Urdoksa

The main property of the drug Urdoksa - protection of the liver (hepatoprotection) from harmful effects.

It also has choleretic, cholelitholytic (promotes dissolution of bile) stones, hypocholesterolemic (reduces the level of harmful blood cholesterol), immunomodulating (strengthens immunity) action.

If you regularly take URDOKSU for a long time, there may be a partial or complete disappearance of cholesterol bile stones, both in men and in women. The drug also has an immunomodulatory effect.

Clinical and pharmacological group

Hepatoprotector with choleretic and cholelitholytic action.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Urdoks cost in pharmacies? The average price is at the level of800 rubles.

.

Composition and form of release

The preparation is available in the form of gelatin capsules of light color, containing white powder.

• One capsule contains 250 mg of ursodeoxycholic acid.

Additional substances in the preparation: corn starch, colloidal silicon dioxide, magnesium stearate.

Capsule composition: acetic acid, methylhydroxybenzoate, titanium dioxide, gelatin, propylhydroxybenzoate.

Pharmacological effect

"Urdoksa" refers to the group of hepatoprotective drugs, that is, it allows to protect and preserve liver cells. The drug also has a number of properties that make its action combined and allow it to be used to treat other pathologies and disorders in the functioning of internal organs.

The main action of the drug:

• prevents bile congestion in the bile ducts;
• stimulates the activity of lipase;
• dissolves stones in the gallbladder (small and medium size) and helps their removal by natural means;
• normalizes the level of cholesterol;
• possesses choleretic properties;
• reduces the amount of toxic bile acids in the intestine.

The therapeutic effect is provided by the biological activity of ursodeoxycholic acid, which is the main active ingredient of the drug.

Indications for use

The drug is given to patients with the following diagnoses:

• biliary cirrhosis in the initial stage;
• biliary reflux-gastritis;
• Cholesterol stones in the gallbladder (while maintaining the functioning of the organ).

In all cases, treatment should be carried out under the close supervision and supervision of a specialist.

Contraindications

When the pancreas, kidneys, liver is damaged, this pharmaceutical purpose is contraindicated. The instructions for use contain other medical contraindications:

• period of pregnancy;
• breastfeeding (lactation);
• presence of bile calculi with high calcium content;
• primary cirrhosis of the decompensated stage;
• exacerbation of peptic ulcer of the stomach, duodenum;
• inflammatory diseases of the bile duct, gall bladder;
• increased sensitivity of the organism to the components of the drug;
• children's age of patients up to 3 years.

Intended use for pregnancy and lactation

During the clinical trials, teratogenic and embryotoxic effects of ursodeoxycholic acid on the fetus were not established. Despite this information, the use of Urdox during pregnancy is undesirable, since the clinical experience of using this drug is limited or absent. Women in the situation with violations of the gallbladder appointed a special diet and choleretic preparations of vegetable origin, and treatment with the drug Urdoksa it will take place after childbirth.

The use of the drug during lactation is not recommended, since there is no evidence of the possibility of ursodeoxycholic acid to be excreted in breast milk. If necessary, the drug should be interrupted breastfeeding.

Dosage and route of administration

As indicated in the instructions for use, Urdox capsules are taken orally, not chewed, washed down with water (in small amounts).

Cholesterol stones of the gallbladder (for their dissolution)

It is recommended to take daily, in the evening (before bedtime), to, 1 g ursodeoxycholic acid per 1 kg of body weight per day.

Daily dose of Urdoksy depending on body weight:

• up to 60 kg: 2 pcs .;
• 61-80 kg: 3 pieces each;
• 81-100 kg: 4 pcs .;
• 100 kg: 5 pieces each.

The duration of the course varies from 6 to 12 months.

For the prevention of repeated cholelithiasis after dissolution of stones, Urdox is taken for several months.

Primary biliary cirrhosis (symptomatic therapy)

The daily dose of the drug depends on the patient's body weight and varies within 3-7 pieces. (approximately, 14 ± 02 g of ursodeoxycholic acid per 1 kg of body weight). During the first 3 months of treatment, capsules are taken in several doses throughout the day. After the improvement of hepatic parameters, the daily dose is taken once a day, in the evening.

The dose of the drug and the frequency of reception, depending on the body weight:

• 34-46 kg: 1 pc. Each. 2 times a day (1 pc. in the morning and 1 pc. in the evening);
• 47-62 kg: 1 piece each. 3 times a day (1 pc. in the morning, 1 pc. in the afternoon and 1 pc. in the evening);
• 63-78 kg: 1 piece each. 4 times a day (1 pc. in the morning, 1 pc. daytime and 2 pcs. in the evening);
• 79-93 kg: 1 pc. 5 times a day (1 pc. in the morning, 2 pcs. daytime and 2 pcs. in the evening);
• 94-109 kg: 1 pc. Each. 6 times a day (2 pcs. in the morning, 2 pcs. daytime and 2 pcs. in the evening);
• 110 kg: 1 piece. 7 times a day (2 pcs. in the morning, 2 pcs. in the afternoon and 3 pcs. in the evening).

Urdox is taken regularly. The duration of the course of therapy is not limited.

Biliary reflux gastritis

It is recommended to take 1 daily a day (in the evening, before going to bed) for 1 pc. The duration of the course is from 10 days to 6 months, if necessary - up to 2 years.

Alcoholic liver disease, non-alcoholic steatohepatitis, chronic hepatitis of various origins

The average daily dose of Urdoksy is 1 to 15 g per 1 kg of body weight divided into 2-3 doses. Duration of treatment - from 6 to 12 months or more.

Biliary dyskinesia

The average daily dose is, 1 g per 1 kg of body weight, divided into 2 doses. Duration of therapy - from 14 days to 2 months with a possible repetition of the course if necessary. For children aged 3 years, the daily dose is set individually according to the calculation of 1 2 g per 1 kg of body weight.

Cystic Fibrosis

The daily dose - on, 12, 15 g per 1 kg of body weight. If necessary, it can be increased to, 2, 3 g per 1 kg of body weight, divided into 2-3 doses. Duration of treatment - from 6 months to several years, or for life.

Adverse Reactions

The drug is well tolerated by patients. Side effects occur mainly in individuals with increased individual sensitivity to the drug:

• allergic reactions - rash like hives, skin peeling, skin yellowness and itching.
• from the gastrointestinal tract - diarrhea, nausea and company, liver enlargement, development of hepatitis, biliary colic attacks.

With the development of such adverse reactions, the patient should consult a doctor for advice, perhaps the dose of the drug should be slightly reduced.

Overdose

With a regular excess of recommended daily doses, side effects are increased. The patient is concerned about diarrhea, paroxysmal pain of the epigastric region. To eliminate such symptoms, it is required to provoke vomiting, to take activated charcoal or another sorbent. Further, symptomatic treatment is carried out according to the individual instructions of the attending physician. There is no specific antidote.

special instructions

Urdox should be taken under medical supervision.

In case of unwanted or severe reactions, the patient should immediately inform the attending physician about them and, in no case, continue taking the drug without his recommendation.

In patients with primary biliary cirrhosis, in rare cases, clinical symptoms may worsen at the beginning of treatment, for example, itching may increase. In this case, the treatment should continue, taking 1 capsule daily, then you should increase the dose (increasing daily dose weekly for 1 capsule) until the recommended regimen is again reached dosing.

When taking the drug for the purpose of dissolution of gallstones, the following conditions must be observed: the stones must be cholesterol (X-ray negative), their size should not exceed 15-20 mm, the gallbladder should remain functional and should be filled with stones no more than half, the permeability of the vesicle and common bile duct should be saved. With prolonged (more than 1 month) taking the drug every 4 weeks in the first 3 months of treatment, in the future - every 3 months, a biochemical blood test should be performed to determine the activity of the hepatic transaminase. Control of the effectiveness of treatment should be carried out every 6 months according to ultrasound of bile ducts. After complete dissolution of the stones, it is recommended that the drug be continued for at least 3 months in order to to dissolve the remnants of stones, the sizes of which are too small for their detection and for the prevention of recurrence stone formation.

Interaction with other drugs

In some cases, the drug Urdoksa can reduce the absorption of ciprofloxacin.

Lipid-lowering drugs (especially clofibrate), estrogens, neomycin or gestagens increase bile saturation with cholesterol and may decrease the ability to dissolve cholesterol bile concrements.

Colestramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide), reduce absorption of ursodeoxycholic acid in the intestine and, thus, reduce its absorption and efficiency. If the use of drugs containing at least one of these substances is necessary, they should be taken at least 2 hours before taking Urdox.

Ursodeoxycholic acid can increase the absorption of cyclosporine from the intestine. Therefore, in patients taking cyclosporine, you should check the concentration of cyclosporine in the blood and adjust the dose of cyclosporine, if necessary.

The patient should inform the doctor about all the medications he is taking.

Reviews

We offer you to read reviews of people who used Urdoks:

1. Olga. Four years ago I had an operation to remove stones from the gallbladder. Periodically I do preventive therapy from time to time. This year, my budget did not allow me to buy my drug. I went to the doctor and asked for a different one. It turned out that there is a Russian Exhol. I accepted him, I did not notice a significant difference between him and the dear. Now I will completely switch to it.
2. Michael. Many years I suffer from chronic gastroduodenitis with dyskinesia of the biliary tract. The doctor appointed Ursosan. I bought 50 capsules for testing, but it only lasted 2 weeks. A drink it should be 2 months. It is very expensive. Asked in the pharmacy, is there anything to replace the cheaper, but it's just as good to be. They recommended Urdoksu. The active substance is the same, but costs less, although the basis for the drug is produced in Italy. I immediately bought a large package of 100 capsules, because her price is the most economical out. I now accept Urdoksu, abdominal pain and nausea decreased - the drug really works.

Analogues

Structural analogs for the active substance:

• Grinterol;
• Livedoksa;
• Urso 100;
• Ursodeoxycholic acid;
• Ursodez;
• Ursodex;
• Ursuliv;
• Ursolit;
• Ursomik;
• Ursoprim;
• Ursor;
• Ursosan;
• Ursofalk;
• Holudexan;
• Exxhol.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the capsules in a cool dry place out of the reach of children.

The shelf life of the drug is indicated on the package and is 4 years from the date of manufacture. Overdue medication should not be taken orally.

How to choose probiotics for the intestine: a list of drugs.

Effective and inexpensive cough syrups for children and adults.

Modern non-steroidal anti-inflammatory drugs.

Review of tablets from the increased pressure of the new generation.

Antiviral drugs are inexpensive and effective.