Orvire Syrup

Orvirem is an antiviral drug. Used for prevention and treatment at the initial stage of the development of influenza A, incl. In pediatric practice, starting with 1 year of life.

It was found that the use of Orvirem reduces the duration of clinical symptoms of influenza by 3, day. No significant changes in peripheral blood parameters were noted during the study. Pathological changes in urine were not detected. For effective prevention of influenza, the drug should be used within 2-3 days before the onset of symptoms of the disease.

For effective treatment, Orvire should be taken 6-7 hours after the appearance of clinical signs of the disease.

Clinical and pharmacological group

Antiviral drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Orvir syrup cost in pharmacies? The average price is at the level of310 rubles.

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Form of issue and composition

The suspension is discharged in a 100 ml glass bottle of brown color. The preparation has a consistence of thick, viscous syrup of a red-pink shade, has a bitter taste. 5 ml (one teaspoon).

• In 5 ml of syrup contains rimantadine hydrochloride - 10 mg, excipients (sugar, water, sodium alginate, E122).

Pharmacological effect

Antiviral drug. Rimantadine is a derivative of adamantane; is active against various strains of the influenza A virus (especially type A2). As a weak base, rimantadine acts by increasing the pH of the endosome, having a membrane of vacuoles and surrounding viral particles after they penetrate the cell. The prevention of acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing the transfer of the viral genetic material to the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, i. E. interrupts the transcription of the viral genome.

The appointment of rimantadine for 2-3 days before and 6-7 hours after the onset of clinical manifestations influenza A reduces the incidence, severity of symptoms and serological reaction. Some therapeutic effect may also occur if rimantadine is prescribed within 18 hours after the onset of the first symptoms of influenza.

Pharmacokinetics

After ingestion by Sir Orvire slowly, but almost completely absorbed in the intestine, reaching a maximum concentration in the blood plasma after 1-4 hours. Its relationship with plasma proteins is 40%, the volume of distribution is 289 l / kg.

The drug is metabolized in the liver, half-life in children aged 4-8 years is 13-38 hours. About 90% of the drug is excreted along with the urine, 15% - unchanged, the rest - in the form of metabolites.

Indications for use

Experts recommend that you prescribe a syrup if the child is in contact with the patient. Timely application of the drug helps to ease the course of the disease, prevents complications, accelerates recovery.

In what cases is the drug shown:

1. Treatment of influenza. Actively works against the strain of virus A in children from one year, is especially effective in the first hours of the disease.
2. Prevention of influenza in children during the epidemic period and in the presence of those infected in children's groups, at home.

It is believed that Orvire copes well not only with influenza, but is effective in the treatment of other acute respiratory infections. However, it is clinically proven that with other acute viral infections of the respiratory tract, Orvirem is ineffective.

Contraindications

It is forbidden to use a medicine:

• for children up to a year;
• with individual intolerance of individual components;
• serious diseases of the kidneys and liver (consultation with the doctor is needed);
• Diabetes mellitus can also cause a failure of a therapeutic syrup (sometimes simply reduce the dosage of Orvirem);
• during lactation and lactation (active components of the drug may adversely affect the formation of the fetus or the development of the already born crumbs).

Dosage and route of administration

The instructions for use indicate that the syrup should be taken by Orvire inside, after eating, with water.

Recommended treatment scheme for children 1-3 years old by day:

• 1st day: 2 h spoonfuls (10 ml / 20 mg) of syrup 3 times a day, maximum dose - 60 mg;
• 2-3 days: 2 hours spoon (10 ml / 20 mg) syrup 2 times a day, the maximum dose - 40 mg;
• 4 th day: 2 h spoonfuls (10 ml / 20 mg) of syrup 1 time per day, maximum dose - 20 mg.

Recommended treatment scheme for children 3-7 years by day:

• 1st day: 3 h spoonfuls (15 ml / 30 mg) of syrup 3 times a day, maximum dose - 90 mg;
• 2-3 days: 3 h spoonfuls (15 ml / 30 mg) of syrup 2 times a day, maximum dose - 60 mg;
• 4 th day: 3 h spoonfuls (15 ml / 30 mg) of syrup once a day, maximum dose - 30 mg.

Recommended treatment scheme for children 7-14 years by day:

• 1-st day: 4 h spoonfuls (20 ml / 40 mg) of syrup 3 times a day, maximum dose - 120 mg;
• 2-3 days: 4 h spoons (20 ml / 40 mg) of syrup 2 times a day, the maximum dose is 80 mg;
• 4 th day: 4 h spoonfuls (20 ml / 40 mg) of syrup 1 time per day, maximum dose - 40 mg.

Prophylactic Orwirem for Children:

• children 1-3 years: 10 ml once a day;
• children 3-7 years: 15 ml once a day;
• children 7-14 years: 20 ml once a day.

The duration of preventive reception of Orvirem is 10-15 days, depending on the focus of the infection.

The maximum daily dose for children is 5 mg per kilogram of body weight.

Side effects

In most cases, Orvire syrup is well tolerated by children and adults, but sometimes there may be some side effects:

1. From the gastrointestinal tract: Attacks of nausea and vomiting, tenderness in the epigastric region, bloating, anorexia.
2. From the side of the central nervous system: Pain in the head, dizziness, trouble sleeping, lowering concentration.
3. From the skin: rash, itching, urticaria.

Overdose

There is no information about drug overdose.

special instructions

Before you start using the drug, read the special instructions:

1. With epilepsy, the risk of epileptic seizures increases.
2. Perhaps the emergence of drug-resistant viruses.
3. Against the background of taking the drug may exacerbation of chronic concomitant diseases.
4. The syrup contains 60% sucrose, which should be taken into account when prescribing the patient with diabetes mellitus.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Cimetidine reduces the clearance of rimantadine by 18%.
2. When combined, acetylsalicylic acid and paracetamol lower the Cmax value of rimantadine by 11%.
3. When combined, Avroviem reduces the effectiveness of antiepileptic drugs.
4. With simultaneous intake of adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.
5. Drugs that acidify urine (acetazolamide, sodium bicarbonate), enhance the effectiveness of rimantadine because of the decrease in its excretion by the kidneys.

Reviews

We picked up some feedback from parents using Orvire syrup:

1. Oksana. This is the same rimantadine, but only in liquid form. I applied "Orvire" to the appointment of our pediatrician, when my son fell ill after visiting the kindergarten. The drug is really good, it helped to put the baby on its feet. Took strictly according to the scheme (it is indicated in the instructions), did not cause allergy and did not notice any other side effects. The price is much higher than that of rimatadina in the form of tablets. But the "Orvirem" (syrup) dosage is more gentle, designed for children.
2. Catherine. The doctor has appointed for the treatment of influenza syrup my daughter's Orvire at 6 years old. Read many positive reviews about this drug. The baby's illness was difficult, with a high fever, a strong cough, the drug gave 3 r./day for five consecutive days with Ingavirin. The drugs helped, the child quickly recovered.
3. Love. My granddaughter, the year, began to go to kindergarten since October. We have been walking for two days, we have been ill for two weeks, practically all of November, we had been taking Citovir, and already when went for 3 times sick, the doctor prescribed an antiviral drug Orvirem, warning that there may be allergy. It is a sweet syrup for children against the flu, colds, and also as a preventative, with a pleasant smell, crimson. We did not have allergies, the drug really helps. A convenient lid on the bottle, but there is no measuring spoon, and not cheap. You can take a year, strictly according to the scheme for four days, already in the morning there was no temperature and did not rise again. I consider him a wonderful assistant and a rescuer.

Analogues

Among the analogs of Orvirem, which are represented on the pharmaceutical market, the following should be noted:

1. Remantadine. Analogue of Orvirem of Russian production, produced in the form of tablets. The main difference Remantadina - a high concentration of active substance, which allows you to prescribe a drug to treat influenza in children only older than 7 years. For prevention, this drug is usually used only for adolescents over 12 years. With prolonged use, a manifestation of a hepatotoxic effect is possible.
2. Rimantadine-Neo. Homeopathic medicine (syrup), is prescribed for newborns and young children for the prevention of acute respiratory viral infections. The advantage of the drug is its good tolerability by its young children, the lack of contraindications to the use and side effects.

Similar in effect on the body of antiviral drugs is much more:

• Kagocel. Such antiviral tablets stimulate the production of interferon and are in demand when infected with herpesviruses, the influenza virus and in other infections. This medication is prescribed for children from the age of three. It is also allowed to be used for prophylaxis, for example, if a child of 4-5 years attends kindergarten during the ARVI season.
• Amiksin. These tablets, containing tilorone, act on viruses of herpes, influenza, hepatitis and other pathogens. They can be prescribed from the age of 7 and are often applied with a preventive purpose to prevent ARVI and influenza in the winter-spring period.
• Ingavirin. These capsules have not only an antiviral effect, but also anti-inflammatory activity. They are used from the age of 13 in the treatment of parainfluenza, adenovirus infection, influenza and other infections.
• Arbidol. Such a preparation has an immunostimulating and antiviral effect, therefore it is used in the treatment of rotavirus infection, influenza, ARVI and other diseases. It is presented as a tablet in a shell, powder for the preparation of a suspension and capsules. A medication with a dosage of 50 mg is allowed for children over 3 years of age, and a dosage of 100 mg is administered from the age of six.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store Orvireum in a dry place at room temperature. Shelf life is not more than 3 years. After the expiration date, the drug is not suitable for use.

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