The best antiviral drug in ARVI

Review of antiviral drugs in cases of influenza and influenza

Any disease, especially ARVI and the Flu is easier, cheaper and safer not to treat, but not to prevent, to prevent its occurrence. Recently, especially worried about the "point" - it's safer. Should I take antiviral pills at all? In today's complex world, how to understand the issues:

• Will the effect of using an expensive antiviral drug?
• Which drug is better for adults to take flu, children?
• Do not it cause harm to health?
• Is there the best cure for flu?
• Effective antiviral drugs - is it advertising, business, dummy or not?

Antiviral drugs for Orvy on the Russian pharmaceutical market are as follows:

Virtually all antiviral drugs for orvi and flu have no evidence base for their antiviral efficacy. Studies are very expensive, conducted by the manufacturers themselves and those interested in the positive conclusion of the parties. Today, most clinical trials of new drugs are regularly falsified in order to bring "miraculous" drugs to the market with a new price tag. Given the fabulous commercial benefits of selling expensive antiviral drugs during the epidemic, honesty and objectivity of research is not believed. As you know, pharmacological publications, even in medical journals today, are about 90 percent - these are custom-made articles of an advertising nature.

Today in the pharmacy chains an abundance of various medicines, some of which in fact "Medicines" are not, because there are a lot of fakes, frank dummies and inefficient means. Advocates of patients' rights in Ukraine, for example, argue that in 4 drugs registered as antiviral - the active substance was not found. However, a wide advertising company allows producers to earn millions of hryvnias on them per year.

Antiviral drugs for Orvi are conventionally divided into:

• Vaccines - stimulation of the production of antibodies before infection with the virus
• Immunostimulants - drugs that temporarily enhance nonspecific immunity, which promote the production of interferons
• Antiviral drugs are agents that affect neuraminidase (a viral enzyme) by suppressing the multiplication of the virus (Oseltamivir, Zanamivir) and blockers of M2-channels Amantadine, Remantadin - these drugs have proven clinical effectiveness, but as any means have a number of side effects effects.

Most antiviral drugs for orvi and influenza are developed and applied no more than 10-40 years. The drug should have a greater "trial period" in order to draw a conclusion about its effectiveness and side effects. As for immunostimulants, these funds can have delayed consequences (development risks autoimmune diseases, oncological diseases of the blood, etc.) and should be prescribed according to strict indications.

Immunity modulators and antiviral agents

The immunostimulants produced today show the activation of immune reactions at the biochemical level (what is called "In vitro"), but their real benefits and long-term consequences of use are rather complex, poorly understood region. Since information on many mechanisms of immunity has become known relatively recently, scientists are getting more and more information about its functioning every year. Therefore, there is no confidence in the safety and correctness of general stimulation of the "under-researched" immune system (see Fig. what is immunity and whether drugs are needed to improve it). Especially prudent should be the preventive use of immunostimulants and the treatment with antiviral medicines for children.

"Pharmacy immunostimulants can not only help the body, but also harm" - says Ph.D. Tatyana Tikhomirova, immunologist-allergist. Such a state as hyperactivation of the immune system, as well as immunodeficiency is extremely dangerous, the human body functions normally only with the balance of the immune system. And if a person each time stimulates ("to increase self-immunity"), then, in the presence of predisposing factors, this may result in pathological inflammation, launching of immune aggression on healthy tissues, hyperactivation of the immune system and theoretically (in extreme cases) to the development of autoimmune or oncological disease.

If the next of kin has any autoimmune disease (rheumatoid arthritis, insulin-dependent sugar diabetes, Sjogren's syndrome, multiple sclerosis, etc.), then under no circumstances should a person use any immunostimulants. Even if a person is healthy, there is already a violation of the immune system, and one can live with them all his life, but if he is rude and persistently try to stimulate their immune system, it can end with the debut of an autoimmune disease.

Fortunately, for most healthy people, without the presence of any predisposing factors, it is difficult to "achieve" your immunity so as to seriously damage your health. Since most of the known immunostimulants either do not work at all, or almost do not work. One part of the drugs - an ordinary deception, another - ineffective means. But it should be remembered that any drug has side effects.

Drug Groups	Act	Names of drugs
Interferon preparations	Blockade of viral mRNA translation, presentation of viral antigens	Recombinant alpha / gamma interferons
Etiotropic means	Neuraminidase inhibitors	Relenza Tamiflu Peramivir
Ion channel blockers	Rimantadine (Remantadin, Orvirem)
Antiviral drugs with varying degrees of evidence of action	Enabling synthesis endogenous interferons	Kagocel Cycloferon Lavomax (Amiksin, Tyloron) Cytovir 3
Specific HA chaperone	Arbidol
NP-Protein Inhibitors	Ingavirin

Alexander Khadzhidis, Chief Clinical Pharmacologist, St. Petersburg states the following: "Some doctors for some reason first appoint patients antipyretic drugs, and then immunomodulators, supposedly for the production of interferon - which is illogical and generally is absurd. That is, first, knocking down the temperature - "forbid" the body to fight the virus (at high temperature, antibodies are produced against the virus and infection), and then artificially "forced" do.

In developed countries, interferonogens (drugs that stimulate the production of interferon) are not at all. Interferons can work only with parenteral (intravenous) administration, and even then, their effectiveness is questionable. In Russia, these drugs are extremely popular, despite the fact that they are useless.

With regard to antipyretics with the virus - to knock down the temperature better with paracetamol and once with a rise in temperature, rather than 4 p / day - "just in case." Taking Aspirin (acetylsalicylic acid) in ARVI, especially in children under 12 years old, is contraindicated, it can become the cause of severe damage to the central nervous system and the liver, it is not recommended to apply it to those who suffered from peptic ulcer disease Gastrointestinal tract. "

Well-known in Russia doctor Alexander Myasnikov says that all immunomodulators widely advertised in our country are a waste of money. In the United States and Western Europe, it is already unequivocally recognized and proven that these remedies are ineffective, but most Russian doctors continue to believe in the power of immunomodulators in treating Orvi.

Cytovir 3

Pharmacological action: Integratedimmunostimulating, an antiviral drug,

has an interferonogenic effect. As part of the drug - Timogen sodium, ascorbic acid, bendazole. Timogen synthetically obtained dipeptide, it enhances the nonspecific resistance of the organism. Ascorbic acid normalizes the permeability of capillaries, reducing the activity of the inflammatory process. Bendazol stimulates the production of endogenous interferon in the body.

Side effects: in people suffering from vegetative-vascular dystonia, causes a decrease in blood pressure.

Contraindications: in pregnancy, children under 1 year, thrombophlebitis, severe hypotension, diabetes mellitus, stomach ulcer, urolithiasis.

Issued: since 2001 in capsules, for children since 2006 in syrup, in powder for the preparation of solution
Research: There is no reliable information about clinical trials confirming its efficacy and safety. Often, doctors and pharmacists recommend this tool for children, but use it to treat children should be used with caution or not used at all.

References: Quite a lot of reviews in patients who use Citovir, about the effectiveness and absence of side effects. Improvement of well-being is observed on the second-third day, in single cases the drug did not help.
Price: Cytovir 3 - average240-580rub.

Kagocel

Pharmacological action: inducer of interferon synthesis, antiviral,immunomodulatingeffect. Composition: the sodium salt of the copolymer, which causes the formation of late interferon, which has high antiviral activity. The greatest effect occurs if you start treatment within the first 24 hours of the disease, but not later than the 4th day after the onset of an acute infection. With a view to prevention, it is possible to take it at any time, preferably immediately after contact with a sick Orvy or a flu.

Side effects: the emergence of allergic reactions.
It is issued: It is registered in 2003, since 2005 it is made in tablets, since 2011 it is resolved to use for children over 3 years old for the treatment of influenza, as an prevention for children can be used for children older than 6 years.

Research efficiency and safety: There is conflicting information. The active ingredient is the sodium salt of the gossypol copolymer with carboxymethyl cellulose.

And Gossipol itself is a natural polyphenol, it has been banned in the world since 1998 due to its toxicity. Gossypol for a long time and actively studied by some countries as a contraceptive, with its continued intake completely stops spermatogenesis. Chinese and Brazilian scientists say that host gossypol boys and men may suffer infertility in the future. However, Kagocel is not pure gossypol, it is the sodium salt of the copolymer, which has other properties that differ from the properties of the chemical itself.

The manufacturer actively advertises the drug and claims that the salt in Kagocel is negligible, 4 times lower than the concentration from the international standards allowed. Multiple stages of purification of the product ensure the absence of free Gossypol in the final drug, which is checked by monitoring the quality of each series of Kagocel tablets. The method used to check the availability of free gossypol is very accurate, it can reveal its content higher, 036%. In early 2013, data were published on tests performed on rats - no changes in reproductive function were detected in animals.

That is, research on primates was not done? It is known that gossypol for different animal species has its maximum dose of toxicity, according to the EFSA (European Food Safety Authority) for rats the limiting toxic dose is 2200-3300 mg / kg.,for pigs 550, for guinea pigs up to 300 mg / kg. The research carried out by the manufacturer consisted in the administration of therapeutic doses to male rats, and doses 25 times higher than therapeutic doses250 mg / kg). Can you trust the rest of the statements and "studies"?

Neither in Western Europe nor in the United States Kagocel is not used, there are no WHO medicines on the list. The effectiveness of the drug is not proven according to the representatives of the Formulary Committee of the RAMS and SDMX. There were no statistical studies on the development of side effects as of autumn 2013.

The drug is actively recommended for use by adults and children, but evidence of the safety of this medicines for children 3-6 years old no, clinical studies for this age group are not was produced.

Reviews: Many help, some children and adults are allergic reactions in the form of rashes, swelling, itching.
Price: Kagocel - average180-280rub. In 2012, the volume of sales amounted to - 2.64 billion. rubles

Tyloron (Amiksin, Lavomax)

Pharmacological action: active ingredient Tiloron, possesses antiviral andimmunomodulatingaction, it is a synthetic inducer of interferon that stimulates the formation of interferons alpha, beta, gamma.

Side effects: short-term chills, allergic reactions, contraindicated in breastfeeding and pregnancy.

Issued: almost 40 years ago, children under 7 years of age are strictly prohibited.

Research: The benefits of the drug are unquestionable for both treatment and prevention of viral diseases, but this can overlap with potential harm to the body. In the 80's in the US, after tests on mice, the drug was banned, as it had a highly toxic effect,in experimental animals, retinal bundle, liver lipidosis and other side effects were observed. It does not apply in the US and the European Union. In our country, continue to produce antiviral Amiksin and doctors appoint it to patients.
A small study involved 14 patients who received tilorone in a dose of 152 and 189 g, in 2 the drug caused keratopathy and retinopathy (while the visual acuity did not decrease), these effects were reversible. The authors of the study concluded about the potential danger of the drug for health.
Reviews: The occurrence of allergic reactions, the high cost of medicine.
Price: Amiksin - on average500-560rub. Sales volume in 2012 amounted to 7 billion. rub.

Additionally! Medicines, the so-called immunomodulators - Lycopid, Polyoxidonium, Cycloferon, Proteflazide, Timogen, Panavir, Isoprinosine, Neovir, Groprinosin and others. - should not be used to treat children (for various diseases) without immunograms and serious indications as they do not have the proper clinical trials of efficacy and safety in the treatment children.

Antiviral drugs

Below are just some of the antiviral medications from Orvi, reviews about them, a brief description, comments on known studies of their effectiveness, the average price in pharmacies.

Ingavirin

Pharmacological action: active substance imidazolylethanamide pentandioic acid. It is active against adenovirus infection, influenza A, B, respiratory syncytial infection, parainfluenza. It is an immunomodulator that affects the functional activity of the interferon system.

Side effects: allergic reactions

Contraindicated: children under 18 years.

Produced: as a drug for the treatment of influenza and orgi from 2008, before that, according to prof. Vlasova Vasilia Vitaglutam (imidazolylethanamide pentane diacid) was used in Russia before 2008 as a stimulant for hematopoiesis in cancer patients receiving an anticancer therapy.

Research: According to the manufacturers, the idea of ​​producing Ingavirin arose in the 1980s, but Only after many years of research into its safety and efficacy was the drug submitted for registration by 2008 year. When Vitaglutam was used in patients with oncological diseases, there was no convincing evidence of its effectiveness. And when in 2008 Ingavirin appeared on the pharmaceutical market without full-fledged studies, the "epidemic of swine flu" began in the country, therefore Ingavirin was actively sold. The drug was recommended by the Ministry of Health and Social Development, even despite the absence of placebo-controlled studies, reasonable evidence of its effectiveness.

One study conducted at 105!!! of patients with confirmed influenza showed the following results:

• Receiving ingavirin reduced the duration of fever to 3 hours (if used in the first 1 days after the onset of the disease)
• In the placebo group, this is 72 hours
• In the group taking Arbidol - 48 hours

Analyzing the duration and intensity of flu symptoms - weakness, headache, dizziness in patients with ingavirin was confirmed to reduce the severity of the disease, side effects are not revealed.

In May 2009, Alexander Chuchalin, chief therapist of the Russian Federation, (he led a team of drug developers) gave an interview to the magazine Ogonek: "The new antiviral agent Ingavirin efficiency is much higher than that of the AmericanTamiflu. The Russian drug is quickly and easily integrated into the genome of the A / H1N1 virus, immediately destroying it. It is also effective with other dangerous viruses. "

Reviews: Most drug does not help, isolated cases confirm the reduction in the timing of the disease.

Price:380-460rub. From January to June 2010, the sales volume of Ingavirin was 220 million. rubles, 467 thousand packages were sold.

Arbidol

Pharmacological action: Antiviral, has the ability to suppress viruses of influenza A and B, SARS - severe acute respiratory syndrome, associated coronavirus. Arbidol is also used in the complex therapy of acute rotavirus intestinal infections.
Active substance: Methylphenylthiomethyl-dimethylaminomethyl-hydroxybromoindole carboxylic acid ethyl ester.

Side effects: use of children under 3 years is prohibited, individual

allergic reactions.
Produced: invented in 1974, in 1992, it began its industrial production.

Research: Until 2013 there was no convincing evidence in its effectiveness and safety. Studies conducted in the USSR have not been published. In Russia in 2008, a study of 300 people showed that Viferon was more effective than Arbidol. In 2004, in China, tests for 230 patients with symptoms of Orvi showed it was not effective, in contrast to Tamiflu and Ingaverin. In 2009, in the journal of the UK "Antiviral Research the authors of the research stated that strains resistant to Arbidol are formed less frequently than those of Remantadine and Amantadine.

The Office of Quality Control of US Medicines denied registration of Arbidol in the United States, and WHO has never considered this drug as an effective antiviral drug.

Update on the drug: At the end of 2013, the World Health Organization Arbidol (umifenovir) as an antiviral drug with a direct effect, assigning it an individual code J05AX13. Thus, Pharmstandard received a nominal permission for widespread use of the drug on the territory of the Russian Federation, where Arbidol is included in the standards of treatment and prevention of influenza and ARVI in children and adults.

Nevertheless, the multicenter test of the effectiveness of Arbidol, which was planned to be completed in 2013, has not been completed to this day, and its terms have been postponed to 2015. The results of this test, which has serious sponsors and does not suffer from a shortage of patients, could put a dot over I in the arbidol epic, but for unknown reasons this is not occurs. I.eevidence of effectiveness is not present until now, it remains to wait ...

Reviews: The same number of positive reviews and opinions about the ineffectiveness of its use. There are isolated cases of allergic reactions in the form of dermatitis, angioedema, pain in the epigastric region.
Price: Arbidol - on average130-710rub. In 2012, the volume of sales - more than 5 billion. rub.

At the pharmaceutical market in Belarus, an analog of Arbidol, producer of JV "Lekpharm" appeared. It is a generic drug, in the Belarusian import-substituting packaging - Arpetol. The instructions to him indicate that the active substance is: arbidol hydrochloride? Once again, the commercialization of today's pharma market and the lack of proper control is proved!

Tamiflu

Pharmacological action: an antiviral drug, which includes oseltamivir carboxylate (active metabolite), suppresses influenza A and B viruses. When Orvi is not effective.

Side effects: Nausea, insomnia, diarrhea, dizziness, lethargy, cough, headaches, with caution to pregnant women and lactation. Contraindicated for children under 1 year.

Produced: since 1996, the pharmaceutical company "F. Hoffmann-La Roche "registered the right to develop

preparations containing oseltamivir.

Research: Tamiflu has a disadvantage - it complicates the diagnosis, because side effects are similar to the symptoms of influenza. It is dangerous in the epidemic period with long-term admission. Optimum effective only short-term use - a few days at the beginning of the flu. Independent researchers demanded a standard report from the Swiss manufacturer of 4-5 research modules. To which the pharmaceutical company provided only the first modules, repeated requests for full information were never satisfied.

Since 2004, cases of neuropsychic disorders began to be registered, more often in children and adolescents, who took Tamiflu during influenza - hallucinations, nightmares, confusion, convulsions, anxiety, etc.

Japanese postmarketing studies of this drug in 2006 have indicated a risk of developing impaired consciousness in humans - psychosis, depression, suicidal tendencies, especially in children. And there were also 54 deaths after Tamiflu, 16 of which were in adolescents 10-19 years (15 killed suicide, 1 died, hitting a car), the rest died of kidney failure (it is possible that due to severe flu).

The latest information about this drug:Back in April 2014, the Cochrane Society (an independent health research network) represented by Tom Jefferson and the British Medical the journal published data from the Cochrane review of studies that did not confirm the efficacy of Tamiflu and Relenza in the treatment and prevention influenza. Also, the efficacy of reducing influenza complications with these drugs has also been questioned. The firm attempts of Roche firm to fight back with a firm promise to provide undeniable evidence in the form of results of randomized trials have so far not been successful. Evidence is expected to present.

April 10, 2014, the Cochrane Collaboration website published the results of these 26 clinical trials Relenza and 20 clinical trials of Tamiflu, in which 2, 00 people participated.

As a result of the research it was found that:

• Oseltamivir as a preventive agent slightly reduces the risk of developing influenza in families, without reducing the ability of the influenza virus to be transmitted from person to person.
• The duration of symptoms is reduced by 16 hours (from 7 to, days), in children this effect is absent altogether.
• The drug has no effect on the risk of serious complications (sinusitis, otitis media, pneumonia, bronchitis), that is, does not reduce the likelihood of complications.
• The medicine is recognized as sufficiently toxic, increasing the risk of nausea, vomiting in both children and adults.
• When used for preventive purposes, the drug was dangerous to health, because it leads to mental disorders, impaired renal function, in some cases found that it helps to reduce the production of their own antibodies to the virus.

Based on these studies, health officials of the world's leading countries should decide to stop mass procurement of antiviral drugs with the current substance Oseltamivir due to the high risk of side effects and low effectiveness as a medicine for the therapy and prevention of influenza virus in the period epidemic.

reference: only on the basis of the claims of the manufacturer Tamiflu that the drug significantly reduces the risk of serious complications and hospitalization of patients during the epidemic, countries such as the United Kingdom and the United States in 2009 in connection with the epidemic of swine flu, these drugs were purchased at 40 million doses (The USA, bln. dollars, Great Britain 424 million. f.St.).

Based on recent data on the low efficacy and non-safety of this antiviral agent, an international group experts in evidence-based medicine called on the governments of the world's leading countries to stop mass purchases of Tamiflu and Relenza.

Reviews: There are enough reviews about side effects in the form of vomiting, dizziness, psychosis, headache. The effectiveness of influenza is confirmed by many.

Price: Tamiflu-on average1200-1300rub.

Remantadine (Rimantadine)

Pharmacological action: antiviral drug, an adamantane derivative, suppresses various strains of the influenza A virus (swine flu including).

Side effects: contraindicated in pregnant women, children under 1 year. Reduces concentration of attention, causes dizziness, nervousness, headache, increased fatigue, nausea, vomiting, dryness in

mouth.

Produced: information on the first uses of the drug are known since 1968.

Research: The tests were conducted from 1981 to 2006, mainly they showed a lower toxicity of Remantadine in comparison with Amantadine. One study showed the effectiveness of preventing Amantadine influenza infection by 61% in compared with the placebo group and in the event that a person fell ill, then for 1 day reduced febrile syndrome. In the same study, he was compared to Tamiflu, he gave an efficacy of 73% of the placebo group. Rimantadine (Remantadine) is currently considered a drug with proven clinical efficacy, but the possible resistance to it of some strains of the influenza virus.

Reviews: There are reviews that Remantadin causes side effects - dizziness, tachycardia, bitterness in the mouth. In general, the reviews are positive.
Price: Remantadine - average50-150rub.

It is during the flu (including swine) with the first symptoms of therapists and pediatricians recommend: adults - Remantadin, Tamiflu. Children over 1 year old are shown by Orvir (rimantadine syrup), Viferon. Children older than 8 years can - Remantadin (in the table), Tamiflu.

Interferon preparations

Interferons are informant proteins, which are excreted by cells infected with viruses. They seem to inform other cells about the infection and the required inactivation of the virus. Alpha interferons produce lymphocytes, beta - fibroblasts. In addition to Viferon, the alpha group includes Intron, Reaferon, Kipferon.

Viferon

The creation of the drug was scientifically justified in the period 1990-1995. group of scientists of the Research Institute of Epidemiology and Microbiology. N.F. Gamaleia under the guidance of prof. Malinovskaya V.V.
Since December 1996 on the basis of the same SRI, serial production of recombinant interferon alfa-2b in suppositories begins. Viferon - a candle with a different content of the active substance.

Application:

• Viferon-1 (150000 IU) is designed for babies from birth to 7 years. It is used in ARVI, herpetic infection, as an additional remedy for prolonged pneumonia or sepsis, including in preterm infants with intrauterine infections. The drug is given a course for 5 days. Children under 7 years are recommended 1 candle 2 times a day. Preterm, born on a period of more than 34 weeks - as children under 7 years. With a shorter gestation period - 1 candle three times a day. If necessary, after a five-day break, the course can be repeated for another 5 days.
• In children older than seven years, an adult drug in candles for 50, 00 IU is used twice a day for five days. Possible use of viferon in pregnant women.
• Candles with viferon content of , 0, 00 and , 0, 00 IU are used in the treatment of viral hepatitis and herpetic infections.
• The preparation in the form of ointment is intended for the therapy of herpes on the skin and mucous membranes in adults and children older than a year.

Side effects: the main side effect of drugs viferon may be an allergic reaction, which happens infrequently.

Research: As for the effectiveness of the drug, it is not included in list A of evidence-based pharmacology. I.e,wide randomized trials in humans consistent with international standards were not performed. However, a positive practical experience of treatment with viferon in pediatric practice is available. (By the way, nitroglycerin also does not have randomized studies that prove its effectiveness, which does not make it an ineffective first-line drug for stenocardia). Publications of these clinical trials of the drug are available only in Russian and were conducted only in domestic clinics. Value for money allows pediatricians to recommend a drug for ARVI treatment in children younger than seven years. For adults in the treatment of acute respiratory viral infections, the drug is of limited use because of rectal administration and the availability of alternative drugs.

The main arguments of the opponents of the drug:

• high molecular weight of protein molecules that can not be absorbed in the gut
• lack of clinical trials that meet international standards.

Kipferon

In candle light a little expensive for the treatment of common colds. Therefore, it is replaced by viferon. But, with severe forms of intestinal dysbiosis in children of the first two years of life, the drug shows good clinical results.

Studies: Randomized trials were not conducted, that is, the drugrefers to the list of drugs with unproven effects. The main claims:

• High molecular weight, which prevents normal absorption
• Adding to the drug components of the donor blood, which can cause fever and allergies.

Cycloferon

Cycloferon was originally registered as a veterinary drug in 1993 for the treatment of animals with viral infections, in 1995 it was already honey. a drug.

The drug Cycloferon is approved for use in adults and children older than four years. Produced in solution for injection, tablets, liniment. Refers to immunomodulating drugs, is an inducer of interferon, enhancing its production and exhibiting antiviral, anti-inflammatory and immunostimulating properties.

Application: on the territory of the Russian Federation is used in the treatment of acute respiratory viral infections, influenza, viral hepatitis, herpes infection, human papillomaviruses and other urological and gynecological pathologies (eg, candidiasis, chlamydia).
Contraindications: The drug is not recommended for pregnant and lactating. May cause an allergic reaction.
Research: Cycloferon is an immunostimulant that stimulates the immune system and the production of interferons. To date, allclinical trialsthis drug, published in the medical literature,were conducted only in the territory of the Russian Federation and do not meet international standards.

There are no serious clinical trials for cycloferon that would prove its effectiveness or refuted the absence of long-term adverse effects of this drug (development of autoimmune diseases). It is not superfluous to recall that all drugs that are on the pharma market for less than five years are still at the fifth level pharmacological tests and it is quite possible to identify previously unknown undesirable effects from drugs such series. In the presence of newly identified harmful effects, the drug will be withdrawn from the pharmacy networks and discontinued, and most of those who have been treated with this remedy and have earned some disruptions in health are unlikely to receive at least some compensation.

Conclusions:

Ineffectiveness of antiviral agents due to the stability of strains of the virus

The lack of a positive effect with the use of certain antiviral drugs for influenza is possible, and because there are drug-resistant viruses and a specific influenza strain may already be resistant to a particular drug (eg, Remantadin).

Other treatments and placebo effect

It is also possible that patients whose reviews indicate the efficacy of such remedies were quickly recovered by other methods of symptomatic treatment, and the placebo effect is not excluded (cf. amazing facts about placebo).

Strong immunity

In a healthy organism, after 2-3 days, the immune system produces enough protective antibodies against the virus, it does not need additional medicines. It is enough to comply with all the known rules - bed rest, plentiful hot drink, vitaminized foods and drinks, clean air in the patient's room, gargling, etc.

Rapid recovery with antiviral drugs

In various life situations, reducing the duration of the disease even for one day can be very important, for example - wedding day, urgent business trip, important business deal, exam, interview and etc. It is in such cases that the use of antiviral drugs, which reduce the duration of the illness by 2-3 days, may make sense.

There are no adequate studies

Absence of benign studies on the study of effectiveness and side effects (on a large group of people, different ages, during long time), most antiviral agents from Orvi and influenza suggest the caution of their use or even the rejection of them.

Do not spend money on pacifiers

Spending money, in some cases, considerable, on drugs with unproved efficacy, side effects, questionable safety, perhaps, is not advisable. Any medicine, even useless or empty, can damage the body.

Video transmission: How the placebo effect works

• sec: 4 min. - about what means are usually prescribed by doctors
• with 2: 0 - about the effect of placebo on the work of the immune system
• with 3: 7 - about the high effect of placebo in children
• with 3: 5 - about preparations-pustachki, appointed or nominated at ORVI
• with 3: 0 - about homeopathy and antiviral drugs in ARVI
• with 4: 7 - on how modern research is conducted

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Antiviral drugs for colds

Antiviral drugs for colds - the main tool in the fight against this category of ailments.

As is known, during the period of activation of catarrhal diseases it is better to be engaged in their prevention, and not to bring them to conditions when treatment is already needed. Activating immunity in the cold season is the most effective measure to protect yourself against colds. Then the disease will not develop or, at least, the situation will not take on a serious form.

If the disease has a viral nature - acute respiratory viral disease (ARVI) - then there can not be no treatment without treatment. And it is best in this case to cope with the problem of antiviral drugs. The essence of their action is in the impact on the virus itself, which is an etiological factor.

Antiviral drugs are used to treat ARVI and influenza. These drugs affect the replication of the virus in such a way as to stop its reproduction. Antiviral drugs are synthetic or natural. They are used both in the fight against the disease, and for its prevention. Different stages of the common cold can be exposed to antiviral drugs. To date, modern science knows about five hundred pathogens of different kinds of colds. Antiviral drugs to fight them quite a bit.

In general, viral diseases are treated with three types of drugs:

• drugs for a wide spectrum of influenza;
• drugs for the treatment of herpes infections.
• means for controlling cytomegalovirus.

In the case of severe disease, antiviral drugs are taken, with the use of interferons is easy. Within a day and a half after the appearance of the first symptoms, it is urgent to begin taking an antiviral drug. If we allow the multiplication of the virus to such a scale that it will occupy the entire body, then it can be brought to the conclusion that taking medications will not have any effect.

Effects of antiviral drugs for colds

With the help of antiviral drugs, the causes of the onset and development of acute respiratory disease are eliminated. The results of this action are:

• reduction of risks of exacerbations of chronic diseases (chronic bronchitis, bronchial asthma, etc.);
• shortening the course of the cold for several days, alleviating its symptoms;
• a reduction in the risk that severe complications will appear after acute respiratory illness.

Antiviral drugs for colds are also used as an emergency prophylaxis in the event that one of the family members becomes ill and needs to reduce the risk of infection of healthy people.

Antiviral tablets for colds

In a class where there are synthetic antiviral drugs that cope well with the influenza virus, there are two groups of effective remedies. The essence of the action of M-channel blockers in the blocking of the virus so that it can not penetrate into cells and multiply. One of the tested preparations against viruses of this category is Amantadine (Midantan), and also Rimantadine (Remantadin). For the desired effect, they should be taken as soon as the disease begins to manifest itself. Another of their drawbacks is that it is not always possible to understand what kind of virus a person has become. And these antiviral drugs are shown in the epidemic from the influenza A virus. In addition, avian and swine flu are resistant to them. It is important to remember that taking an antiviral drug for a cold should be done not only by the sick person himself, but by all members of his family.

Effective antiviral agent for colds

But neuraminidase inhibitors act on influenza A and B viruses. The essence of their action in suppressing the enzyme, which is responsible for the multiplication of the virus. Representatives of this group of drugs are "Oseltamivir" ("Tamiflu") and "Zanamivir" (Relenza). You can start taking them within two days from the initial manifestations of the disease.

List of antiviral drugs for colds

• Tamiflu;
• "Relenza
• "Grippferon
• Anaferon;
• "Amiksin
• Kagocel;
• Remantadin;
• "Viferon
• Arbidol;
• "Ribavirin
• "Amizon
• "Cycloferon."

Antiviral drug for cold "Zanamivir"

"Zanamivir" is prescribed for influenza in adults and children over 5 years of age for 5 mg of inhalation twice a day for 5 days. The total daily dose reaches 10 mg. The drug is not combined with other inhaled medications (including bronchodilators), because of that exacerbations are possible in patients with bronchial asthma and other nonspecific diseases lungs. In a number of people without pulmonary pathology, there may be signs of nasopharyngeal irritation, reaching in rare cases before the appearance of bronchospasm.

Antiviral drug for cold "Oseltamivir"

For influenza for adults and children over 12 years, the recommended dose of "Oseltamivir" is 75 mg 2 times a day for at least 5 days. "Oseltamivir" is prescribed for children older than 1 year - with a body weight of less than 15 kg of 30 mg, 15 to 23 kg of 45 mg, 23 to 40 kg of 60 mg, more than 40 kg - 75 mg twice daily for five days.

The drug is administered with caution in renal failure, it can cause nausea and vomiting during admission.

Antiviral drugs for a cold of a wider spectrum of action - "Ribavirin" ("Ribarin") and "Inosin Pranobeks" ("Grosprinozin").

Antiviral drug for cold "Ribavirin"

"Ribavirin" acts on influenza A and B-viruses, parainfluenza, respiratory syncytial virus, coronaviruses, rhinoviruses. The specificity of the drug is its high toxicity, therefore it is used only if a respiratory syncytial infection is confirmed that often leads to bronchiolitis in children.

"Ribavirin" is used to treat influenza in adults over 18 years (200 mg 3-4 times a day in meal time for 5-7 days) in the absence of pregnancy, kidney failure and hemolytic anemia.

Antiviral drug for cold "Inosin pranobeks"

"Inosin pranobeks" fights against viruses of influenza, parainfluenza, rhinoviruses, adenoviruses. This antiviral drug for cold stimulates the defenses of the human body. To treat influenza and other acute respiratory viral infections it is recommended to take: adults 2 tablets 3-4 once a day at regular intervals for 5-7 days; children a daily dose of 50 mg per kilogram of weight body.

The daily dose should be taken at 3-4 times at regular intervals. The duration of treatment is 5-7 days.

Interferons and interferon inducers

Another large group of antiviral drugs for colds are interferons and interferon inducers. Interferons are protein substances that synthesize the body as a response to infection, due to them the body is more resistant to viruses. They have a wide spectrum of action, which favorably differ from many other synthetic drugs. But some experts say that they are not very effective in ARVI. In the case of colds, they are prescribed as drops in the nose and rectal suppositories. The native leukocyte interferon is digested four or six times a day, Reaferon (interferon alfa-2a) two drops twice-four times a day. Viferon (alpha-2b interferon) usually goes like a candle, adults usually use Viferon 3 and 4.

There are also inducers of interferon. These are drugs that stimulate the body to produce its own interferons. Catarrhal diseases are treated with "Tyloron" ("Amiksin"), "Meglumina acridonacetate" ("Cycloferon") and a number of other antiviral drugs for colds.

Antiviral drug for cold "Amiksin"

For treatment of influenza and acute respiratory disease, "Amiksin" is prescribed inside after eating two tablets, 25 g for adults and 6 g for children over 7 years on the first day of illness and then 1 tablet every other day.

The course of treatment - up to 6 tablets. Contraindicated in pregnant women and children younger than 7 years.

Antiviral drug for cold "Cycloferon"

"Cycloferon" is used to treat influenza and ARI in the form of intramuscular injections at a dose of 250 mg (1% 2 ml) for two consecutive days, then every other day or 1 tablet, 5 g every other day for 20 days.

Antiviral drug for cold "Kagocel"

"Kagocel" is an inducer of interferon with direct antiviral and immunomodulating action.

Usually it is prescribed for influenza and ARI adults 2 tablets 3 times a day for the first two days (daily dose is 72 mg), then 1 tablet 3 times a day (daily dose of 36 mg). A total of 18 tablets per 4-day course.

Antiviral drug for cold "Arbidol"

Effective in treating the common cold is an antiviral drug, like Arbidol. It acts against viruses A, B, it also treats parainfluenza, syncytial infections, adenoviruses. The essence of the drug in stimulating the production of endogenous interferon, it has an antioxidant effect, strengthens the immune system.

Arbidol for colds without complications appoint: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days. With the development of complications (bronchitis, pneumonia, etc.) children from 3 to 6 years take Arbidol 50 mg each, from 6 to 12 years - 100 mg, over 12 years, adults - 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose once a week for month.

Antiviral drug for cold "Amizon"

Antiviral drug for cold "Amizon" is an inducer of endogenous interferon, has antiviral, immunomodulating and anti-inflammatory action.

Adults take "Amizon" 2-4 times a day after a meal with an average flow of influenza and acute respiratory disease, 5 g, with a heavy - on, g for 5-7 days; the course dose of treatment is 3 Children aged 6-12 years drink on, 25 g 2-3 times a day for 5-7 days.

Antiviral drug for cold "Anaferon"

"Anaferon" refers to homeopathic remedies with antiviral and immunomodulating effect. It is also used to treat colds and flu. Usage for adults: 1 tablet, sublingually from three times a day to six, depending on the severity of the disease.

Treatment begins with the first respiratory symptoms. After improving the condition, it is recommended to switch to taking the drug once a day, for 8-10 days. Children from six months to three years, one tablet dissolved in 15 ml of water and give a drink. For prevention, Anaferon is prescribed one tablet once a day, for one to three months.

Antiviral drug for colds "Grippferon"

"Grippferon" is an immunomodulatory, antiviral and anti-inflammatory drug for intranasal use. The duration of the course of application and dose of the drug "Grippferon" is usually determined by the doctor in charge.

The recommended dose for children younger than 1 year is 500 IU (1 drop of the drug) 5 times a day; for children from 1 year to 3 years is 1000 IU (2 drops of "Grippferon") 3-4 times a day; from 3 to 14 years is 1000 IU (2 drops of the drug "Grippferon") 4-5 times in a day. The recommended adult dose is 1500 IU (3 drops) 5-6 times a day. The course duration is 5 days.

Herbal antiviral drugs for colds

Some herbs also have an antiviral effect. The effect of many herbal medicines is directed against viruses belonging to the herpes family. Catarrhal diseases are often accompanied by herpes rash, in addition, the course of cytomegalovirus infection also often occurs with the same symptoms as ARVI. This category of drugs includes "Alpizarin". The active substance in it is an extract of such plants as an alpine penny, a yellow penny, mango leaves. The antiviral preparation "Flacoside" has in its composition an active substance, which is obtained from velvet Amur and velvet Laval. For external use, the ointments "Megozin" (cottonseed oil), "Helepin" (ground part of the cheesecake), "Gossipol" (are obtained when processing the cotton seeds or the roots of cotton).

Antiviral drugs that are used for colds also include Altabor. It is based on an extract of stems of gray and black (sticky) alder.

The pendulous shank and ground reed give life to the drug "Proteflazidu it is also used in the treatment of colds, influenza and for their prevention. Antiviral and immunomodulating action is possessed by the German preparation "Imupret". It consists of field horsetail, walnut leaves and oak bark.

The price of antiviral drugs for colds

The run-up of prices for antiviral drugs for colds is quite wide - from 20 to 200 hryvnia (of course, it still depends on the packaging and the number of tablets). In any case, it is better to consult with the attending physician who will prescribe the drug, which in the particular case will prove to be the most effective.

If you call the approximate prices for the main antiviral drugs used to treat colds, in pharmacies in Ukraine they are: "Amizon" - from 20 UAH, "Arbidol" - from 50 UAH, "Amiksin" - from 30 UAH, "Anaferon" - from 40 UAH, "Remantadin" - from 11 UAH, "Kagocel" from 70 UAH, "Viferon" - from 70 UAH - from 110 UAH.

Inexpensive antiviral drugs for colds

Inexpensive antiviral drugs for colds, often prescribed by doctors and commonly used - Amizon, Amiksin, Anaferon. For 20-40 hryvnia you can buy 10 tablets. But once again pay attention: before making a decision to purchase an antiviral drug for a cold, it is worth consulting with the treating doctor.

With the help of antiviral drugs, it is not the consequence, but the cause of the catarrhal disease that is eliminated. This is the great advantage of antiviral drugs in the treatment of colds, which also explains their effectiveness. Antiviral drugs shorten the cold for two to three days, ease its course. Due to the use of antiviral drugs for colds, the risk of other chronic diseases worsening (exacerbation bronchial asthma, chronic bronchitis and other diseases), also there will be no various complications, as often happens with other preparations. In addition, antiviral drugs for colds give excellent effect in the prevention of acute respiratory viral infections, influenza, including among healthy family members when the patient is at home.

ilive.com.ua

What antiviral drugs to use in ARVI?

ARVI (acute respiratory viral infections) are very widespread, thousands of people of all ages worldwide suffer from these diseases every year. The treatment of these pathologies is a topical task for doctors, since ARVI can provoke the development of severe complications, especially in children and the elderly. Many experts firmly believe that antiviral drugs in ARVI allow for faster cure of the patient.

Why do we need antiviral drugs?

At the moment, scientists know about 300 different viruses that can cause an ARVI in a person. The most common cause of the disease are the following:

• adenoviruses;
• rhinovirus;
• influenza viruses;
• parainfluenza viruses;
• respiratory syncytial viruses.

Even if the virus penetrates the human respiratory tract, this does not always lead to a disease. The fact is that in healthy people the immune system is able to withstand the impact of any damaging agents. In this case, the activation of humoral factors of protection occurs, the content of biologically active substances that block the vital activity of the pathogens or even destroy them in the blood increases.

If the person's immunity is normal, then he can recover from acute respiratory infections in mild form or even avoid this unpleasant disease. And in people with low immunity, the disease can result in the development of severe bacterial complications, for example, pneumonia. Sometimes ARVI provokes an exacerbation of various chronic pathologies available to the patient, which greatly aggravates the severity of his condition.

That is why doctors insist that ARVI should be treated, using not only modern drugs for symptomatic therapy, but also antiviral drugs. When selecting a suitable antiviral drug, difficulties may arise due to the fact that it is not known which virus caused the disease. Typically, doctors recommend taking funds that have a broad therapeutic activity against various respiratory viruses, and at the same time, as little as possible damage the cells organism.

Doctors prescribe antiviral drugs for ARVI treatment, as they are:

• eliminate the cause of the disease;
• reduce the period of the disease to 2-3 days;
• significantly facilitate the course of the disease;
• reduce the risk of exacerbations of already existing chronic pathologies (for example, bronchial asthma);
• reduce the risk of developing severe complications (eg, pneumonia).

And also these drugs are excellent for the prevention of ARVI in all healthy family members, if someone from the household is already sick. Of course, taking any antiviral drugs is possible only after consulting a doctor, because even if they are dispensed without a prescription, this does not mean that they are absolutely safe.

Are antiviral drugs necessary?

Today, pharmacies have an extremely wide range of different antiviral drugs, the cost of which can vary significantly. Unfortunately, the effectiveness of most of these drugs has not yet been fully proven, and many of them cause side effects.

Some antiviral drugs do not have the proper therapeutic effect due to the appearance of strains of the virus that are resistant to them, i.e. are stable. Therefore, specialists are constantly striving to create new drugs that can fight specific strains of the virus.

Many drugs were developed only 10-30 years ago, so it's too early to judge their effectiveness. Some scientists believe that uncontrolled and long-term use of such drugs can disrupt the immune system and even lead to the development of autoimmune and oncological pathologies. Of course, antiviral drugs are sometimes just necessary, for example, if you need to cure ARVI as soon as possible (before a business trip or an exam).

Chemical antiviral drugs

Drugs from this group can be used to treat both children and adults. One of the most well-known medicines isRemantadine, which suppresses a variety of strains of the influenza A virus. Tests of this drug, carried out for many years, proved its rather high efficiency. True, it often causes side effects: vomiting, nausea, dry mouth, headaches, weakness, dizziness, nervousness and decreased concentration. It is not prescribed for children under one year and pregnant women.Another effective drug is considered to beTamiflu, which is able to suppress influenza A and B viruses. This comparatively new drug, which has been produced since 1996, is contraindicated in children under 12 years of age, and pregnant and lactating women can be prescribed only if urgently needed.

Tamiflu can cause the following side effects: headaches, weakness, cough, nausea, diarrhea, dizziness, insomnia and even psychosis. Doctors agree that it is suitable only for short-term use.

One of the most common drugs is considered to beArbidol, which has anti-influenza and immunomodulating efficacy. This medicine can suppress influenza A and B viruses, associated coronavirus and SARS. Despite the fact that he invented it back in 1974, there is still no convincing evidence that it is really effective and safe for health. It is known that it can cause allergies in the form of Quincke's edema, dermatitis and pain in the epigastric region. Children under 7 years of arbidol is not prescribed.

Interferons

Interferons, as well as inducers of interferon are often used as antiviral drugs. Interferons are protein substances that the body synthesizes in response to infection. They significantly increase the resistance of the human body to a variety of viruses. In addition, these drugs differ in a wide range of actions, although many experts are still not convinced of their effectiveness.

Most often for the treatment of acute respiratory infections, such drugs as influferon, viferon and kipferon are used.

If it is necessary to treat a small child, the most appropriateViferon, which is available in the form of rectal suppositories and has virtually no side effects.

Kipferon- these are also suppositories, but they contain antibodies against viruses that were taken from donor blood, which can cause caution in some parents.Grippferon, which is released in the form of drops, it is necessary to dig in the nose, which is very convenient and leads to a rapid absorption of the medicine, because in the nasal passages there are many blood vessels.

In pharmacies are constantly emerging new drugs designed to combat viruses. One of them becameDerinath, which activates the rapid production in the body of its own interferons. Like many other effective and quick-acting medicines, Derinat is available in the form of drops for the nose. In addition, it can be used to treat even newborn babies without fear of side effects.

So, in order not to harm your health and not spend money in a drugstore in vain, if you have signs of ARI it is worth consulting with your doctor. Only a qualified specialist, taking into account the severity of the disease and the patient's condition, will be able to prescribe the most effective treatment. As a rule, some antiviral drugs are not enough, and the doctor makes a whole list of drugs that will help to quickly cope with the infection.

ingalin.ru

Effective antiviral drugs for influenza and ARVI

p & g; antiviral drugs are medicines today, about the appropriateness, effectiveness and safety of which are many disputes among specialists. This group of drugs has been used relatively recently, is actively advertised and is often prescribed by therapists for signs of influenza and ARVI. Consider which of these tools can be considered the most effective.

What antiviral drugs are most effective in ARVI?

To the causative agents of acute respiratory diseases, which are the most common infectious diseases, there are more than two hundred types of viruses. Drugs that act directly on these respiratory pathogens, like antibiotics when there are no bacterial infections in our pharmaceutical market (with the exception of preparations against viruses influenza).

But there are a number of drugs that contribute to increasing the body's defenses, increase its resistance to the oppressive effects of viruses that create barriers to their spread. Their use, according to manufacturers, can achieve a speedy recovery, reduce the intensity of unpleasant co-occurring symptoms, reduce the risk of complications.

These drugs include:

• interferons;
• inducers of interferon;
• means of plant origin.

It should be noted that almost all such drugs do not have proven effectiveness and have a lot of side effects. In addition, some experts believe that artificial stimulation of immunity can be dangerous and have long-term adverse effects in the form of development of autoimmune and even oncological diseases.

Despite this, many patients note that the antiviral drugs they take really work and allow you to cope faster with the disease. Here are some names of antiviral drugs for ARVI treatment, about which there is the greatest number of positive reviews:

• Immunal;
• extract of echinacea;
• Amiksin;
• Viferon;
• Gripferon;
• Polyoxidonium.

It should be understood that only a doctor should prescribe this or that drug, taking into account the individual characteristics of the human body, the available accompanying pathologies. Independent and uncontrolled use of antiviral drugs in ARVI can cause significant harm.

What antiviral drug is the most effective for influenza?

At the moment, the main drugs for the treatment of influenza types A and B, the use of which is effective, are:

• Relenza (zanamivir);
• Tamiflu (oseltamivir).

The action of these medicines is based on the ability to block the propagation of pathogens in the body, thereby increasing the chances of a speedy recovery without the development of complications. An important condition for the effectiveness of the use of these funds

is the timely beginning of their application - no later than 48 after the onset of symptoms of the disease. Otherwise, their reception is practically useless. Unfortunately, the drugs in question are not devoid of many side effects and in some cases can be contraindicated for use even with very severe flu.

In conclusion, once again, the use of any, the most effective antiviral drugs in the treatment of influenza and SARS should be agreed with the attending physician and conducted under his supervision. And in order not to lower the development of diseases, it is recommended to apply preventive measures, temper the body and adhere to a rational diet.

WomanAdvice.ru

Remantadin and Kagocel are really drugs that kill viruses? Or are they dummy?

Answers:

DIN

Rimantadine is the first antiviral agent in the world against the influenza virus A1. It must be understood that antiviral drugs have a narrow focus and the drug is not effective even against strains of A, 3... A5, etc., not to mention even other viruses.
Since Rimantadine has been used for more than 60 years, almost all strains of the A1 virus have developed resistance to it and there is no sense in its application anymore.
Kagocel is a drug with an extremely low evidence base (it is practically non-existent), there are no more large randomized trials of efficacy there. As I suppose - and they can not be because there is not and can not be a drug from all the viruses at once. So someone "rowing loot" selling the people such "drugs".
But, since no-prescription drugs are decided in the long run, you, a good doctor here can only advise.

Ron Jeremy

Remantodyne is an old proven antiviral, predominantly against the Flu

Bad Wolf

yes it's good drugs killing the virus

Fairy

Kagocel is recommended always, with the slightest symptoms of a cold, flu, orvi. But here everything is individual. Kagocel does not affect me at all. I often drank his course, but there was no sense. But one acquaintance has the opposite, Kagocel acts perfectly on him.

Margarita Petrova

remantadine - antiviral, works best against influenza A, from the rest is worse, kagocel stimulates the production actually immunity, also works, but it is not worth waiting for miracles and both act, if only start drinking at the beginning disease

Max

all drugs are foreign to the human body.
our body is a self-regulating and self-healing system.
learn to take care of the body, train the body, temper the body and you will never get any viruses.
Well, and since there is no disease, then no super-duper wheels will swallow.

Igor Bovtunov

KAGOTSEL DREAM PREPARATION ...

Yesenia Spasskaya

Kagotsel is used only in Russia, children can not, especially boys, the drug is not fully understood

Nos

remantadine acts on the influenza virus. kagocel is a dummy.

Victoria Radchenko

Hello, rimantadine only against the influenza virus works, kagocel also causes the production of interferons... but I'm more like drugs that already contain interferon, so from the first days of illness, as I was prescribed by a doctor, I lubricate my nose with ointment Viferon. In its composition, just human interferon and antioxidants (vitamins E and C) are an antiviral and immunomodulating action. Mucous nose is lubricated for 5 days, several times a day. All this I do for dried, previously cleaned, if necessary, mucous saline solution - here the choice of desire as self-made can be (water with salt 1 liter / 1 teaspoon), and pharmacy can be (aqua maris, dolphin and td). I choose mostly pharmacy. In addition, I start to drink a lot of warm liquid. I read somewhere that it is water that I need, so I alternate, because it is sometimes difficult to drink a lot of water, even tea or honey can add honey or raspberry jam. A liquid is needed to restore the body during an illness. After all, our body consists of 90 percent of the liquid and during illness it is spent a lot on fighting viruses, and so that there is no intoxication, a copious drink is needed. Also, airing the room and wet cleaning are also important measures during the illness, as everything needs to be taken into account.

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