which reaches 3 to 4 weeks (when injected into the muscle) and from 3 days to 3 weeks with topical use (introduction of the substance into the affected area).

Indications

"Dexamethasone" in the form of injections is usually used for pronounced inflammatory processes, as well as allergic reactions to external stimuli(as a rule, in case of emergency).

Indications for the use of injections of "Dexamethasone" are:

• brain tumors accompanied by swelling;
• Puffiness of the brain, formed as a result of craniocerebral trauma or surgical intervention;
• bronchial asthma (in the stage of exacerbation);
• acute bronchitis;
• dysfunction (acute failure) of the adrenal cortex;
• shock state (including anaphylactic shock);
• therapy of lymphoma and leukemia patients older than 18 years;
• leukemia (acute) in patients of childhood;
• Hypercalcemia on the background of cancer (if oral use is not possible);
• the need for a diagnostic study of the adrenal cortex;
• conjunctivitis and other eye diseases (if there is a risk of vision loss or significant deterioration);
• fibrous-compacted folliculitis;
• annular granuloma;
• sarcoidosis;
• severe attacks of allergies (extreme);
• joint damage, accompanied by inflammation of non-infectious nature.

Dosing and Administration

Dexamethasone is a prescription hormone drug, the injection form should be prescribed and administered by a specialist. Self-medication is fraught with consequences.

"Dexamethasone" before use can be diluted with saline or glucose, while categorically It is forbidden to mix the drug with other medicinal products (in one syringe or vial for droppers).

The initial dosage for adult patients is, mg (administered intravenously or intramuscularly), after which the dosage regimen can be adjusted if necessary.

For allergic diseases, the drug is administered intramuscularly to the first injection of 4-8 mg. Further treatment is preferably carried out with tablets.

Intravenous injection through a syringe is done when emergency help is needed. Even in this case, the administration of the drug should last several minutes.

Intravenous is preferably administered by the infusion method (dropper). To carry out the infusion, isotonic sodium chloride solution or 5% dextrose solution is used.

For the treatment of shock - in / in 20 mg in the first administration, then 3 mg / kg for 24 hours in the form of intravenous infusions or / in struyno - from 2 to 6 mg / kg in a single injection or 40 mg in the form of a single injection, administered every 2 to 6 hours; possibly intravenously 1 mg / kg once. The shock therapy should be canceled, as soon as the patient's condition stabilizes, the usual duration is not more than 2-3 days.

With oncology:

Dosage of the drug in other ways of administration:

Type of administration	Dosage
Intra-articular (general)	, -4 mg
Introduction to large joints	2-4 mg
Introduction to small joints	, -1 mg
Introduction to the synovial bag	2-3 mg
Introduction to the tendon vagina	, -1 mg
Introduction to the tendon	1-2 mg
Local introduction (in the affected area)	, -4 mg (maximum 2 times)
Introduction to soft tissue	2-6 mg

Important!

The drug in the joint area is introduced only once, subsequent administration is allowed after 3-4 months. The total number of injections per year (in one joint) should not exceed 3-4 times, otherwise there is a risk of damage to the cartilage tissue.

Dosing of the drug when used in children (only by intramuscular route)

Indications	Dosage	Multiplicity of application
Insufficiency of the adrenal cortex	2, μg / kg	3 injections (put once every three days)
, 6-1, 5 μg / kg	1 time in knocking every day
Other indications	2, 6-16, 5 μg / kg	Every 12-24 hours

Contraindications

"Dexamethasone" in injections is used in short courses, however, there are certain limitations for its use, for example:

• osteoporosis;
• fungal and viral damage to the organs of vision, purulent infections of the eyes, trachoma, glaucoma, corneal pathology (for use in ophthalmology);
• infectious diseases in the absence of treatment (viral, fungal and bacterial);
• lactation;
• Cushing's syndrome;
• idiopathic thrombocytopenic purpura (for injections into the muscle);
• intolerance of the components of the drug.

Caution should be applied "Dexamethasone" to persons who have the following diagnoses:

• cirrhosis of the liver;
• hepatitis;
• impaired renal function;
• psychosis.

Use during pregnancy and GW

Use during pregnancy is possible only for life indications. The drug penetrates through the placenta, the action category on the fetus by FDA-C (animal studies have revealed a negative effect on the fetus, proper studies in pregnant women were not).

Unfortunately, sometimes there is a situation of a threat to the life of the patient, in this case there are no alternatives. All glucocorticoids are categorized as C.

Side effects

When injecting "Dexamethasone the following undesirable consequences were diagnosed:

• redness of the skin in the face and neck;
• convulsions;
• heart failure;
• nervous excitability;
• a feeling of anxiety;
• violation of orientation in space;
• euphoria, hallucinations;
• cataract;
• glaucoma;
• increased intraocular pressure;
• local reactions (with local administration);
• burning and numbness at the injection site;
• loss of vision.

Important!With prolonged intraarticular administration, there is a risk of rupture of the tendon.

Other

The drug is sold by prescription. Shelf life - 2 years from the date of production. Store in the refrigerator or at room temperature (not above 25 degrees).

A source: http://xnbtbfgpcpblyt3f.xnp1ai/deksametazon-ukoly/

Dexamethasone injections - instructions for use, for which purpose eye drops and tablets are prescribed, the price

07.02.2017

DEXAMETAZON instructions for use (injections in ampoules, eye drops, pills).

DEXAMETHASONE is a powerful synthetic glucocorticoid (containing hormones of the adrenal cortex and their synthetic analogues) with a preparation intended for regulation of protein, carbohydrate and mineral exchange. Also recommend reading the article: Kanefron - instructions for use

Dexamethasone instructions for use, reviews, analogs and forms of release (tablets, mg, injections in ampoules (injection solution), ophthalmic octane drops) drugs for the treatment of inflammation in adults, children and pregnancy.

Composition

• Active substance - dexamethasone sodium phosphate (in terms of dexamethasone phosphate) mg / mg;
• Excipients - glycerin, disodium phosphate dihydrate, disodium edetate, water for injection.

Forms of release

1. Tablets 0.5 mg .;
2. Solution in ampoules for intravenous and intramuscular injection (injections for injections) 4 mg / ml;
3. Drops of eyes Oftan,%;
4. Eye suspension,%

Dexamethasone instructions for use

Oral administration of Dexamethasone in the form of tablets suggests the administration of 10-15 mg of the drug in day at the initial stage of treatment with a subsequent decrease in the daily dose to 2 mg with a maintenance therapy. The daily dose of the drug Dexamethasone recommends that you divide by 2-3 admission (after or during meals).

DEXAMETASON nyxes in ampoules, eye drops, tablets - instructions for use

Supportive small doses should be taken once a day, preferably in the morning.

Dexamethasone in ampoules is intended for intravenous (drip or jet), intramuscular, perarticular and intraarticular administration. The recommended daily dose of Dexamethasone for these methods of administration is 4-20 mg.

Dexamethasone in ampoules is usually applied 3-4 times a day for 3-4 days with the subsequent transition to tablets.

Dexamethasone drops are used in ophthalmology: in acute conditions 1-2 drops of the drug are instilled into the conjunctival sac every 1-2 hours, with improvement of the condition - every 4-6 hours. Chronic processes suggest the use of Dexamethasone drops 2 times a day.

Indications for use of Dexamethasone

Diseases requiring the introduction of high-speed GCS, as well as cases where oral administration of the drug is not possible:

• Shock (burn, traumatic, operating, toxic) - with ineffectiveness of vasoconstrictors, plasma-substituting drugs and other symptomatic therapy;
• Severe allergic reactions, anaphylactic shock;
• Diseases of the blood: acute hemolytic anemia, agranulocytosis, idiopathic thrombocytopenic purpura in adults;
• Endocrine diseases: acute adrenal cortex insufficiency, primary or secondary adrenocortical insufficiency, congenital hyperplasia of the adrenal cortex, subacute thyroiditis;
• Local application (in the area of ​​pathological education): keloids, discoid lupus erythematosus, annular granuloma;
• Rheumatic diseases - Dexamethasone instructions for use;
• In ophthalmic practice (subconjunctival, retrobulbar or parabulbar injection): allergic conjunctivitis, keratitis, keratoconjunctivitis without epithelial damage, iritis, iridocyclitis, blepharitis, blepharoconjunctivitis, scleritis, episcleritis, inflammatory process after eye injuries and surgical interventions, sympathetic ophthalmia, immunosuppressive treatment after corneal transplantation;
• Acute severe dermatoses;
• Malignant diseases: palliative treatment of leukemia and lymphoma in adult patients; acute leukemia in children; hypercalcemia in patients with malignant tumors, with the inability of oral treatment;
• Severe infectious diseases (in combination with antibiotics);
• Cerebral edema (with a brain tumor, craniocerebral trauma, neurosurgical intervention, cerebral hemorrhage, encephalitis, meningitis, radiation injury);
• Systemic diseases of connective tissue;
• Asthmatic status; severe bronchospasm (exacerbation of bronchial asthma, chronic obstructive bronchitis).

For what purpose tablets Dexamethasone

• With hypothyroidism (a condition with a persistent deficiency of thyroid hormones);
• With rheumatoid arthritis in the phase of exacerbation;
• With congenital adrenogenital syndrome (hyperfunction of the adrenal cortex and increased content of androgens in the body);
• With Addison-Birmer disease (loss of adrenal glands ability to produce enough hormones);
• When pemfigus (skin disease, manifested in the form of blisters on the hands, genitals, mouth, etc.);
• With acute and subacute thyroiditis (inflammation of the thyroid gland);
• With acute erythroderma (redness of the skin);
• With progressive ophthalmopathy (increased volume of eye tissue) associated with thyrotoxicosis (intoxication with thyroid hormones);
• With acute eczema;
• In diseases of connective tissue;
• In malignant tumors (symptomatic therapy);
• With autoimmune hemolytic anemia;
• With edema of the brain;
• With agranulocytosis (a decrease in the level of neutrophils in the blood);
• With bronchial asthma;
• With serum sickness (immune reaction to foreign whey proteins).

What is the purpose of the drops Dexamethasone

Eye Drops Dexamethasone

• With scleritis (inflammation of deep layers of the sclera of the eye);
• In keratitis (inflammation of the cornea of ​​the eye);
• With sympathetic ophthalmia (inflammatory lesions of the eye);
• With neognoynom and allergic conjunctivitis (inflammation of the mucous membrane of the eye);
• With iritis (inflammation of the iris of the eye);
• With blepharitis (inflammation of the edges of the eyelids);
• In inflammatory processes after eye injuries or surgeries;
• With iridocyclitis (inflammation of the iris and ciliary body);
• With episcleritis (inflammation of connective tissue between conjunctiva and sclera);
• With keratoconjunctivitis (simultaneous inflammation of the conjunctiva and the cornea of ​​the eye) without damage to the epithelium.

What are the prescribed injections in ampoules Dexamethasone

Dexamethasone injections (ampoules)

• In acute hemolytic anemia;
• In acute adrenocortical insufficiency;
• With asthmatic status;
• In acute lymphoblastic leukemia (malignant disease affecting the bone marrow, spleen, lymph nodes, thymus gland and other organs). Dexamethasone instructions for use;
• With edema of the brain;
• In severe infectious diseases;
• With shock of different genesis;
• In diseases of joints;
• With thrombocytopenia;
• In severe allergic reactions;
• With acute croup (inflammation of the larynx and upper respiratory tract);
• With agranulocytosis.

Contraindications

For short-term use according to vital indications, the only contraindication is hypersensitivity to dexamethasone or the components of the drug.

In children during the growth period, SCS should be used only in absolute indications and under the strictest supervision of the attending physician.

Carefullythe drug should be prescribed in the following diseases and conditions:

• Pregnancy;
• Diseases of the cardiovascular system (including the recently transferred myocardial infarction - in patients with acute and subacute myocardial infarction, the outbreak can spread necrosis, slowing the formation of scar tissue and, as a result, the rupture of the heart muscle), severe chronic heart failure, arterial hypertension, hyperlipidemia);
• Parasitic and infectious diseases of a viral, fungal or bacterial nature (currently or recently transferred, including recent contact with patients) - herpes simplex, herpes zoster (viremic phase), chicken pox, measles; amebiasis, strongyloidiasis; systemic mycosis; active and latent tuberculosis. Dexamethasone instructions for use. The use in severe infectious diseases is permissible only against the background of specific therapy;
• Hypoalbuminemia and conditions predisposing to its occurrence;
• Diseases of the gastrointestinal tract - peptic ulcer of the stomach and duodenum, esophagitis, gastritis, acute or latent peptic ulcer, newly created intestinal anastomosis, ulcerative colitis with perforation or abscessing threat, diverticulitis;
• Systemic osteoporosis, myasthenia gravis, acute psychosis, poliomyelitis (except for the form of bulbar encephalitis), open and closed angle glaucoma;
• Immunodeficiency conditions (including AIDS or HIV infection);
• Endocrine diseases - diabetes (including a violation of carbohydrate tolerance), thyrotoxicosis, hypothyroidism, Itenko-Cushing's disease, obesity (3-4 items);
• Severe chronic renal and / or hepatic insufficiency, nephrourolythiasis;
• Pre- and post-vaccination period (8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination.

Interaction with other drugs

Therapeutic and toxic effects of Dexamethasone reduce barbiturates, phenytoin, rifabutin, carbamazepine, ephedrine and aminoglutethimide, rifampicin (accelerate metabolism); somatotropin; antacids (reduce absorption), increase - estrogen-containing oral contraceptives. Simultaneous use with cyclosporine increases the risk of seizures in children.

The risk of arrhythmias and hypokalemia increases cardiac glycosides and diuretics, the likelihood of edema and arterial hypertension - sodium-containing drugs and nutritional supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin B and inhibitors of carbonic anhydrase; risk of erosive and ulcerative lesions and bleeding from the gastrointestinal tract - non-steroidal anti-inflammatory drugs. Dexamethasone instructions for use.

With simultaneous use with live antiviral vaccines and against other types of immunization, increases the risk of virus activation and infection.

Simultaneous use with thiazide diuretics, furosemide, ethacrynic acid, carbonic anhydrase inhibitors, amphotericin B can lead to severe hypokalemia, which can enhance the toxic effects of cardiac glycosides and nondepolarizing muscle relaxants.

Weaken the hypoglycemic activity of insulin and oral antidiabetics; anticoagulant - coumarins; diuretic - diuretic diuretics; Immunotropic - vaccination (suppresses antibody formation).

It worsens the tolerance of cardiac glycosides (causes potassium deficiency), reduces the concentration of salicylates and praziquantel in the blood. It can increase the concentration of glucose in the blood, which requires correction of the dose of hypoglycemic drugs, sulfonylurea derivatives, asparaginase.

A source: https://MirOtvet.ru/zdorove/lekarstva/deksametazon-instrukciya-po-primeneniyu.html

Dexamethasone Nyxes: Instructions for Use

The drug Dexamethasone belongs to the group of glucocorticosteroid hormones and has a pronounced anti-inflammatory, anti-allergic, anti-edema property on the body.

Form of formulation and composition of the preparation

Dexamethasone is available in several dosage forms.

Solution for injection is a clear liquid without any smell and impurities, colorless or slightly yellowish tinge.

The solution is produced in glass ampoules of brown color with a volume of 1 or 2 ml of 25 pieces in a cardboard bundle with a detailed description for use.

The main active ingredient of the drug is dexamethasone sodium phosphate, and also auxiliary components: methylparaben, water for injection, sodium metabisulphate, sodium hydroxide, disodium edetate.

Pharmacological properties of the drug

Solution for injection Dexamethasone is a glucocorticosteroid of synthetic origin. The drug has a pronounced anti-inflammatory, immunosuppressive, anti-allergic and anti-edematous effect.

After the injection, the injected therapeutic effect develops almost instantly and persists for a long time.

Indications for use

The drug Dexamethasone in the form of injections is prescribed to patients who have the following diseases and pathologies:

• Diseases of the endocrine system - insufficiency of adrenal function, thyroiditis in subacute flow, congenital hyperplasia of the adrenal cortex;
• Different types of shock - traumatic, burn, surgical, hypovolemic - in those cases when other drugs do not give proper effectiveness;
• Systemic diseases of connective tissue - lupus erythematosus, rheumatoid arthritis and others;
• Asthmatic status, bronchospasm, when the patient's condition is not stopped by habitual medicinal preparations;
• Anaphylactic shock, severe angioedema;
• Cerebral edema caused by infectious diseases, craniocerebral trauma, neurosurgical intervention, hemorrhagic stroke and other conditions;
• Severe course of dermatitis and neurodermatitis in the phase of exacerbation;
• Complex treatment of malignant oncological diseases in adults and children;
• Treatment of idiopathic thrombocytopenic purpura in adult patients;
• Severe diseases of the organs of the visual canal;
• Common infectious diseases with severe course as part of complex therapy with antibiotics.

Contraindications to use

The drug Dexamethasone can be used for treatment only as directed by a specialist.

Before starting therapy, the patient should carefully read the attached instructions, since Dexamethasone has some contraindications and limitations to use.

Absolute contraindication to injections of Dexamethasone is the individual intolerance of the preparation by the patient's body. The drug with special caution and only under strict indications is prescribed in the presence of the following conditions:

• Gastric or duodenal ulcer in an exacerbation phase or in an anamnesis;
• The period of intensive growth in children;
• Nonspecific ulcerative colitis with a high risk of perforation;
• Herpes simplex;
• Diseases of infectious, viral, fungal, parasitic origin;
• The period before and after the vaccination (from 2 weeks to 2 months);
• Lymphadenitis caused by the introduction of a vaccine against tuberculosis;
• Human immunodeficiency syndrome;
• Recently suffered myocardial infarction, acute myocardial infarction;
• Severe course of arterial hypertension;
• Chronic heart failure in the stage of decompensation;
• Diabetes;
• Disease of Itenko-Cushing;
• Obesity in patients 3-4 degrees;
• Severe renal or hepatic insufficiency;
• Pregnancy in the first trimester;
• Glaucoma.

Method of administration and dosage

The drug Dexamethasone in the form of a solution for injection is intended for intravenous fluid administration, intravenous drip infusions, intramuscular injections. In addition, local administration of the solution to the pathological focus is allowed, if necessary and according to indications.

The dose of the drug is determined by the doctor strictly individually for each individual patient, depending on the indications and its general condition.

To prepare a solution for intravenous infusion, a saline solution of sodium chloride or a 5% dextrose solution is used as the solvent.

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The dose of the drug for the treatment of acute allergic reactions in children is calculated individually, based on the body weight and general condition of the patient.

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After achieving the desired therapeutic effect, the dose of Dexamethasone is reduced gradually, so that there is no withdrawal syndrome and severe disruption of the functioning of the adrenal cortex. If further therapy is necessary, the patient can be gradually transferred to oral treatment with Dexamethasone tablets.

Use of the drug during pregnancy and breastfeeding

Use of this medication in the first trimester of pregnancy is not recommended. If necessary, the drug in the 2nd and 3rd trimesters of pregnancy, doctors carefully evaluate the potential risks to the fetus.

Studies have shown that prolonged administration of Dexamethasone in the body of a pregnant woman can lead to impairment fetal growth and fetal growth, in addition, there is also a chance of developing adrenal cortex atrophy newborn.

The drug Dexamethasone during breastfeeding women is not assigned. If it is necessary to treat the drug, lactation is recommended to stop and transfer the child to artificial feeding with milk formula.

Side effects

Against the background of treatment with Dexamethasone in the form of injections, the following side effects can be observed in patients:

• On the part of the organs of the endocrine system - the development of steroid diabetes, a violation of the adrenal glands, a decrease tolerance to glucose, development of the Itenko-Cushing syndrome, delay in puberty in adolescents, increase in indices blood pressure;
• On the part of the organs of the digestive canal - the development of pancreatitis, nausea. Desires for vomiting, abdominal pain and dyspepsia, increased appetite, changes in liver transaminases;
• From the heart and blood vessels - bradycardia, violations of the heart rhythm, violation of the function of blood coagulability, change in the parameters of the electrocardiogram;
• From the nervous system - overexcitation, emotional lability, violation of orientation in space, the development of depression or hallucinations, insomnia, dizziness, in rare cases, development seizures;
• On the part of the organs of vision - increased indicators of intraocular pressure, cataracts, atrophy cornea and optic nerve, development of eyelashes, decreased visual acuity, sensation of foreign body in the eye;
• Increased sweating, weight gain;
• Allergic reactions to the skin;
• Poor healing of wound surfaces, bruising under the skin, increased or decreased pigmentation, hypotrophy of subcutaneous fat;
• Thrombophlebitis, pain along the veins, burning, numbness of the skin, in rare cases, necrosis of surrounding tissues at the injection site (as a rule, when the vein is punctured) can develop;
• Feeling of heat in the face, withdrawal syndrome.

An overdose of the drug

When too large doses of dexamethasone are administered or if the drug is used for a long time, the patient develops symptoms of overdose, which are expressed in the enhancement of the above-described side effects and inhibition of cortical function adrenal glands. In severe cases with an overdose of hormones, adrenal insufficiency develops in patients.

Treatment of an overdose is symptomatic. Therapy with the drug is completely canceled or simply reduces the dose.

Interaction with other medicinal products

At simultaneous appointment to the patient of injections of Dexamethasone and phenobarbital, ephedrine, rifampicin, a decrease in the therapeutic effect of hormones is observed.

With the simultaneous administration of injections with diuretics in patients, there is an increase in the excretion of potassium from the body, which can cause the development of severe heart failure.

With concurrent administration of the drug dexamethasone with sodium-containing drugs, the risk of developing severe edema and increasing blood pressure values ​​increases.

Dexamethasone can weaken the therapeutic effect of indirect anticoagulants, so patients need to adjust their dose.

Anticoagulants for oral use, which the patient takes concomitantly with Dexamethasone injections, may increase the risk of gastric and duodenal ulcer.

Simultaneous use of Dexamethasone with non-steroidal anti-inflammatory agents or ethanol increases the risk of ulceration on the mucous membranes of the digestive system channel.

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When using injections of the drug with paracetamol or its analogs, the risk of toxic damage to the liver increases.

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Dexamethasone weakens the therapeutic effect of insulin and hypotensive drugs, so patients need to adjust their dose.

special instructions

During the treatment with Dexamethasone, patients should constantly monitor the indices arterial pressure, the state of the organs of vision, water-electrolyte balance and clinical picture blood.

In order to reduce the risk of side effects, the patient should follow a diet with high potassium content. Food should be rich in protein, carbohydrate intake and salt should be somewhat reduced.

Patients with abnormalities in the work of the liver Dexamethasone prescribe with extreme caution.

When using the drug in pediatric practice, you should closely monitor the dynamics of growth child, since prolonged use of the drug in large doses can lead to growth inhibition patient.

Patients with diabetes should constantly monitor blood glucose levels and, if necessary, adjust the daily dose of hypoglycemic drugs.

Analogues of injections Dexamethasone

Analogues of the drug Dexamethasone solution for injection are the following:

• Dexamed;
• Dexaven;
• Dexazone;
• Dexamethasone-ferein.

Conditions of dispensing and storage of the drug

The drug Dexamethasone in the form of a solution for injection is dispensed from pharmacies according to a doctor's prescription.

Store the drug in a place inaccessible to children, avoiding direct sunlight on the package, at a temperature of not more than 25 degrees. Do not freeze the contents of the ampoule.

Shelf life of the drug in the form of a solution is no more than 3 years from the date of production, subject to compliance with the temperature regime. If there are any impurities or suspensions in the ampoule, the drug should be discarded!

Dexamethasone in ampoules

The average cost of the drug Dexamethasone in the form of a solution for injections in pharmacies in Moscow is 90 rubles per package.

A source: http://bezboleznej.ru/deksametazon

Dexamethasone in ampoules intravenously, intramuscularly and for inhalation - which is prescribed and contraindications

In diseases of the endocrine system, doctors use the drug Dexamethasone in ampoules, the effect of which is to influence the metabolism of carbohydrates and proteins in the body.

This is a strong medicine containing hormones, so it should be used with caution and control.

Find out when treatment with ampoules of the drug is applied, how to properly inject, whether there is a risk of side effects.

What is Dexamethasone

In diseases of the endocrine system and the brain, doctors can prescribe injections of Dexamethasone.This drug is hormonal, contains a substance from the group of glucocorticosteroids, secreted by the adrenal cortex.

It has a strong effect on carbohydrate-protein metabolism, so the drug is prescribed to children only on absolute indications because of the risk of violations.

Getting inside, the active substance starts to act very quickly, providing anti-stress, anti-inflammatory and anti-allergic effects.

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Dexamethasone acts within the cells. The drug regulates the exchange of sodium, potassium, water balance, glucose level, increases the synthesis of fatty acids.

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The anti-shock, immunoregulating effect develops eight hours after intramuscular injection of the ampoules, the action lasts from a few hours to four weeks.

The drug solution, which is sold in pharmacies in ampoules, contains dexamethasone sodium phosphate. This active substance takes 4 or 8 mg.

Dexamethasone solution for internal administration looks like a transparent colorless or yellowish liquid.

pharmachologic effect

Dexamethasone is used as a long-acting systemic drug, has a desensitizing effect and has an immunosuppressive activity.

The main fat-soluble substance of the drug binds to albumin proteins, accumulates in the liver, kidneys and other organs.

From the body, the compound is excreted in the urine.

For what purpose

Intramuscular, intravenous or intra-articular injections are prescribed at the following indications:

• dysfunction of the endocrine system - acute insufficiency of the adrenal cortex, surgical interventions, severe injuries;
• shock - resistant to therapy, anaphylactic;
• cerebral edema caused by metastases, tumors, neurosurgical interventions, craniocerebral trauma;
• Oncology - leukemia, lymphoma, leukemia, hypercalcemia;
• exacerbation of obstructive bronchitis, bronchial asthma;
• severe allergies;
• inflammation of the joints;
• fibro-compressed folliculitis, annular granuloma, sarcoidosis;
• eye diseases of inflammatory or allergic nature, treatment after corneal transplantation.

Instructions for dexamethasone in ampoules

The drug is available in the form of tablets, ampoules for injections and eye drops. Solutions for injections have a dosage of 4 mg of active substance per 1 ml, are presented in a package of 10 pieces.

Each tube is made of clear glass.

Dexamethasone's other form of ampoule contains five injection units inside a contour cell pack of polymer film, two pieces in a cardboard bundle.

Instructions for use of the drug call for caution in using the drug for patients with Arterial hypertension, heart failure, glaucoma, epilepsy, myasthenia and thromboembolism. There are other limitations:

• the action of the drug may increase liver cirrhosis, hypothyroidism;
• treatment can mask infectious signs, exacerbate systemic fungal diseases, latent amoebiasis, pulmonary tuberculosis;
• during therapy, contraindications are vaccination with live viruses due to the lack of expected antibody production, preventive action;
• Do not use for eight weeks before and for two weeks after vaccination;
• It is not recommended for use in treatment after surgery or fracture of bones.
• the drug slows the healing and formation of the bone callus;
• the drug is stored for two years at a temperature of up to 25 degrees, it can not be frozen;
• specific conditions of leave from the pharmacy - according to the prescription.

When bearing a child, therapy with Dexamethasone is possible, but only with the benefit of treating a mother exceeding the risk to the fetus.

The doctor prescribes the medication according to the vital indications, so he has the right to prescribe the medicine for the pregnant woman.

During breastfeeding, you can not use the medicine, because the active substance enters the milk, adversely affects the health and development of the child.

Children

Dexamethasone for inhalations can be used by children with a nebulizer. Such a safe way of use eliminates the risk of burns of the laryngeal mucosa.

For the procedure, you need to prepare a solution - dilute 1 ml of the ampoule in 6 ml of saline. In its pure form, use of the medicine is prohibited. Diluted means strictly before inhalation, the amount - 3-4 ml.

The course of therapy with ampoules of Dexamethasone lasts a week, procedures can be performed up to four times a day.

There are a number of rules for the use of inhalations:

• do not give the child an hour before the procedure;
• make sure that the baby is not active for half an hour before inhalation, so breathing, heartbeat and body temperature will return to normal;
• inject the inhalation solution into a nebulizer, then use a mouthpiece or put a mask on the baby;
• the child should sit in front of the nebulizer, inhale the couple 5-10 minutes;
• Inhaled infantile babies are lying in a dream: put a mask on the sleeping child;
• the baby must breathe calmly, evenly, shallow-deep breaths lead to spasm and coughing;
• Watch out for the baby's slow exhalations until his lungs are completely empty.

How much can I apply

Depending on the patient's medical history, the doctor prescribes a course of application of Dexamethasone ampoules. If the effect is achieved, the dosage of the drug is reduced.

Long ampoules should not be used because there is a risk of developing acute adrenocortical failure. Approximate the duration of the course of treatment is up to four days, then the patient takes the pill as a supportive treatment.

How to stab

Enter Dexamethasone intravenously, intramuscularly or intraarticularly. The first two methods involve jet or injection through a dropper with glucose or saline.

It is forbidden to mix Dexamethasone intramuscularly with other medicines in one syringe.

The initial dose is, -9 mg, in just a day it is allowed to inject up to 20 mg of medication into 3-4 times in soft tissues.

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With intra-articular use, the dose of the active substance from the ampoule is -4 mg once, the course is repeated after 3-4 months.

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The drug in one joint is allowed to enter no more than four times a year, at the same time it is allowed to treat only two joints. If you use Dexamethasone more often, according to reviews, there is a risk of damage to the cartilage.

Dose depends on the size of the joint - in large to 4 mg, small - up to 1.

Side effects

Ampoules of Dexamethasone contain a steroid hormone, so there is a risk of side effects:

• anaphylaxis;
• redness of the face due to the influx of blood into the vessels;
• malfunctions of the heart;
• convulsions;
• confusion, agitation, restlessness;
• disorientation, paranoia, depression, euphoria;
• hallucinations, glaucoma, cataract;
• increased intraocular pressure;
• allergic reactions to the skin, striae, tendon ruptures, subcutaneous tissue atrophy;
• the occurrence of disorders of the gastrointestinal tract;
• development of sudden blindness, burning numbness, pain at the injection site.

Contraindications

Instructions for the use of ampoules Dexamethasone distinguishes the following contraindications:

• osteoporosis;
• acute viral infections, bacterial or fungal diseases;
• lactation;
• lesions of the eyes, purulent infection, corneal defects, epithelium, trachoma, glaucoma;
• the state of sensitivity to the composition of the drug;
• chronic renal failure, cirrhosis of the liver, development of hepatitis, acute psychosis.

Overdose

With too active use of Dexamethasone for several weeks, an overdose is possible, which is manifested by the symptoms listed among the side effects.

Treatment is made according to the manifested factors, is to reduce the dose or the temporary withdrawal of the drug. When an overdose is not a particular antidote, hemodialysis is not effective.

Interaction

Instructions for use Dexamethasone distinguishes the following drug interactions:

• phenobarbital, ephedrine reduce the effectiveness of the drug;
• Dexamethasone lowers the effectiveness of hypoglycemic, anticoagulant, antihypertensive medications;
• taking with other glucocorticosteroids leads to an increased risk of hypokalemia;
• when used with oral contraceptives, the half-life of Dexamethasone increases;
• Ritodrin is not allowed to be used concomitantly with the drug in question due to the risk of death;
• the possibility of enhancing the action of antibiotics;
• for the prevention of nausea and vomiting after chemotherapy, it is recommended to apply simultaneously Dexamteazone and Metoclopramide, Diphenhydramine, Prochlorperazine, Ondansetron, Granisetron.

Analogues

The following analogs of Dexamethasone stand out for the active ingredient and indications for use:

• Vero-Dexamethasone;
• Dexaven;
• Dexamethasone-Betalek;
• Decadron;
• Dexamed;
• Dexazone;
• Dexamethasone-Vial;
• Maxidex;
• Dexamethasone-lang;
• Dexapos;
• Dexon;
• Dexafar;
• Megadexan;
• Fortecortin;
• Oftan Dexamethasone.

The price of dexamethasone in ampoules

The medicine can be bought inexpensively in the online store or ordered from the pharmacy department. From the level of pharmacy and format depends on how much Dexamethasone costs in ampoules. Approximate cost is indicated in the table:

Format, manufacturer	Price on the Internet, rubles	Price in pharmacy, rubles
4 mg 1 ml 25 pcs. Slovenia	186	200
4 mg 1 ml 25 pcs. Russia	129	150
4 mg 1 ml 25 pcs. Ukraine	175	190

: Use of Dexamethasone

A source: http://sovets.net/12383-deksametazon-v-ampulah.html