Nemux

Nemux refers to the pharmacological group of non-narcotic analgesics.

The drug has antipyretic, analgesic, antiaggregational, as well as anti-inflammatory therapeutic effect. In this case, Nemux has an exclusively systemic effect.

It allows you to eliminate painful symptoms, without curing the disease itself, which provoked it. It is prescribed for patients suffering from rheumatoid arthritis, malingia, algodismenosis, osteoarthritis or bursitis.

Clinical and pharmacological group

NSAIDs. Selective inhibitor of COX-2.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Nemux in pharmacies? The average price is at the level of100 rubles.

Form of issue and composition

Nemux powder is yellow, with a pleasant smell and orange flavor. Packed in sealed bags.

• Dosage of 1 packet - 100 mg of the main active substance Nimesulide in granules.
• Together with it the preparation contains: 100 mg macrogol, 19 mg citric acid (anhydrous), 40 mg colloid dioxide, 1721 mg sucrose, 20 mg orange flavor.

To take the medicine inside, it is necessary to dissolve the granules of the powder in water. The resulting suspension should be applied according to the instructions in accordance with the prescription of the doctor.

Pharmacological effect

"Nemux" is a broad-spectrum medicament that exerts a multifaceted influence on the human body. In the complex, the drug has antipyretic, anti-inflammatory, analgesic and anti-aggregative (aggregation - cell adhesion into a large multicellular formation) effects. Take the medicine to non-steroidal anti-inflammatory drugs.

Unlike all other drugs in this group, the drug "Nemux" selectively has a suppressive effect (inhibits) on COX-2, slows down and completely stops the synthesis of prostaglandins in the area of ​​inflammation. At the same time, the influence of Nemulex on COX-1 is much less pronounced. As a consequence, side effects due to inhibition of prostaglandin synthesis in healthy cells and tissues develop less frequently than in other NSAIDs.

Indications for use

Indications for use:

• tendovaginitis (inflammation of the tendon);
• algodismenarea (painful menstruation);
• osteoarthritis;
• arthritis, including rheumatoid (chronic systemic joint disease);
• Myalgia (pain in the muscles);
• arthralgia (pain in the joints);
• Bursitis (inflammation of the periarticular mucosa bag);
• toothache and headache;
• postoperative and traumatic pain.

The drug has no therapeutic effect, it removes only pain and inflammation of an episodic nature.

Contraindications

Before starting therapy with the drug, the patient is advised to consult a doctor and read the attached instructions in detail. Nemux is contraindicated in the following conditions:

1. Chronic heart failure in the stage of decompensation;
2. Crohn's disease;
3. Severe liver or kidney disease, accompanied by hepatic or renal insufficiency;
4. Pregnancy 1 and 3 trimester and the period of breastfeeding;
5. Severe cases of bronchospasm and respiratory depression in history;
6. Propensity to bleeding, hereditary blood diseases - vasculitis, hemophilia;
7. Recently transferred operations;
8. Age at children till 12 years;
9. Exacerbation of chronic diseases of the digestive canal, accompanied by erosive or ulcerative lesions of the mucous membranes;
10. Intolerance to acetylsalicylic acid or aspirin ulcer;
11. Bronchial asthma;
12. Polyps of the nasal cavity;
13. Individual intolerance to the drug.

The drug with particular caution is prescribed to persons with coronary heart disease, cardiovascular disease, diabetes mellitus.

Use in pregnancy and lactation

In these periods, as well as during pregnancy planning from the use of the drug should be discarded.

Dosage and route of administration

The instructions for use indicate that the nemulex is taken internally. The contents of 1 packet of granules are dissolved in 80-100 ml of water.

1. The recommended dose for adults and adolescents aged 12-18 years is 100 mg (1 sachet) 2 times / day after meals. The maximum daily dose for adults and adolescents aged 12-18 years is 200 mg.
2. Older patients do not need a dose reduction.
3. Patients with chronic renal failure require a reduction in the daily dose to 100 mg.

To minimize the risk of adverse reactions, the drug should be given at the lowest effective dose for as short a period of time as possible. The maximum duration of the drug is 15 days.

Side effects

Against the background of drug treatment, patients may develop side effects:

1. Reactions from the eyes: vision damage.
2. Allergic reactions: urticaria, angioedema, hypersensitivity reactions, facial swelling, anaphylactoid reactions.
3. Reactions from the side of breathing: bronchospasm, shortness of breath.
4. Reactions from the nervous activity: a sense of fear, dizziness, nervousness, headache, drowsiness, nightmares, encephalopathy.
5. Reactions from the circulation: tachycardia, arterial hypertension, hot flashes, hemorrhages.
6. Reactions from hematopoiesis: eosinophilia, anemia, thrombocytopenia, purpura, pancytopenia, lengthening of bleeding.
7. Reactions from the genitourinary sphere: dysuria, edema, hematuria, oliguria, hyperkalemia, urinary retention, interstitial nephritis, renal insufficiency.
8. Reactions from the skin: skin rash, itching, increased sweating, dermatitis, erythema, exudative erythema multiforme, epidermal toxic necrolysis.
9. Reactions from the digestive side: nausea, diarrhea, vomiting, flatulence, constipation, gastritis, stomatitis, abdominal pain, tarry stool, bleeding, ulcer 12 duodenum or stomach, jaundice, increased levels of "liver" transaminases, fulminant hepatitis, cholestasis.
10. Other reactions: weakness, hypothermia.

Overdose

Signs of an overdose of the drug are:

• nausea;
• vomiting;
• drowsiness;
• increased pressure;
• respiratory depression;
• bleeding from the gastrointestinal tract;
• apathy.

There is no antidote for this remedy. It is necessary to do a lavage of the stomach and drink a laxative, in addition, the reception of activated charcoal is prescribed.

The liver and kidneys are monitored.

special instructions

Before you start using the drug, read the special instructions:

1. If the kidney function worsens, the drug should be discarded.
2. If the drug is used for more than 2 weeks, it is necessary to monitor the liver function.
3. It is necessary to stop taking the drug in case of fever or development on the background of its intake of influenza-like symptoms.
4. Gastrointestinal bleeding or ulcer / perforation of the stomach or duodenum can develop in any the moment when using the drug and not be accompanied by clinically pronounced symptoms (including pain syndrome). If there is a gastrointestinal bleeding or ulcers, the drug should be discarded.
5. To reduce the risk of side effects, it is necessary to apply the drug at the lowest effective dose with the shortest duration. If the patient's condition does not improve, treatment should be stopped.
6. When symptoms appear in patients taking Nemulex, indicating liver damage (eg, anorexia, nausea, vomiting, abdominal pain, increased fatigue, dark urine), or increased activity of hepatic transaminases, the drug should be discontinued. It is not recommended for such patients to prescribe Nemuxle in the future.
7. In patients with cirrhosis of the liver or with renal insufficiency with hypoalbuminemia or hyperbilirubinemia, the binding of nimesulide is reduced.
8. In elderly patients, the most common side effects are when taking the drug, incl. gastrointestinal bleeding, perforation, impaired function of the heart, kidneys and liver. Therefore, regular clinical monitoring of the patient's condition is recommended.

If the application of the drug there are undesirable phenomena from the side of the central nervous system and sensory organs, then patients should refrain from driving vehicles and occupations that require an increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Nemulex can enhance the action of cyclosporin on the kidneys.
2. The physiological concentrations of unsaturated fatty acids do not affect the binding of nimesulide to serum albumin.
3. In therapeutic concentrations, the binding of nimesulide was not affected by warfarin, furosemide, glibenclamide, digitoxin.
4. It is not recommended to take the drug Nemux at the same time as diuretics, which have a damaging effect on renal hemodynamics.
5. In the presence of nimesulide, free fractions of methotrexate can increase significantly.
6. The concentration of lithium in the plasma increases with simultaneous administration of lithium preparations and the drug Nemux.
7. Taking the drug Nemux in therapeutic doses for a short period does not change the serum digoxin profile in patients with mild heart failure.
8. Nemux has no effect on drugs that affect the concentration of glucose in the blood and glucose tolerance in diabetic patients treated with sulfonylurea derivatives.
9. There is evidence that nimesulide is able to reduce the bioavailability of furosemide, compete for binding to plasma proteins of fenofibrate, salicylic acid, tolbutamides. Nemux can replace salicylic acid and furosemide (but not warfarin) in plasma proteins.
10. With the simultaneous use of the drug Nemuxle with GCS, serotonin reuptake inhibitors, the risk of developing gastrointestinal bleeding increases.

Reviews

We picked up some reviews of people who used Nemuxle powder:

1. Sasha. Well obezbalivaet. The main thing is quickly, not more than an hour. I drink from rheumatoid arthritis. Not constantly, but with increased inflammation of the joints.
2. Elena, the doctor. Excellent working generic, besides containing less sugar than the original version, which is important in some patients with carbohydrate metabolism. The price is normal compared to the same original. Efficiency showed no worse. Side effects - like all nimesulids, no more and no less.
3. Anton. Wonderful drug. The leg is strongly twisted, with all the resulting, swelling is strong, bruise pain infernal - not to step on his leg. After a tablet of diclofenac and two packets of non-moleks, I somehow began to move. The pain was definitely asleep.

Analogues

Structural analogs for the active substance:

• Actasulide;
• Amoeolin;
• Aponil;
• Aulin;
• Mesulide;
• Nyz;
• Nysulid;
• Nimegesic;
• Nimesan;
• Nimesil;
• Nimesulide;
• Nimika;
• Nimulid;
• Novolide;
• Prolid;
• Sulaydine;
• Fllolid.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Granules should be stored away from children in a cool dry place. The shelf life of the medicine is indicated on the package and does not exceed 3 years from the date of manufacture.

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