Suprax solute

Suprax solutab (cefixime) is a semisynthetic antibiotic of the cephalosporin series for oral administration.

It has bactericidal (causing the death of microorganisms) by the action, suppressing the process of formation of the plasma membrane of the infectious agent. Resistant to beta-lactamases, produced by most bacteria.

Effects on streptococcus agalactia, hemophilic rod, proteus, klebsiella oxytok, klebsiella pneumonia, pasteurella, providential, salmonella, shigella, tsitrobakter, serratium, pyogenic and pneumonia streptococcus, mora-kissella, E. coli, Neisseria.

Clinical and pharmacological group

Semisynthetic cephalosporin antibiotic III generation.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Suprax solute in pharmacies? The average price is at the level of850 rubles.

Composition and form of release

Suprax Solutab is available in the form of tablets of dispersible, oblong, pale orange color, with a risk on both sides, with strawberry odor (1, 5 or 7 pcs. in blisters, in a cardboard package 1 blister; for 5 pcs. in blisters, in a cardboard package of 2 blisters).

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Composition per 1 tablet:

active ingredient: cefixime (in the form of cefixime trihydrate) - 400 mg;
auxiliary components: magnesium stearate, low-substituted giprolase, calcium saccharate trisesquihydrate, microcrystalline cellulose, dye sunset yellow, povidone, strawberry flavor, silicon dioxide colloid.

There are capsules Supramx 400 mg - oblong with a white body and a violet cover, inside of which there are small granules of yellowish color. Each capsule contains 400 mg of cefixime + auxiliary components. This form of the drug is intended for adult patients. Capsules of 6 pcs. packaged in blisters and placed in cardboard packages

pharmachologic effect

Suprax Solutab is a broad-spectrum bactericidal antibiotic whose mechanism is due to the suppression of the synthesis of the cell membrane of the microorganism. Cefixime is resistant to beta-lactamases, produced by the majority of gram-negative and gram-positive bacteria.

In studies outside the living organism (in vitro), cefixime exhibited activity against the following microorganisms:

Gram-positive bacteria: Streptococcus agalactiae;
Gram-negative bacteria: Proteus vulgaris, Klebsiella oxytoca, Klebsiella pneumoniae, Providencia spp., Shigella spp., Citrobacter diversus, Citrobacter amalonaticus, Haemophilus parainfluenzae, Pasteurella multocida, Salmonella spp., Serratia marcescens.

In clinical practice and in vitro studies, cefixime exhibited activity against the following microorganisms:

Gram-positive bacteria: Streptococcus pyogenes, Streptococcus pneumoniae;
Gram-negative bacteria: Moraxella (Branhamella) catarrhalis, Proteus mirabilis, Haemophilus influenzae, Neisseria gonorrhoeae, Escherichia coli.

The drug is resistant to: Enterococcus (Streptococcus) serogroup D, Enterobacter spp., Clostridium spp., Pseudomonas spp., Bacteroides fragilis and most Staphylococcus spp. (including methicillin-resistant strains).

Indications for use

What helps? Suprax is prescribed in the presence of infectious and inflammatory diseases caused by microorganisms sensitive to cefiphil trihydrate. Among them are respiratory tract infections and other diseases:

sinusitis;
angina;
uncomplicated infections of the genitourinary system and urinary tract;
shigellosis;
acute form of otitis media;
streptococcal forms of pharyngitis and tonsillitis;
bronchitis (acute and chronic in the stage of exacerbation);
gonococcal infection of the cervix and / or urethra;
uncomplicated gonorrhea.

Contraindications

Absolute:

chronic kidney failure in children;
body weight less than 25 kg in children;
the period of breastfeeding;
individual intolerance of components contained in tablets, penicillins or cephalosporins.

Conditions / diseases in which Supraks Solutab tablets are administered with caution:

colitis in history;
kidney failure;
elderly age;
pregnancy.

Suprax for children

Children under the age of 12 can be given Suprax only in the form of tablets or suspensions. Capsules Supraks are permissible for use only for children over 12 years of age with a body weight of at least 50 kg. This means that capsules can not be taken by children, even if they are 12 years old, but their body weight is less than 50 kg.

Supraks tablets are allowed for use in children with a body weight of at least 25 kg. This means that, regardless of the age of the child, if its weight is 25 kg or more, it can be given Supraks Solutab in the form of dispersible tablets.

Supraks suspension can be used for children from the age of 6 months. This dosage form is optimal for children under 12 years of age. Therefore, doctors recommend giving the drug to children in the form of a suspension, preferring it to tablets and capsules.

Children under 6 months of age should be given Supraks in the form of a suspension only under the supervision of a doctor if there is no way to replace this antibiotic with another safer for the baby.

Intended use for pregnancy and lactation

In pregnancy, Suprax can be used only if the intended benefit for a woman exceeds all possible risks to the fetus. In practice, antibiotics of the cephalosporin group are often prescribed to pregnant women, as compared to other antibacterial drugs, they are relatively safe.

Suprax is contraindicated in breastfeeding. Therefore, if a nursing woman needs to take the drug, then during the treatment should wean the baby from the breast and transfer to artificial feeding. One day after receiving the last dose of Suprax, you can again return to breastfeeding the baby.

Dosage and route of administration

As indicated in the instructions for use, Suprax Solutab is taken internally, regardless of food intake. The tablet can be swallowed whole with a sufficient amount of water or pre-diluted in water (drink the suspension right after cooking).

The daily dose for adults and children weighing 50 kg is 400 mg (can be divided into 2 parts), with a weight of 25-50 kg - 200 mg in 1 dose.

The duration of therapy is determined by the nature of the disease and the type of infection. After the disappearance of the symptoms of fever / infection, it is advisable to continue treatment for 48-72 hours.

Recommended duration of use of Suprax tablets Solutab 400 mg:

infection of ENT organs and respiratory tract: 7-14 days;
tonsillopharyngitis caused by Streptococcus pyogenes: not less than 10 days;
uncomplicated gonorrhea: 1 day;
uncomplicated infections of the lower and upper urinary tract in men: 7-14 days;
uncomplicated infections of the lower / upper urinary tract in women: from 3 to 7-14 days.

In cases of presence of violations of renal function, the dose is determined by the creatinine clearance:

21-60 ml / min or patients on hemodialysis: a 25% reduction in the daily dose (it is recommended to use other dosage forms);
≤ 20 ml / min or patients on peritoneal dialysis: a 2-fold reduction in the daily dose.

Side effect

The frequency of adverse reactions on a special scale (very often more than 10%, often more than 1%, but less than 10%, infrequently - more than 0.1%, but less than 1%, rarely - more 0.01%, but less than 0.1%; extremely rarely - less than 0.01%; with an uncertain frequency - it is impossible to estimate the frequency of side effects based on available data):

from the digestive system: often - nausea, vomiting, diarrhea, digestive disorders, abdominal pain; very rarely - pseudomembranous colitis;
from the respiratory system: with an uncertain frequency - dyspnea;
from the hepatobiliary system: rarely - increased bilirubin in the blood, increased activity of hepatic transaminases and alkaline phosphatase; very rarely - hepatitis and cholestatic jaundice;
from the hemopoietic system: very rarely - thrombocytopenia, eosinophilia, pancytopenia, transient leukopenia, agranulocytosis; with an uncertain frequency - hemolytic anemia, blood clotting disorders;
from the urinary system: very rarely - a small increase in urea and creatinine in the blood, hematuria; with an uncertain frequency - the development of an acute form of renal failure with concomitant tubulointerstitial nephritis;
from the side of the central nervous system: infrequently - dysphoria, headaches, anxiety, dizziness;
allergic reactions: rarely - hives, itching, erythema multiforme, rash; very rarely - toxic epidermal necrolysis, drug fever, a reaction resembling serum sickness, hemolytic anemia, interstitial nephritis, Stevens-Johnson syndrome, anaphylactic shock; with an uncertain frequency - a syndrome of drug rash with systemic manifestations and eosinophilia.

Overdose

Most often occurs with an increase in the daily dose, the frequency and intensity of side effects increase. Treatment is symptomatic, gastric lavage, prescribe antihistamines and glucocorticoids.

special instructions

Before starting treatment, read the special instructions:

During treatment, a positive direct Coombs reaction and a false positive urine reaction to glucose are possible.
With prolonged use, there may be a violation of normal intestinal microflora, which can lead to the growth of Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.
In patients with a history of allergic reactions to penicillins, there may be manifestations of hypersensitivity to cephalosporin antibiotics.
Caution should be used in elderly patients, patients with chronic renal failure or pseudomembranous colitis (in the anamnesis), in children under 6 months of age.

Interaction with other drugs

When prescribing the drug, it is necessary to take into account interactions with other drugs:

Possible bleeding when taking with anticoagulants at the same time.
With simultaneous use with normotimics in plasma, the content of carbamazepine increases.
Urikozuricheskie means inhibit the removal of the active substance in the urine, which can lead to increased adverse reactions.
When used simultaneously with polypeptide antibiotics, aminoglycosides, diuretics in large doses, monitoring of the kidneys is necessary.

Reviews

We offer you to read reviews of people who used Suprax solute:

Olga. My husband had cystitis, Supraks was appointed, he quickly put it on his feet. A fairly powerful drug, but you must be careful when applying and follow the doctor's instructions.
Elena. The brother picked up a strong otitis. The district doctor appointed Supraks. I went to the pharmacy, I bought two packages. We took strictly according to the instructions, followed all the recommendations of the doctor. A couple of days later, his brother felt better, and a week later he was already in an absolutely normal state, even he could go to work. I will all advise this antibiotic. Works well and no side effects.
Anna. My daughter was prescribed suprax from cystitis, did not help, eventually they said later to drink monoal, though once, but still he costs five cents. In general, I do not understand why doctors prescribe antibiotics from themselves, without any analysis. Everywhere, after all, it is written that the analysis of the flora for sensitivity must first be made.

Analogues

The modern pharmaceutical market offers a wide choice of cephalosporin antibiotics. For some patients, Suprax is not suitable because of hypersensitivity to the components of the drug, so you have to look for an alternative.

The most widely used analogues are listed below:

Ceforal Solutab;
Cefix;
Azithromycin;
Panzef;
Cemidexor;
Sumamed;
Ixim Lupine.

Before buying an analogue, consult your doctor.

Supraks or Sumamed - which is better?

Active substance Sumameda - azithromycin, belonging to the subclass of azalides. Azalides are fundamentally different in structure from cephalosporins and macrolides. The main difference of Sumamed is the bacteriostatic type of effect. In other words, Sumamed does not destroy pathogenic bacteria, but only stops the processes of their growth and development in the human body. However, Sumamed has a prolonged action and is able to maintain therapeutic concentrations up to 5-7 days, which will allow it to be prescribed in short courses.

Both drugs have a wide range of microorganisms sensitive to them. However, the results for determining the susceptibility of the isolated pathogens for each specific infection should be taken into account.