Sorbifer Durules

width = Sorbifer Durules is a medicinal product belonging to the group of anti-anemic drugs. It is used in order to fill the lack of iron in the body.

Durules is a special technology for manufacturing the drug, which allows iron ions to gradually and gradually It is not released in the intestines by digestive juices, but as a result of peristalsis (undulating movements of the walls intestines). Such a gradual (over 6 hours) release of iron ions prevents the creation of increased their quantity in the digestive organs and does not allow the irritating effect of iron ions on the mucosa the digestive tract.

The main active ingredients of the drug are ferrous sulfate (320 mg) and ascorbic acid (60 mg), which increases the absorption of the drug by the walls of the duodenum.

Clinical and pharmacological group

Anti-anemic drug.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Sorbifer Durules in pharmacies? The average price is at the level of430 rubles.

Composition and form of release

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Medicinal form Sorbifer Durulesa - tablets: round, biconcave, coated with light yellow color, with engraving "Z" on one side; on the fracture core of gray color, having a characteristic smell (30 or 50 pcs. in dark glass bottles, in a cardboard bundle 1 bottle).

Active substances (in 1 tablet):

Iron sulfate (II) - 320 mg (which is equivalent to the content of Fe2 + - 100 mg);
Ascorbic acid - 60 mg.

Auxiliary components: polyethylene powder, povidone K-25, carbomer 934P and magnesium stearate.

The composition of the shell: paraffin solid, titanium dioxide, macrogol 6000, hypromellose, iron oxide yellow.

pharmachologic effect

Sorbifer Durules is a combined remedy that is used to normalize the level of iron for different types of anemia. Due to the action of the active components of the drug, ferrous sulfate and ascorbic acid, this drug has an anti-anemia property.

The drug is characterized by high absorption with gradual release of iron ions, which helps to avoid over-saturation of iron in the blood and gastrointestinal tract. Vitamin C and ferrous sulphate provide transportation of oxygen and the production of hemoglobin. Ascorbic acid acts as an antioxidant and collagen, which contributes to the regeneration of tissues. Sorbifer Durules is used in the presence of a patient's iron absorption impairments, as well as with his chronic deficiency in the body.

Pharmacokinetics

Durules is a technology that provides a gradual release and a uniform intake of iron ions. When Sorbifer Durules is taken in a dose of 100 mg twice a day, there is a 30% increase in iron absorption compared with the use of conventional iron preparations.

Iron is characterized by high bioavailability and absorption. It is absorbed mainly in the duodenum and the proximal part of the jejunum. Its relationship with plasma proteins is at least 90%. Deposited in the cells of the phagocytic macrophage system and hepatocytes in the form of ferritin or hemosiderin, in the muscles - in the form of myoglobin.

The half-life of iron is approximately 6 hours.

Indications for use

Sorbifer is prescribed for iron deficiency anemia, low blood hemoglobin, loss of iron in certain physiological (breastfeeding, late pregnancy, blood donation), for prevention, as iron-containing food additive.

As a preventive agent, blood donors, pregnant and breast-feeding women can be prescribed.

Contraindications

Absolute:

Children up to 12 years;
Hypersensitivity to the components of the drug;
Violation of iron utilization (sideroblastic, lead or hemolytic anemia);
Increased iron content in the body (hemochromatosis, hemosiderosis);
Stenosis of the esophagus and / or other obstructive changes in the digestive tract.

Relative (special care is required):

Stomach ulcer and duodenal ulcer;
Inflammatory bowel disease: Crohn's disease, ulcerative colitis, enteritis and diverticulitis.

Intended use for pregnancy and lactation

In pregnancy, almost all women are diagnosed with varying degrees of iron deficiency and the development of anemia, which is dangerous for both women and children. Therefore, during the II and III trimesters of pregnancy with the preventive purpose of all pregnant women prescribe iron preparations.

The drug of choice among the iron-containing preparations for pregnant women is most often Sorbifer Durules, which can provide a fairly rapid increase in the level of iron in the body of a woman. With the preventive purpose, the Sorbifer is prescribed 1 tablet per day. In case of anemia in a pregnant woman with a medical purpose, Sorbifer is prescribed 1 tablet 1-2 times a day (depending on the severity of the anemia). As a rule, in the III trimester of pregnancy and for the period of breastfeeding, Sorbifer is prescribed in a daily dose of 200 mg divided into 2 doses.

The length of the course of treatment is determined by the doctor, taking into account the hemoglobin levels. In some cases, after recovery, treatment with Sorbiferum is prolonged for another 2 months (to replenish iron stores).

Dosage and route of administration

As indicated in the instructions for use Sorbifer Durules take inside. The tablets covered with a cover, it is impossible to divide or chew. They should be swallowed whole and drink at least half a glass of liquid. Are taken for 40-45 minutes before meals or 2 hours after meals.

Adults and adolescents are prescribed 1 tab. 1-2 times / day. If necessary, patients with iron deficiency anemia, the dose can be increased to 3-4 tablets / day in 2 divided doses (morning and evening) for 3-4 months (before replenishing the iron depot in the body).
During pregnancy and lactation for the purpose of prevention, appoint 1 tablet / day; for treatment appoint 1 tab. 2 times / day (morning and evening).

Treatment should continue until the optimal level of hemoglobin. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months.

Side effect

The most common side effects are gastrointestinal reactions, such as diarrhea or constipation, abdominal pain, nausea, vomiting. The frequency of effects increases with increasing doses up to 400 mg.

In rare cases (<1/100): headache, dizziness, allergic reactions (rash and itching), skin hyperthermia, esophageal stenosis, ulcerative esophagitis, weakness.

Overdose

Symptoms: pallor of the skin, fatigue or weakness, diarrhea with an admixture of blood, vomiting, cold sticky sweat, paresthesia, hyperthermia, acidosis, palpitations, low blood pressure, weak pulse.

In severe overdose after 6-12 hours, muscle cramps, kidney failure, liver damage, coagulopathy, hypoglycemia, signs of peripheral circulatory collapse, possible coma.

In case of taking the drug in a dose that is much higher than recommended, it is necessary to urgently consult a doctor. As a first aid, you should wash your stomach, drink milk or a raw egg (to bind iron ions in the gastrointestinal tract). As a therapeutic measure, deferoxamine (a complexing agent that binds free iron) is administered and symptomatic therapy is administered.

special instructions

With the use of the drug, darkening of the stool is possible, which has no clinical significance.

Interaction with other drugs

Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.

Sorbifer Durules can reduce the absorption of concomitantly used enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and hormones thyroid gland.

Simultaneous use of the drug Sorbifer Durules and antacid preparations containing aluminum hydroxide and magnesium carbonate can reduce iron absorption. Between taking the drug Sorbifer Durules and any of these drugs should be kept as long as possible. The recommended minimum time interval between doses is 2 hours, except for tetracyclines, when the minimum interval should be 3 hours.

Reviews

We offer to familiarize with reviews of people who used the drug Sorbifer Durules:

Masha. The second trimester of pregnancy, hemoglobin fell, a sorbee was prescribed for 2 tablets a day, propyl 3 weeks, hemoglobin did not rise either One unit, which was such and stayed, added another 1 tablet, now I will take 3 a day, then we'll see the result, I eat OK.
Marina. Took Durules during the third trimester of pregnancy, in the form of tablets. The doctor has appointed or nominated, has told or said, that the hemoglobin is strongly lowered. I did not feel a particular effect, the skin itch intensified, but he did not pass the entire pregnancy, so it was unlikely that this was due to taking the drug.
Irina. Saw sorbifer for a month and from the fifth reception terrifying constipations began. I had to combine with laxatives, and then I had to give it up. The anemia suffered for many years and I'm on the hematologist's account. I will say this with milk is not worth taking for everything will go "to the toilet" for it does not suck. So do not recommend drinking tea or coffee (the effect is the same). now I take pills chewing ferrum lek. Also iron, but different valence. The hematologist said that it will rise more slowly, but there will be .a February was hemoglobin 53, now 99, but without constipation.

Analogues

To compensate for iron deficiency, treatment and prevention of anemia, drugs similar in composition to Sorbifer may be used:

Fenuls Zinc is the cheapest alternative. Unfavorable with a long course of admission because of the small capacity of the package - only 10 capsules.
Aktiferrin - is represented by capsules coated with enteric-coated shell.
Tardiferone - is characterized by a much lower content of ferrous sulfate (80 mg).
Ferro-Folgamma - has a wider range of both indications and contraindications to use, since in the composition of the drug, in addition to iron, there are two other active substances: cyanocobalamin (vitamin B12) and folic acid.
Totem - is a solution. Contains additional active substances: gluconates of copper, iron and manganese.
Aktiferrin - it happens in the form of oral drops, syrup and capsules. Additionally contains, -serine.

Before buying an analogue, consult your doctor.