Neurobion

width = Neurobion - a complex of three vitamins of group B. It is available in the form of tablets, as well as in the form of a solution for intramuscular injection.

These vitamins (pyridoxine, thiamine and cyanocobalamin) play an important role in the intermediate metabolism that occurs in the peripheral and central nervous system. They act as coenzymes.

Joint use of vitamins B1, B6 and B12 is due to the fact that in complex their effect is more effective than for each component separately. The combination of B vitamins accelerates regeneration processes in damaged nerve fibers.

Clinical and pharmacological group

Complex of B vitamins.

Conditions of leave from pharmacies

Available without a prescription.

Price list

How much does Neurobion cost in pharmacies? The average price is at the level of300 rubles.

Form of issue and composition

The drug Neurobion is available in the form of white tablets coated with protective film shells in blisters of 10 pieces for 1 or 2 blisters in a cardboard bundle. The drug is accompanied by an instruction with a detailed description.

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Active ingredients and their content in 1 ampoule and 1 tablet:

Thiamine hydrochloride (vitamin B1): 100 mg;
Pyridoxine hydrochloride (vitamin B6): 100 mg and 200 mg (respectively);
Cyanocobalamin (vitamin B12) (respectively): 1 mg and, 4 mg (including 20% excess).

Tablet excipients: methylcellulose, gelatin, corn starch, lactose monohydrate, magnesium stearate, talc.

Composition of the tablet coating: methylcellulose, glycerol 85%, acacia, silicon colloidal dioxide, povidone 25, titanium dioxide, kaolin, calcium carbonate, gelatin, wax, sucrose, talc.

Pharmacological effect

Neurobion contains a complex of vitamins of group B, which are neurotropic active substances:

Vitamin B1 (thiamine hydrochloride). Takes direct part in the work of the human nervous system, as well as the conductivity of nerve impulses. In addition, vitamin is an important catalyst in the metabolism of carbohydrates and the synthesis of proteins and lipids. Its lack in the body provokes the development of such conditions as nervousness, fatigue and depression.
Vitamin B6 (pyridoxine hydrochloride). It is necessary for most chemical reactions taking place in cells and tissues. It normalizes protein and protein metabolism in the body. The lack of vitamin B6 leads to a decrease in the production of serotonin, the hormone responsible for controlling the emotional state, sleep and appetite.
Vitamin B12 (cyanocobalamin). He takes an important part in hematopoiesis due to his ability to form red blood cells. Promotes active growth of the epithelium, which positively affects the regeneration of damaged tissues. In addition, B12 increases the amount of myelin produced - a substance involved in the formation of nerve endings.

Indications for use

What helps? Neurobion is used in the complex therapy of neurological diseases. Indications for the use of the drug are:

intercostal neuralgia;
pain syndrome caused by diseases of the spine - lumboeishalgia, plexopathy, radicular, cervical, cervico-brachial syndrome,
degenerative disorders;
Neuropathic pain caused by diabetic or alcoholic polyneuropathy;
neuritis, trigeminal neuralgia;
paresis of the facial nerve;
attacks of herpes zoster on the back.

Contraindications

Contraindicated in pediatric practice (due to a high dose of components), with increased sensitivity to the components of the drug. Tablets contain fructose and lactose, therefore they are contraindicated for the corresponding enzymatic deficiency.

Also, according to some researchers, do not use group B vitamins in the presence of malignant oncology pathology, tk. theoretically, drugs in this group can lead to accelerated growth of the tumor, especially in tumors nervous tissue.

Use in pregnancy and lactation

It is not recommended to take the drug Neurobion during pregnancy, as well as during lactation due to the high content of B vitamins.

Dosage and route of administration

The instructions for use indicate that Neurobion tablets are taken orally, without chewing, with a small amount of water, during or after a meal.

The drug should be taken on 1 tab. 3 times / day or as directed by a doctor.
The duration of treatment is determined by the doctor and on average is 1-1.5 months.

It is recommended to correct the dose of the drug for more than 4 weeks.

Side effects

Reviews about Neurobion indicate that the drug causes side effects rarely. The use of Neurobionum inside can trigger the occurrence of allergic reactions, mainly in the form of skin rashes.

With intramuscular injection of the drug are possible: tachycardia, rashes and skin itching, sweating, acne, eczema, urticaria. According to reviews about Neurobion, rarely happen: anaphylactic shock, exanthema and difficulty breathing.

Overdose

With the introduction of high doses of the drug for a long time (more than 2 months), patients may experience symptoms of intoxication.

Vitamin B1: allergic reactions, headache, arrhythmia, muscle weakness, muscle spasm, paralysis.
Vitamin B6: epileptiform seizures with EEG changes, sensitivity disorders, neuropathies with ataxia. After the introduction of more than 2 grams per day, cases of seborrheic dermatitis and hypochromic anemia have been described.
Vitamin B12: allergic reactions, benign form of acne and eczematous skin disorders.

In case of an overdose, the use of the drug is canceled and symptomatic treatment is performed.

special instructions

Before you start using the drug, read the special instructions:

When signs of peripheral sensory neuropathy (paresthesia) appear, it is necessary to adjust the dose and, if necessary, stop taking the drug.
With prolonged use (more than 6-12 months) of vitamin B6 at a dose of 50 mg / day, peripheral sensory neuropathy may occur. Therefore, prolonged therapy is recommended to regularly monitor the patient's condition.
With the introduction of vitamin B12, the clinical picture, as well as the laboratory parameters with funicular myelosis or pernicious anemia, may lose their specificity.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

Antacids reduce the absorption of thiamine.
The intake of alcohol and black tea leads to a decrease in the absorption of thiamine.
Drinks containing sulphites (eg, wine), enhance the degradation of thiamine.
With simultaneous application with levodopa, pyridoxine can reduce the antiparkinsonian action of levodopa.
Thiamine is inactivated by fluorouracil. Fluorouracil competitively inhibits thiamine phosphorylation to thiamine pyrophosphate.
Simultaneous use of pyridoxine antagonists (eg, isoniazid, hydralazine, penicillamine or cycloserine) may increase the need for pyridoxine.
"Loop" diuretics, for example, furosemide, can block tubular reabsorption, thus, enhancing the excretion of thiamine with prolonged use, which leads to a decrease in thiamine in blood.

Reviews

We picked up some reviews of people who used the drug Neurobion:

Olesya. At me on it the urticaria such has begun, three weeks went with a red face, drank from an allergy of a tablet. And all the same, I need to get these vitamins, I tried to go to milgamma compositum (there B1 and B6), so he went to me, does it without money and helps me well. The neck has stopped hurting though .
Victoria. Mom began severe pain in the neck, shingles appeared, the inflammation of the trigeminal nerve began, it hurt so much that she could not sleep. The doctor appointed Neurobion in complex therapy. I pierced 10 ampoules, I do not say that he cured, but it became better, there were no side effects, although mum for 60, now in the medicine cabinet she has "Neurobion" in the form of tablets, periodically drinks when the old sores.
Alexander. For the second year I have suffered from chronic herpes zoster. Doctors say that it is necessary to strengthen immunity, but I can not. A little help injecting vitamins B - I'm prescribed Neurobion. The drug relieves the exacerbation, but not for long, a month later the symptoms reappear and make me feel uncomfortable. I will try to cope.

Analogues

Replace Neurobionum can be a number of drugs with the same composition or other, but approximately the same effect. Popular pharmacological analogues include:

Vitaxon - contains the same vitamins, but in a slightly different form;
Neuromultivitis - tablets with a combination of B vitamins;
Neurorubine is a tablet drug with a regular and reinforced vitamin B content;
Neurobex is a combined preparation with the same vitamins.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug should be stored in a place inaccessible to children and protected from exposure to ultraviolet rays. The optimum temperature for tablets should not exceed 25 C, and for a solution it is 2-8 C.

If the storage conditions are met, the expiration date of the medicinal product is 3 years.