At what pressure Berlipril is prescribed: instructions for use and reviews

Berlipril is an antihypertensive agent related to ACE inhibitors.

This is a prodrug that, when hydrolyzed, creates enalaprilate, which already inhibits ACE. As a result, the load on myocardium, diastolic and systolic type arterial pressure, OPSS decreases and the arteries expand (to a greater extent than, say, veins).

On this page you will find all information about Berlipril: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Berlipril. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

ACE inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Berlipril? The average price in pharmacies is at the level of145 rubles.

Form of issue and composition

One tablet contains:

Enalapril maleate - 5, 10 or 20 mg;
Excipients: lactose monohydrate, gelatin, magnesium carbonate, silicon dioxide colloid, sodium carboxymethyl starch, magnesium stearate, iron oxide brown (E172).

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Form release: tablets, 5 mg or 10 mg or 20 mg - 20, 30, 50 or 100 pcs.

Pharmacological effect

Berlipril belongs to the group of ACE inhibitors (angiotensin-converting enzyme inhibitors). Penetrating into the human body, the drug is hydrolyzed, resulting in an active substance called enalaprilat.

This component inhibits an enzyme that converts angiotensin 1 to angiotensin 2. It is the latter element that has a noticeable vasoconstrictor effect, and also promotes the production of aldosterone, which provokes the retention of water and sodium ions in the body. Enalaprilat also slows down the destruction of bradykinin, which produces a vasodilating effect and increases the production of prostaglandins - substances that dilate the vessels.

As a result, Berlipril helps to reduce the overall vascular peripheral resistance. Thus, diastolic and systolic blood pressure decreases, post- and preload on the heart muscle. The active component of the drug improves coronary and renal blood flow. From the instruction to Berlipril, patients can learn that the drug has an antihypertensive effect, and also prevents an increase in heart failure.

Indications for use

At what pressure is the drug prescribed? According to the instructions, Berlipril is used when:

Arterial hypertension (including renovascular hypertension);
Asymptomatic left ventricular dysfunction as part of combination therapy;
Chronic heart failure.

Contraindications

Hypersensitivity (including to other ACE inhibitors), angioedema, associated with the treatment of an ACE inhibitor in history, porphyria, pregnancy, the period of breastfeeding, age under 18 years (efficacy and safety not established).

Application in pregnancy and lactation

Pregnant women and lactating mothers are contraindicated.

Instructions for use

The instructions for use indicate that the initial daily dose of Berlipril in the treatment of hypertension is 5 mg. In case of insufficient effect within 1-2 weeks, a gradual increase in the daily dose to 40 mg is possible. The average dose is 10 mg. Multiplicity of reception of berlipril per day - 1-2 times.

With CHF, therapy begins with taking the drug at a daily dose of 2.5 mg. In the future, the dose is selected taking into account the effect and tolerability, depending on the values of blood pressure. The average daily dose, ranging from 5 to 20 mg, is taken once or divided into two doses.

With renal failure, a daily dose adjustment is performed depending on the creatinine clearance (CC). With CC equal to 80-30 ml / min Berlipril is prescribed in a daily dose of 5-10 mg, with a QC equal to 30-10 ml / min - 2.5-5 mg. At a lower filtration rate, the drug is prescribed only in days of hemodialysis at a dose of 1.25-2.5 mg.

For elderly patients, the initial dose of the drug is 1.25 mg.

Side effects

Side effects can be classified about the body system to which they affect.

With the nervous system and sensory organs	dizziness, weakness, headache, confusion. panic condition, insomnia or drowsiness, increased fatigue, problems with hearing, vision, vestibular apparatus, tinnitus, nervousness, paresthesia, depression.
Interaction with the digestive system	anorexia, dry mouth, dyspeptic disorders such as nausea, diarrhea, vomiting, abdominal pain or constipation, pancreatitis, hepatitis, jaundice, intestinal obstruction, liver problems and bile secretion.
With the cardiovascular system and hematopoiesis	excessive blood pressure lowering, angina pectoris, orthostatic-type collapse, myocardial infarction, arrhythmia, changes in the heartbeat, fainting, thromboembolism in the branches of the pulmonary artery, lowering of the hemoglobin level, agranulocytosis, eosinophilia, neutropenia, thrombocytopenia, pain in the heart area.
Interaction with the respiratory system	rhinorrhea, dyspnea, bronchospasm, pharyngitis, interstitial type pneumonitis, dry cough of an unproductive type.
Other	flushes to the face, decreased libido, increased urea levels, hypercreatininaemia, and other negative symptoms.
Interaction with the genitourinary system	proteinuria, impaired renal function.
Skin and other allergic reactions	angioedema, edema of the extremities, face, tongue, lips, and glottis or larynx, skin rash, dysphonia, Stevens-Johnson syndrome, exfoliative dermatitis, erythema polymorphic type, necrolysis of the epidermal toxic type, urticaria, pruritus, pemphigus, photosensitivity, vasculitis, myositis, arthritis, stomatitis, serositis, myositis, glossitis.

Overdose

Possible symptoms of overdose: severe arterial hypotension that occurs 6 hours after taking the pill, simultaneous blockade of the renin-angiotensin-aldosterone system with a stupor. Possible circulatory failure, loss of electrolytes, hyperventilation, renal failure, tachycardia, bradycardia, increased heart rate, cough, a sense of fear.

Treatment - intravenous infusion of sodium chloride solution

special instructions

During the period of therapy with the drug, it is necessary to monitor blood pressure, as well as potassium, urea, hemoglobin and creatinine. Before conducting a surgical intervention, you must warn about the use of Berlipril anesthesiologist or surgeon.

The drug affects the reaction speed and concentration of attention, therefore, during the period of treatment driving is undesirable.

Drug Interactions

With the simultaneous use of berlipril with potassium-sparing diuretics (spironolactone, triamterene, amiloride), it is possible to develop hyperkalemia.
With the simultaneous use of berlipril with NSAIDs, a decrease in its antihypertensive effect is possible.
Enalapril weakens the effect of drugs containing theophylline.
With the simultaneous use of ethanol with Berlipril, it is possible to develop severe arterial hypotension.
With the simultaneous use of Berlipril with lithium salts, lithium release may be slowed (control of lithium concentration in blood plasma is shown).
Immunosuppressants, allopurinol, cytostatics increase hematotoxicity. Drugs that cause bone marrow depression, increase the risk of developing neutropenia and / or agranulocytosis.
Anti-hypertensive effects of enalapril increase diuretics, beta-adrenoblockers, methyldopa, nitrates, calcium channel blockers dihydropyridine series, hydralazine, prazosin.

Reviews

We picked up some feedback from people about the drug Berlipril:

Lyudmila. After taking 1/2 pill Berlipril plus (my father) an hour later, there was a burning sensation in the liver, a general weakness in the whole body, which turned into a headache, a clouding in the eyes. A / D from 160/70 decreased to 120/60 (50) and this state lasted almost a day. It is surprising that the doctor who appointed (this drug was not previously prescribed) absolutely did not warn about a possible situation, and what our actions are in this case. In addition, in the annotation to the drug, I deducted that with caution! give elderly people over 65 years old (my father is 80 years old), under the supervision of a doctor. Tablets take him appointed at home, i.e. No monitoring by the doctor was implied.
Anna. I take the drug for 1/2 tablets in the morning and in the evening for 3 months. At the doctor of the neurologist who conducted a course of treatment from hestertania 2st. I was especially interested about the side events that I assured that everything that is written in the instruction is nonsense. The last 2 months, a dry, debilitating cough sinned on anything until quite accidentally did not get to her therapist. It turned out that my trouble was from Berlipril. Only here it is strange, the appointment - in the morning 1/2 Berlipril plus 10/25, and in the evening 1/2 Lercamena. Coughing will not go away from reducing the dose?
Vasilisa. I take antihypertensive therapy for more than 10 years. But I broke my arm and the drug Hartil accepted stopped helping. I was shocked herself on the Internet and found the drugs inhibitors ACE-only they help me in the pharmacies do not have anything with diuretics, and after the treatment of such drugs, attacks of arrhythmia and here she herself appointed berlinpril-1 month AD 120 \ 90 thanks to the drug. If I go to polyclinic then the doctor does not seem to know such a drug. He was in a swoon from Hartil-a beautiful drug by the way.

Analogues

Analogies according to ATC code: Bagopril, Invoril, Myopril, Renitek, Enalakor. Do not make the decision to replace the drug yourself, consult a doctor.

Before using analogues, consult your doctor.