Teraflex Advance: instructions for use composition

Teraflex Advance

Composition

1 capsule of the drug consists of:glucosamine sulfate250 mg,chondroitin sulfate200 mg,ibuprofen100 mg; additional substances: corn starch, cellulose, sodium carboxymethyl starch, stearic acid,crospovidone, silicon dioxide, magnesium stearate, povidone.

In the capsules gelatinous: gelatin, titanium dioxide, dye blue.

Form of issue

Capsules gelatinous, with a lid of blue color and white case, inside - a white powder. Capsules of 30, 60 or 100 pcs. in polyethylene bottles.

pharmachologic effect

Stimulates the restoration of cartilage, reduces inflammation.

• Chondroitin sulfate- a substance involved in the formation of healthy cartilaginous tissue. At the same time, the viscosity of the synovial fluid is preserved, enzymes that destroy cartilage are inhibited. When osteoarthritis reduces the manifestations of the disease and helps reduce the dose of non-steroidal anti-inflammatory drugs.
• Glucosamine sulfateimproves the synthesis of substances that are the main components of cartilage, joints and synovial fluid.
• Ibuprofenprovides anti-inflammatory effect, reduces pain, renders antipyretic effect due to blockadecyclooxygenase - 1andcyclooxygenase - 2.

Glucosamineandchondroitinincrease analgesic effectibuprofen.

Pharmacodynamics and pharmacokinetics

Bioavailabilityglucosamine- about 25%, with the largest concentration of the substance in the cartilage of the joints, liver and kidneys, the highest concentration is found in the liver, kidneys and cartilage of joints. Almost 30% of the incoming substance is in the muscles and bones for a long time. Half-life - about 3 days, is excreted in the urine.

Bioavailabilitychondroitin sulfateafter absorption in the gastrointestinal tract is approximately 13%.

The maximum concentration occurs after 4 hours in the blood, and in the intra-articular fluid - within 5 hours.

After oral administrationibuprofenits maximum concentration occurs within 1 hour. It is capable of 99% binding to plasma proteins and penetrating into the intra-articular fluid. Metabolized in the liver, excreted by the kidneys. The half-life is about 3 hours.

Indications for use

Contraindications

• ulcerative lesions of the digestive tract (stomach ulcer, Crohn's disease, nonspecific ulcerative colitis);
• gastrointestinal bleeding;
• intracranial hemorrhages;
• bleeding disorders;
• aspirin asthma;
• hemorrhagic diathesis;
• children under 12 years;
• individual intolerance of the constituent components of the drug;
• pregnancyand breastfeeding;
• hypersensitivity toaspirinand NSAIDs.

Assign cautiously with arterial hypertension, heart failure, severe lesions kidney and liver function, gastrointestinal diseases, hyperbilirubinemia, nephrotic syndrome, diseases blood,diabetes mellitus, bronchial asthma, in elderly patients.

In the case of intolerance to sea products, the likelihood of developing an allergy to the drug increases.

Side effects

There may be nausea,diarrhea, abdominal pain, flatulence, constipation and allergic reactions. In case of drug cancellation, side effects disappear.

Most adverse reactions occur onibuprofen, which is a part of the preparation.

• The digestive system: dry mouth, stomatitis, abdominal pain, heartburn, nausea and vomiting, flatulence, constipation and diarrhea,pancreatitisand hepatitis.
• Respiratory system:bronchospasmand shortness of breath.
• CNS: dizziness, headache, irritability, insomnia, drowsiness, depression, hallucinations and confusion.
• Organs of the senses: changes in hearing (noise or ringing in the ears, hearing loss), dry eyes, double vision, eyelid edema and conjunctiva.
• Heart and blood vessels: heart palpitations, increased blood pressure, heart failure.
• Urinary system:nephrotic syndrome, cystitis, nephritis, acute renal failure.
• The system of hematopoiesis:thrombocytopenia, anemia, leukopenia, thrombocytopenic purpura, an increase in the duration of bleeding.
• Allergic reactions:erythematous rash, itching of the skin, urticaria,anaphylactic shock, angioedema, bronchospasm, exudative erythema multiforme, Lyell syndrome, allergic rhinitis, eosinophilia.

Instructions for use Teraflex Advance (Method and dosage)

Take three times a day for 2 capsules after meals, washed down with water in small amounts.

Instructions for Teraflex Advance recommends that the treatment should not be more than 3 weeks without consulting a specialist.

Overdose

Symptoms are mainly associated withibuprofen: abdominal pain, nausea, headache, vomiting, hypotension, drowsiness, retardation, tinnitus, renal failure, metabolicacidosis, faster or slower heartbeat.

For treatment, gastric lavage is used,Activated carbon, alkaline drink, symptomatic therapy.

Interaction

Ethanol, tricyclic antidepressants, rifampicin, barbiturateswith joint admission increase the risk of liver damage.

Teraflex Advance is able to reduce the effectantihypertensive drugs(ACE inhibitors and calcium channel blockers),furosemide, hydrochlorothiazideand uricosuric means.

The drug intensifies the effectsantiplatelet agents, anticoagulantsandfibrinolytic agents, thereby increasing the risk of bleeding.

Potentiates the side effects of drugs that provideulcerogenic action- NSAIDs, ethanol, estrogens, GCS.

Preparationsantacid actionreduce absorptionibuprofen.

Teraflex Advance increases the effectinsulinand other hypoglycemic drugs, raises the concentration of cardiac glycosides, methotrexate and lithium-containing drugs in the blood.

The analgesic effect of the drug may increasecaffeine.

Ibuprofenreduces the anti-inflammatory and antiplatelet effect of aspirin.

Cefoperazone, cefamandol, valproic acid, plikamycin, cepostetanincrease the risk of hypoprothrombinemia.

Joint application withmyelotoxic drugsincrease the toxic effect on the blood system.

Admission with drugs of gold and cyclosporin increasenephrotoxicityandhepatotoxicity.

Glucosaminecan reduce the effectdoxorubicin, hypoglycemic drugs,teniposide, chloramphenicol, semi-synthetic penicillins and increase the absorption of tetracyclines.

Terms of sale

Without recipe.

Storage conditions

Away from children and at a temperature of no higher than 25 ° C.

Shelf life

2 years.

special instructions

In case of necessity of long reception of a preparation, it is necessary to control blood and kidney and liver functions.

In case of symptomsgastropathiesa survey is necessary to prevent the formation of ulcers and bleeding.

If it is necessary to use other analgesics and NSAIDs, remember about the composition of the drugibuprofen.

Analogues Teraflex Advance

There are no complete analogs in Russia.

It is only possible to use chondroprotectors (Chondroxide, Structum, Mukosat, Arthra, Chondroglucose, Hondroflex) in combination with NSAIDs to achieve the effect similar to Teraflex Advance.

What is the difference between Teraflex and Teraflex Advance?

Teraflex Advance in addition toibuprofen.

Children

Contraindicated in children under 12 years.

In pregnancy and lactation

The use is contraindicated.

Reviews of Teraflex Advance

Patients respond to the drug as a remedy that has an effect in the case of prolonged use. The disadvantage is the presence of side effects from the gastrointestinal tract in the form of stomach pains and exacerbationsgastritisandulcers.

Comments of doctors who use Teraflex Advance in their practice relate to the convenience of use for treatment of joint lesions - one capsule contains both NSAIDs and substances that restore cartilaginous the cloth.

Price Teraflex Advance, where to buy

Price Teraflexa Advance is from 406 rubles. for 30 capsules to 1464 rubles. for 120 capsules. In Ukraine, the cost of the medication is about 373 UAH. for 120 capsules.

• Online pharmacies in RussiaRussia
• Internet pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

WER.RU

1. Teraflex Advance capsule 60 pcs. Bayer [Bayer]
2. Teraflex Advance capsule 30 pcs. Bayer [Bayer]

ZdravZona

• Teraflex Advance №30 capsulesTHERAFLEX
• Teraflex Advance №120 capsulesBayer / CONTRACT PHARMACAL
• Teraflex Advance №60 capsulesBayer / CONTRACT PHARMACAL
• Teraflex Advance №60 capsules / Bayer / Bayer / CONTRACT PHARMACAL

IFK Pharmacy

1. Teraflex AdvanceContract Pharmacal Corporation, USA
2. Teraflex AdvanceContract Pharmacal Corporation, USA

PaniApoteka

• Teraflex Advance Caps. №120Sagmel
• Teraflex Advance Caps. №120Sagmel
• Teraflex Advance Caps. №120Sagmel
• Teraflex Advance Caps. №120Sagmel

BIOSPHERE

• Teraflex Advance №60 caps. Contract Farmakal Corporation (USA)

NOTE! Information about medicines on the site is a reference-generalizing, collected from public sources and can not serve as a basis for making a decision about the use of medications in the course of treatment. Before using the drug Teraflex Advance, always consult your doctor.

A source: http://medside.ru/terafleks-advans

Teraflex Advance - instructions for use, price and analogues of tablets

The sedentary, sedentary lifestyle of modern man leads to the fact that an increasing number of people collides with disabilities of the locomotor system, spine and joint diseases.

American anti-inflammatory drug Teraflex Advance can help to cope with these problems. The use of this drug indicates that the analgesic effect of Ibuprofen in its composition helps to reduce pain Feel.

What is Teraflex Advance

The agent prescribed for inflammatory diseases of the musculoskeletal system, Teraflex Advance is a drug produced in the form of gelatin capsules.

Active active substances in its composition remove the inflammatory process and are involved in the restoration of the affected cartilage tissue.

The doctor can recommend the patient to take Teraflex with Ibuprofen for osteoarthritis and osteochondrosis of moderate severity with moderate pain.

In addition to these diseases, this remedy can be prescribed to a patient with inflammation of joints accompanied by pain syndrome. Indications for use according to the instructions:

• degenerative-destructive diseases of the bone system;
• post-traumatic conditions;
• intraarticular inflammatory processes.

Drugs called Teraflex have the same indications for use as indicated in their instructions. They have the same form of release - capsular, a similar number of capsules in the package.

Differences Teraflex and Teraflex Advance are the main active substances and possible negative consequences of the application. In Advance added Ibuprofen - a substance of the group of NSAIDs (nonsteroidal anti-inflammatory drugs), which lowers the temperature and refers to strong analgesics.

The volume of chondroitin sulfate also differs - in the usual Teraflex it is more than in Advance.

Teraflex Advance has a number of side effects that Teraflex does not have, because the concentration of the active substances is lower and Ibuprofen is present.

When using Advance, allergic reactions are possible, it is contraindicated in patients with low blood clotting rate, respiratory diseases, stomach ulcer.

Composition Teraflex Advance

Active active substances Teraflexa are glucosamine sulfate, chondroitin sodium sulfate and ibuprofen. In addition, the structure of Teraflex Advance, according to the instructions, contains:

• starch (gelatinized, corn and carboxymethylated sodium);
• stearic acid;
• silica;
• magnesium stearate;
• crospovidone;
• Povidone.

Due to the side components, the effect of the main components is enhanced by increasing their absorption. The drug is quickly absorbed, easily excreted from the body.

Chondroitin and glucosamine refer to chondroprotectors of artificial origin - their components are capable of stimulating the restoration of cartilage tissue.

Form of issue: capsule

No other forms of release Teraflex Advance, except for encapsulated, does not exist. One gelatinous blue-white opaque capsule in a natural shell contains 600 mg of white powder with a slightly yellowish tinge.

In the pharmacy, you will be offered three options for packaging the medicine - 30, 60, 120 capsules in one bottle. Focus on the estimated duration of the course.

Each unit of the package is accompanied by an instruction for the use of the medicinal product

How to take Teraflex

According to the instructions for use, adult patients are recommended a daily dose of 6 capsules, which should be divided into three doses. Take Teraflex should be after eating, squeezed with water.

The manufacturer warns that without agreement with the attending physician, the duration of the course can not exceed twenty one days.

Older people over the age of sixty should not drink this medicine without prescribing and observing their therapist because of the strong side effects of ibuprofen.

Instructions for use Teraflex Advance

The instructions for use of Teraflex Advance indicate two main diseases in which treatment with use of this drug: articular osteoarthritis and osteochondrosis of the spine of all stages. However, due to the chondroprotectors included in their composition, their ability to heal cartilage tissues, the practice of prescribing during the treatment of fractures and sprains is practiced.

Bioavailability of the main substances is: up to 30% for glucosamine and up to 15% for chondroitin. The highest concentration after absorption through the gastric mucosa occurs in the intra-articular synovial fluid, cartilage tissue and liver.

The maximum level is reached within four hours after administration. The total half-life from the body can be up to three days.

Ibuprofen combines with plasma proteins, after metabolism, the liver is excreted from the body within twenty-four hours.

The use of Teraflex during pregnancy and during breastfeeding is strictly contraindicated. Ibuprofen is 95% bound to the plasma of a future mother.

Once inside the fetus, it can cause irreversible damage in the formation of internal organs, lead to damage to the nervous or cardiovascular systems of the child.

If you have indications for the use of this medication, the attending physician must offer an alternative, gentle method of therapy.

Overdose for longer than 21 days

During long courses of intake exceeding 21 days, the risk of getting poisoning by Teraflex is not ruled out, followed by intoxication of the body. In case of an overdose, the following symptoms may be observed:

1. stomach ache;
2. kidney failure;
3. tachycardia;
4. dizziness;
5. nausea and vomiting;
6. headache.

If you suspect an overdose, stop taking the medication, read the instructions for use again and contact your doctor.

After washing the stomach, you will be prescribed therapy to restore the acid-base state, correction of blood pressure.

Cases of overdose can occur with regular excess of the recommended daily dose or during a long course of treatment. Take the medicine in strict accordance with the instructions of the instructions and your doctor.

Side effects

When using the drug, the side effects of Teraflex Advance may occur.

This is due to the fact that the active substances of its composition are potent agents, which increases the risk of failure of the digestive tract, respiratory, cardiovascular and nervous systems.

When taking Teraflex, nausea, dizziness, attention deficit disorder, abdominal pain are possible. If one or more of the symptoms described above appear, discontinue therapy and undergo a test to reduce the likelihood of serious complications.

Contra-indications Advance

Teraflex Advance is a potent drug, so there is an impressive list of diseases and conditions in which taking it is strictly contraindicated. In the instructions for use, the following contraindications are prescribed: Teraflex Advance:

• peptic ulcer of the stomach or duodenum;
• colitis;
• Crohn's disease;
• bleeding disorders;
• asthma;
• bleeding GIT;
• intracerebral hemorrhage;
• liver and kidney disease;
• pregnancy and lactation period;
• age to 18 and after age 65;
• period after coronary bypass;
• individual intolerance of the components of the drug and aspirin.

It is not recommended to make a decision on the use of the drug on its own - the appointment should be made by a doctor. With special care follow the therapy should people suffering:

1. heart failure;
2. renal or hepatic insufficiency;
3. diabetes mellitus.

The relationship between the body's allergic reaction to seafood and the components of the drug has been identified.

If eating shellfish, crustaceans, shrimp, cephalopods and other sea dwellers causes unpleasant sensations in you, reaction from the digestive or limbic systems of the body, there is a high probability of allergy to this medical a drug.

Interaction with other medicinal products

Teraflex Advance can be assigned together with other medical devices. The patient will be aware of the possible consequences of concurrent therapy, since in this case, interactions with other medications can not be avoided.

The main active substances Teraflexa can enhance or reduce the effect of vasodilators, hypoglycemic drugs, insulin, thrombolytic, anticoagulant. More detailed information on the interaction contains instructions for use.

Analogues

Russian analogues of Teraflex Advance are inexpensive, contain the same active active substances in different dosage, and also have a number of additional advantages, for example, are issued as an injection solution. The analgesic effect of intramuscular injection is not as slow as when taking a capsule preparation, the activity of the main substance is higher.

To choose an analogue, be guided by the composition and dosage of the active substance. Anti-inflammatory drugs for joints produced in Russia and Belarus are known and widely used:

• Chondroglucide;
• Chondrolon;
• Chondroitin-AKOS;
• Elbon;
• Mucostat;
• Chondrosamine.

Price Teraflex Advance

This drug is dispensed without a doctor's prescription, so you can order it and buy it from an online store or at any pharmacy.

How much does Teraflex cost from joints? In Moscow pharmacies the price starts from 600-650 rubles for thirty capsules and reaches 2500-2900 for a package of 120 pieces.

How much is Teraflex Advance? The price is slightly higher, on average, ten to fifteen percent for a similar dosage.

There are Russian and foreign analogues of medicine, which have a lower cost.

Depending on the manufacturer and packaging, you can purchase a drug of a similar spectrum of action at a price almost two times lower than the price of Teraflex Advance.

A source: http://sovets.net/11358-terafleks-advans-instrukciya-po-primeneniyu.html

Teraflex Advance: instructions for use

Teraflex Advance refers to a group of drugs that stimulate the regeneration of damaged areas of cartilaginous tissue and have a pronounced anti-inflammatory effect.

Form of formulation and composition of the preparation

The drug Teraflex Advance is available in the form of gelatin capsules for ingestion of white with a blue lid and an inscription of the blue color of the name of the drug in Latin. When the capsule is opened, a white powder with a weak specific odor is inside.

Each capsule contains active ingredients:

• Ibuprofen 100 mg;
• Chondroitin sodium sulfate 200 mg;
• Glucosamine sulfate 250 mg.

In addition, the formulation includes auxiliary components: microcrystalline cellulose, corn starch, magnesium stearate, silicon dioxide. The anti-inflammatory effect of the drug is due to the ibuprofen capsule included.

Indications for use

Capsules Teraflex Advance are prescribed to patients in the complex treatment of the following conditions:

1. osteochondrosis of cervical, thoracic and lumbar spine with moderate pain;
2. ostearthrosis of large joints;
3. received injuries of the joints.

Contraindications

Capsules of the drug should be taken only as prescribed by the doctor, before using It is recommended that you read the accompanying instructions, since the Teraflex Advance has a number of contraindications:

• increased individual sensitivity to the components of the drug;
• age under 18 years (experience of use in patients younger than this age is absent, and the safety of the drug is not established);
• cases of an allergic reaction to acetylsalicylic acid and NSAIDs in the anamnesis;
• chronic erosive gastritis or peptic ulcer of the stomach and duodenum;
• Crohn's disease, ulcerative colitis;
• Hyperkalemia, confirmed by analysis;
• blood diseases with violation of the clotting function;
• tendency to bleeding;
• bronchial asthma or polyposis of the nose;
• renal or hepatic insufficiency;
• pregnancy and the period of breastfeeding;
• suspicion of intestinal bleeding;
• diseases of the liver and kidneys, accompanied by a violation of the function of organs.

The drug has a number of relative contraindications, that is, you can take capsules only under the supervision of a doctor and after preliminary tests. These contraindications include:

1. age of the patient over 65;
2. disorders of the heart rhythm, diseases of the cardiovascular system;
3. arterial hypertension;
4. diabetes;
5. concomitant therapy with anticoagulants of indirect action;
6. cardiac ischemia.

Method of administration and dosage

Capsules are taken orally after a meal. The preparation should be washed down with the necessary amount of water.

The dose of the drug is determined by the doctor individually, but according to the instructions, adults are prescribed 2 capsules 3 times a day, the duration of the course of treatment is 21 days.

If no improvement is observed or the patient's condition, on the contrary, worsens, then the treatment is stopped and the doctor is consulted to correct the treatment.

Application of the drug during pregnancy and lactation

Capsules Teraflex Advance are contraindicated in women at any time of pregnancy.

Ibuprofen, which is part of the drug, increases the risk of bleeding in the fetus, complications of the respiratory system and kidneys, as well as the formation of congenital anomalies such as the wolf's mouth and hare's lips in the event that the drug was taken in the early stages pregnancy.

Since the active ingredients of the drug are excreted in breast milk, you can not take capsules during breastfeeding. If it is necessary to treat the drug with a nursing mother, stop lactation.

Side effects of the drug

On the background of taking capsules of the drug Teraflex Advance, the following side effects often occur in patients:

• from the organs of the digestive tract - pain in the stomach, nausea, vomiting, burning along the esophagus, decreased appetite, stool, swelling of the intestine, flatulence, exacerbation of chronic diseases (gastritis, ulcers), in rare cases, develops aphthous stomatitis and reactive pancreatitis;
• inflammation of the liver;
• shortness of breath, bronchospasm;
• from the side of the nervous system - headaches and dizziness, increased irritability, nervousness, impaired consciousness, depression, aggression;
• on the part of the cardiovascular system - violation of the heart rhythm, tachycardia, increased blood pressure, the development of heart failure;
• from the senses - hearing loss, ringing in the ears, deafness, impaired vision, dry eyes, reddening of the mucous membranes of the eyes, swelling of the conjunctiva, scotoma;
• from the organs of the urinary system - the development of renal failure, allergic nephritis, cystitis, polyuria, edema of limbs and face;
• hemopoiesis - aplastic and hemolytic anemia, thrombocytopenic purpura, leukopenia, agranulocytosis;
• rash on the skin, hives, itching, dermatitis, Quincke's edema, anaphylactic shock, fever.

In the case of the development of the above-described side effects, the drug is stopped and consulted by a doctor.

Overdose

With prolonged administration of Teraflex Advance capsules in large doses, the patient gradually develops signs of an overdose caused by the toxic effect of ibuprofen. Clinically, an overdose manifests itself as follows:

1. cutting pains in the stomach;
2. nausea and vomiting;
3. retardation, lethargy, drowsiness;
4. heart rhythm disturbance, atrial fibrillation;
5. bradycardia and lowering blood pressure;
6. acute renal insufficiency;
7. stopping breathing;
8. noise in the ears, ringing in the ears.

Treatment consists in washing the patient's stomach, injecting into the sorbents and performing symptomatic therapy if necessary.

Interaction of the drug with other drugs

Capsules Teraflex Advance is not recommended for patients with barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants. This drug interaction increases the toxic effect of ibuprofen, respectively, the risk of side effects is great.

With the simultaneous appointment of the drug with vasodilators, the hypotensive effect of the latter decreases, which patients should be warned about and, possibly, the dose of the drug should be adjusted.

Under the effect of Teraflex Advance capsules, the therapeutic effect of Furosemide and hydrochlorothiazide is reduced.

Due to the ibuprofen incorporated into the preparation, the therapeutic effect of indirect anticoagulants increases with the simultaneous administration of these drugs to the patient. This, in turn, increases the risk of side effects and bleeding.

When concomitant administration of Teraflex Advance with oral hypoglycemic drugs or insulin is enhanced the therapeutic effect of the latter, which should be taken into account and adjust the dose for diabetics.

With the simultaneous administration of the drug with enterosorbents or antacids, the therapeutic effect of the Teraflex Advance capsules is reduced. If this drug interaction is necessary, a time interval of at least 3 hours should be maintained.

The drug is not recommended to be prescribed to patients simultaneously with non-steroidal anti-inflammatory drugs and acetylsalicylic acid, since in this case the risk of side effects increases sharply in view of complications from the gastrointestinal tract and system blood.

Glucosamine in the drug reduces the therapeutic effect of tetracyclines and antibiotics of penicillin a number of things that should be considered in this drug interaction and adjust the dose to patients individually.

Special instructions are important!

With prolonged use of the drug (more than 21 days), patients are advised to take blood tests to assess the functioning of the liver and kidneys.

If side effects occur on the part of the digestive tract, the patient should consult a doctor immediately, therapy is possible only after examination (gastroduodenoscopy, feces for occult blood, ultrasound) of the patient and exclusion of gastrointestinal bleeding.

If it is necessary to prescribe additional analgesics or NSAIDs to patients, it should be taken into account that the preparation Teraflex Advance includes ibuprofen.

During the treatment period, care should be taken when driving a car or managing complex equipment that requires a high concentration of attention. This is due to possible visual impairment, ringing in the ears and dizziness on the background of therapy.

Teraflex Advance Analogues

A similar action with the drug Teraflex Advance has the following medicines:

• Hondrogaard;
• Teraflex;
• Chondroitin;
• Diaflex Rompharm;
• Chondrolon powder.

All these preparations have different composition, indications and contraindications, therefore it is not recommended to take them without consulting a doctor.

Conditions of dispensing and storage of the drug

Capsules Teraflex Advance can be bought in a pharmacy without a prescription. Keep the drug out of reach of children, avoiding direct sunlight on the package. Optimum storage temperature should not exceed 25 degrees, shelf life 2 years from the date of production.

Teraflex Advance Price

In pharmacies in Moscow, the average cost of the drug Teraflex Advance in the form of capsules is 745 rubles.

A source: http://bezboleznej.ru/terafleks-advans

Teraflex Advance: instruction manual, price 120 capsules, reviews and similar products

Wide application in the treatment of locomotor disorders, in particular, osteochondrosis, received Teraflex Advance capsules.

This drug accelerates the recovery processes in the cartilage and has an anti-inflammatory effect on the affected joints.

Form release and composition of the medicine

The drug is available in the form of hard gelatin capsules of white and blue color with the name of the drug on the surface. Inside each capsule is an off-white powder.

Capsules of 30, 60 or 120 pieces are packed in polyethylene jars with a protective film on the lid.

Under the lid is also present a protective membrane of thin paper with the name of the drug.

Each capsule consists of:

1. Glucosamine;
2. Chondroitin;
3. Ibuprofen;
4. Auxiliary components like magnesium stearate, silicon dioxide, povidone, crospovidone, cellulose, corn starch, stearic acid, sodium carboxymethyl starch;
5. The capsule shell is made of dye, gelatin and titanium dioxide.

How it works

The action of the capsules differs in a combined character and is determined by the main active ingredients: chondroitin, glucosamine and ibuprofen.

• Glucosaminehas a beneficial effect on the processes of synthesis of the main cartilage components (hyaluronic acid, proteoglycans, etc.), intraarticular fluid and shells of joints;
• Chondroitincontributes to the early formation of a new cartilage tissue, blocks the formation of the degrading cartilage of enzyme substances, reduces the intensity of clinical manifestations, allows you to reduce the dosage of non-steroid preparations. In addition, this component returns to the joints the former mobility and protects them from destruction;
• Ibuprofen, relating to anti-inflammatory drugs, is able to relieve soreness, has antipyretic properties. A complex chondroitin-glucosamine effect promotes an increase in the analgesic effect.

Chondroprotectors should be used for a long time, because they begin to have therapeutic effects only when the necessary concentration is accumulated in the body.

Indications for use

Contraindications

Teraflex Advance has a wide range of contraindications:

1. The presence of erosions or ulcers in the gastrointestinal organs (like ulcerative colitis, Crohn's disease, ulcers of the duodenum, or stomach, etc.);
2. Hypersensitivity to aspirin and other non-steroidal anti-inflammatory drugs;
3. Bleeding in the organs of the digestive tract;
4. Children's age (under 12);
5. Individual intolerance to the drug or its individual component;
6. Hemorrhages of intracranial localization;
7. Period of gestation or breastfeeding of the child;
8. Aspirin asthma - when bronchial asthma rapidly develops in response to taking aspirin or its derivatives;
9. All sorts of disturbances of blood flow;
10. Diathesis of hemorrhagic character - a group of diseases associated with pathologically increased bleeding, arising spontaneously or due to minor trauma.

With particular caution, you should take capsules when:

• Diabetes;
• Myocardial insufficiency;
• Renal or hepatic functional impairment;
• Hypertonic disease;
• Gastrointestinal pathologies;
• Increased bilirubin content;
• Pathologies of blood;
• In the elderly;
• Bronchial asthma;
• Nephrotic syndrome is a disease characterized by the appearance of severe puffiness in brushes, feet and throughout the body, high blood-swallowing, deficiency of albumin and protein in the blood and etc.

Side effects of the drug

Capsules have an impressive list of adverse reactions. Patients often experience flatulence, gastralgic pains, diarrhea, nausea and vomiting, constipation, allergic manifestations.

The predominant majority of pills is due to the presence of ibuprofen. If you cancel the admission, all the side symptoms will go away by themselves.

Possible adverse reactions can affect almost any body system:

1. Heart, blood vessels- Increases blood pressure, cardiac beat increases, myocardial insufficiency may develop;
2. Hemopoiesis- occurrence of predisposition to bleeding, anemia, thrombocytopenia (pathologically lowered the content of platelets), bleeding and subcutaneous hemorrhage arising from a low level thrombocytes;
3. Breathing system- shortness of breath and bronchospasm;
4. Urination- Cystitis, nephritis, acute kidney failure, nephrotic syndrome (severe swelling and increase in the amount of fats and protein in the urine, excessive blood loss);
5. Systemic abnormalities- headaches and sleep disorders, dizziness and irritability, depressive states and drowsiness, confusion in the mind and hallucinogenic manifestations;
6. Digestion- Gastralgic pain or dryness in the oral cavity, vomiting or vomiting or heartburn, stomatitis, diarrhea or constipation, bloating, hepatitis, pancreatitis;
7. Allergic Symptoms- itching, multiple rashes, urticaria, bronchospasm or Quincke's edema, anaphylactic shock or allergic rhinitis, pustular eruption, Lyell's syndrome (acute process of necrosis of skin and mucous tissues, accompanied by numerous toxic lesions internal organs);
8. Sense organs- Dichroism and dryness in the eyes, conjunctivitis or swelling of the eyelids, auditory disorders like poor hearing or extraneous noise in the ears.

Instructions for the use of medicament

After taking capsules, the instruction prohibits engaging in activities that require quick attention and psychomotor reactions. Also, during the treatment, refrain from taking any alcoholic products.

How to take capsules

Teraflex Advance should take 2 capsules three times a day after meals, washed down with a small amount of water.

The need for a recurrence or prolongation of the course of therapy should only be decided by the attending physician.

Overdose - manifestations

At abuse of doses of a preparation at the patients there were displays, characteristic for influence ibuprofena. So, the patients complained about:

• Nausea and vomiting symptoms;
• Stomach ache;
• Drowsiness;
• Headache;
• Some retardation;
• A sharp slowdown or a rapid heart beat;
• Kidney failure;
• Extraneous noise in the head and ears.

To eliminate such manifestations are shown gastric lavage, drinking alkaline solutions, activated charcoal, elimination of symptoms.

Compatibility with other drugs

Teraflex Advance is characterized by increased requirements for interaction with other medicines, which are extremely important to consider when simultaneous reception is necessary.

1. Capsules enhance the effect of thrombosassing (fibrinolytic), reducing blood flow (anticoagulants) and reduce thrombus formation (antiaggregants) drugs, provoking the development of strong bleeding;
2. Promotes increased therapeutic effect of lithium agents, Mototrexate, insulin and other hypoglycemic agents, increases cardiac glycosides in the blood;
3. Reduces the therapeutic effect of drugs like Furosemide, calcium blockers and ACE inhibitors;
4. Absorption of ibuprofen decreases with simultaneous administration with antacids (neutralize hydrochloric acid in gastric juice, used for heartburn);
5. When combined with drugs such as NSAIDs, estrogens, corticosteroids or with ethanol, capsules increase the likelihood of adverse reactions from taking these drugs;
6. When the drug is taken together with myelotoxic drugs, the toxic effect on the circulatory system is significantly increased;
7. When taking with aspirin, there is a decrease in its hemorrhaging and anti-inflammatory efficacy;
8. Under the influence of caffeine, an increase in the analgesic effect of capsules is possible;
9. Simultaneous use with gold-containing medicines or Cyclosporin causes increased toxic effects on the kidneys and liver.

What is the difference between Teraflex Advance preparations from Teraflex

Unlike the usual Teraflex in Teraflex Advance capsules, there is a non-steroidal anti-inflammatory component in the form of ibuprofen.

What's better

Both drugs are highly effective. If long-term treatment or administration of strong NSAIDs is required, the appointment of an ordinary Teraflex is recommended.

If the treatment is supposed to be short-term, aimed at relieving the attack, and the dose of ibuprofen present in the combination capsules will be enough, then Teraflex Advance is appointed.

Price

In Russian pharmacies and in Moscow, the cost of preparations of different types is roughly the same:

• Teraflex Advance № 30 - 440-620₽;
• №60 - 1104 - 1453₽;
• No. 120 - 1634-2158.

A source: http://OsteoHondroza.net/medikamenty/preparaty/terafleks-advans.html