Glucophage Long belongs to the number of oral hypoglycemic drugs from the biguanide group, which lower the basal and postprandial plasma glucose levels in the blood.
For tablets of prolonged action, slow suction is characteristic. Therefore, the therapeutic effect persists for at least 7 hours. Absorption of the drug is not dependent on food and does not cause cumulation.
On this page you will find all information about the Glucophage long: full instructions for use on this medicated medium, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Glucophage Long. Want to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Oral hypoglycemic drug.
Conditions of leave from pharmacies
It is released on prescription.
Price list
How much is Glucophage Long? The average price in pharmacies is at the level of130 rubles.
.Form of issue and composition
Tablets that have a prolonged action, contain 500, 750 or , 00 mg of the active substance - metformin hydrochloride.
Composition of 1 tablet:
- active ingredient: metformin hydrochloride - 500, 750 or 1000 mg;
- auxiliary components (500/750/1000 mg): carmellose sodium - 50/3, / 50 mg; microcrystalline cellulose - 102/0/0 mg; hypromellose 2208 - 358/29, 4/39, mg; hypromellose 2910 - 10/0/0 mg; magnesium stearate /, / 7 mg.
Pharmacological effect
The pharmacological action of metformin is aimed at reducing the level of sugar in the blood, which can increase from eating. For the human body, this process is natural, and it involves the pancreas responsible for the production of insulin. The task of this substance is the cleavage of glucose to fat cells.
As a remedy against diabetes mellitus and correction of the figure, Glucophage Long performs several useful functions:
- Stabilizes lipid metabolism.
- Controls the reaction of splitting carbohydrates and their transformation into fatty deposits.
- Normalizes the level of glucose and the body's cholesterol.
- Establish natural production of insulin, because of which appetite is reduced, and attachment to sweets is lost.
When the blood glucose level goes down, sugar molecules are sent directly to the muscles. Finding a home, sugar burns, fatty acids are oxidized, the process of absorbing carbohydrates takes place at a slowed pace. As a result, the appetite becomes moderate, and fat cells do not accumulate, or deposited in different parts of the body.
Indications for use
Glucophage Long is prescribed for the treatment of type 2 diabetes in cases of ineffectiveness of diet and exercise (especially in obesity).
The drug can be used as a monotherapy either in combination with other oral hypoglycemic drugs or insulin.
Contraindications
- diabetic ketoacidosis;
- diabetic precoma;
- diabetic coma;
- renal dysfunction (CC less than 60 ml / min);
- kidney failure;
- liver failure;
- impaired liver function;
- chronic alcoholism, acute ethanol poisoning;
- laktatsidoz (including in the anamnesis);
- adherence to a hypocaloric diet (less than 1000 kcal per day);
- pregnancy;
- period not less than 48 hours before and within 48 hours after radioisotope or X-ray studies with the introduction of iodine-containing contrast agent;
- acute conditions in which there is a risk of kidney dysfunction: dehydration, (with diarrhea, vomiting), severe infectious diseases, conditions, shock;
- clinical manifestations of acute and chronic diseases that can lead to the development of tissue hypoxia (including respiratory failure, heart failure, acute myocardial infarction myocardium);
- extensive surgery and trauma (when carrying out insulin therapy);
- hypersensitivity to the components of the drug.
Instructions for use
The instructions for use indicate that Glucophage Long is taken orally 1 time / day, during dinner. Tablets are swallowed whole, without chewing, squeezed with enough liquid.
The dose of the drug should be selected individually for each patient based on the results of measuring the concentration of glucose in the blood. Glucophage Long should be taken daily, without interruption. If the treatment is discontinued, the patient should be informed about this by the doctor. If the next dose is missed, the next dose should be taken at the usual time. You can not double the dose of Glucophage Long.
Monotherapy and combination therapy in combination with other hypoglycemic agents:
- For patients who do not take metformin, the recommended initial dose of Glucophage Long is 1 tablet. 1 time / day.
- After every 10-15 days of treatment, the dose is recommended to be adjusted based on the results of measuring blood glucose. Slow increase in dose helps reduce side effects from the digestive tract.
- The recommended dose of Glucophage Long is 1500 mg (2 tablets) 1 time / day. If, when taking the recommended dose, you can not achieve adequate control of glycemia, it is possible to increase the dose to a maximum of , 50 mg (3 tablets) 1 time / day.
- If adequate control of glycemia is not achieved when taking 3 tablets. 750 mg 1 time / day, it is possible to switch to the preparation of metformin with the usual release of active substances (for example, Glucophage, film-coated tablets) with a maximum daily dose 3000 mg.
- For patients already receiving metformin tablets, the initial dose of Glucophage Long should be equivalent to the daily dose of tablets with normal release. Patients taking metformin in the form of tablets with a normal release at a dose exceeding 2000 mg are not advised to switch to Glucophage Long.
- In case of planning a transition from another hypoglycemic agent: it is necessary to stop taking another drug and start taking Glucophage Long in the dose indicated above.
Combination with insulin:
- To achieve better control of blood glucose concentrations, metformin and insulin can be used as a combination therapy. The usual initial dose of Glucophage Long is 1 tablet. 750 mg once a day during supper, with the insulin dose selected based on the results of measuring the glucose in the blood.
Side effects
The use of Glucophage Long 500 tablets gives smoother side effects than regular glucosophage. Gentle effect on the body due to the long absorption of metformin and its entry into the circulatory system. Nevertheless, those who want to lose weight should know about all the negative reactions that the body can respond to using the drug.
- Allergic reactions. In the form of urticaria eruptions they manifest themselves from the individual rejection of metformin.
- Metabolism. In metabolic processes, weight loss with Glucophage Long 500 is reflected by an imbalance of lactic acid due to weak isolation of organic compounds. The mild form of the disorder is manifested by the release of acetone and acetoacetic acid in the urine. Heavy - a coma. The second variant of the unsuccessful development of events when using Glucophage is associated with poor assimilation of vitamin B It is observed with uncontrolled use of the drug.
- Gastrointestinal tract. Sometimes responds to the drug with vomiting, diarrhea, flatulence, the appearance of a taste of metal in the mouth. In the case of diarrhea and persistent nausea from the drug should minimize the consumption of simple carbohydrate food (more precisely - sugar and flour). Persistent symptoms that can not be eliminated by such an exercise are eliminated by spasmolytics. They relieve colic, pain, spasm. In addition, you can drink antacids. If the described measures are ineffective, you should contact the clinic.
- Lactacidosis. The phenomenon is rare, but dangerous for the body. Occurs with renal dysfunction. If Glucophage causes muscle pain, acidotic dyspnoea, increased respiration, lower body temperature before confluence in a coma, as well as confusion and loss of consciousness, taking pills for weight loss is necessary to cease. The expediency of further consumption should be discussed with a specialist.
Overdose
Symptoms: when metformin was used at a dose of 85 g (42.5 times the maximum daily dose), there was no development of hypoglycemia, but in this case development of lactic acidosis was observed. Significant overdose or associated risk factors may lead to the development of lactic acidosis.
Treatment: in case of signs of lactic acidosis, the drug should be discontinued immediately, the patient must be hospitalized and, having determined the concentration of lactate, clarify the diagnosis. The most effective measure for excretion from the body of lactate and metformin is hemodialysis. Conduct also symptomatic treatment.
special instructions
- Before the start of treatment and regularly in the future it is necessary to determine the clearance of creatinine: in the absence of violations - at least 1 time in year, in elderly patients, as well as in patients with creatinine clearance at the lower limit of the norm - from 2 to 4 times in year. When the creatinine clearance is less than 45 ml / min, the use of Glucophage Long is contraindicated.
- Patients are advised to continue to follow a diet with an even intake during the day of carbohydrates.
- Any infectious diseases (infection of the urinary and respiratory tract) and the treatment should be reported to the doctor.
- It is necessary to take into account the likelihood of lactic acidosis with the appearance of muscle cramps, which are accompanied by pain in the abdomen, dyspepsia, severe malaise and general weakness.
- The drug should be discontinued 48 hours before the planned surgical operations. Renewal of therapy is possible after 48 hours, provided that during the examination the kidney function was recognized as normal.
- Lactic acidosis is characterized by abdominal pain, vomiting, acidotic dyspnea, hypothermia and muscle cramps followed by coma. Diagnostic laboratory indicators - a decrease in blood pH ( 5 mmol / l, an increased lactate / pyruvate ratio and an increased anion gap. If suspected of lactic acidosis, Glucophage Long is immediately withdrawn.
- If there is a possible violation of renal function against a background of combined use with antihypertensive drugs, diuretics or non-steroidal anti-inflammatory drugs in elderly patients need to exercise a special caution.
- A higher risk of developing hypoxia and kidney failure is observed in patients with heart failure. This group of patients during the therapy needs regular monitoring of cardiac function and functional state of the kidneys.
- With excess body weight should continue to adhere to a hypocaloric diet (but not less than 1000 kcal per day). Patients also need to exercise regularly.
- To control diabetes, regular laboratory tests should be performed regularly.
- With monotherapy Glucophage Long does not cause hypoglycemia, but when used in combination with insulin or other oral hypoglycemic agents, caution should be exercised. The main symptoms of hypoglycemia: increased sweating, weakness, dizziness, headache, heart palpitations, impaired concentration or sight.
- Due to the cumulation of metformin, a rare but serious complication, lactic acidosis, is possible, which is characterized by high mortality in the absence of emergency treatment. Basically, during the application of Glucophage Long, such cases occurred in diabetes mellitus against the background of severe renal failure. Other related risk factors should also be considered: ketosis, poorly controlled diabetes, prolonged starvation, liver failure, excessive alcohol consumption and any conditions associated with severe hypoxia.
- Inactive components of Glucophage Long can be excreted through the intestine in an unchanged form, which does not affect the therapeutic activity of the drug.
Drug Interactions
Simultaneous use with medications of indirect hyperglycemic effect - hormonal agents or tetracosactide, as well as with β2-adrenomimetics, danazol, chlorpromazine and diuretics, can affect the concentration of glucose in the composition blood. Therefore, you need to monitor its performance, and if necessary, adjust the dosage.
In addition, in the presence of renal failure diuretics contribute to the development of lactic acidosis. The combination with derivatives of sulfonylurea, acarbose, insulin, salicylates often causes hypoglycemia.
The development of lactic acidosis can cause a combination of the drug with iodine-containing radiopaque agents. Therefore, 48 hours before and after a radiological study using iodine-containing radiopaque, the abolition of Glucophage Long is recommended.
Combinations with amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim and vancomycin, which are secreted in the renal tubules, compete with metformin for tubular transport, which increases its concentration.
Reviews
We picked up some reviews of those who lose weight about the Glucophage Long drug:
- Basil. I take medicine on the prescription of the doctor to reduce sugar. Have written out on 1 tablet on 750 mg once a day. Prior to taking the drug, sugar was,. Two weeks later, it fell to, on an empty stomach. But my response is not only positive. At first, my stomach ached, my diarrhea started. After a week, itched. Although the instruction says this, you will have to go to the doctor.
- Marina. After delivery, insulin resistance was established and they said that it often happens in people who are overweight. Have appointed or nominated Gljukofazh Long 500. Took and slightly adjusted the food. Has thrown off about 20 kg. There are, of course, side effects, but they themselves are to blame. That we sing a little after taking the pill, then I'll get too physically physically - then my head hurts badly. And so - the tablets are wonderful.
- Irina. I decided to drink Glucophage Long 500 for weight loss. Before him there were many attempts: both different food systems, and a gym. The results were unsatisfactory, excess weight returned as soon as the next diet was discontinued. The result of the medication surprised me: I lost 3 kg per month. I will continue to drink, and it is inexpensive.
- Svetlana. My mother has type 2 diabetes. The drug is effective. The sugar level has significantly decreased. My mother still had a diagnosis of obesity. With this drug it was possible to lose a little weight, which is difficult in the elderly. Now she feels much better. What is more convenient - Glucophage Long should be taken only once a day. And before that there were tablets that had to be taken twice - not always convenient.
According to feedback, Glucophage Long is an effective drug for long-term use. On the development of side effects reported infrequently. With excess weight, its gradual decrease is noted.
Analogues
The following medicines are analogues of the medicinal product:
- Bagomet;
- Glicon;
- Gliiformin;
- Gliminfor;
- Langerin;
- Methospanin;
- Metadiene;
- Metformin;
- Siafor and some others.
Before using analogues, consult your doctor.
Storage conditions and shelf life
Keep out of the reach of children at temperatures up to 25/30 ° C (tablets of 500 and 750 mg / 1000 mg).
Shelf life - 3 years.
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