Furadonin

Furadonin is a drug from the group of nitrofurans, which breaks the permeability of the cell membrane and protein synthesis in bacteria, having a bactericidal, bacteriostatic effect.

This drug is effective for the treatment of diseases of the genitourinary system, as it accumulates in large concentrations in the urine and is excreted by the kidneys. Well tolerated for short-term use. The therapeutic effect develops fairly quickly and persists for a long time. It is shown in the development of infectious disease of the prostate in men and symptomatic treatment of STI.

The drug is well absorbed from the gastrointestinal tract, penetrates the placenta and into breast milk, cerebrospinal fluid, and is excreted by the kidneys. Can give urine a dark color. Concentration in blood at usual therapeutic doses is insignificant.

Clinical and pharmacological group

A broad-spectrum antimicrobial agent, a derivative of nitrofuran.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

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Price

How much does Furadonin cost in pharmacies? The average price is at the level of110 rubles.

Composition and form of release

The preparation is made in the form of tablets, suspension and powder for internal administration. The pills cover the shell, which dissolves in the intestine. The package contains 12, 20, 30, 40 or 50 tablets.

The structure of Furadonin includes the active ingredient nitrofurantoin, also in the composition of tablets is colloidal silicon dioxide, potato starch, calcium stearate.

Pharmacological effect

Furadonin is a broad-acting antimicrobial agent derived from nitrofuran, but is not part of the antibiotic group. Due to the active substance, the drug has bactericidal and bacteriostatic effects in infections of the urinary tract. The medicine destroys the membranes of bacteria, inhibits the synthesis of proteins, destroys the E. coli, Klebsiella, enterobacteria, protea, staphylococcus. The agent is well absorbed by the digestive tract, its bioavailability increases with the ingestion of food.

According to these instructions, the rate of absorption of antibacterial agent depends on the size of the crystals (the powder dissolves more rapidly, absorbed, and concentrates as quickly as possible in the urine). The substance binds to plasma proteins by 60%, is metabolized by the liver and muscle tissues, the half-life is 20-25 minutes. Nitrofurantoin penetrates the placental and blood-brain barrier, is excreted by the kidneys.

Indications for use

Furadonin is used to treat and prevent infectious-inflammatory diseases of the urinary tract (caused by drug-susceptible pathogens):

cystitis;
pyelitis;
pyelocystitis;
pyelonephritis;
urethritis.

With preventive purpose, Furadonin is prescribed for cystoscopy (examination of the bladder with an optical device of the cystoscope), catheterization of the bladder (introduction of a special rubber tubule into the bladder - catheter), with urological operations.

Contraindications

According to the instructions to Furadonin, this drug is contraindicated when:

acute porphyria;
insufficiency of glucose-6-phosphate dehydrogenase;
pregnancy, lactation;
hypersensitivity to nitrofurantoin;
chronic heart failure;
chronic renal failure;
cirrhosis of the liver;
chronic hepatitis;
at the age of up to 1 month.

Intended use for pregnancy and lactation

Given the fact that Furadonin penetrates the placenta and can have toxic effects on the fetus, it is contraindicated to take it during pregnancy.

Experimental studies in animals have revealed a risk to the fetus. The clinical experience of using Furadonin during pregnancy has not been studied.

Doctors-gynecologists sometimes use Furadonin in the treatment of urinary tract infections in women after 12 weeks of pregnancy. In this case, it is necessary to compare the possible risk to the fetus and the therapeutic effect of using Furadonin.

Dosage and route of administration

As indicated in the instructions for use, Furadonin tablets are intended for oral administration as an independent bacteriostatic agent or as part of complex therapy for the treatment of urinary tract diseases caused by microorganisms sensitive to nitrofurans. The dose of the drug and the duration of the course of treatment is determined by the doctor strictly individually for each patient.

According to the instructions, adult patients and children over 12 years of age are prescribed 50-100 mg of the drug 4 times a day. For children younger than 12 years, a single dose of the drug is calculated based on the weight - 5 mg / kg body weight. The duration of the course of therapy with the drug is 3-5 days, if necessary, treatment can be extended up to 14 days under the supervision of a doctor. If during this period the patient does not experience any improvement in the condition or, conversely, if deterioration is seen, then taking the pills should be stopped and consult a doctor.

Adverse Reactions

During treatment with Furadonin, the following adverse reactions were observed:

Drowsiness.
Pancreatitis, hepatitis, enterocolitis.
Diarrhea, abdominal pain.
Vomiting, nausea.
Shortness of breath, broncho-obstructive syndrome, cough.
Chills, fever.
Pain in muscles and joints.
Skin rash.
Cholestatic syndrome.
Change in blood counts.

With renal failure, the risk of developing peripheral neuropathy increases.

Often, in the treatment of Furadonins, diarrhea occurs, which is caused by clostridia. The fact that the drug is able to change the balance of microflora in the intestines, promoting the growth and reproduction of this species of bacteria. When this symptom appears, the treatment is stopped.

Overdose

When ingesting Furadonin in high doses, the patient may develop signs of overdose that are clinically expressed in the intensification of the above-described side effects, impaired renal and hepatic function, development of hepatic insufficiency.

Treatment of an overdose of the drug consists in washing the stomach, introducing enterosorbents into the patient, carrying out symptomatic treatment if necessary.

special instructions

The risk of developing peripheral neuropathy is increased in patients with anemia, diabetes, impaired electrolyte balance, insufficiency of B vitamins, marked renal failure.

Nitrofurantoin should not be used to treat diseases of the cortex of the kidneys, with purulent paranephric and prostatitis. Nitrofurantoin is not prescribed in combination with drugs that cause renal dysfunction.

Compatibility with other drugs

Nitrofurantoin is not compatible with fluoroquinolones.

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of nitrofurantoin.

With simultaneous use of drugs that block tubular secretion, reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in urine) and increase its toxicity (blood concentration increases).

Reviews

We offer a look at the reviews of women who used Furadonin:

Olga. The daughter always drinks it, there are no visible side effects. Chronic cystitis during the exacerbation very well relieves the symptoms, it becomes easier. But the doctor said, if you want to avoid exacerbations 3 times a year, drink kanefron in tablets for 1 month. She began to drink until she worried, we are waiting for September - the period of exacerbation, kanefron lies at the ready.
Svetlana. With the acute manifestation of cystitis, I immediately took 2 pills of furadonin, after 15-20 minutes, a terrible sensation of nausea started, and strong weakness, plus it cuts below the abdomen. I already thought that I would not survive until the morning. Whom you ask, everyone says that it causes vomiting and nausea.
Galina. Furadonin removes only the symptoms of cystitis, and the disease as it is remains. You can take if you just catch a cold, And if it's gone far, then an excellent drug is Kanefron. He perfectly cures, and during pregnancy it is possible, which is very important, because pregnant women often have cystitis. Earlier took Furadonin, now only Kanefron. If in time to have time to drink enough to not take a course, and take two times.

Analogues

There are no structural analogs to the active substance of the drug Furadonin. Analogues on the effect (antibacterial drugs, nitrofuran derivatives):

Furagin;
Furazidine;
Furamag;
Monural;
Furasol.

Before buying an analogue, consult your doctor.

Furadonin or Furagin - which is better?

Furagin belongs to the same group (nitrofuran derivatives). Indications for the use of both drugs are similar, and at the same time they provoke the development of almost identical side effects. It is generally believed that Furagin is a softer medicine. But the final decision on the choice of the drug should be made only by a specialist, for which the doctor's consultation is needed.

Shelf life and storage conditions

Keep the drug out of the reach of children, away from moisture, avoiding direct sunlight on the package. Shelf life of the tablets is 3 years from the date of manufacture, after the end of this period, tablets should not be taken orally.