What helps the drug Gordoks

Gordoks is a medical preparation of hemostatic action.

It also has an anti-proteolytic and antifibrinolytic effect on the processes occurring in the body. The properties of this drug are used to reduce bleeding of various types, especially in cases of surgical operations of the prostate and lungs.

On this page you will find all information about Gordox: a complete instruction on the application to this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Gordoks. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The fibrinolysis inhibitor is a polyvalent plasma proteinase inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Gordox cost? The average price in pharmacies is at the level of190 rubles.

Form of issue and composition

The drug Gordoks is available in the form of a concentrate for the preparation of a solution, which will be administered intravenously.

1. The active substance of the drug is aprotinin, whose concentration reaches 100 000 units of kallikrein inhibition (KIE). This compound refers to the organic, as it is derived from light cattle and is a protease inhibitor.
2. Auxiliary compounds are represented by a solution of sodium chloride, benzyl alcohol and water for injection.

Concentrate looks like a colorless or slightly yellowish liquid without foreign inclusions.

Pharmacological effect

The active substance aprotinin is a polypeptide compound that has the ability to suppress the activity of various proteolytic enzymes - trypsin, plasmin, kallidogenase, etc.

Aprotinin is an active inhibitor of kallikrein and has an effective antiproteolytic, hemostatic and antifibrinolytic action. Well distributed in tissues, inactivated in the digestive tract, mainly excreted by the kidneys in the form of inactive metabolites.

The use of Gordox is extremely effective in the defeat of the pancreas, for the prevention and treatment of various shock conditions.

Indications for use

According to the instructions, Gordox is recommended for taking pancreatitis (chronic and acute), pancreatic necrosis, bleeding induced by hyperfibrinolysis, polymenorrhea. The drug is effective in angioneurotic edema, shock, extensive and traumatic tissue damage.

Gordoks can be used for the prevention of acute nonspecific postoperative parotitis, bleeding and embolism, and also as an auxiliary therapy.

Contraindications

Gordoks is contraindicated in people with an individual intolerance to aprotinin, women in the first and third trimesters of pregnancy, and also during lactation. The drug should be used very carefully with a background of deep hypothermia and stopping normal blood circulation systems and organs (DVS-syndrome) and in case of allergic reactions in the anamnesis to previous aprotinin therapy.

The drug can be used after 12 weeks of pregnancy under strict medical supervision and only in the event that, when for the mother the intended use of the drug exceeds the potential threat to the fetus.

Application in pregnancy and lactation

Studies concerning the effect of the drug on the body of pregnant women have not been conducted.

When pregnancy is prescribed, Gordox is allowed only if the potential benefit of therapy for the mother substantially outweighs the possible risks to the fetus. In assessing the benefit / risk relationship, it is necessary to take into account the adverse effects on the fetus of severe adverse reactions, sometimes manifested when a drug means, which include heart failure, anaphylactic reactions, etc., as well as the medical procedures that are carried out to eliminate these reactions.

The influence of Gordox on lactation is not well understood. The drug is considered potentially safe when it enters the body of a child with breast milk, because with oral intake bioavailability of aprotinin is minimal.

Instructions for use

In the instructions for use, it is indicated that Gordox is administered iv, slowly. The maximum rate of administration is 5-10 ml / min. When the drug is administered, the patient should be in the supine position. Gudox should be injected through the trunk veins, do not use them for the administration of other drugs.

1. In connection with a high risk of allergic / anaphylactic reactions, a trial dose of 1 ml (10 ks) should be administered to all patients 10 minutes prior to the introduction of the main dose of Gordox. KIE). In the absence of negative reactions, a therapeutic dose of the drug is administered. It is possible to use blockers of histamine H1 and H2 receptors 15 minutes before the administration of the drug Gordoks. In any case, standard emergency measures should be provided to treat an allergic / anaphylactic reaction.
2. Adults should be given an initial dose of 1-2 million. KIE; is administered iv slowly for 15-20 min after the onset of anesthesia and before sternotomy. The following 1-2 million KIE added to the primary volume of the heart-lung device. Aprotinin should be added to the primary volume during the recycling period to ensure sufficient dilution of the drug and prevent interaction with heparin.

After the end of the bolus injection, a constant infusion is established with a rate of administration of 250-500 thousand. KIE / h before the end of the operation. The total amount of aprotinin administered during the entire course should not exceed 7 million. KIE.

Patients with impaired renal function, elderly patients do not need dose adjustment.

Side effects

Particular attention should be paid to the side effects of Gordox.

1. From the cardiovascular system may occur hypotension, tachycardia, as well as the increased incidence of myocardial infarction with a second aorto-coronary bypass surgery compared with control groups (mortality rates, however, are still the same).
2. From the side of the central nervous system, psychotic reactions, confusion and hallucinations are possible.
3. Allergic reactions can be noted conjunctivitis, rhinitis, urticaria, bronchospasm, pruritus, anaphylaxis and anaphylactoid reactions (dyspnea, skin rash, increased heart rate, nausea).

When administering aprotinin in high doses and during surgical operations on the heart, a temporary increase the level of creatinine, which in very rare cases is accompanied by clinically significant symptoms.

Overdose

At the moment, cases of Gordox overdose are not registered. There is no specific antidote to the drug.

special instructions

If symptoms of side effects of Gordox occur during the administration of the drug, it is necessary to urgently stop the introduction. With hyperfibrinolysis and ICE syndrome, aprotinin administration is possible only after elimination of all symptomatology of the syndrome and against the background of preventive administration of heparin.

With special care should be prescribed to patients who received in the previous 2-3 days muscle relaxants.

It is counter-indicative to apply Gordox together with preparations containing dextran - this combination provokes the risk of allergic reactions.
Contents of the opened ampoule Gordoks should be used at a time, with repeated use to enter the solution from an open ampoule can not.

In cases where, for any reason, you can not perform a long drop infusion, Gordoks can be administered SC every 2-3 hours.

Drug Interactions

When Gordox is used with other drugs, undesirable interactions may appear, which are caused by the mutual influence of active or auxiliary compounds on each other.

So, the active substance of Gordox blocks the effect of thrombolytic agents and enhances the effect of heparin preparations. When used in conjunction with dextran, the effect of both drugs intensifies, which increases the risk of acute intolerance to these drugs.

Reviews

We picked up some feedback from people about the drug:

1. Artem. I have chronic pancreatitis. In a seasonal exacerbation, only Gordox is saved in / in. The drug is not new, but today it is better than this medicine.
2. Sasha. The surgeon introduced 2 times gordoks for the treatment of parotid salivary gland. First he pumped the liquid out of the cyst, then introduced the gordox in approximately the same volume. The injection was done after 3 days. The surgeon prescribed 5 injections of gordox, then 3 injections of the kenologist into the cyst cavity.
3. Zhenya. The last acute attack of HP was in early March. The gordoks dripped, it seemed to get better, but a month later the pains appeared again, not strong. The diet is meager, strong weight loss. On ultrasonic have told or said, pancreatic in norm or rate, changes are not present.

Reviews about Gordox, which are found on the network, mainly indicate a positive experience of using the drug in the treatment of acute forms of pancreatitis. It is reported, in particular, that in acute pancreatitis, Gordox removes acute manifestations of the disease within 2-3 days. The testimonies indicate that Gordoks is also used to treat children, but only when appointing a specialist.

Analogues

Substitutes and analogs Gordoks for the active substance and field of medical use, the list of preparations:

• Aprothex,
• Traskolan,
• Aprotinin,
• Aeros,
• Trasylol 50, 00
• Ingridry
• Counter.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep the drug in a dark, cool, dry place, protected from light and children at a temperature of no more than 20 ° C. The shelf life of drugs from the date of issue, if all recommendations are observed, is 5 years.

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