Capsules Penzinorm 10 000: instructions for use

Panzinorm is a combined polyenzyme preparation intended for correction of digestive processes.

It stimulates the secretion of bile, the proper enzymes of the stomach, small intestine and pancreas. The drug helps to improve the functional state of the gastrointestinal tract and normalize the digestive process.

The panzinorm in any of the dosage forms (tablets and capsules) has a protective coating, which protects enzymes from destruction in the stomach and releases them when ingested. Peak activity of the drug is observed 30-40 minutes after its administration.

Clinical and pharmacological group

Enzyme preparation.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Panzinorm at pharmacies cost? The average price is at the level of135 rubles.

.

Form of issue and composition

Dosage form: capsules: gelatinous, solid, opaque, white; the contents are pellets of beige-brown color (7 pcs. each). in blisters, in a cardboard box of 3 or 12 blisters).

Active substance: pancreatin (in the form of pellets), in 1 capsule - from 9, to 12, mg, which corresponds to the activity:

• Lipase - 10 000 ED Ph. Eur .;
• Amylase - not less than 7 200 ED Ph. Eur .;
• Proteases - not less than 400 units Ph. Eur.

Auxiliary components: dry mass (polysorbate 80, sodium lauryl sulfate), methacrylic copolymer acid and ethyl acrylate (:), dry weight (23%), simethicone emulsion 20%, talc, triethyl citrate, dispersion 30%.

The composition of the capsule: gelatin, sodium lauryl sulfate, titanium dioxide (E171).

Pharmacological effect

Pansinorm is a combined preparation that has an enzymatic action, since it contains its composition, three optimally balanced enzymes of the pancreas - lipase, amylase and protease. With the help of these substances, normal cleavage of fats, proteins and carbohydrates in the intestine is ensured.

This drug has been successfully used to treat various pathologies associated with impaired digestion of food in children and adults. Penzinorm contains enzymatic substances Pancreatin, so it is sometimes called "combined Pancreatin."

The active substances that are contained in this drug are obtained from the pancreas of cows or pigs - this means that the components of the drug are completely natural and balanced. A special acid-resistant coating covering the capsules and tablets of the drug dissolves only in the small intestine. When released, the enzymatic substances of the Panzinorm are mixed with partially processed intestinal food and help it to digest it better.

Pharmacokinetics

Pancreatic enzymes are natural constituents that ensure the digestion of nutrients. Acid-resistant coating protects active enzymes from the action of hydrochloric acid in the stomach. Enzymes are proteins, and like all enzymes produced by the body, in most cases they are inactivated and decomposed in the intestines by proteolysis or autolysis. A small part of undigested enzymes are excreted with feces.

Indications for use

What helps? The panzinorm of 10 000 will work effectively in the following cases:

• In chronic inflammatory diseases of the intestine, liver, stomach or gallbladder (hepatitis, pancreatitis, enterocolitis, cholecystitis, gastroduodenitis, chronic gastritis, dysbiosis intestines).
• With digestive problems associated with impaired pancreatic function (chronic pancreatitis, cystic fibrosis, Remkheld syndrome, dyspepsia, pancreatectomy, eating disorders, flatulence).
• In the presence of post-traumatic (including after irradiation or surgical interventions) conditions of the digestive system.
• For degassing the patient's bowels before performing various diagnostic tests (ultrasound, x-ray and others).
• In the case of a violation of digestion of food with normal functionality of the gastrointestinal tract (irregular nutrition, the use of oily food or a large amount of food, a violation of the masticatory function, a prolonged immobilization, a sedentary image life).

At the same time, Pansinorm 2, 00 is shown:

1. After radiation therapy.
2. In the postoperative period with operations on the pancreas and other organs of the digestive tract.
3. For relief of pain in chronic pancreatitis.
4. For replacement therapy with insufficient isolation of pancreatic enzymes (with pancreatic cancer, dyskinesia biliary tract, cholestatic hepatitis, liver cirrhosis, stomach and duodenal ulcer diseases guts).

Contraindications

1. Hypersensitivity to the components of the drug or pork protein;
2. Acute pancreatitis;
3. The initial stage of exacerbation of chronic pancreatitis;
4. Age to 3 years;
5. Children under 15 years of age suffering from cystic fibrosis.

There are no data on the use of the panzinorm during pregnancy and lactation.

Use in pregnancy and lactation

Clinical data on the treatment of pregnant women with drugs containing pancreatic enzymes are absent. In the course of animal studies, no absorption of pancreatic pancreatic enzymes origin, therefore, toxic effects on reproductive function and development of the fetus are not it is assumed. Prescribe the drug to pregnant women with caution if the intended benefit to the mother exceeds the potential risk to the fetus.

Based on animal studies, during which there was no systematic negative effect of enzymes pancreas, no harmful effect of the drug on the infant is expected through breastfeeding milk women. During breastfeeding, you can take pancreatic enzymes. If you need to take during pregnancy or breast-feeding, the drug should be taken in doses sufficient to maintain adequate nutritional status.

Dosage and route of administration

The instructions for use indicate that Pansinorm 1, 00 is taken orally during a meal or snack. Capsules should be taken whole, not liquid, squeezed with enough liquid.

The dose and duration of therapy is determined individually, depending on the age, degree of pancreatic function deficiency and diet.

• Adultsat the beginning of treatment it is recommended to take minimum doses - 1-2 capsules 3 times / day, during each main meal (breakfast, lunch, dinner) and 1 capsule - during each snack. If necessary, the single dose is gradually increased. The effective daily dose is from 4 to 15 capsules.

The lowest effective doses should be given, especially in patients with cystic fibrosis.

Childrenthe drug is used only as directed by the doctor.

• Children over the age of 3 years are prescribed 1-2 capsules with meals or snacks.

Duration of treatment can vary from a single dose or several days (if the process is broken digestion due to inaccuracies in the diet) up to several months or years (if necessary permanent substitution therapy).

Side effects

According to the patients' reviews, the use of the Pansinorm in rare cases can be accompanied by:

• At the beginning of treatment and with prolonged use of small doses - skin rash, itching, skin flushing, hyperuricemia, folate deficiency, airway obstruction, hyperuricosuria;
• With prolonged therapy with high doses of the drug - diarrhea, nausea, irritation mucous membrane of the oral cavity, abdominal pain (including intestinal colic), constipation, skin irritation in zone of the anus.

The presence of cystic fibrosis, if the prescribed dosage is not observed, in rare cases may cause development of fibrotic (fibrosing) colonopathy in the ileocecal region of the intestine and ascending colonic gut.

Overdose of Pansinorm does not lead to systemic intoxication. This condition is accompanied by nausea, diarrhea, hyperuricemia, vomiting, perianal irritation, hyperuricosuria. When such reactions are observed, treatment should be discontinued, gastric lavage and symptomatic therapy performed.

Overdose

Capsules Panzinorm 10000 do not have a systemic effect. If the recommended therapeutic dose is significantly exceeded, nausea, vomiting, diarrhea, perianal irritation may develop. With concomitant cystic fibrosis, the development of stricture of the large intestine is possible.

In case of an overdose, the drug is canceled and symptomatic therapy is performed.

special instructions

Before you start using the drug, read the special instructions:

1. With prolonged use, iron preparations are simultaneously prescribed.
2. If, on the background of taking Penzinorm 1, 00 capsules, symptoms of intestinal obstruction appear, fibrotic colonopathy should be excluded.
3. In cystic fibrosis in case of excess of the necessary dose of pancreatin (more than 10 000 ED Ph. Eur. lipase / kg body weight) may develop strictures (fibrous colonopathy) in the ileocecal region and in the ascending colon. Therefore, in cystic fibrosis, the dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Pancreatin can reduce the effectiveness of acarbose and miglitol.
2. When used simultaneously with cimetidine, bicarbonates, it is also recommended that folate levels and / or folic acid are periodically monitored.
3. With simultaneous long-term use of pancreatin in high doses, it is possible to reduce absorption of iron preparations (clinically insignificant) and folic acid. It is recommended that folate levels and / or folic acid are monitored periodically.
4. Acid-resistant pellet shell Penzinorm 1, 00 dissolves in the duodenum. At a low pH in the duodenum, pancreatin is not released. Simultaneous use of blockers of histamine H2 receptors (cimetidine), hydrocarbons, inhibitors proton pump can increase the effectiveness of pancreatin, which allows you to reduce the dose of Pansornorm 10 000.

Reviews

We picked up some reviews of people who used the drug Panzinorm:

1. Tanya. This drug was prescribed to me by the gastroenterologist in connection with a mild form of gastritis and dyskinesia of the bile ducts. Not only after fatty, salty or pickled food, but even after dietary products, I had a serious stomach, heartburn, trouble with the intestines, strong rezi in the liver. This drug should be drunk immediately after eating, it adds the missing enzymes necessary for digestion. He helped me a lot during the entire treatment. Now constantly there is no need to drink it, but during festive feasts like New Year's, I definitely take it.
2. Vitaliy. I felt a discomfort in my stomach. Hopefully it will pass by itself. After a couple of days I could not take a breath in full. It was too hard to bend. Sway and sit for a long time in one position, too, could not (work in a sitting, as well as a standing position). I went to the clinic to the specialists. They told us to drink Penzinorm. Two days later, there was relief, and when poprinimal drug a dozen days, then generally forgot about the pain and discomfort.
3. Stanislav. The difference between Panzinorm and Creon is in price. The first is much cheaper at the same efficiency. But here's what's important: Panzinorm, unlike Creon and other similar drugs, does not contain lactose, which can cause a serious reaction in those who suffer from its intolerance.

Analogues

Pansinorm analogues, as well as the drug itself, as they say, are heard: these medicines are among the most popular in pharmacies and often enter into every possible hit-parade of the best-selling medicines. Some names, no doubt, will be familiar to our readers:

• Creon (Germany);
• Mezim (Germany);
• Gastenorm (India);
• Hermitage (Germany);
• Enzistal (India);
• Festal (India);
• Penzital (India);
• Mikrazim (Russia);
• Pangrol (Germany).

Before using analogues, consult your doctor.

Storage conditions and shelf life

Storage Pansinorm should be carried out under normal conditions at a temperature of not more than 30 C˚. Shelf life is 3 years.

How to choose probiotics for the intestine: a list of drugs.

Effective and inexpensive cough syrups for children and adults.

Modern non-steroidal anti-inflammatory drugs.

Review of tablets from the increased pressure of the new generation.

Antiviral drugs are inexpensive and effective.