Famotidine

Famotidine is a drug that belongs to the group of histamine H2 receptor antagonists. This tool is used in the treatment of peptic ulcer and reflux esophagitis.

The drug suppresses the secretion of hydrochloric acid as its own. This is due to the stimulation of gastrin, histamine and acetylcholine. In this case, the activity of enzymes that break down proteins - pepsin - decreases. The therapeutic effect occurs 60 minutes after a single dose and lasts from 12-14 hours.

Before using the medication, you need to remember that it can hide symptoms caused by carcinoma of the stomach. Therefore, before the start of therapy, it is necessary to exclude any malignant neoplasms. The refusal to take should be gradual, since there is a risk of developing a bounce syndrome due to a sharp cancellation. With prolonged therapy of patients with weakened immune system and nervous disorders, bacterial lesions of the stomach and further spread of infection are possible.

Clinical and pharmacological group

The blocker of histamine H2 receptors. Antiulcer drug

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Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much is Famotidine in pharmacies? The average price is at the level of25 rubles.

Composition and form of release

The drug Famotidine is available in the form of a tablet for oral (oral) use. They have a round shape, brown color, biconvex smooth surface.

Tablets contain the active ingredient famotidine in an amount of 20 or 40 mg.
Additional elements are: starch, magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, talc, as well as titanium dioxide, hydroxypropylmethylcellulose, iron oxide, macrogol 600.

Tablets are packaged in a blister for 10 pieces. Cardboard pack contains 2 or 3 blisters with tablets, as well as instructions for using the drug.

Pharmacological effect

The blocker of H2-histamine receptors of the third generation. Suppresses basal and hydrochloric acid products stimulated by histamine, gastrin and acetylcholine.

Reduces the activity of pepsin. Strengthens the protective mechanisms of the mucous membrane of the stomach and promotes the healing of the damage associated with the action of hydrochloric acid (incl. cessation of gastrointestinal bleeding and cicatrization of stress ulcers) by increasing the formation of gastric mucus, the content of glycoproteins in it, stimulation of the secretion of hydrocarbonate by the gastric mucosa, endogenous synthesis of prostaglandins in it and the rate of regeneration. Essentially does not change the concentration of gastrin in the plasma.

It weakly inhibits the oxidase system of cytochrome P450 in the liver. After oral administration, the effect begins after 1 hour, reaches a maximum within 3 hours. The duration of the drug in a single dose depends on the dose and is from 12 to 24 hours.

Indications for use

This medication is recommended for use in such diseases and conditions as:

erosive gastroduodenitis - pathological lesion of the mucous membrane of the duodenum and stomach;
unpleasant sensations and pains in the stomach against the use of antibiotics, severe stress;
Zollinger-Ellison syndrome is a specific symptomatic complex that is caused by a gastrin-producing tumor of the duodenum or pancreas;
ulcerative diseases of internal organs;
functional dyspepsia - discomfort and discomfort in the pancreas after eating;
increased gastric acidity, which is accompanied by eructations and heartburn;
bleeding in the gastrointestinal tract of various etiologies;
polyendocrine adenomatosis - a disease that is characterized by the formation of increases in 2 or more endocrine glands.

Contraindications

Famotidine is not prescribed for breastfeeding, intolerance to the components, during pregnancy.

With cirrhosis of the liver with concomitant portosystemic encephalopathy, with pathology of the kidneys, liver system, in pediatrics appoint with caution.

Intended use for pregnancy and lactation

The use of the drug during pregnancy is possible only if the potential benefit to the mother exceeds the risk to the fetus.

The drug penetrates into breast milk. During lactation, famotidine should be discontinued or breastfeeding should be discontinued.

Dosage and route of administration

As indicated in the instructions for use Famotidine taken orally, without chewing, squeezed with sufficient water.

When reflux-esophagitis - 20-40 mg 2 times a day for 6-12 weeks.
For dyspepsia associated with increased secretory function of the stomach, appoint 20 mg 1 -2 times a day.
To prevent relapse of peptic ulcer of the stomach and duodenum: 20 mg once before bedtime.
With Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and can be increased to 160 mg every 6 hours.
With peptic ulcer of the stomach and duodenum in the phase of exacerbation, symptomatic ulcers, erosive gastroduodenitis usually prescribed 20 mg twice a day or 40 mg once a day at night. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.
To prevent the aspiration of gastric juice with general anesthesia appoint 40 mg in the evening and / or in the morning before the operation.

In renal failure, if the CK is less than 30 ml / min or the serum creatinine content is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 20 mg.

For the prevention of recurrent bleeding from the upper gastrointestinal tract - 20 mg twice a day for 3-4 weeks.

Adverse Reactions

On the background of taking Famotidine tablets Side effects from various organs and systems can develop:

Allergic reactions: skin rash, itching, urticaria, bronchospasm, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic shock.
From the hematopoiesis: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.
On the part of the digestive system: dry mouth, nausea, vomiting, abdominal pain, constipation, diarrhea, loss of appetite, increased activity of "liver" transaminases, cholestatic jaundice, hepatitis, acute pancreatitis.
From the side of the nervous system: headache, dizziness, asthenia, drowsiness, insomnia, fatigue, depression, excitement, ringing in the ears, hallucinations, confusion, blurred vision.
From the cardiovascular system: lowering blood pressure, bradycardia, atrioventricular blockade, arrhythmia, vasculitis.
On the part of the reproductive system: with prolonged intake of large doses - hyperprolactinaemia, gynecomastia, amenorrhea, decreased libido, decreased potency.
Other: acne, alopecia, fever, arthralgia, myalgia.

The appearance of signs of the development of negative pathological reactions against the background of taking tablets is the basis for stopping the drug and calling a doctor.

Overdose

In the event of a significant excess of the recommended therapeutic dose of Famotidine tablets, vomiting occurs, motor excitement, tremor (trembling) of limbs, more frequent heart contractions (tachycardia). In this case, the stomach, intestine, intestinal sorbents, and symptomatic therapy are washed.

There is no specific antidote for the drug to date.

special instructions

Patients with burns may need to increase the dose of the drug due to increased clearance.

The effectiveness of the drug in inhibiting night secretion of acid in the stomach can be reduced by smoking.

If a dose is missed, it must be taken as soon as possible; Do not take if it is time to take the next dose; do not double the dose.

Symptoms of duodenal ulcer can disappear within 1-2 weeks, therapy should be continued until the scarring is confirmed by endoscopic or X-ray data. May mask symptoms associated with carcinoma of the stomach, so before starting treatment, you must exclude the presence of malignant neoplasm. They are being canceled gradually because of the risk of developing the "rebound" syndrome with a sharp cancellation.

With long-term treatment of weakened patients, as well as under stress, bacterial lesions of the stomach are possible with the subsequent spread of infection. Blockers of H2-histamine receptors should be taken 2 hours after the administration of itraconazole or ketoconazole in order to avoid a significant reduction in their absorption. It counteracts the influence of pentagastrin and histamine on the acid-forming function of the stomach.

Suppresses the skin reaction to histamine, thus leading to false negative results (before carrying out diagnostic skin tests it is recommended to stop the use of H2-histamine receptor blockers to detect an allergic skin reaction of an immediate type).

During treatment, avoid eating foods, beverages and other medications that can cause irritation of the gastric mucosa.

Compatibility with other drugs

When used simultaneously with antacids, sucralfate, the intensity of absorption decreases famotidine, therefore a break between taking these drugs should be at least 1-2 hours.

Inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, metoprolol, lidocaine, phenytoin, theophylline, indirect anticoagulants, glipizide, buformin, metronidazole, caffeine, blockers of "slow" calcium channels, tricyclic antidepressants. Increases the absorption of amoxicillin and clavulanic acid.

Due to the increase in the pH of the contents of the stomach with simultaneous intake may decrease absorption of ketoconazole and itraconazole.

Drugs that depress the bone marrow increase the risk of developing neutropenia.

Reviews

We suggest you read the reviews of people who used Falimint:

Julia. Papa accepts famotidine, he has something with his stomach, and somehow he was not in the pharmacy and the pharmacist gave ranitidine, said it was the same. Nothing of the kind, maybe the composition is similar, but ranitidine does not help as much as famotidine. Here you have the same drugs.
Vika. Once this drug saved me. I drank in the morning on an empty stomach kefir at work and for about 15 minutes I was so twisted, I could not straighten. Guts twisted, twisted, I do not know what it was. But my friend gave me a tablet famotidine and in about 20 minutes I started to let it go, and after another half hour as if nothing had happened I already worked. I do not know what happened and why it happened, but now I carry this drug all the time in my purse. Suddenly something like this will happen again, but nothing will be on hand.
Lydia. At me a chronic pancreatitis and a preparation Famotidine I accept not so long ago (long time accepted Ranitidinum). When the severity and pain in the left hypochondrium appear during the exacerbation, Famotidine quickly and, most importantly, gently removes these unpleasant sensations. But since the drug has a high degree of purification it is much safer to take it than other drugs of this group.