Ambiside Tablets

Ammiside is a combined bactericidal antibiotic of a wide spectrum of action.

It consists of two active substances: ampicillin and sulbactam. Ampicillin belongs to semisynthetic penicillins of the third generation. It inhibits the formation of the cell membrane of the bacterium, which leads to its death.

Sulbactam inhibits the specific bacterial enzyme beta-lactamase, thereby enhancing the antibacterial effect of the drug. The oral form of ampicillin with a sulbactam is called sultamycillin.

On this page you will find all information about Ammiside: the complete instructions for use for this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Ammiside. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic - penicillin semisynthetic + beta-lactamase inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Ammiside cost? The average price in pharmacies is at the level of300 rubles.

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Form of issue and composition

The drug is available in the form of tablets and powder.

One tablet of Ammiside contains 375 mg of sultamycillin. They are covered with a film sheath, in an amount of 10 pieces packed in dark glass bottles. The vials are located in cardboard packs.

The main active components of the powder are ampicillin and sulbactam.

The powder is of two types: for the preparation of a suspension for oral administration and for the preparation of a solution for intramuscular and intravenous administration. In the first case Ammisid volume of 250 ml is packed in a bottle of dark glass. In the second case, a powder with an ampicillin content of 500 mg and a sulbactam of 250 mg is supplied with water for the preparation of injections (1.8 ml) At the same time Ammiside is packed in bottles, and the solvent - in ampoules.

Pharmacological effect

The preparation contains two active substances - ampicillin and sulbactam. The drug is resistant to acids and is used to treat various diseases. Ampicillin has antibacterial activity, but is destroyed by beta-lactamase. The second component is sulbactam, it does not fight microorganisms, but it is an inhibitor of beta-lactamases. Consequently, the drug is an antibiotic with the ability to withstand lactamase strains.

The use of Ammiside because of its pharmacological properties is inexpedient in eliminating penicillin-forming strains of staphylococci, strains of Pseudomonas aeruginosa, Klebsiella strains and most enterobacteria.

According to the instructions to Ammiside, the pharmacokinetics of the main components are similar. They are resistant to the acidic environment of the stomach and are well absorbed in the gastrointestinal tract. If, at the same time that the food is ingested, then the absorption of the drug is reduced. The maximum concentration of Ammisid components is reached after 1-2 hours, if oral administration was given. After that, this indicator slowly declines for six hours. About 28% of the drug is bound by plasma proteins.

Indications for use

In accordance with the instruction, Ammiside is prescribed in cases of infections, the causative agents of which are bacteria sensitive to the medicine, namely:

Pneumonia, chronic bronchitis, lung abscess and pleural empyema (respiratory tract infection);
Cholecystitis and cholangitis (bile duct infection);
Middle otitis media, tonsillitis and sinusitis (ENT organs infections);
Roger, secondarily infected dermatitis and impetigo (infections of soft tissues and skin);
Pyelitis, prostatitis, pyelonephritis, urethritis, endometritis and cystitis (genital and urinary tract infections);
Meningitis, peritonitis, septic endocarditis, gonococcal infection, sepsis and scarlet fever;
Infections of joints and bones;
Dysentery, salmonellae and salmonellosis (GI tract infections).

Contraindications

According to the instructions to Ampiside, the use of the drug is not recommended for persons with infectious mononucleosis, hypersensitivity to the components of the drug, and also for women during lactation.

It is important to keep in mind that patients with renal or hepatic insufficiency and pregnant women do not have Ammiside's contraindication, but treatment should be done with caution.

Application in pregnancy and lactation

The drug should be given with extreme caution to pregnant women. The doctor determines the degree of risk of harm to the fetus, after which he can only prescribe the drug to the patient. Taking a drug during lactation it is better to transfer the child to artificial feeding.

Instructions for use Ammisiad

The instructions for use indicate that Ammiside is used orally, intramuscularly and intravenously.

The method of administration and the necessary doses of the drug (1.5 - 12 or more g / day) are determined by the doctor, depending on the localization and severity of the pathological process. The general rule is to conduct an intradermal test to determine the individual sensitivity of the body to the antibiotic, before starting treatment to avoid allergic reactions. Consistent with the half-life, the daily dose of Ammisid is broken down into 3-4 injections. Sometimes, the drug is administered 2 times a day. The course of treatment, as a rule, does not exceed 2 weeks. It is necessary to continue receiving Ammiside within 2 days after clinical recovery and the disappearance of productive symptoms.

Orally, Ammiside is prescribed before meals, for 1-2 hours, breaking the daily dose by 2-4 admission. Intravenously the drug is used in severe clinical cases (a single dose is dissolved in 100-200 ml of 5-10% solution glucose or isotonic solution), in the early days, gradually switching to intramuscular injection. Usually, the daily dose of the drug for children, weighing less than 30 kg, is calculated from the ratio: 0.15 g of Ammiside for each kilogram of the child's weight, in uncomplicated cases. Immediately before the surgery, with the goal of preventing postoperative infections, the administration of 1.5-3 g of Ammiside is shown.

Side effects

From the hematopoietic system: decreased hemoglobin, lymphocytosis, thrombocytopenia, eosinophilia, agranulocytosis, thrombocytosis (from ≥0.1% to <1%).
From the urinary systeminterstitial nephrosis (from ≥0.1% to <1%).
From the skin: itching, hives, erythema multiforme.
From the side of the digestive tract: nausea, diarrhea, glossitis, enterocolitis, pseudomembranous colitis (rarely enough).
Other: with prolonged use of the drug candidiasis of the vagina, in patients with reduced resistance of the body, the development of superinfection is possible.

Overdose

When an antibiotic is overdosed, dizziness, increased fatigue, headaches, drowsiness, general malaise, sleep disturbance, emotional lability, depressive state, increased anxiety. At very high concentrations of the drug in the cerebrospinal fluid, the normal functioning of the central nervous system is disrupted, up to the development of seizures.

special instructions

In patients suffering from hypersensitivity to penicillins, a cross-allergic reaction with cephalosporin antibiotics is possible.

During treatment, the kidneys, liver and hematopoiesis should be monitored.

Perhaps the development of superinfection due to the growth of insensitivity to the preparation of microflora. In this case, the antibacterial therapy is adjusted.

In the treatment of sepsis, the Yarisch-Gerxheimer reaction may develop.

Drug Interactions

Bacteriostatic agents have an antagonistic effect, and bactericidal antibiotics are synergistic.
The drug reduces the effectiveness of oral contraceptives and drugs, in the process of metabolism which forms PABC. Increases the effectiveness of indirect coagulants.
Ammiside is incompatible with blood products, aminoglycosides and protein hydrolysates.
Laxatives, glucosamine, antacids and aminoglycosides decrease and slow down absorption, and vitamin C - increases.
NSAIDs, allopurinol and diuretics increase the concentration of ampicillin in the blood.
Allopurinol increases the risk of skin rash.

Reviews

Reviews about Ammiside talk about the unconditional effectiveness of the drug in the treatment of infectious diseases caused by sensitive microorganisms.

Describe the various side effects of the drug, which are passing and most often mildly expressed. With the proper selection of the treatment regimen and in the absence of contraindications, the Ammiside drug shows good results.