Heptral tablets and ampoules: instructions for use and reviews of people

Heptral is a hepatoprotector with antidepressant activity.

The main active substance is ademethionine, which possesses regenerating, detoxifying, antifibrozing, antioxidant and neuroprotective properties. The drug fills the deficiency of ademetionine (active ingredient Geptral) and stimulates its production in the body, primarily in the liver and brain.

On this page you will find all information about Geptral: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Geptral. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Hepatoprotector, has antidepressant activity.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Heptral? The average price in pharmacies is at the level of, 00 - , 00 rubles.

Form of issue and composition

Medicinal forms of Heptral - tablets for oral administration and lyophilizate, from which a solution for IM and IV administration is prepared.

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Composition of tablets:

400 mg of ademethionine ion (in the form of ademethionine , -butanedisulfonate);
Excipients: sodium carboxymethyl starch, silicon colloidal dioxide, magnesium stearate, microcrystalline cellulose;
Sheath composition: polysorbate 80, macrogol 6000, methacrylic acid-ethyl acrylate copolymer (1: 1 ratio), simethicone (emulsion 30%), talc, sodium hydroxide, water.

For sale tablets of 10 pcs. in blisters, packed in cardboard packs.

In 1 bottle of Heptral solution contains 400 mg of ademethionine ion (in the form of ademethionine , -butanedisulfonate).

The composition of the supplied solvent: injection water, sodium hydroxide and L-lysine.

Pharmacological effect

Heptral promotes the provision of antioxidant, antidepressant, neuroprotective, hepatoprotective, choleretic, detoxifying effects.

When using medicament, detoxification of bile acids is enhanced.
The work of transport systems of bile acids improves and the output of bile in the bile excretory system is normalized. The choleretic and hepatoprotective action is maintained for 12 weeks after the discontinuation of the use of the drug Heptral.
Antidepressant activity manifests itself gradually, beginning with the end of the first week of treatment, and stabilized within 2 weeks of treatment. Has the ability to interrupt recurrence of depression.
Effective in recurrent endogenous and neurotic depressions resistant to amitriptyline.
The appointment in osteoarthritis reduces the severity of the pain syndrome, increases the synthesis of proteoglycans and leads to partial regeneration of the cartilaginous tissue.
Prolonged use of the drug increases cysteine and taurine in the blood plasma, as well as glutamine - in the liver. Methionine decreases, and the metabolic processes in the liver region normalize, the organ's functioning is normalized.

The active component of the drug contributes not only to recovery of ademetionine, but also stimulation of its production in the liver, brain and spinal cord, as well as in other organs.

Indications for use

What helps? Indications for the appointment of Geptral are:

Cholangitis.
Hepatitis of chronic course.
Pronounced cirrhosis of the liver.
Signs of severe depression.
Chronic galloping cholecystitis.
Intrahepatic cholestasis in pregnant women (impaired synthesis and outflow of bile).
Encephalopathy, including those caused by hepatic insufficiency (including alcoholic).
Intrahepatic cholestasis against cirrhotic and precirculatory conditions (including fatty liver dystrophy).
Toxic liver damage of various origins, including viral, alcoholic, medicinal (oral contraceptives, tricyclic antidepressants, antibiotics, anti-tuberculosis, antitumor and antiviral drugs).

Contraindications

Despite the numerous positive qualities of this drug, there are a number of restrictions on its administration, which just act as contraindications. These include individual intolerance to one of the components of Heptral, due to increased sensitivity of the organism.

Caution is prescribed to patients with bipolar disorders.

Application in pregnancy and lactation

The use is contraindicated for women in the I and II trimester of pregnancy.

The drug can be prescribed in the last trimester of pregnancy if the effectiveness of the use of the remedy for the mother is higher than the potential risk for the child. In many reviews about Heptral it is recommended to stop breastfeeding while taking the drug.

Instructions for use

The instructions for use indicate that heptral is available in the form of tablets and a solution for injection.

Heptral tabletsare covered with an enteric coating and are intended for oral administration, they should be swallowed whole, not liquid, squeezed with water (in small amounts). The recommended single dose, corresponding to 1 tablet of Hepral, should be taken 3-4 times a day. The duration of treatment is usually 3-4 weeks. Heptral tablets should preferably be taken between meals in the morning.
To the lyophilized Heptral in ampoulesthe solvent L-lysine is applied. Intravenous drip or intramuscularly the drug is prescribed in a daily dose of 400-800 mg. Intensive therapy with Heptral in ampoules is carried out in the first 2-3 weeks of treatment, supporting - the next 2-4 weeks (800-1600 mg / day).

Side effects

Most often, against the background of drug treatment, there was diarrhea, abdominal pain and nausea. Sometimes the use of heptral (iv, in / m or in tablets) can cause:

anxiety, insomnia, headache, confusion, paresthesia, dizziness;
disturbance of the activity of blood vessels and heart, inflammation of the walls of superficial veins, tides;
digestive tract, liver cirrhosis;
muscular spasm, joint pain;
hypersensitivity reactions, laryngeal edema;
skin manifestations of allergy, pruritus, rash, sweating, swelling of Quincke;
UTI (urinary tract infection);
malaise, fever, flu-like syndrome, chills, asthenia, peripheral edema;
dry mouth, abdominal distention, esophagitis, abdominal pain, dyspepsia, diarrhea, flatulence, vomiting, hepatic colic, nausea, bleeding from various parts of the gastrointestinal tract, functional disorders.

Overdose

If the dose or prolonged uncontrolled use is exceeded, the patient may develop an overdose that manifests itself in the form of an increase in the side effects described above. Antidote of the drug does not exist. In case of an overdose with Heptral, the patient should be given to take enterosorbents and sent to a doctor.

special instructions

Patients with depression need careful monitoring and ongoing psychiatric care in the treatment of ademetionine in order to monitor the effectiveness of treatment.
Insufficiency of vitamin B12 and folic acid may lead to a decrease in ademetionin concentrations, therefore, their concomitant use in usual doses is recommended.
When used in patients with cirrhosis of the liver against a background of hyperaemia, systematic monitoring of the level of nitrogen in the blood is necessary. During prolonged therapy, it is necessary to determine the content of urea and creatinine in the blood serum.
With care apply ademetionin in patients with renal insufficiency, with bipolar disorders, simultaneously with selective serotonin reuptake inhibitors, tricyclic antidepressants (such as clomipramine); preparations of plant origin and preparations containing tryptophan; in elderly patients.

When using ademetionine, dizziness is possible. Patients should not drive vehicles or work with other mechanisms until full the disappearance of symptoms that may affect the reaction rate for these activities.

Drug Interactions

There is a report on the development of serotonin syndrome in a patient who used ademetionine and clomipramine.

Ademetionine should be used with caution at the same time as selective serotonin reuptake inhibitors, tricyclic antidepressants, drugs and herbal products containing tryptophan.

Reviews

We picked up some of the people's comments about the Heptral drug:

Natalia. I take Heptral for more than a month, at the same time I follow the diet number 5. I passed an intermediate blood test, all the indicators improved much and feel much better. I really hope for a good result.
Elena. For several years I have been using the drug Heptral 2 times a year, droppers, and between them tablets. I have type 2 diabetes, sugar is high, I have to drink glucose. For the liver, it is harmful. The doctors talked all the time, and it was evident on the uzi that the liver has fatty degeneration and the parenchyma is loose, etc. Recently made MRI and CT and just fell down - everything is fine. Moreover, doctors commented that they rarely see such a healthy liver. Clear borders are dense, nowhere is there any stagnation or anything else bad. The drug is very good, although of course expensive. But what to do…
Tanya. I Heptral pricked, but only in a hospital, helped. And here at home tried or tasted tablets-zero to sense. And then deducted that the doctors do not prescribe him normal in this form. Yes, it is convenient, but... And it costs a lot. In tablets I like Maxarichnichut not worse in action than Heptral in pricks. It's also a hepatoprotector, but on vegetable raw materials (Maakia wood extract of Amur). I accept as well as Heptral with Tyoktatsidom.
Vasya. Good day to all. I want to share my experience about how I took this medicine. Unfortunately, my liver is not the strongest organ in the body. I took various medications, did not help, then the doctor wrote out "Geptral". Began to take, according to the instructions, the appointed doctor. The result was noticed after the course of reception of "Heptral", it turns out to be very effective. It is a pity that I did not know about him before, I would not have suffered so much time in vain. One is bad, it is expensive, but I think that health is more expensive. Now I'm not bothered by weakness and poor appetite, nausea, bloating, and mood improved. I recommend it to all, health to you and happiness!
Lesya. Only today did the 10th injection of Geptral. They did intramuscular to not go to the hospital. As pobochka, strong dizziness. A couple of days just fell, get up afraid. Completed every other day. The liver reacts 20 minutes after the injection with a kind of contented, warm sigh with a smacking.)) I like it very much. Immediately after the introduction, warmth through the veins is felt, hands become hot. Excellent acted as an antidepressant - a good share of pofigizma was added to everything. Adds tone, sleep after it does not work. Today I bought pills, tomorrow I'll start the reception. Then I'll give biochemistry and see what's wrong with the transaminases. But the sensations - the liver really liked it!