Colchicine: instructions for use, analogues

Colchicine: medicinal properties and instructions for the use of the drug

Colchicine is the drug most effective for treating gout, as well as some other diseases.

The active substance - colchicine - has a plant base and is a poison (alkaloid).

With gout in the body of the patient as a result of impaired metabolism, an excess of uric acid is produced, the accumulation of crystals of urate salts on the surfaces of the joints that injure the tissues during movement, which causes their sharp and very painful inflammation.

Taking colchicine allows you to reduce the production of uric acid, quickly and effectively removing acute attacks of gout. But exceeding the dose of the drug is dangerous poisoning.

How correctly to be treated with colchicine? And what analogues of the drug are used in Russia?

Colchicine is available in the form of tablets. Each tablet contains mg, mg or 1 mg of active ingredient. Outside, the tablets are covered with a membrane that dissolves in the intestine and prevents the absorption of colchicine in the stomach.

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Colchicine is imported to Russia from the European Union countries: Germany, Austria, Italy, Portugal, as well as from India and Vietnam.

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Producers of drugs:

• Pharmafar Srl (Italy) - the trade name of the preparation "Colchicina
• Johannes Bürger Ysatfabrik GmbH (Germany) and Acarpia / Pharmafar S.r.l. (Portugal) - produce the preparation "Colchicum-Dispert
• Brown Laboratories Ltd. for "Rotec Ltd, India / Great Britain - produces" Colchicine ".

pharmachologic effect

Colchicine regulates the formation and excretion of uric acid. As a result, inflammation decreases, joint pain decreases. The drug launches the following processes:

• reduces the production of uric acid;
• retards its crystallization;
• reduces the number of lysosomal enzymes, which ensure the flow of chemical reactions in the inflammation zone;
• reduces the movement of leukocytes to the site of inflammation;
• suppresses cell division in the inflammation zone;
• prevents the growth of yeast-like bacteria.

Analgesic (analgesic) action of the drug is supplemented with anti-inflammatory effect. Colchicine not only anesthetizes, but also cures (reduces inflammation).

Indications for use

Colchicine is indicated in the following diseases:

• gout and gouty arthritis;
• phlebitis (inflammation of veins);
• Behcet's disease (medium and small arteries are affected, which causes the mucous membranes of the eyes, mouth, genitals, and skin to inflame, externally the lesions of the mucous resemble herpes);
• Chondrocalcinosis or pseudogout (deposition of calcium in the form of salts on articular cartilage);
• scleroderma (a form of arthritis in which the skin and connective tissues become denser and thicker with scarring);
• ENT-inflammation;
• dental inflammations;
• Mediterranean fever is a family hereditary disease that is manifested by periodic fever, inflammation of the lungs, arthritis, skin lesions. Taking colchicine during recurrent relapse prevents the complication - the development of amyloidosis (a violation of protein metabolism).

Since the active substance of the drug is a poison, Colchicine is only possible after consultation with the doctor and under his constant supervision.

It should be remembered that you can not apply the medicine to everyone and not always. Do not take the drug when:

1. severe forms of hepatic or renal insufficiency. The drug is absorbed in the intestine, then accumulates in three organs: kidney, liver and spleen. If the kidney or liver function is disrupted, the drug is withdrawn slowly, symptoms of severe poisoning are formed;
2. serious violations in the organs of the digestive tract;
3. pregnancy. Colchicine, penetrating the placenta, destroys the chromosomes of the fetus during the period of intrauterine formation;
4. breastfeeding;
5. neutropenia (a decrease in the number of neutrophils - white blood cells, and the subsequent decreased immunity, development of purulent processes, inflammations, high susceptibility to infections and viruses);
6. alcoholism;

   Alcohol is a poison. Thus, the effect of the two toxins is mutually reinforced, and as a result, the greatest poisoning is possible!

7. elderly (often accompanied by a special susceptibility to toxic substances).
8. high sensitivity to the active substance - colchicine or components of its shell.

Side effects of taking colchicine

In small doses, the poison heals. But there are possible side effects:

• Pain in the stomach, diarrhea, nausea, vomiting.
• Violation of the kidneys.
• Reduction of the formation of erythrocytes.
• Temporary infertility in men (colchicine stops spermatogenesis).
• Cramps and weakness in the muscles.
• Alopecia (baldness).

Overdose

At significant excess of the admissible doses of the drug, a state of severe poisoning arises that manifested as vomiting, diarrhea with blood, severe pain in the abdomen, as well as a burning sensation in the throat and skin.

In case of signs of overdose, it is necessary to immediately stop taking the drug.

Urgent hospitalization, gastric lavage, control of breathing, blood pressure, heart rhythm will be required.

The drug is taken orally, swallowing without chewing. The patient's condition is markedly improved already within the first 12 hours after taking the drug.

Scheme of treatment during acute gout:

1. During the first day of treatment, take 1 mg of colchicine in three divided doses.
2. On the second and third days, the total dose is reduced to 2 mg (in two doses of 1 mg).
3. On the fourth and subsequent days - 1 mg once a day, it is better to do it in the evening.

To prevent bouts of gout, take one tablet (1 mg of the drug) daily or every other day for 3 months.

In amyloidosis, the drug is taken for a long time at doses of 1 to 3 mg per day.

If an acute painful attack is repeated, then treatment with colchicine can be resumed no earlier than 3 days after the end of the previous course.

Analogues of Colchicine

The pharmacological industry in Europe produces various preparations based on colchicine:Colchymine(the cheapest of a number of drugs),Colchicine, Colchicum-dispersant(the most expensive drug).

Drugs used also in the treatment of gout and similar in their therapeutic effects:

• Ambene - used for the treatment of rheumatoid arthritis, gout, neuralgia.
• Allopurinol - anti-gouty drug.
• Voltaren - except for the treatment of arthritis and gout, has analgesic effect, is used for migraines.
• Diclofenac - rheumatism, Bechterew's disease, inflammation of the joints.
• Naproxen - arthritis, arthrosis, neuralgia, radiculitis, postoperative pain syndrome, pharyngitis, tonsillitis, otitis media.
• Revmadore - exacerbation of gout, pain in the spine, traumatic inflammation, neuralgia.
• Flexen - with phlebitis, joint pain, arthrosis, radiculitis.

Colchicine is a herbal preparation that does not have full analogues in modern medicine. Treatment with colchicine must be very literate, therapy requires taking into account the age of the patient and carefully monitoring the condition of his body.

A source: http://pomogispine.com/lechenie/lekarstva/kolxicin.html

Analogues of Colchicine. "Colchicine" preparation: instructions for use, price, analogues

"Colchicine" is a drug prescribed for stopping gout attacks. The disease affects the joints and is difficult to treat.

Completely get rid of it is impossible, which forces the patient to take certain medications regularly.

Analogues of "Colchicine" contain the same active substance as the original drug, but they should be selected only after consulting a doctor. Substitutes may differ in price and efficiency.

Description of "Colchicine"

Medication "Colchicine" refers to antipodal, the therapeutic effect of which is based on the suppression of phagocytosis microcrystals of salts of uric acid.

The drug is an alkaloid, which is isolated from bulbs and seeds of a cedar.

The active substance - colchicine - prevents cell division, prevents the development of amyloidosis and degranulation of neutrophils.

"Colchicine" (tablets - not the only form of release of the drug) is most often prescribed for relief of an acute attack of gout.

Getting into the body, the drug is well absorbed from the intestine and stomach, mainly associated with the liver, tissues of the kidneys, the spleen. In the circulatory system, the active substance is practically not retained.

When can not do without "Colchicine"?

The main purpose of this drug is to prevent the development of gout attacks. As you know, this joint disease is chronic and brings a lot of suffering to patients. "Colchicine" has proved effective in the treatment of gout - a recurrent form of arthritis.

Initially, experts prescribed a large dose of the drug, which caused a lot of negative reactions and complications. Currently, the daily dosage of the drug is significantly reduced. The attending physician, depending on the severity of the course of the disease, determines the individual treatment regimen with the "Colchicine" remedy.

The medicine, according to the official instructions, can be used to treat and prevent the following diseases:

• gouty arthritis;
• amyloidosis;
• as part of complex therapy for chondrocalcinosis;
• familial Mediterranean fever;
• phlebitis;
• Behcet's disease;
• inflammatory processes in dentistry and ENT-practice.

Contraindications and side effects

Not all patients for the treatment of gout and prevention of exacerbations "Colchicine" is suitable.

The use of the drug is contraindicated in people with impaired functionality of the kidneys and liver, because the bulk of the active substance accumulates in the tissues of these organs.

Do not prescribe an alkaloid in the pathology of the digestive system, pregnancy and lactation, severe diseases bone marrow, hypersensitivity to the active component, neutropenia, purulent inflammatory processes.

It is forbidden to take medicine, as are the analogs of "Colchicine in the presence of alcohol dependence. It is established that alcohol causes exacerbation of chronic joint disease and can not be combined with drug therapy.

Side effects on the background of taking tablets most often appear with an overdose. Symptoms of increased concentration of colchicine in the body are:

• cutting pains in the stomach;
• fits of vomiting;
• indigestion disorder;
• dehydration of the body against diarrhea;
• hypotension;
• convulsions;
• leukopenia;
• myopathy;
• thrombocytopenia (in rare cases);
• allergic skin reactions;
• temporary alopecia;
• neuropathy;
• depression.

If these symptoms occur, you should cancel the medication and seek qualified medical help.

Analogues of "Colchicine"

The drug has several analogs that provide a similar therapeutic effect and can be prescribed in place of the original drug.

It should be noted that "Colchicine" is considered one of the best drugs for the treatment and prevention of gout attacks. Treatment should be under the strict guidance and constant monitoring of the attending physician.

Appoint the analogues of "Colchicine" specialist can only after excluding contraindications and conducting a survey of the patient.

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Changing the treatment scheme "Colchicine" or its analogs is not recommended, especially to increase the daily dosage of drugs.

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Some substitutes have a less pronounced therapeutic effect than the preparation "Colchicine". The price of analogues can be higher. The average cost of the original means is 1300 rubles.

(20 tablets per package). Among the analogues of the medication the most famous are Colchicum-Dyspert, Kolchitsein.

The drug "Colchicum-Dispert"

Tablets of dark red color have in the composition also an active substance, as the preparation "Kolkhitsin". The price of the analogue is much higher and is 6500-7200 rubles. The medicine contains an extract of seeds of a cedarberry and auxiliary components.

An Austrian medication has the same therapeutic effect and suppresses the migration of leukocytes to the focus of the inflammatory process. Compared to cheaper substitutes, Colchicum-Dispert operates much faster.

To suppress an acute attack, patients are shown to take in the first day, -2 mg of the active substance. In the future, the dosage will decrease. The repeated course of therapy is carried out not earlier than 3 days after the last pill intake.

Patient Reviews

"Colchicine" is one of the main medicines used to treat gout. Many patients noted the positive effect of this drug.

It should be borne in mind that for successful therapy it is important to comply with the treatment plan drawn up by a specialist and not to adjust the dosage of tablets. In the first day, the dose of the drug should not exceed 2 mg.

With caution, the drug is used to treat patients with renal and hepatic insufficiency. In such cases, the dose of the active ingredient is reduced by 50%.

In addition to medicamental effects, compliance with the diet is shown. It is important to reduce the intake of protein of animal origin and digestible carbohydrates. It is forbidden to use table salt.

A source: http://.ru/article/232958/analogi-kolhitsina-preparat-kolhitsin-instruktsiya-po-primeneniyu-tsena-analogi

Colchicine

Composition

1 tablet contains 1 mg of active substancecolchicine.

Form of issue

Produced in tablet form.

pharmachologic effect

Colchicine isantidotal agent.

Pharmacodynamics and pharmacokinetics

The principle of action is based on the inhibition of phagocytosis of microcrystals of saltsuric acid, at a decrease in the rate of migration of leukocytes to the focus of inflammation.

Colchicine inhibits (partially or completely) the process of cell division in the metaphase and anaphase stage, exerts aantimitotic effect, prevents degranulation of neutrophils.

Drug prevents developmentamyloidosisby reducing educationamyloid fibrils.

It effectively suppresses attacks of acute gout. In 75% of patients there is an improvement in the state of health in the first 12 hours of treatment.

In 80% of patients, adverse reactions from the digestive system are recorded.

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Intravenous administration of the drug allows avoiding side reactions from the gastrointestinal tract, accelerate the onset of clinical effect. The probability of repeated acute gout attacks decreases and ¾ of patients with daily intake of 1-2 mg colchicine.

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The drug reduces the activity of dopamine-beta-hydroxylase, it helps to prevent acute attacks in patients withfamily Mediterranean fever. In patients with primary AL-amyloidosis, colchicine prolongs life expectancy.

Whensystemic sclerodermathe drug has a positive effect on the skin, reduces dryness, softens the skin.

Indications for use

Colchicine tablets are prescribed forgout, amyloidosis, inflammatory diseases in otorhinolaryngological and dental practice, withMediterranean fever, phlebitis, scleroderma, chondrocalcinosis, gouty arthritis.

Contraindications

Medication is not prescribed for severe pathology of the digestive system, for neutropenia, for the elderly, with alcoholism, intolerance of the main component, with purulent infections, bone marrow pathology, liver diseases and kidney,of pregnancy.

Side effects

The digestive tract: nausea,malabsorption syndrome, increased liver enzymes, vomiting, decreased appetite, epigastric pain, diarrhea syndrome, vitamin B12 deficiency.

Nervous system: neuropathy,peripheral neuritis, depression.

Organs of hematopoiesis: thrombocytopenia, neutropenia, agranulocytosis, aplastic anemia, leukopenia.

An allergic response in the form of a koreal-like rash,urticaria.

Also noted is myopathy,azoospermia, disturbances in the work of the renal system, temporary alopecia.

Tablets Colchicine, instructions for use (Method and dosage)

Tablets are taken orally.

Inflammatory process, a gout attack: on the first day of therapy 3 times a day for 1 mg; on the second and third Day of therapy appoint a double intake of 1 mg; from the fourth day of treatment shows the intake of 1 mg in the evening time. Alternatively, an initial dosage of 1 mg is possible, then they switch to an appointment, mg, the interval between doses is 2 hours until the pain syndrome disappears.

Preventing gout attacks: for three months in the evening take 1 mg, effective for gout without tofusov. In a day not more than 8 mg.

According to the instructions for the use of colchicine, the duration of therapy for amyloidosis is 5 years, daily take 1 mg per day.

Overdose

It is manifested by severe diarrhea, severe dehydration with a drop in blood pressure, epigastric pain, vomiting, nausea,hemorrhagic gastroenteritis, respiratory depression, seizures, oliguria, ascending paralysis, hematuria, decreased myocardial contractility.

Rarely, the development of pulmonary infiltrates, acute renal failure,hepatocellular injury.

On the sixth day after an overdose, severe oppression of bone marrow hematopoiesis with the development of coagulopathy, thrombocytopenia, and leukopenia is possible.

Patients are treated at a toxicological center.

At the moment, a specific antidote is not developed.

Control is requiredelectrolyte balance, normalization of the gas composition of the blood, carrying out anti-shock measures, conducting auxiliary ventilation, control of the passability of the respiratory tract. Hemodialysis did not prove its effectiveness.

Interaction

Probability of developmentmyopathiesincreases in patients with pathology of the renal system, with simultaneous admissioncyclosporine.

Colchicine can be taken in combination therapy with erikozuric medicines andallopurinol.

The drug enhances the effectiveness of sympathomimetic and de-priming agents.

Colchicine disrupts the absorption of cyanocobalamin.

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Thrombocytopenia and leukopenia develop with the administration of NSAIDs and medications that causemyelodepression.

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Drugs that acidify urine and cytostatics reduce the anti-arthritic activity of the drug. The reverse effect is recorded when taking alkalinizing agents.

Terms of sale

A recipe is needed.

Storage conditions

In a dark, dry place inaccessible to children at a temperature of up to 25 degrees Celsius.

Shelf life

Up to two years.

special instructions

Therapy of colchicine preparations requires regular clinical andhematological control. When registering side effects from the digestive tract, the drug is canceled or the dosage is reduced.

With a decrease in platelets below 100 thousand / μl, and leukocytes below 3 thousand / μl, the drug is canceled before the blood stabilizes.

During treatment, false positive reactions to erythrocytes and Hb in the urine are possible.

Analogues of Colchicine

Matches by ATC code of 4th level:

Are preparations:Colchicum-Dyspert, Colchymine, Colchicine.

The price of Kolgicin analogs is generally higher.

Reviews about Colchicine

The medicine is characterized as one of the best tools for treating gout. And it effectively helps both in attacks, quickly stopping pain, and for prevention.

From negative reviews about Kolkhitsin it should be noted that the drug is very difficult to buy in Russia, and this medication has contraindications.

Price Colchicine, where to buy

In Moscow, as well as throughout Russia (in St. Petersburg, Novosibirsk and other cities), the drug is very difficult to find.

In large and specialized pharmacies in Moscow and St. Petersburg, sometimes you can find this tool, we advise you to call in advance large pharmacy chains to find out about the availability of the drug.

Large online pharmacies do not sell this product. You can buy the medicine at your own risk and risk of ads on the Internet, however, remember that the sent goods may be fake or may not be sent at all. The price of packaging is also very high: 800-2000 rubles.

In Minsk, Colchicum-Dyspert tablets, mg with colchicine, cost 260000 for 20 packs.

NOTE! Information about medicines on the site is a reference-generalizing, collected from public sources and can not serve as a basis for making a decision about the use of medications in the course of treatment. Before using the drug Colchicine necessarily consult with your doctor.

A source: http://medside.ru/kolhitsin

Colchicine: analogues, instructions for use, price, testimonials

Gout - unpleasant both externally and internally, a disease. To get rid of painful sensations and recover from constant discomfort, pharmacology has developed a number of medications.

The best anti-arthritis drug is Colchicine. is hecan neutralize the pain at the time of exacerbation of the disease,reduce the amount of uric acid produced.

Before applying Colchicine or its analogs, it is recommended to read the instructions for use on the drug to know the composition and properties of this drug, prices and reviews.

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Colchicine is a herbal preparation, the main effect is on the malaise of the joints.

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The active substance in the drug is poison,under the same name "colchicine".

It is recommended for use in inflammatory processes of the following diseases:

• Gouty arthritis and gout;
• Chondrocalcinosis (pseudogout);
• Phlebitis;
• Scleroderma;
• Behcet's disease;
• Inflammation of the mouth;
• With ENT diseases;
• Mediterranean fever.

It is not produced in Russia, the place of production of medicines is Italy, Germany and India. Therefore, it is problematic to acquire in the territory of our country.

The drug appears periodically in specialized pharmacies, but its presence must be monitored.

The cost varies from 800 to 2000 rubles.

It is not recommended to buy through online ads - there is an opportunity to purchase a substandard fake. Counterfeit goods can significantly affect the occurrence of serious complications.

Form of issue and composition

Release of the medication is carried out in the form of tablets and intravenous injections. The quantity in the package is 20 pcs. One pellet contains 1 mg of active ingredient.

Each of the tablets is covered with a special shell, which dissolves only in the intestines, bypassing the stomach.

Take the medicine orally.Dragee in no case can not break, divide or chew.When taking it, be sure to wash it with water or another liquid.

In addition to pills, ampoules for intravenous (parenteral) drug administration are on sale. The ampoule contains, mg active ingredient in 1 ml. It is administered in the proportion of 2 mg of injection, combined with 20 ml of saline.

Properties of the preparation

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In the body of a man suffering from gout, there is a process of metabolic disorders. As a result, there is an increased formation of uric acid, as well as the formation of salt crystals and their deposition on the surface of the joints.

Salt crystals are called urates. They negatively affect the state of the limbs of a person, provoking deformation of appearance, as well as strong inflammatory processes.An exacerbation of gout occurs during the rest period.

After the application of colchicine, the following processes occur in the human body:

• The level of migration of leukocytes in the inflamed area is reduced;
• In the inflammation zone, the process of cell multiplication decreases;
• The number of lysosomal enzymes that cause a pathogenic reaction in the problem zone is decreasing;
• Neutralization of the development of yeast-like bacteria;
• The process of producing an acid that promotes the formation of gout is blocked;
• It stops the procedure of crystallization of uric acid.

Still about anesthesia: non-prescription analogues of Ketanov.

In addition to these properties, colchicine has the ability to anesthetize. Himapplication causes a general anti-inflammatory effect,preventing not only the elimination of the problem that has arisen, but also prevention during periods of fading.

Any drug has analogues - Colchicine was no exception. European pharmacological companies are engaged in the production of such medicines, which are based on the same active substance as in the original preparation.

There are a number of medications that have similar properties in the treatment of gout:

• Colchicum-dispersant;
• Ambien;
• Allopurinol;
• Diclofenac (tablets);
• Ibuprofen (in a pellet);
• Diclobene (gel);
• Voltaren;
• Naproxen;
• Revmadore;
• Fleksen;
• Ketonal;
• Arthrosylen.

All of themare aimed at arresting bouts of gout and gouty arthritis.Most of the drugs in the list provided are anti-inflammatory, and also have the property of reducing the formation of uric acid.

At cost

Analogues of Colchicine vary greatly in price. Some cost a lot of money, but their healing effect is equivalent to the money spent. Others in monetary terms are valued lower in order, but also their period of influence is postponed to a later date.

The mostA cheap option from the Kolkhitsin analoguesare Ibuprofen (25-50 rubles.), Naproxen (from 75-110 rubles.), Allopurinol (84-140 rubles.

) and Revmadore (from 100-350 rubles.). Slightly more expensively are given in drugstores Flexen, Voltaren, Artrozilen and Ketonal.

These funds are located in approximately the same price category - 200-300 rubles.

More expensive analogues are represented by medicines (the price is averaged): Diclobene - 410 rub. and Diclofenac - 522 rubles. Ampoules for internal Ambene injection cost more than gels and tablets, ranging from 600 to 800 rubles.

The cost of various drugs varies within significant limits. You can choose a remedy for any purse, most importantly, to achieve the necessary result to eliminate inflammation.

According to the active substance

The main factor that helps to neutralize a painful attack of gout is the active substance in the medicine. Colchicine is the active agent in colchicine. This component is also predominant in Colchicum-dispersion. This analogue of Colchicine is available both in Russia and in Ukraine.

It affects the blocking of the movement of leukocytes to the foci of inflammation, thereby neutralizing the onset of a painful attack of gout or gouty arthritis.

A similar action has an active substance - diclofenac sodium.

It acts as the main component in Diclofenac, Dicloben, Voltaren.

In their influence, the latter eliminate the pain syndrome at the time of acute attacks of joint diseases, affect the reduction of the inflammatory process.

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As an active agent, the component of many Colchicine substitutes, ketaprofen, is isolated. It is available in Flexen, Arthrozilene and Ketonal.

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At the time of exposure, the inflammatory effect decreases in the upper parts of the epidermis.

In most cases, it can not be used in children and adolescents.

Other preparations contain other active components.

For example, Ambene ampoules have phenylbutazone (375 mg), lidocaine hydrochloride (4 mg), sodium hydroxide (50 mg), sodium salicylamide acetate, dexamethasone (mg) and water for injections. The solution is injected intramuscularly, acts as an analgesic and antipyretic agent.

Effectiveness of drugs

Another helper in the battle for joint health.

All medicines perform one function - eliminate gout attacks, reduce pain and remove the external discomfort state of the limbs.

Medicines with the main component of colchicine are considered more effective. All other drugs affect only at times of acute attacks or in the initial stages of the painful process.

To influence the duration of the absence of gout, except for Colchicine and similar medicines with the same active ingredient, no medicine is capable offrom the above medicines.

The effectiveness of colchicine is proved on the basis of the opinions of people who have tried on its influence. Analogs are also effective drugs, but they do not possess the full range of action inherent in the original anti-gout remedy.

A source: http://100lkrstv.com/kostno-myshechnaya-sistema/2166.html

Instructions for use Colchicine and its analogues

The drug Colchicine is an effective universal drug, designed specifically to eliminate gout. The medicine easily limits the movement of leukocytes to the focus of the inflammatory process.

The drug can weaken the production of components such as glycoproteins and lactates. The agent suppresses the formation of the crystalline structure of uric acid phagocytosis.

It is able to inhibit the activity of leukocytes of the granular structure, interacting with the protein. With ease restrains the crushing of cells under mitotic pressure. Suppresses the appearance of amyloidosis and its derivatives of fibrillar proteins.

Easily prevents the appearance of gouty attacks of an acute form.

Experiments have shown that in 75% of all cases the drug helps, eliminating unpleasant manifestations, within ten or twelve hours after the first application.

Structure of the medicine

The composition of the preparation of additional components is not included. The drug contains only the main active ingredient colchicine, containing:

• , -tetrahydroyl;
• , 0-tetraoxyl;
• 9-oxobenzoyl;
• Heptalonyl;

The substance belongs to the alkaloids of the tropolone series. Is homomorphine. Produced from the bugs of medicinal plants of the Melantiev family. In most cases, it is extracted from the dried seeds of autumn cedarwood - meadow saffron.

Thanks to anti-inflammatory effects and fast efficacy of beneficial properties, squeezes from plants have been taken since 1810.

At that time, the remedy not only eliminated gout, but also was used to eliminate cirrhosis of the liver, fever, dermatitis, amyloidosis, Adamantiadis disease. The drug, made on the basis of these debris, is a cellular poison.

A completely safe dosage of the drug does not exist. Even at small dosages, side effects develop, which can lead to death.

At the moment, the effect of the substance on the cellular level is studied.

Manufacturer

• For ten years from September 7, 1990 to October 9, 2000, the preparation was produced by the French company Roussel Uclaf.
• For several years, the Netherlands company Colchicum-dispersion "Solvey Pharma Kali Chemie Pharma" had the right to manufacture the drug, as well as most of the controlling interest.

To date, the preparation is manufactured by the following companies:

1. Italian company "Pharmafar Srl". The trade name of the preparation is Colchicina.
2. German firm "Johannes Bürger Ysatfabrik GmbH and also company "Acarpia" together with the Portuguese company "Pharmafar S.r.l.". with the trade name of the prefect "Colchicinum-Dispert".
3. The Indian company, together with Great Britain, "Brawn laboratories ltd for Rotec Ltd., produces the drug under the trade name" Colchicine ".

In Russia, the drug is imported from the countries of the European Union, as well as from Vietnam and India.

Forms of output and cost

The drug is produced in a medicinaltableted form of release. One tablet contains 1 milligram of active ingredient.

The tablets are packed in sealed blisters. Blisters are in paper boxes. One box contains 20 tablets with 20 milligrams of the active ingredient.

There is a release of tablets containing, milligrams of the substance. On top, they are covered with an easily soluble coat, which prevents the absorption of the active substance directly in the stomach. Such tablets are packed in blisters and paper boxes.

• The cost of 20 tablets varies in the range of 1000-1200 rubles, depending on the manufacturer and the cheaters of dealers.
• The price of 40 tablets is 1250-1400 rubles.
• The cost of 60 tablets is about 2000 rubles.

In very rare cases, the remedy is releasedin the form of pills. In one dragee is 5 milligrams of the active ingredient. Dragee packaged in sealed blisters, located in cardboard boxes. In one package can be 20 or 50 dragees.

• The cost of 20 dragees is 1000-1800 rubles.

• The price of 50 tablets varies between 1900-2500 rubles.

It is worth noting that finding a drug in ordinary pharmacies is not easy. It is sold only in specialized pharmacy chains of large cities.

In addition to providing a prescription from a doctor, you must pre-order the drug, making an advance payment.

You can call pharmacy networks by finding out on the multi-channel phone about the presence of a medication.

It is not recommended to buy tablets from gout through the World Wide Web. In most cases, such drugs are fakes.

Application Scheme

Dosages depend on the nature, extent and form of the disease. Therefore, the exact dose and duration of treatment should be consulted by a specialist.

The drug is taken during meals. Tablets and dragees should be washed down with a small amount of distilled water.

If side effects occur, stop using the medication or reduce the dosage.

For more information, consult your doctor.

How to take colchicine for gout?

Tablets must be taken internally.

Recipe # 1

• On the first day of intake, one milligram (1 or 2 tablets, depending on the form of release) should be drunk. The procedure is repeated 3 times a day. The daily dosage should be 3 milligrams.
• On the second and third day of intake it is necessary to drink 1 milligram of the drug twice a day. The daily dosage should be 2 milligrams.
• Beginning with the 4th day of therapy, one milligram should be taken once a day.

  The daily dosage should be 1 milligram. Tablets should be taken in the evening hours during dinner.

Recipe # 2

• On the 1st day of therapy, 1 milligram of the drug is taken once a day.
• On day 2, take a milligram of the component at a time.
• Further dosages of therapy are prescribed by a specialist.

  Patients can take from, to, milligrams of substance per day.

As a prophylaxis of gout attacks, take 1 milligram of component per day in the evening hours. Prophylaxis should last no more than three months.

Max dosage per day should not exceed more than 8 milligrams.

Serious diseases such as arthritis, scleroderma and phlebitis easily cure Colchicine. Instruction for use recommends taking the drug with developing amyloidosis in a dosage, milligram.

The course of therapy should last for five years.

Treatment of gout with colchicine in the form of pills

On the first day of therapy, initially take 2 dragees, squeezed them with a small amount of distilled water. Then they drink 1-3 tablets every 1-2 hours.

The course of treatment should continue until the disappearance of pain. Do not take more than 16 tablets in a single day.

Otherwise, an overdose of the drug may occur, which will cause side effects.

As a preventive measure, you should drink 1-3 tablets in the evening. Reception can be conducted every evening or every two days.

The duration of therapy lasts 90-100 days.

Indications for use

Medication for gout Colchicine should be taken to eliminate or suppress the following diseases:

• Gout, and also formed gouty arthritis;
• FOL. This disease is genetic. It manifests itself in the form of manifestations of defects on the skin, arthritis or pneumonia. But it should be taken into account that when treating these diseases with this medication, a complication manifested in the form of amyloidosis development can be formed in patients. At the first manifestations of the disturbance of protein metabolism, the medication should be discontinued.
• Inflammation of veins, manifested in the form of phlebitis;
• ENT-inflammations, including lesions of the mucous membrane and otitis.
• Diseases of Adamantiadis, in which lesions of small and medium arteries occur. In patients, the skin, genital organs, mucous membranes of the mouth and eyes become inflamed. In appearance, this disease is very similar to herpes.
• With any dental diseases, manifested in the form of inflammation.
• With an autoimmune disease of scleroderma. This disease is a form of arthritis. At the same time, connective tissues and skin become thickened and compacted. Scars are formed.
• With pseudogout and chondrocalcinosis. In this disease on the articular cartilage is observed the deposition of calcium in the form of salts.

Contraindications

Use of the drug is not recommended in the following cases:

• In case of serious failure of the gastrointestinal tract;
• During a decrease in the number of neutrophils, manifested as neutropenia. In this case, the patient feels a strong decrease in immunity, a constant weakness. There is a formation of purulent processes, inflammations begin. The patient becomes vulnerable to various viruses and infections;
• Patients with bone marrow pathologies;
• With developed purulent infections;
• The drug is not recommended for hypersensitive patients with allergies;

special instructions

The drug is not recommended for patients with renal and hepatic insufficiency, manifested in severe form. The drug is absorbed into the body in the large intestine. After this begins to accumulate in three organs:

1. Spleen;
2. Kidneys;
3. Liver;

If the working capacity of the liver and kidneys is broken, then the medicine begins to be excreted from the human body in a slowed pace. Because of this, the symptoms of severe intoxication begin to appear. Patients feel headache, nausea, vomiting reflex, bitterness in the mouth.

Nuances of application

• Colchicine for gout is prohibited for pregnant girls. The component that is part of the drug begins to penetrate the placenta. Because of this, the fetus is destroyed by chromosomes during the period of intrauterine formation.

  A child can be born with deviations.

• The drug is prohibited for lactating mothers. The component is absorbed into breast milk and negatively affects the development of the baby's body.
• The medication is forbidden to people of advanced age over 65 years of age.

  In most cases, the use of the drug is accompanied by a special susceptibility to toxic components.

• Children should be prescribed by a specialist to take the drug, the specific dosages and the duration of the course of treatment.

  Use remedy for babies younger than 6 years is not recommended.

Overdose and side effects

When using unacceptable dosages, patients feel symptoms of intoxication. They manifest themselves:

• Pain in the abdomen;
• Diarrhea with blood clots;
• Vomiting reflex;
• Burning on the mucous membrane of the throat;
• Court of the skin;

As side effects can be formed:

• Stopping spermatogenesis in men. But after a while after stopping the drug, temporary infertility disappears.
• Muscle weakness, convulsions;
• Premature baldness, manifested in the form of alopecia;
• Abnormality of the kidneys;

Interaction with other medicines

• With the simultaneous administration of cyclosporins, pathologies of the renal system are formed;
• There is a failure in the absorption of cyanocobalamines;
• Together with NSAIDs, there is a formation of myelodepression, leukopenia and thrombocytopenia;
• Further development of gout and decreased efficacy are caused by urea-mediated drugs;
• Strengthening the effect of increasing alkalinizing drugs;
• There is an intensification of the effect of depressing and sympathomimetic drugs;
• Combined treatment with allopurinol is allowed;

Storage, leave from pharmacies

The drug is sold only by providing a prescription form from a specialist. Shelf life of the drug is from 2 to 4 years, depending on the manufacturer. Store the product at a temperature not higher than 25 ° C.

Interaction with alcohol

The drug is prohibited for patients with chronic alcoholism. During the course of treatment from taking alcohol-containing products should be completely abandoned.

The fact is that any alcohol-containing product is a poison of delayed action. The combination of two toxic substances begins to interact intensively.

When receiving two incompatible components, the patient develops severe intoxication.

Analogues of Colchicine

Name	Description	Contraindications	Cost, rub
Colchicum-Dyspert Colchicine Colchymine	Substitute Colchicine. Slows down the development of gout. Affects the exchange of uric acid.	Inhibition of bone marrow hematopoiesis.	From 828
Ambien	Possesses an analgesic effect. It is administered intramuscularly.	Acute form of gastritis.	The price of one ampoule is 600 rubles.
Allopurinol	Suppresses the formation of gout and hyperuricemia.	Patients with malfunction of the kidneys and liver.	From 84

Reviews

Most of the reviews are positive. Patients noted the high efficacy of the agent, rapid action after the first intake.

The medicine easily removes pain. Reduces the development of gout. In negative reviews, patients report strong side effects.

Premature aging, alopecia and temporary infertility may occur.

Colchicine is an effective tool used to treat gout. Contains in its composition the medicinal components of plants.

It is prescribed for patients older than 6 years. Produced by several manufacturers.

The video tells about the personal experience of the patient in the treatment of this drug

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A source: http://zdorovya-spine.ru/preparaty-i-lekarstva/kolhitsin.html