Trimetazidine

Trimetazidine is a medicinal product of antihypoxic and antianginal action. Improves the metabolism of neurosensory organs and cardiac muscle in ischemic conditions.

The main active component of the drug Trimetazidine has an antihypoxic effect on cardiomyocytes (cardiac muscle cells) and neurocytes (cells of the nervous system). It helps to increase the resistance of cells to insufficient intake of oxygen (hypoxia) by improving the flow of metabolic processes, accumulation of ATP (adenosine triphosphoric acid, which is the main supplier of energy within cells). The antihypoxic effect leads to an improvement in the functional state of the heart, its contractility.

Time to reach the maximum plasma concentration in the blood - about 5 hours. Over 24 hours, the concentration of the substance in the blood plasma is maintained at a level greater than and equal to 75% of the maximum concentration determined over 11 hours. With regular intake, the equilibrium concentration is reached after 60 hours.

Clinical and pharmacological group

A drug that improves the metabolism of the myocardium and neurosensory organs under conditions of ischemia.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much is Trimetazidine in pharmacies? The average price is at the level of130 rubles.

Composition and form of release

Medicinal forms of the release of Trimetazidine MB:

• modified release tablet, film-coated / film-coated: pink to brownish pink, round, biconvex, on one side with risk; the core on the transverse section - from almost white or white to white with a yellowish tinge.
• tablets prolonged action, film-coated: from light pink to pink, round, biconvex; the core on the cross section is white or almost white.

Composition 1 modified release tablet:

• active substance: trimetazidine dihydrochloride 35 mg;
• additional components: colloidal silicon dioxide - 2 mg; anhydrous calcium hydrogen phosphate 157 mg; hypromellose - 50 mg; magnesium stearate - 1.5 mg; crospovidone - 2.5 mg; talc - 2 mg;
• shell: Opadry II pink (85F34610) (polyvinyl alcohol - 40%, titanium dioxide - 24.24%, macrogol 3350 - 20.2%, talcum - 14.8%; dye iron oxide yellow - 0.37%; red iron oxide dye 0.36%; dye iron oxide black - 0.03%) - 8 mg.

Composition 1 tablet prolonged action:

• active substance: trimetazidine dihydrochloride 35 mg;
• additional components: magnesium stearate - 1.55 mg; colloidal silicon dioxide - 1.55 mg; hypromellose - 93 mg; microcrystalline cellulose - 178.9 mg;
• shell: Opadry II 85F240012 pink (macrogol-3350 - 2.438 mg, talc - 1.48 mg, polyvinyl alcohol - 4 mg, dye iron oxide red - 0.04 mg; coloring iron oxide yellow - 0.022 mg; titanium dioxide - 2.02 mg) - 10 mg.

Also, conventional trimetazidine is produced (without a CF prefix) at a dosage of 20 active ingredients.

pharmachologic effect

Trimetazidine is a drug that helps normalize the energy metabolism of cells that have undergone ischemia or hypoxia. The drug prevents the decrease in the content of ATP inside the cells, ensures normal operation ionic membrane channels, transmembrane transfer of potassium and sodium ions and supports cellular homeostasis. Trimetazidine inhibits the oxidation of fatty acids due to the selective inhibition of 3-ketoacetyl-CoA thiolase, leading to increased processes oxidation of glucose and the restoration of the connection between oxidative decarboxylation and glycolysis, thereby contributing to the protection of the myocardium from ischemia.

The basis of antianginal action of the drug is the process of switching the oxidation of fatty acids to the process of oxidation of glucose. The drug helps maintain the energy metabolism of the neurosensory organs and the heart during ischemic episodes; reduces intracellular acidosis and changes in the ischemic ionic transmembrane flow that occurs during ischemia; reduces the degree of infiltration and migration in reperfusion and ischemic tissues of the heart of polynucleated neutrophils, reduces the degree of damage to the myocardium, without affecting hemodynamics.

With stenocardia, Trimetazidine reduces the frequency of attacks, after two weeks of taking the drug increases tolerance to physical exertion, blood pressure drops decrease. The drug improves hearing, reduces tinnitus and dizziness.

In the presence of vascular pathology, the eye contributes to the restoration of the functional activity of the retina.

Indications for use

Indications for the appointment of Trimetazidine are:

1. Chorioretinal vascular disorders.
2. Vertigo of vascular origin.
3. Cohleo-vestibular disorders (hearing impairment, tinnitus, dizziness).
4. Prevention of angina attacks, ischemic heart disease (as part of complex treatment or as a monotherapy).

Contraindications

• glucose-galactose malabsorption, lactase deficiency, lactose intolerance;
• Parkinson's disease and Parkinson's symptoms;
• renal failure of severe degree (creatinine clearance less than 30 ml / min);
• pregnancy;
• lactation period;
• age to 18 years;
• hypersensitivity to any ingredient in the drug.

Trimetazidine is taken with caution in the following cases:

• hepatic failure of severe degree;
• renal failure of moderate degree (creatinine clearance 30-60 ml / min);
• age over 75 years.

Dosage and route of administration

As indicated in the instructions for use, Trimetazidine MB (35 mg active ingredient) is taken orally, without chewing, wholly, with water, preferably with food.

• The recommended scheme of application: 2 times a day (morning and evening) for 1 tablet (maximum). The duration of the course is determined by the doctor individually.

Patients with moderate renal failure, including elderly patients (with clearance of creatinine 30-60 ml / min), tablets Trimetazidine CF 35 mg should be taken 1 time per day in the morning. To select a dose for patients older than 75 years is necessary with extreme caution.

Tablets or capsules Trimetazidine 20 mg

Intended for oral administration (ingestion). They are taken with food, do not chew and drink with enough liquid.

• The recommended therapeutic dosage is 20 mg 3 times a day. It is allowed to increase to 40-60 mg if necessary.

The regime and duration of the use of this medication is determined by the attending physician individually, which depends on the severity of the heart ischemia or brain structures.

Side effects

Against the background of taking tablets or capsules of Trimetazidine, it is possible to develop unwanted pathological reactions from some organs and systems:

• allergic reactions: often - hives, itching, rash on the skin;
• digestive system: often - dyspeptic disorders, vomiting, nausea, abdominal pain;
• cardiovascular system: rarely - flushes of blood to the skin of the face, orthostatic hypotension;
• central nervous system: often - headache and dizziness; very rarely - akinesia, tremor and rigidity, occurring after the abolition of Trimetazidine;
• other reactions: often - asthenic cider.

Overdose

Data on overdose of capsules or tablets of Trimetazidine are limited today. In case of an overdose, symptomatic therapy is performed in a medical institution. There is no specific antidote for the drug.

special instructions

In the case of an attack of angina pectoris, the treatment should be reviewed and adapted.

The drug is not intended for relief of angina attacks, for the initial course of therapy of stable angina or myocardial infarction.

Care must be taken when driving vehicles and other potentially hazardous Activities that require increased concentration and speed of psychomotor reactions.

Interaction with other drugs

Trimetazidine increases the anti-ischemic activity of other antianginal agents.

Reviews

We offer you to read reviews of people who used Trimetazidine:

1. Natalia. The therapist prescribed "Preductal", but when I found out the cost in the pharmacy, I almost went away... Well, the pharmacist recommended that I replace it with a cheaper analogue, "Trimetazidine." After five days of treatment, I forgot about heart trouble. Gradually began to feel a surge of strength and now I feel much better!
2. Alexander. On the recommendation of a doctor, I regularly use trimetazidine 20 mg on a single tablet in the morning and in the evening for many years. At the same time I accept the Egilok and Sidnofarm. I think that it is in connection with this that I have an equilibrium in the body: much less frequent attacks of angina, which I immediately stop, normalized AD, the noise in my ears disappeared. And in order not to be afraid of sudden dizziness, I always walk with a cane. For my age (82 years) I consider this a normal situation. The effect of trimetazidine and its cost is acceptable.
3. Olga. Trimetazidine acted somewhere in the second week, I take 2 tablets a day. It happens that the head hurts from the medicine, but infrequently, his doctor advised to take it constantly, very glad that at least it is inexpensive.

Analogues

Analogues of Trimetazidine with a similar pharmacological effect, list:

1. Medarum,
2. Angiosyl,
3. Metagard,
4. Antistene,
5. Prekard,
6. Preductal.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Tablets or capsules Trimetazidine should be stored in its original packaging, in a dark, dry place inaccessible to children at an ambient temperature of no more than + 25 ° C.

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