Combined Duo - an antibacterial drug that has a pronounced anti-inflammatory effect, is actively used in ENT and ophthalmology. Eye drops are a clear solution. The dosage depends on the site of inflammation localization (for treatment of inflammatory diseases of the ear it will be twice as much as for the treatment of inflammation of the cornea of the eye). The drug is highly effective in the treatment of major eye diseases and ENT organs, but there are contraindications. More details on the principles of its operation, composition and methods of use, read on.
Content
- 1Description of the preparation
- 2Pharmacological action and group
- 3Indications and contraindications
- 4Possible complications
- 5Video
- 6conclusions
Description of the preparation
Combined Duo is a topical preparation with a pronounced anti-inflammatory, antibacterial effect.It is used in ophthalmology and ENT-practice. Drops of ear and eye have the form of a clear solution (colorless or light yellow). The composition of 1 ml of the drug includes 3 mg of ciprofloxacin (in the form of hydrochloride) and 1 mg of dexamethasone. There are also auxiliary substances - water, mannitol, benzalkonium chloride, disodium edetate, hydroxypropyl betacyclodextrin. The volume of bottles-droppers - 5 ml.
For 1-2 drops of solution in the conjunctival sac should be instilled regularly - every 4-6 hours. The course of treatment is 5-14 days with blepharitis, 2-4 weeks with keratitis, for preventive purposes, the drug should be used for at least 5 days.If the ear becomes inflamed for one week, drip 4 drops into the outer passage of the patient ear twice a day.
Pharmacological action and group
The drug Combinil Duo has a pronounced antibacterial and anti-inflammatory effect. It is used for topical application in the treatment of ophthalmic, ENT diseases.The therapeutic effect is due to the antibacterial action of such a component as ciprofloxacin, as well as the anti-inflammatory effect of dexamethasone.
The main active substances of drops are Combin Duo - ciprofloxacin and dexamethasone.
Ciprofloxacin belongs to the group of fluoroquinolones.The component has a wide spectrum of action and has a pronounced bactericidal effect. It inhibits the DNA enzyme enzyme of bacteria, disrupting DNA replication and the processes of synthesis of bacterial cell proteins. In this case, the effect is also on those microorganisms that are actively multiplying, and on those that are at rest.
Ciprofloxacin disrupts the synthesis of bacterial cell proteins.
Dexamethasone is a synthetic SCS.With local use, the therapeutic activity of the component is determined by anti-inflammatory, antiproliferative and anti-allergic action. Dexamethasone reduces capillary permeability and proliferation, local exudation, phagocytic activity, the rate of collagen deposition, fibroblast activity, cellular infiltration, inhibits scar formation tissue. That is, dexamethasone reduces the symptoms of inflammation.
Dexamethasone (synthetic GCS) stops the inflammatory process.
When used in ophthalmology, ciprofloxacin rapidly penetrates into any tissues of the eye, with the exception of the lens.The maximum concentration of the active substance of the preparation in the moisture of the anterior chamber is noted 30 minutes after instillation. Systematic reabsorption.
Indications and contraindications
Eye drops Combin Duo are used in the therapy of the following eye diseases:
- acute, subacute conjunctivitis;
- keratitis;
- anterior uveitis;
- blepharitis.
Also, the drug is used in the prevention of complications after eye injuries and surgeries.
Eye drops Combin Duo in ophthalmology is used for therapeutic and preventive purposes.
Infectious-inflammatory ENT pathologies, which are treated with drops Combinil Duo:
- external acute otitis media;
- middle acute otitis with a tympanic membrane shunt;
- medium acute otitis media with granulations, otorei with a shunt.
Long-term therapy with the drug can lead to increased intraocular pressure and subsequent damage to the optic nerve, reduced visual acuity, and the formation of subcapsular cataracts.
Contraindications for treatment are the following conditions:
- herpetic keratitis, other viral diseases of the cornea and conjunctiva;
- fungus;
- tuberculosis of the eye;
- viral infections of the ear canal;
- age to 18 years;
- pregnancy and lactation;
- perforation of the tympanic membrane;
- hypersensitivity to the active components of the drug.
Children and pregnant drug Combinil Duo is not prescribed.
Possible complications
During the treatment of inflammatory ophthalmic diseases, complications such as itching, redness of the eye, burning, conjunctivitis, keratitis, periocular edema, foreign body sensation in the eye, photophobia, blurred vision,dry eyes, eyelid edema, conjunctival hyperemia, glaucoma and optic nerve damage,reduction of visual acuity and narrowing of visual fields, in some cases secondary infection occurs. The main complications on the part of auditory organs are a delayed wound healing process, a rash on the skin, a face swelling, taste perversions.
Long-term therapy with the drug leads to a decrease in the immune response and causes the development of a secondary infection of the eye.
Video
conclusions
Antibacterial anti-inflammatory drug topical application Combin Duo shows high efficiency in the treatment of diseases of the organs of vision and hearing. Systemic reabsorption, the maximum concentration of active substances in the plasma is observed after half an hour after instillation. There are contraindications.
