Sinecode Syrup

Sinecod is an antitussive drug of central action, does not belong to the alkaloids of opium, either chemically or pharmacologically.

Suppresses cough, having direct influence on the cough center. Has bronchodilator effect. Promotes respiration, improving spirometry (reduces airway resistance) and oxygenation of the blood.

Sinecod is a non-narcotic drug, so it can be used to stop dry cough for a sufficiently long period of time.

Clinical and pharmacological group

Antitussive drug.

Terms of sale from pharmacies

You can buy without a doctor's prescription.

Price

How much does Sinecode syrup in pharmacies cost? The average price is at the level of240 rubles.

Composition and form of release

Sinecod for oral administration is issued by a Swiss company Novartis. For the convenience of children and adults, it has 3 forms:

Syrup. Sold in bottles of dark glass with a volume of 100 and 200 ml. The package includes a box, an abstract and a cap with a marking in ml. The bottle cap is protected from curious toddlers. They can not unscrew it and drink a sweet liquid with vanilla flavor.

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Transparent drops. Poured into 10 and 20 ml vials. For a comfortable use of the drug, a dispenser is provided. It also smells like vanilla.
Red dragee. You can buy in blisters for 10 units in each. Convenient for junior and senior students.

Syrup Sinecode:

in 1 ml - 1.5 mg of butramate citrate.

Excipients:

sodium saccharinate;
glycerol;
vanillin;
benzoic acid;
water.

Composition of drops:

in 1 ml - 5 mg of butyrate citrate.

Excipients:

sodium saccharinate;
glycerol;
vanillin;
benzoic acid;
water.

Dragee (many mistakenly believe that this is a pill):

the main substance is dihydrogenocitrate butramate (in one pellet 50 mg);
lactose;
Excipients.

pharmachologic effect

Sinecod is an effective antitussive drug that affects the cough center, does not belong to the alkaloids of opium, facilitates breathing, has a bronchodilator effect, improves blood oxygenation and spirometry. When administered, butamirate is absorbed completely and quickly.

The maximum concentration after taking 150 mg of the drug is achieved in plasma on average after an hour and a half and is 6.4 μg / ml. In the blood, the hydrolysis of butamirate begins initially to diethylaminoethoxy ethanol and 2-phenylbutyric acid, which have antitussive activity. These metabolites almost as much as 95% bind to plasma proteins, this explains the long half-life of plasma, which is 6 hours.

Excretion of metabolites occurs mainly with urine.

Indications for use

All the medicinal variants of Sinecode are designed to suppress a blistering dry cough that develops in various diseases. These include:

cough of smokers;
whooping cough;
dry cough with tracheitis, bronchitis, pharyngitis;
emphysema of the lungs;
pneumonia;
bronchial asthma.

Also, the drug is used to suppress cough in diagnostic procedures, for example, bronchoscopy. Before carrying out the surgical operations, the use of Sinecode as a means of inhibiting the cough reflex is also shown.

Contraindications

All dosage forms of Sinecode are contraindicated for use in the presence of the following diseases or conditions in a person:

Individual hypersensitivity to the components of drugs;
I trimester of pregnancy (from 1 to 13 weeks of gestation inclusive);
The period of breastfeeding;
The age is less than 2 months (for drops);
Age under 3 years (for syrup);
Age is less than 6 years (for pills).

With care and under medical supervision, it is necessary to use Sinecode in the second and third trimesters of pregnancy (from the 13th week before the birth).

Intended use for pregnancy and lactation

Clinical trials of Sinecode on pregnant women for understandable ethical reasons were not carried out, therefore, from the point of view The view of evidence-based medicine can not be considered completely safe for women bearing a child. However, animal experiments did not reveal any negative effect of Sinecode on the fetus and course of pregnancy, so the drug can be considered conditionally safe.

In view of this conditional safety, Sinecode should not be taken during the first trimester of pregnancy, that is until the 13th week of gestation, because it is during this period that the unlikely, but theoretically possible adverse effect of the drug on the fetus may most strongly manifest itself. In the second and third trimesters of pregnancy (from the 13th week until the birth), the sinecode can be used provided that the benefit exceeds the hypothetical risk. In principle, gynecologists consider Sinekod to be a sufficiently safe drug, and therefore they allow it to be used pregnant women for the relief of dry cough, starting from the 13th week of gestation and until the birth. However, in order to make a decision in each specific case, it is necessary to get a doctor's advice, and not to prescribe the drug yourself.

Currently, it is not known whether Sinecodus is excreted in breast milk, therefore it is not recommended to take the drug during the breastfeeding period. If you need to take the drug, doctors recommend that for several days, interrupt breastfeeding, transferring the child to artificial mixtures. 12 hours after taking the last dosage of Sinecod, you can again breast-feed your baby.

Dosage and route of administration

As indicated in the instructions for use Sinecode should be taken orally before meals.

Recommended doses of syrup:

children 3-6 years - 5 ml 3 times a day;
children 6-12 years - 10 ml 3 times a day;
adolescents 12-18 years - 15 ml 3 times a day;
adults - 15 ml 4 times a day.

For the convenience of dosing, a measuring cap is provided complete with a bottle. After each use, it should be washed and dried.

Recommended dose of Sinecode drops for children, depending on age:

2-12 months - 10 drops 4 times a day;
1-3 years - 15 drops 4 times a day;
older than 3 years - 25 drops 4 times a day.

The duration of therapy is not more than 7 days.

If you need to treat children under 2 years old, you should consult your doctor.

Side effect

If the dose recommended by the doctor is observed, patients will rarely develop negative reactions to Sinecod. In hypersensitive patients on the background of taking the drug, the following reactions may occur:

from the nervous system - lethargy, inhibition, drowsiness, dizziness;
from the respiratory system - shortness of breath, shallow breathing;
on the part of the organs of the digestive canal - nausea, vomiting, stomach pain, diarrhea, flatulence.

In some cases, rashes may appear on the skin like a urticaria.

Overdose

In case of an overdose Sinecodom noted dizziness, nausea, vomiting. The blood pressure may drop sharply. Treatment is symptomatic, including gastric lavage, reception of activated charcoal. Does not have a specific antidote.

special instructions

Syrup and drops for ingestion contain as sweeteners saccharinate and sorbitol, so the drug can be prescribed to patients with diabetes mellitus.

The drug contains a small amount of ethanol: syrup - 11.73 mg / 5 ml, drops for ingestion - 2.81 mg / ml. Therefore, the drug should be used with caution in patients with a tendency to develop drug dependence, with diseases liver, alcoholism, epilepsy, brain diseases, in pregnant women (II and III trimesters) and in children.

Sinecode can cause drowsiness, so caution should be exercised when driving and when performing work, requiring concentration of attention (for example, when working with mechanisms) after taking the drug.

Interaction with other drugs

The drug interaction of butamirate is not described.

Due to the fact that butamir inhibits the cough effect, simultaneous use of expectorants should be avoided to avoid congestion of sputum in the respiratory tract with the risk of developing bronchospasm and respiratory tract infection.

Reviews

We offer you to get acquainted with the opinions of people using the syrup Sinekod:

Victoria. Helps perfectly! The baby has whooping cough, coughs cope with URA. At night even with such a disease sleeps calmly!
Pauline. Sinecode to me from a cough did not help at all, as there was a dry and heavy cough, so nothing has changed after taking the drug! Besides all the time during this week there was nausea, tolerable of course, but constant. I had to give up such a medicine.
Marina. All trimester of pregnancy cleared, but tried to be treated folk remedies, because she was afraid of drugs to harm the fetus. After the birth, a cough started again (probably in the ward I got cold). I was prescribed Synecode syrup, but the baby was transferred to artificial nutrition, because the drug can penetrate into breast milk, as I was told.

Analogues

Synecoda has analogies and synonyms in the pharmaceutical market. The following medicines can be classified as analogues with another active agent:

Libexin;
Estozin;
Berodual;
Broncholitin;
Bithiodine.

Among the Sinecodal-like drugs, the most inexpensive are:

Bronhitusen Vramed;
Bronchoton;
Broncholine sage.

There are full synonyms of Sinecode with other trade names. They include:

Omnitus;
Kodelak Neo;
Panathus and Panathus Forte.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The syrup should be protected from direct sunlight and heat. Optimum storage temperature of the preparation is 15-18 degrees. The shelf life is indicated on the package and is 60 months from the date of production.

At the end of this period, the syrup is disposed of in the usual way.