Tablets and injections Meloksikam: instructions for use

Meloxicam is a non-steroidal, anti-inflammatory agent.

The acting substance of the drug with the same name "meloxicam" - has analgesic, antipyretic and anti-inflammatory effect. Selectively blocks cyclooxygenase of the second type - the main enzyme responsible for the formation of pathological mediators of inflammation.

After 5-6 hours after ingestion (once), the maximum concentration of the active substance is reached by the blood plasma. After 3-5 days of regular repeated administration of Meloxicam, the equilibrium state of the active substance in the blood is reached. The half-life is determined on average within 20 hours.

Clinical and pharmacological group

NSAIDs.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much are the tablets for Meloxicam? The average price in pharmacies is at the level of40 rubles.

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Form of issue and composition

Meloksikam is produced in the following dosage forms:

1. Tablets, mg and 15 mg.
2. Solution for intramuscular injection (injections in ampoules for injection).
3. Candles for rectal administration, mg and 15 mg.

The preparation contains the main active substance meloxicam and the following auxiliary substances: MCC, aerosil 380 (silica colloidal dioxide), magnesium stearate, starch 1500 (pregelatinized starch) and sodium citrate dihydrate.

Pharmacological effect

Meloxicam is a nonsteroidal anti-inflammatory drug that belongs to the group of oxycamides and has antipyretic and analgesic properties.

Meloksikam is completely absorbed into the digestive tract. For this reason, eating does not have any effect on the absorption of the drug. The maximum concentration of the drug after a single application of Meloxicam inside is achieved after five to six hours.

Indications for use

Meloksikam, according to the instructions, is prescribed for exacerbation of arthrosis, rheumatoid arthritis, chronic polyarthritis, for the treatment of ankylosing spondylitis (Bekhterev's disease).

Contraindications

Contraindications to the use of Meloxicam according to the instructions are:

• Exacerbation of peptic ulcer of stomach and duodenum;
• Hypersensitivity, including sensitivity to other non-steroidal anti-inflammatory drugs;
• Active gastrointestinal bleeding;
• Lactation period;
• Severe hepatic impairment;
• Diseases of the liver in the active phase;
• Pregnancy;
• Kidney disease in the progressing phase;
• Confirmed hyperkalemia;
• Condition after surgery for aortocoronary bypass surgery;
• Age under 12 years;
• Inflammatory bowel disease.

Injections and pills Meloxicam should be used with caution:

• Against the background of coronary heart disease;
• To people of advanced age;
• On a background of cerebrovascular diseases;
• With chronic heart failure;
• Against the background of diabetes mellitus;
• With dyslipidemia;
• When smoking;
• In diseases of peripheral arteries;
• Against the background of severe somatic diseases;
• In the presence of H. infectious disease Poulori;
• With ulcerative lesions of the gastrointestinal tract in the anamnesis;
• Against the background of alcoholism;
• With prolonged use of non-steroidal anti-inflammatory drugs;
• Simultaneously with oral administration of anticoagulants (including warfarin), glucocorticosteroids (including prednisolone), antiplatelet agents (including clopidogrel), selective serotonin reuptake inhibitors (including citalopram, paroxetine, fluoxetine, sertraline).

For rectal administration, Meloxicam is contraindicated for use on the background of a rectal or anal bleeding and inflammatory diseases of the rectum and anal area both during treatment and in the anamnesis.

Use in pregnancy and lactation

The use of this drug in pregnant women is strictly contraindicated.

The drug can be excreted in breast milk, so the use of tablets Meloksikam during breastfeeding is contraindicated. If you need treatment, a woman should stop lactation.

Dosage and route of administration

The instructions for use indicate that the pill Meloxicam is taken orally with meals at a daily dose of 7.5-15 mg.

Recommended dosing regimen:

1. Rheumatoid arthritis: 15 mg per day. Depending on the therapeutic effect, the dose can be reduced to 7.5 mg per day.
2. Osteoarthritis: 7.5 mg per day. If the dose is ineffective, it can be increased to 15 mg per day.
3. Ankylosing spondylitis: 15 mg per day. The maximum daily dose should not exceed 15 mg.

In patients with an increased risk of side effects, as well as in patients with severe renal failure who are on hemodialysis, the dose should not exceed 7.5 mg per day.

Instruction for driving

Solution for injection Meloxicam is intended exclusively for intramuscular injection. Intravenous administration of the solution can not be done, because it can provoke severe allergic reactions or inflammation of the vein wall with thrombosis and embolism.

The duration of application of injections of Meloxicam during one course of therapy is 3 - 5 days. After this, for subsequent maintenance treatment, it is necessary to switch to taking Meloxicam in tablets. The dosage of the injection solution depends on the type and severity of the disease, and is usually determined individually. Currently, the standard standard dosages of the solution for various diseases are as follows:

1. Rheumatoid arthritis - administer 15 mg (, ml, 1 ampoule) once a day for 3 to 5 days.
2. Ankylosing spondylitis - administer 15 mg (, ml, 1 ampoule) once a day for 3 to 5 days.
3. Osteoarthrosis - enter, mg, (5 ml of solution, which corresponds to half the ampoule) once a day for 3 to 5 days, then go to the reception in the form of tablets. If after the first injection the condition has not improved, then the dosage is increased to 15 mg (, ml, 1 ampoule) and also administered 1 time per day for 3 to 5 days.
4. Other inflammatory and degenerative diseases of the joints (arthritis, arthrosis) - inject, mg, (5 ml, 1/2 ampoule) once a day for 3 to 5 days.

Elderly people (over 65 years of age) should be administered for only 7, 5 mg (0, 75 ml, 1/2 ampoules) of Meloxicam once a day for 3 to 5 days for any diseases. People with kidney failure, but who have creatinine clearance greater than 25 ml / min, can use Meloxicam in usual dosages without reducing them. And with a creatinine clearance of less than 25 ml / min, it is necessary to reduce the dosage of the drug and administer, for any disease, no more than, mg (5 ml, 1/2 ampoule) per day.

The maximum allowable daily dosage in adults and relatively healthy people is 15 mg (1 ampoule, ml), and for those with a high risk of side effects, mg (5 ml, 1/2 ampoule).

Side effects

With intramuscular injection of Meloxicam may occur:

1. Respiratory system: acute asthma attack;
2. Urinary system: impaired renal function;
3. Organs of vision: conjunctivitis, impaired vision;
4. Skin: photosensitization, urticaria, skin rash, itching;
5. Cardiovascular system: edema; rarely - high blood pressure, strong palpitations;
6. Central nervous system: confusion of thoughts, headache, disorientation, dizziness, drowsiness, tinnitus;
7. Gastrointestinal tract (GIT): inflammation of the mouth, digestive disorders, gastritis, nausea, diarrhea, vomiting, bleeding from the gastrointestinal tract, flatulence, ulceration of the stomach and duodenum, pharyngitis, constipation;
8. Organs of hematopoiesis: thrombocytopenia, leukopenia, anemia.

When using Meloxicam in the form of tablets, there may be:

1. Organs of hematopoiesis: often - anemia; infrequently - a change in the blood formula (including thrombocytopenia, leukopenia);
2. Digestive system: often - dyspepsia, including nausea, vomiting, constipation, flatulence, diarrhea, abdominal pain; infrequently - esophagitis, gastroduodenal ulcer, belching, transient increase in hepatic transaminase activity, bleeding from the gastrointestinal tract (including latent), stomatitis, hyperbilirubinemia; rarely - gastritis, perforation of the gastrointestinal tract, hepatitis, colitis;
3. Cardiovascular system: often - peripheral edema; infrequently - tides of blood to the face, increased blood pressure, palpitations;
4. Skin: often - skin rash, itching; infrequently - hives; rarely erythema multiforme, including Stevens-Johnson syndrome, photosensitivity, bullous eruptions, toxic epidermal necrolysis;
5. Nervous system: often - headache, dizziness; infrequently - drowsiness, vertigo, noise in the ears; rarely - emotional lability, disorientation, confusion;
6. Respiratory system: rarely - bronchospasm;
7. Urinary system: infrequently - hypercreatininaemia and / or increased urea concentration in blood serum; rarely - acute renal insufficiency; hematuria, albuminuria, interstitial nephritis (association with drug administration is not installed);
8. Organs of the senses: rarely - conjunctivitis, impaired vision, including blurred vision;
9. Allergic reactions: rarely - anaphylactic / anaphylactoid reactions, angioedema.

Overdose

In case of an overdose, an increase in the severity of the side effects described above is recorded. It requires timely post-dandruff therapy, gastric lavage.

Specific antidote and antagonists are not developed.

special instructions

Before you start using the drug, read the special instructions:

1. Meloksikam, as well as other NSAIDs, can mask symptoms of infectious diseases.
2. In patients with a slight or moderate decrease in renal function (creatinine clearance more than 30 ml / min), dosage adjustment is not required. Patients taking both diuretics and meloxicam should take a sufficient amount of fluid.
3. If in the course of treatment there were allergic reactions (itching, skin rash, urticaria, photosensitivity), as well as patients, marking against the background of taking the drug of a visual impairment, it is necessary to consult a doctor with the purpose of resolving the issue of discontinuing admission preparation.
4. The use of meloxicam, as well as other drugs that block the synthesis of prostaglandins, can affect fertility, so it is not recommended for women planning a pregnancy.
5. During the treatment period, care must be taken when driving vehicles and occupying others Potentially hazardous activities requiring increased concentration and speed psychomotor reactions.

Care should be taken when using the drug in patients who have a history of ulcerative disease of the stomach and duodenum, as well as in patients on anticoagulant therapy. In such patients, the risk of erosive and ulcerative gastrointestinal lesions is increased. Caution should be exercised and the renal function should be monitored when the drug is used in elderly patients, patients with chronic cardiac insufficiency with circulatory failure, in patients with cirrhosis of the liver, as well as in patients with hypovolemia as a result of surgical interventions.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. With simultaneous application with colestyramine, the excretion of the drug from the body is accelerated.
2. With simultaneous use with antihypertensive drugs, it is possible to reduce the effectiveness of the latter.
3. When used simultaneously with other non-steroidal anti-inflammatory drugs (as well as with acetylsalicylic acid) increases the risk of erosive ulcerative lesions and bleeding GIT.
4. With simultaneous use with methotrexate, the side effect of the latter on hematopoietic system (the risk of anemia and leukopenia, the periodic analysis of the general analysis blood).
5. With simultaneous use with lithium preparations, development of cumulation of lithium and increase of its toxic effect (it is recommended to control the concentration of lithium in the blood).
6. With simultaneous use with diuretics and with cyclosporine, the risk of developing kidney failure increases.
7. When used simultaneously with anticoagulants (heparin, ticlopidine, warfarin), as well as with thrombolytic drugs (streptokinase, fibrinolysin) increases the risk of bleeding (periodic monitoring of indicators is necessary coagulability of blood).
8. With simultaneous use with intrauterine contraceptives, the effectiveness of the latter may be reduced.
9. When used simultaneously with selective serotonin reuptake inhibitors, the risk of developing gastrointestinal bleeding increases.

Reviews

We picked up some reviews of people taking pills Meloxicam:

1. Regina. Saw arkoxia, it did not help. Began to drink meloxicam and already on 3 day polegchalo. Gonarthrosis of the knees 2 st.porazhenie all the joint, oksartroz. But I punctured meloxicam in injections for 5 days and midokalm 10 days. After meloksikama, drink it for 10 days I'll start beating alflutop and don. I can not walk, now I walk with a cane, oli have become smaller. And yet, I noticed, each of us has his own medicines, oh there is a need to find it, the organization is different for everyone. Dear arkoksia not come, meloxicam approached. Look for friends your medications and listen to your body.
2. Tatyana. The doctor prescribed 10 injections for coxaratosis of 2 degrees accompanied by severe pain during walking and at night. I pierced all 10, I had to stop after the 5th, because the side effects in the form severe dizziness, confusion, headaches, disorientation, at first thought that from weather. But it has not been 4 weeks already.
3. Oleg. I had a case, I injured an ankle during a game of football. The pain was strong, and the edema did not take long. Immediately began taking ibuprofen, but there was not much sense in it. I went to a traumatologist, he advised Meloksikam. The drug is not cheap, but the effect is good. On the second day of pain, the pain decreased noticeably, and by the end of the week they completely subsided. After, weeks completely restored the joint.

Analogues

Complete analogues of the preparation Meloxicam are:

• Amelotex;
• Arthrosan;
• Bee-ksikam;
• Lem;
• M-Kam;
• Matarin;
• Medsikam;
• Melbeck;
• Melbek forte;
• Meloks;
• Meloksam;
• Meloksikam DS;
• Meloksikam Pfizer;
• Meloxicam Sandoz;
• Meloksikam SHTADA;
• Meloksikam Prana;
• Meloksikam Teva;
• Meloflam;
• Meloflex Rompharm;
• Mesipol;
• Mixol Aud;
• Mirlocks;
• Movalis;
• Movasin;
• Movix;
• Exen Sanovel.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in a dry place, protected from light, out of reach of children, at a temperature not exceeding +25 ° С. Shelf life - 2 years.

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