Tyrosol

Tyrosol is a medicinal product that is used in the treatment of thyrotoxicosis due to its property of inhibiting the production of thyroid hormones.

The effects of thiamazole in the thyroid gland are characterized by a decrease in basal metabolism, an acceleration in the excretion of iodides, and an increase in reciprocal activation of the processes of synthesis and secretion of thyroid-stimulating hormone by the pituitary gland, which may be accompanied by the development of thyroid hyperplasia.

The once-taken dose of thiamazole continues to work for almost 24 hours.

Clinical and pharmacological group

Antithyroid medication.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tirozol cost in pharmacies? The average price is at the level of200 rubles.

Composition and form of release

Tirozol is available in the form of tablets coated with a film membrane.

• The main active substance of Tyrosol is thiamazole. Depending on the amount of thiamazole included in one tablet, Tirozol 5 and 10 mg are produced.

Tyrosol auxiliary substances are: sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate, cellulose powder, hypromellose, talc, corn starch, lactose monohydrate.

pharmachologic effect

The effect of the active component of Thyrozole on the thyroid gland depresses the production of hormones due to the blocking of enzymes, in particular peroxidase involved in iodination of tyrosine. The drug intake accelerates the excretion of iodides from the thyroid gland and reduces basal metabolism.

In parallel, the use of Tyrosol increases the activation of synthesis and secretion of the thyroid-stimulating hormone by the pituitary. This can sometimes be accompanied by a slight increase in the volume of the thyroid gland. The drug is very effective in symptomatic therapy of thyrotoxicosis. A single dose of Tirozol guarantees its effect for at least 24 hours.

Indications for use

According to the instructions Tyrozol is applied:

• with thyrotoxicosis;
• when preparing for therapy with radioactive iodine;
• when preparing for an operation in thyrotoxicosis;
• in order to prevent thyrotoxicosis when taking iodine-containing drugs with latent thyrotoxicosis, having a history of thyrotoxicosis, autonomic adenomas;
• as a treatment in the latent period of action of radioactive iodine;
• as a long-term maintenance therapy for thyrotoxicosis, when due to the general condition of the patient or for other reasons radical treatment can not be performed.

Contraindications

Absolute:

• Glucose-galactose malabsorption, galactose intolerance, lactase deficiency;
• hypersensitivity to thiourea derivatives and any ingredient in the preparation;
• granulocytopenia (including in the anamnesis);
• the development of agranulocytosis during previous therapy with thiamazole or carbimazole;
• therapy with thiamazole and levothyroxine during pregnancy;
• age up to 3 years.

Tirozol is used with caution in the following cases:

• a strong increase in goiter, leading to a narrowing of the trachea (the drug is used only for short-term treatment in the preoperative period);
• liver failure.

Intended use for pregnancy and lactation

Absence of thyroid hypertension therapy during pregnancy can cause serious complications, including fetal malformations and premature birth. In turn, hypothyroidism, formed due to the appointment of inadequate doses of Tyrozole, may lead to miscarriage.

Characteristic for thiamazole is its penetration through the placental barrier, after which the fetal blood concentration is similar to the mother. For this reason, the appointment of Tyrozol during pregnancy can be justified only in extreme cases, after a full evaluation of the benefits / risks of it application for mother / fetus, in minimum effective daily dosages (up to 10 mg) and without parallel use of levothyroxine sodium.

Taking a pregnant woman with high doses of thiamazole may lead to hypothyroidism and goitre in the fetus, as well as to a decrease in the body weight of the baby at birth.

During breastfeeding, thyrotoxicosis therapy in the mother can be continued at the lowest dosages, since the concentration of thiamazole in breast milk corresponds to its content in the mother's blood and can cause the development of hypothyroidism in the newborn. The admission of Tyrosol with lactating women requires control of the functionality of the thyroid gland in newborns.

Dosage and route of administration

As indicated in the instructions for use, thyroxine is taken orally after ingestion. Tablets should be taken without chewing, squeezed with enough liquid.

The daily dose is prescribed in a single dose or divided into 2-3 single doses. At the beginning of treatment, single doses are taken during the day at a strictly defined time. The maintenance dose should be taken in one session after breakfast.

1. In thyrotoxicosis, depending on the severity of the disease, the drug is prescribed in a dose of 20-40 mg / day for 3-6 weeks. After the normalization of the thyroid function (usually in 3-8 weeks), they switch to a maintenance dose of 5-20 mg / day. Since this time, an additional intake of levothyroxine sodium is recommended.
2. When preparing for surgical treatment, thyrotoxicosis is prescribed 20-40 mg / day until the euthyroid state is reached. Since this time, an additional intake of levothyroxine sodium is recommended. In order to reduce the time needed to prepare for the operation, additionally prescribe beta-blockers and iodine preparations.
3. When preparing for treatment with radioactive iodine, 20-40 mg / day is prescribed before the euthyroid state is reached.
4. During therapy in the latent period, the action of radioactive iodine, depending on the severity of the disease, is prescribed 5-20 mg / day until the onset of action of radioactive iodine (4-6 months).
5. With prolonged thyostatic maintenance therapy, Tyrozol is prescribed in doses of 1.25-2.5-10 mg / day with an additional intake of levothyroxine sodium in small doses. In the treatment of thyrotoxicosis, the duration of therapy is from 1.5 to 2 years.
6. In order to prevent thyrotoxicosis when prescribing iodine preparations (including cases of using iodine-containing radiocontrast agents) in the presence of latent thyrotoxicosis, autonomic adenomas or thyrotoxicosis in a history of Tyrosol is prescribed at a dose of 10-20 mg / day and potassium perchlorate 1 g / day for 8-10 days before taking iodine-containing drugs.

To children aged 3 to 17 years, tyrosol is prescribed in an initial dose of 0.3-0.5 mg / kg of body weight in 2-3 equal divided doses daily. The maximum recommended dose for children weighing over 80 kg is 40 mg / day. The maintenance dose is 0.2-0.3 mg / kg / day. If necessary, additionally prescribed levothyroxine sodium.

It is not recommended to use in children aged 0 to 3 years.

In pregnancy, the drug is prescribed in minimal doses: single dose - 2.5 mg, daily - 10 mg.

In case of liver failure, the drug is prescribed in the minimum effective dose under careful medical supervision.

When preparing for the operation of patients with thyrotoxicosis, the drug is administered before the euthyroid state is reached in for 3-4 weeks before the planned day of operation (in some cases - longer) and ends the day before it.

Side effects

Against the background of oral administration of tablets Tyrozol, patients had some side effects:

• Connective tissue and musculoskeletal system: often - arthralgia (slowly progressing) without clinical symptoms of arthritis;
• Skin and subcutaneous tissues: very often - skin itching, rashes, redness of the skin; very rarely - baldness, generalized rash on the skin, lupus-like syndrome;
• Gastrointestinal tract, liver and bile ducts: very rarely - vomiting, toxic hepatitis, salivary gland enlargement, cholestatic jaundice;
• Blood and lymphatic systems: infrequently - agranulocytosis; very rarely - thrombocytopenia, generalized lymphadenopathy, pancytopenia;
• Nervous system: rarely - dizziness, reversible change in taste; very rarely - polyneuropathy, neuritis;
• Endocrine system: very rarely - Hirata's disease (autoimmune insulin syndrome) with hypoglycemic conditions;
• Other reactions: rarely - weakness, fever, weight gain.

Overdose

With the long-term administration of the tablets in high doses, the patient gradually develops signs of an overdose, which are expressed by an increase in the above described adverse reactions, an increase in the size of the gland, the formation of goiter.

Treatment of signs of an overdose is symptomatic - the patient is washed with a stomach, appointed enterosorbents, and after them an antithyroid drug of another group is selected.

special instructions

Before you start using the drug, read the special instructions:

1. At early termination of the course of treatment, a relapse of the disease is possible.
2. Rarely after the end of treatment, late hypothyroidism may be noted, which is not due to the administration of the drug but to inflammatory and destructive processes in the thyroid tissue.
3. In severe craw Tyrozole is prescribed in combination with levothyroxine sodium, to avoid further narrowing of the lumen of the trachea.
4. During the period of treatment, control of the peripheral blood pattern is necessary.
5. The drug may reduce the sensitivity of thyroid tissue to radiation therapy.
6. If there is pain in the throat, difficulty swallowing, fever, signs of stomatitis or furunculosis on the background of treatment, the drug should be canceled and immediately consult a doctor.
7. The drug is canceled when hemorrhages or bleedings of an unknown genesis, generalized skin rash and itching, persistent nausea or vomiting, jaundice occur. severe pain in the abdomen, severe weakness.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Gentamicin increases the antithyroid effect of thiamazole.
2. The lack of iodine enhances the action of thiamazole.
3. Lithium preparations, beta-adrenoblockers, reserpine, amiodarone increase the effect of thiamazole (correction of its dose is required).
4. Leukogen and folic acid with simultaneous use with thiamazole reduce the risk of developing leukopenia.
5. When prescribing the drug after using iodine-containing radiocontrast agents in a high dose, the effect of thiamazole may be weakened.
6. When used simultaneously with sulfonamides, metamizole sodium and myelotoxic drugs, the risk of developing leukopenia increases.
7. Data on the effect of other drugs on the pharmacokinetics and pharmacodynamics of the drug are absent. However, it should be borne in mind that when thyrotoxicosis is accelerated metabolism and elimination of substances. Therefore, in a number of cases it is necessary to adjust the dose of other drugs.
8. In patients taking Tirozol for thyrotoxicosis, after reaching the euthyroid status (normalization of the hormone content of the thyroid glands in the blood serum), it may be necessary to reduce the intake of cardiac glycosides (digoxin and digitoxin), aminophylline, as well as increased doses of warfarin and other anticoagulants - coumarin derivatives and indanedione (pharmacodynamic interaction).

Reviews

We offer you to read reviews of people who used the drug Tyrozol:

1. Anna. This drug is now being taken by my mother-in-law. A couple of years ago began to lose weight very much. The reason for a long time could not be established. And then it was found out that to all fault shchitovidka and not unknown hormone TTG. The result of the treatment was not long in coming. Soon my mother-in-law became a living blooming woman again. She drinks it to this day. The only thing you need to periodically monitor TTG, so as not to overdo with the reception of "Tyrozol".
2. Sofia. The only medicine that endocrinologists prescribe for thyrotoxicosis and DTZ. It is worth noting that it will not solve the problem forever, rather it will remove the acute crisis and will maintain the level of the hormone TSH in the norm. The main thing is the correct dosage. And here's an ambush. This hormone constantly jumps, and yesterday's dose can become either insufficient or excessive... Therefore it is extremely important to regularly check the level of TSH, donate blood. If you adjust the correct dosage and adhere to general recommendations, diet and lifestyle, then you can go on for a long time in a state of remission. But, alas, do not cancel the whole tyrosol. After the cancellation, a large percentage of the return of the hormone drop.

Analogues

Structural analogs for the active substance:

• Mercazolyl;
• Metizol;
• Thiamazole.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the drug in a cool place inaccessible to children, no more than 4 years from the date of manufacture, which is indicated on the box.

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