Oletketrin

Oletetrin is a bacteriostatic combined preparation that has a wide range of effects on microorganisms.

The drug can be used to treat a wide variety of diseases, if they are caused by microorganisms that are sensitive to the combination of active substances.

The market is offered in the form of tablets and a solution for injection. Among the merits of this antibiotic is the slow development of resistance to it in bacteria, due to the complex composition.

Clinical and pharmacological group

Combined antibacterial agent with a broad spectrum of action, bacteriostatic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Oletketrin cost in pharmacies? The average price is at the level of160 rubles.

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Form of issue and composition

Dosage form - coated tablets: round, biconvex, pink; On the cross-section, two layers are visible (25 pcs. in polymer cans or 10 pcs. in contour mesh packages, in a cardboard bundle of 1 can, 1 or 2 packs).

Active substances in 1 tablet:

• Tablets of 125 mg: oleandomycin phosphate - 4, mg g and tetracycline - 7, mg;
• Tablets of 250 mg: oleandomycin phosphate - 95 mg and tetracycline - 155 mg.

Additional components: potato starch, talcum medical, calcium stearate.

The composition of the shell: vaseline oil, titanium dioxide pigment, vanillin, tween-80, methylcellulose, acid red 2C.

Pharmacological effect

The drug disrupts the synthesis of bacteria and microorganisms. The active substances interfere with the formation of peptides and the bonds between them.

Highly sensitive strains of streptococci, Staphylococci, Brucella spp., Neisseria gonorrhoeae, Corynebacterium diphtheriae, Ricketsia spp., And Spirochaetaeceae. Bacillus anthracis, Legionella spp., Haemophilus influenzae, Bordetella pertussis, Klebsiella spp. and Enterobacter spp., Clostridium spp. It is quite effective in relation to chlamydia and ureaplasmas, mycoplasmas - can be prescribed for the treatment of STIs. It also helps with barley.

The key advantage of a bacteriostatic is that it is combined. Resistance develops less often than with monotherapy with tetracycline.

Indications for use

Instructions for use indicate the list of pathologies in which this antibiotic is effective:

Diseases of the ENT area:

• tonsillitis;
• pharyngitis;
• angina;
• otitis media.

Diseases of the respiratory system:

• sinusitis;
• bronchitis;
• pneumonia of focal and croupous;
• abscesses in the lungs;
• bronchiectatic disease.

Skin diseases:

• erysipelas;
• purulent skin infections

Diseases of the kidneys and the reproductive system:

• prostatitis;
• endometritis;
• cystitis;
• pyelonephritis;
• gonorrhea.

Also, oletetrin is effective in purulent meningitis, brucellosis, osteomyelitis, tularemia, and other diseases caused by a bacterial infection sensitive to oleandomycin and tetracycline.

Contraindications

The use of oletetrine is contraindicated:

1. With leukopenia;
2. With mycosis;
3. During lactation;
4. Children under 8 years - in the form of tablets, up to 12 years - in the form of capsules;
5. With renal / hepatic insufficiency;
6. Pregnant women;
7. When hypersensitivity to any active or auxiliary component of the drug, as well as to other antibiotics of the group of tetracyclines and / or macrolides.

With caution apply the drug in patients with impaired liver function.

Use in pregnancy and lactation

During pregnancy, the reception of "Oletetrine" is excluded. Tetracycline can have a negative effect on the fetus. Also, do not plan a pregnancy if the drug has already been prescribed and taken.

In the lactation period, the reception of a bacteriostatic is highly undesirable. Otherwise, it is necessary to stop feeding.

Dosage and route of administration

The instructions for use indicate that the pill Oletetrin should be taken orally, washed down with water after eating.

Average applied doses:

• Adults: 1 tablet 250 mg 4 times a day, if necessary, the daily dose is increased, but not more than 2000 mg;
• Children older than 8 years: 20-30 mg / kg body weight in 4 divided doses.

In / m, daily intake for adults - 0.2-0.3 g; the frequency of administration is 2-3 times. For children older than 8 years, the daily dose is 10-20 mg / kg. In / in jet, adults - 0.2-0.3 g in distilled or bidistilled water; rate of administration - 2 ml / min. In / in drip - 0.1% solution in 0.9% solution of sodium chloride or in a 5% solution of dextrose at a rate of 60 cap / min.

The duration of treatment is 5-10 days, depending on the severity of the disease.

Side effects

During clinical trials and practice, the following side effects were recorded:

• nausea;
• decreased appetite;
• vomiting;
• constipation;
• abdominal pain;
• diarrhea;
• glossitis;
• exophagitis;
• dysphagia;
• various allergic reactions (in the form of redness on the skin, itching, rash, eosinolia).

Among the side effects of long-term treatment are most often dyspeptic disorders, thrombocytopenia, intestinal dysbacteriosis, candidiasis, hypercreatininaemia, increased activity of liver enzymes, azotemia, hypercreatininaemia, photosensitivity, hyperbilirubinemia, hemolytic anemia, development of vitamin deficiency (vitamin K and group B).

Overdose

In case of an overdose of the drug, there may be an increase in the severity of the above-described side effects. Treatment is symptomatic.

special instructions

It is not recommended simultaneous use of oletetrin with bactericidal drugs and retinol.

Oletetrin reduces the effectiveness of oral contraceptives and increases the risk of uterine bleeding in women who take hormonal contraceptives.

After taking the drug for at least two hours, it is not recommended to drink milk and eat dairy products, as they reduce the absorption of oleandomycin and tetracycline. For the same reason, a 2-hour interval is recommended, and if necessary, simultaneous reception of colestipol, cholestyramine or preparations containing calcium, magnesium, aluminum, iron.

Oletetrin can influence the effectiveness of antithrombotic medications, so it is necessary to monitor their concentration in the blood and, if necessary, adjust the dose.

Oletetrin is contraindicated during pregnancy, since tetracycline can lead to fatty infiltration of the liver in the fetus and slow the growth of skeletal bones. Therefore, before starting taking medicine for women of childbearing age, it is recommended to exclude pregnancy in order to prevent the use of Oleletrin in the early stages. For the same reason, the whole barrier period and some time after the end of the course of therapy should use reliable barrier methods of contraception.

Drug Interactions

Oletetrin is less absorbed when taken concomitantly with antacids, iron preparations, dairy products, because of the content of calcium, aluminum, magnesium and iron in them. If a parallel course with these facilities is required, then the interval between receptions should be at least two hours.

Also, oletetrin is not prescribed together with bactericidal antibacterial agents. A parallel course with vitamin A increases the risk of rising intracranial pressure. Carefully recommend Oletketrin with anticoagulants, as it affects their effectiveness.

Analogues

There are no structural analogs to the active substance of the drug Oletketrin. Analogues on the pharmacological group (macrolides and azalides):

• Azitroxy;
• Azithromycin;
• AsitRus;
• Binocular;
• Wilprafen;
• Wilprafen solute;
• Dynabac;
• Zinerit;
• Zitrolide;
• Zitrolid forte;
• Klabaks;
• Clarithromycin;
• Clacid;
• Macropean;
• Oleandomycin phosphate;
• Pylobact;
• Rovamycin;
• Roxithromycin;
• Romiklar;
• Rulid;
• Safotsid;
• Sumamed;
• Sumamed forte;
• Sumamecin;
• Sumamox;
• Sumatrolide solute;
• Fromromide;
• Fromyloid Uno;
• Hemomycin;
• Ecomed;
• Erythromycin;
• Eryfluid;
• Hermitage;
• Esparoxy.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store the drug in a dry place, at a temperature of no higher than 25 ° C. Shelf life - 2 years. Do not use after the expiration date.

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