How to take the drug Victoria in diabetes mellitus type 2

width = The drug is intended for patients with diabetes.

However, it can be used only for type 2 pathologies. The main goal of the drug is to provide a clear control over the level of sugar, help the patient to reduce weight.

On this page you will find all information about Victoria: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Victoria. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Hypoglycemic agent.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Victoria cost? The average price in pharmacies is at the level of11 000 rubles.

Form of issue and composition

The substance of liraglutide is considered to be an active active ingredient. Its content in 1 ml reaches 6 mg. One syringe-pen has a volume of drug of 3 ml, which contains 18 mg of liraglutide. The auxiliary components are represented by propylene glycol, hydrochloric acid, phenol, sodium hydrogen phosphate dihydrate, water for injection.

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Secondary cartons may contain 3, 2 or 1 syringes - a pen made of plastic. The kit also includes detailed instructions.

Pharmacological effect

Liraglutide is an analog of human glucagon-like peptide-1 (GLP-1), produced by the biotechnology of recombinant DNA with using a strain of Saccharomyces cerevisiae having 97% homology to human GLP-1, which binds and activates the GLP-1 receptor in rights. The GLP-1 receptor serves as a target for native GLP-1, the endogenous hormone of incretin, which stimulates glucose-dependent insulin secretion in beta cells of the pancreas. Unlike native GLP-1, the pharmacokinetic and pharmacodynamic profiles of liraglutide allow it to be administered to patients on a daily basis once a day.

Under the action of liraglutide glucose-dependent stimulation of insulin secretion occurs. Simultaneously, liraglutide suppresses excessively high glucose-dependent secretion of glucagon. Thus, with increasing blood glucose concentration, stimulation of insulin secretion and suppression of glucagon secretion occur. On the other hand, during hypoglycemia, liraglutide reduces insulin secretion, but does not inhibit the secretion of glucagon. The mechanism of lowering the level of glycemia also includes a slight delay in gastric emptying. Лираглутид reduces weight of a body and reduces fatty weight of a body by means of the mechanisms causing decrease of feeling of hunger and decrease in the charge of energy.

Indications for use

Why helps? The drug Victoria is shown in adult patients with type 2 diabetes on the background of diet and exercise to achieve glycemic control as:

monotherapy;
combined therapy with basal insulin in patients who did not achieve adequate glycemic control on therapy with Victoria and metformin;
combination therapy with one or more oral hypoglycemic drugs (with metformin, derivatives sulfonylureas or thiazolidinediones) in patients who did not achieve adequate glycemic control in the preceding therapy.

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Contraindications

Acceptable price of Victoria and positive reviews make this pharmacological product quite popular. However, even relative safety, perfect chemical formula and universality of use for therapy of all patients are not a reason to forget about contraindications:

Severe renal insufficiency;
Acute liver failure;
Pregnancy and lactation;
Heart failure of I-II functional class;
Hypersensitivity to the components of Victoria, regardless of the manufacturer (this is a standard contraindication, relevant for any pharmacological product);
Thyroid cancer of a medullary type in history (even family history);
Neoplasia of endocrine origin (multiple nature).

Instructions for use

In the instructions for use, it is indicated that the drug Victoria is administered SC once / day in the abdomen, thigh or shoulder. Place and time of injection can be changed without dose adjustment. However, it is preferred to administer at approximately the same time of day, at the most convenient time for the patient. Do not inject in / in or / m.

The initial dose is 0.6 mg / day. After application for at least one week, the dose should be increased to 1.2 mg. There is evidence that in some patients the effectiveness of treatment increases with increasing dose of the drug from 1.2 mg to 1.8 mg. In order to achieve the best glycemic control in the patient and taking into account the clinical effectiveness, the dose can be increased to 1.8 mg after applying it at a dose of 1.2 mg for a minimum of one week. Use in a daily dose of more than 1.8 mg is not recommended.
It is recommended to apply in addition to the existing therapy metformin or combined therapy with metformin with thiazolidinedione. Therapy with metformin and thiazolidinedione can be continued in the previous doses.

Liraglutide is recommended to add to the ongoing therapy sulfonylurea derivatives or to combined therapy with metformin with sulfonylurea derivatives. When adding liraglutide to therapy with sulfonylurea derivatives, a reduction in the dose of sulfonylurea derivatives should be considered in order to minimize the risk of undesirable hypoglycemia.

Side effects

The drug Victoria can have a negative impact on some other systems and organs. Able to arise:

From the heart: often - increased heart rate;
From the skin and subcutaneous tissues: often - a rash; infrequently - itching, hives;
From the immune system: rarely (≥ 1/10 000 to <1/1000) - anaphylactic reactions;
Infections and invasions: often - infections of the upper respiratory tract;
From the nervous system: often - headache;
Metabolic and nutritional disorders: often - decreased appetite, anorexia, hypoglycemia (when the drug is used in combination with insulin); infrequently (≥ 1/1000 to <1/100) - dehydration;
From the side of the kidneys and urinary tract: infrequently - impaired renal function, acute renal failure;
From the gastrointestinal tract: very often (≥ 1/10) - nausea, diarrhea; often (≥ 1/100 to <1/10) - pain in the upper abdomen, dyspepsia, gastritis, bloating, flatulence, constipation, eructation, vomiting, gastroesophageal reflux disease; very rarely (<1/10 000) - pancreatitis (incl. pancreatic necrosis);
Other: often - reactions at the injection site; infrequently - a malaise.

Overdose

With the introduction of a dose that exceeds the average dose by a factor of 40, severe nausea and vomiting develop. Symptomatic therapy is performed.

special instructions

Data on the influence of Victoria on pregnant women are absent. However, in studies on animals, it was found that the drug has reproductive toxicity. When pregnancy is recommended for insulin therapy, Victoria is contraindicated. If the pregnancy is only planned or the time is short, then injections of Victoria are prohibited. They must be stopped immediately.

The penetration of liraglutide into the milk of lactating women is low, however, at this time, Victoria is not assigned.

Drug Interactions

The quiz may contribute to a slight delay in gastric emptying, which may result in a change in the rate of absorption of concomitant oral preparations. According to the research data, this is not a clinically significant value, therefore dosage adjustment is not required. There are isolated cases of acute diarrhea during treatment with liraglutide (may affect the absorption of concomitantly used oral medicines).

With the combined administration of warfarin or other coumarin derivatives, it is necessary to monitor INR (International Normalized Ratio) more often.

Substances added to Victoria may cause degradation of liraglutide, so it should not be confused with other medicines, with infusion solutions.

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Reviews

We picked up some feedback from people about the preparation of Victoria:

Timur. I have diabetes-2. Victoria has reduced sugar from 10 to. Weight has not changed. But the prostate gland has greatly increased. I do not know whether there is a connection or not, but the mention of the risk of thyroid cancer leads to reflection.
Svyatoslav. Diabetes mellitus type 2, insulin is always prohibitive, no drug allowed to stabilize the condition and feel really good. What really bothered me was unreal appetite and constantly growing weight. After my doctor appointed me to Victoria, the situation changed dramatically. I felt vivacity and a surge of strength, there is no binding to food. For the first week immediately dropped 2 kg. The indicators of sugar came in relative norm, but there is still something to work on. Faced one of the side effects - sometimes my head hurts. But this is a trifle, which you do not pay attention to, again feeling full and healthy person.
Olga. I've been sitting on Victor for more than 2 years. Has thrown off weight and has normalized a metabolism. Sugar is always perfect. The expensive price confuses, but for comfort and health it is necessary to pay. The doctor repeatedly offered cheap analogues, which are not so convenient to use, and the pharmacological effect seems to me insignificant against the background of the results achieved with Victoria. While not ready to give up such a comfortable drug.
Victoria. She came to the endocrinologist at the end of November 2016. The sugar level was then 10-11 moles. With a height of 172 weighed 103 kg. She was prescribed a diet, Glucophage and Victoria preparations. After 3 weeks of strict treatment, sugar came back to normal. I started to lose weight from the second week of treatment. Within 2 months I managed to lose 15 kg. Now the sugar level is stable and amounts to, mol.

Analogues

Similar pharmacological effects, but with another active ingredient, are the following medications:

Baeta is a medicinal product that is prescribed as an auxiliary in complex therapy for the treatment of non-insulin dependent diabetes mellitus. It is available in the form of a solution for subcutaneous injection. The main active ingredient is exenatide. The average price of such a drug in pharmacies is 4 thousand rubles.
Novonorm is a tablet drug that has a sugar-reducing effect on the body. The manufacturer of such a medication is Germany. The main active ingredient is repaglinide. It is often used in non-insulin-dependent diabetes mellitus, as the main drug or in complex therapy with metformin or thiazolidinedione. The cost of the drug, depending on the dosage, varies from 170 to 230 rubles.

Before using analogues, consult your doctor.