Tablets Bisoprolol 2.5 and 5 mg: instructions and reviews of people

Bisoprolol belongs to the group of selective beta-blockers that affect the smooth muscle cells of the heart and blood vessels.

The substance blocks beta-adrenergic receptors, which receive impulses from the nervous system, which leads to a slowing of the heartbeat. Blood pressure decreases, it becomes easier for the heart to pump blood.

On this page you will find all information about Bisoprolol: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used bisoprolol. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Beta1-adrenoblocker.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does bisoprolol cost? The average price in pharmacies is at the level of50 rubles.

Form of issue and composition

The drug is available in the form of film-coated tablets, packaged in contoured cell packs, 20, 30 or 50 pieces in a cardboard bundle. Tablets of round shape, biconvex, their color varies from beige to beige with a yellowish tint, on a break from white to almost white.

• Active substance - bisoprolol fumarate, in 1 tablet - 2.5 mg, 5 mg or 10 mg.

Excipients - microcrystalline cellulose, calcium hydrophosphate dihydrate, corn starch, silicon dioxide colloidal anhydrous, magnesium stearate, sodium starch glycolate (type A), opedrai II (including polyvinyl alcohol, partially hydrolysed, talc, macrogol 3350, white coloring pigment (contains titanium dioxide E 171)).

Pharmacological effect

Bisoprolol is a drug that affects the cardiovascular system through selective blockade of beta1-adrenergic receptors.

The drug produces an anti-ischemic effect, expressed in the ability of the active component to reduce the heart rate and contractility of the myocardium. This ability of the drug reduces the need for myocardium in oxygen and improves the blood flow that feeds the muscle with blood. The hypotensive effect of the drug is due to the fact that the use of bisoprolol reduces the overall peripheral resistance and cardiac output. Bisoprolol also contributes to the relief of tachycardia, the suppression of the activity of the sympathetic nervous system, pressure, delayed atrioventricular conduction, which suggests an antiarrhythmic effect of the drug.

As the active substance acts bisoprolol fumarate. The maximum clinical effect is observed one to three hours after ingestion and is maintained for 24 hours.

Indications for use

What is it for? Bisoprolol is indicated for the following diseases:

• sinus tachycardia;
• ventricular and supraventricular extrasystole;
• arterial hypertension;
• angina pectoris (IHD);
• arrhythmia on the background of mitral valve prolapse.

Bisoprolol is prescribed for patients suffering from chronic heart failure as part of complex therapy in conjunction with inhibitors, ACE, diuretics, cardiac glycosides.

Contraindications

Bisoprolol is contraindicated in the following conditions:

• arterial hypotension (systolic pressure less than 100 mm Hg);
• severe forms of bronchial asthma and obstructive pulmonary disease;
• severe violations of peripheral circulation, Raynaud's syndrome;
• lactation period;
• syndrome of weakness of the sinus node;
• bradycardia (heart rate less than 60 beats per minute);
• cardiomegaly (no signs of heart failure);
• acute heart failure or chronic heart failure in the stage of decompensation (requiring inotropic therapy);
• cardiogenic shock;
• atrioventricular blockade of 2 and 3 degrees, without an electrocardiostimulator;
• sinoatrial blockade;
• simultaneous administration of floktaphenin, sultopride;
• simultaneous intravenous administration of verapamil, diltiazem;
• age under 18 years (effectiveness and safety not established);
• simultaneous administration of MAO inhibitors with the exception of MAO-B;
• hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;
• pheochromocytoma (without simultaneous use of alpha-blockers);
• metabolic acidosis;
• hypersensitivity to bisoprolol, the components of the drug and to other beta-blockers.

Additional medical advice is required regarding the use of bisoprolol in a strict diet and desensitizing (anti-allergic) therapy.

Application in pregnancy and lactation

Use during pregnancy and lactation is possible if the benefit to the mother exceeds the risk of side effects in the fetus and the baby.

Instructions for use

In the instructions for use indicated that take bisoprolol inside, in the morning, on an empty stomach, without chewing.

• The initial dose of 5 mg 1 time / day. If necessary, increase the dose to 10 mg 1 time / day. The maximum daily dose is 20 mg / day.
• In patients with impaired renal function with CC less than 20 ml / min or with severe impairment of liver function, the maximum daily dose should be 10 mg.

Dose adjustments in elderly patients are not required.

Side effects

The use of bisoprolol can cause various side reactions from the organs and body systems.

• The appearance of various reactions of hypersensitivity;
• Reproductive system: a violation of potency;
• Exchange processes: increased sweating;
• Musculoskeletal system: convulsions, weakness in the muscles;
• Respiratory system: narrowing of the lumen of the bronchi;
• Digestive system: various disorders of stool, abdominal pain;
• Sense organs: decreased secretion of tear fluid, inflammation of the conjunctiva of the eyes;
• Lesions of skin: the appearance of psoriasis-like rashes, itchy skin, increased symptoms of psoriasis;
• central nervous system: fatigue, headaches, various mental disorders, involuntary muscle contractions limbs, increased weakness, dizziness, sleep disorders, sensation of coldness in the limbs;
• The cardiovascular system: decreased heart rate, the appearance of severe symptoms of functional failure of the heart, increased manifestation of the syndrome Reynaud, a sharp drop in blood pressure with a change in body position, a violation of the conduction of the heart muscle.

Overdose

Exceeding the recommended therapeutic dose may lead to the development of arrhythmia, atrioventricular blockade, a pronounced decrease in speed heart attacks (bradycardia), difficulty breathing and bronchospasm, increased manifestations of cardiac and respiratory failure.

In this case, detoxification measures are carried out - washing the stomach and intestines, intravenous drip introduction of sorbing, saline solutions, symptomatic therapy.

special instructions

Treatment with the drug is usually long. The patient should not independently change the prescribed dosage or arbitrarily interrupt the course of treatment. Abrupt cancellation of the drug can provoke unwanted complications, so treatment is gradual, with a gradual decrease in dose. This rule is especially important for patients with chronic heart failure and coronary artery disease.

Treatment with bisoprolol requires regular medical supervision. The specialist should control the heart rate, blood pressure, ECG, blood glucose in patients with diabetes, kidney and liver function.

In rare cases, the use of bisoprolol may provoke the development of scaly lichen or lead to psoriatic rashes on the skin. Doctors warn that the effectiveness of the drug decreases in smoking patients, and in the category of patients using contact lenses, there may be a decrease in the production of tear fluid. With the development of depressive conditions, drug therapy should be discontinued.

Drug Interactions

With these drugs, bisoprolol is not recommended:

• blockers of calcium slow channels, for example, verapamil (myocardial contractility may decrease);
• antiarrhythmic drugs of the first class, for example, phenytoin and quinidine (cardiac contractility may decrease);
• antihypertensive agents of central action, for example, moxonidine and rilmenidine (heart failure may decrease).

Bisoprolol can be used with these drugs, but with the following limitations:

• parasympatomimetiki (the risk of bradycardia increases);
• antiarrhythmic drugs of the third class, for example, amiodarone (may be aggravated by violation of AV-patency);
• mefloquine (increased risk of bradycardia);
• some adrenomimetics, for example, isoprenaline and dobutamine (the effect of both drugs may decrease);
• radiopaque iodine-containing diagnostic intravenous drugs (the risk of developing various anaphylactic reactions increases);
• allergens used for immunotherapy (the risk of systemic allergic reactions increases)

The list is incomplete, so if you need a one-time use with other drugs, Consult your doctor in advance about any potential side effects.

Reviews

We picked up some feedback from people about the drug Bisoprolol:

1. Karina. Every time when pressure rises, "Bisoprolol" helps me. By nature, my pressure jumps in any stressful situations, so this drug always lies in my medicine cabinet. It also helps her husband, no side effects have ever been observed and the body reacts to him quite positively. It helps quite quickly, half an hour and everything is fine. At one time there were serious health problems, the doctor prescribed "Bisoprolol" and after that I accept it practically, always when I feel that it becomes bad. Although before that I used various medications, but this particular drug works best.
2. Zhenya. After a half-year reception of bisoprolol (10 mg in the morning), a blood test showed sugar 7. Handed the blood two more times - the same result. Before that, sugar did not rise above 4.7. Has changed a preparation for the lizorethik. Now everything is normal.
3. Elena. I am 34 years old. My pressure is 110/70. For the last 5 years, it has already reached 140 \ 100, the pulse is 80-104. The doctor prescribed Enalapril 2.5 mg once a day and Verapamil 40 mg 2 times a day. After drinking 3 months, nothing has changed. The pharmacy advised bisoprolol 5 mg once a day, if nothing changes, then add Amlodipine. Constant burning of the chest, hard breathing, fatigue, bad sleep, I hear my heart beating, nausea. And to everything else in the morning within an hour after awakening, low blood pressure, and after dinner strongly rises. Tell me, please, do not take less. My local doctor said: "What kind of pressure can there be in your years?" Having looked at a cardiogram 3 years ago, she prescribed Verapamil.
4. Natalia. A year ago there was a problem with pressure. She did not go to the doctor until they took her directly from the street to the ambulance. The doctors diagnosed hypertension. Long could not find a medicine. "Bisoprolol" came up perfectly. One tablet in the morning, and the whole day I'm in good condition. Cost cheap. Although the price is different. Each pharmacy has its own. I went to visit Belarus. She forgot the pills at home. There they are released in the pharmacy only on prescription. But the people there are good. We went to meet them and sold one packet. Although they say, it is not suitable for everyone. I forgot about the pressure. But you should drink regularly, not occasionally.
5. Sasha. The drug is well tolerated, gently and gradually lowers blood pressure, prevents attacks of angina pectoris. My grandmother takes this drug for several years, during which time the pain in the heart stopped, you can perform normal physical, you can lead a normal lifestyle. Dyspnea significantly decreased with exercise. At rest, shortness of breath does not bother. Arterial pressure is normalized at the second week of taking bisoprolol. "

Analogues

Bisoprolol has quite a number of structural analogs to the active substance. The most popular of them are:

• Concor;
• Concor Cor;
• Coronale;
• Niperten;
• Bisocardium;
• Thyrez;
• Aritel Cor.

Before using analogues, consult your doctor.

Which is better - Concor or Bisoprolol?

Concor is a trademark, under which the original bisoprolol is produced. The manufacturer of the drug is the German pharmaceutical company Merck KGaA. However, the term of the patent for this medicine has long expired, therefore, a large number of more affordable bisoprolol generics are currently on the market.

It is believed that they are not inferior in quality to the original drug, however, official data that would confirm this is not enough today.

Storage conditions and shelf life

The drug should be stored in a dark place inaccessible to children at a temperature of no higher than + 25 ° C. Shelf life - 3 years.

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