Cytoflavin

Cytoflavin is a medical preparation of the metabolic direction possessing the property of a cytoprotector.

Pharmacologists note the effectiveness of the drug due to active ingredients that stimulate nutrition, saturation of nutrients at the cellular level, restore the protective barriers of the body, improve the synthesis of protein formations. The drug has a number of positive effects on the metabolic processes of the body: Cytoflavin prevents excessive oxidation processes, increases the efficiency of cellular respiration and processing of molecules oxygen.

In addition, during the application positive effect of cytoflavin on the cells of the central nervous system is noted, which leads to a significant improvement in the conductivity of nerve impulses and the improvement of patients with various pathologies of nervous activity.

Clinical and pharmacological group

A drug that improves brain metabolism.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does cytoflavin cost in pharmacies? The average price is at the level of500 rubles.

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Composition and form of release

Cytoflavin tablets are coated with an enteric film membrane. They have a red color, a round shape and a biconvex surface.

1 tablet contains:

• active ingredients: succinic acid - 300 mg, nicotinamide - 25 mg, riboxin (inosine) - 50 mg, riboflavin (riboflavin sodium phosphate) - 5 mg;
• auxiliary components: hypromellose, calcium stearate, povidone, polysorbate 80;
• enteric coating: ethylacrylate-methacrylic acid copolymer [:], dye azorubin (E 122), propylene glycol.

In 1 ml of the solution contains:

• active ingredients: succinic acid - 100 mg, nicotinamide - 10 mg, riboxin (inosine) - 20 mg, riboflavin (riboflavin sodium phosphate) - 2 mg;
• auxiliary substances: sodium hydroxide, N-methylglucamine (meglumine), water for injection - up to 1 ml.

Tablets are packaged in a blister for 10 pieces. A cardboard bundle contains 5 or 10 blisters with the appropriate total number of tablets, as well as an instruction for the drug.

Pharmacological effect

Active components of the drug stimulate cerebral circulation, improve the process of oxygen supply to tissues, accelerate the metabolism of cells of the nervous system. During the course of treatment with the drug, cellular respiration normalizes, the synthesis of enzymes responsible for antioxidant activity is restored. Activated intracellular protein synthesis, which facilitates the utilization of fatty acids and glucose, the resynthesis of GABA in neurons via Roberts' shunt. Improves cerebral and coronary blood flow, metabolic activity in nervous tissues.

Metabolism of riboflavin positively influences the parameters of the neurological status: the severity of asthenic, cephalgic, vestibulo-cerebellar, cochleovestibular syndrome decreases. Disorders of the emotional-volitional sphere are removed (anxiety level is lowered). Improves the cognitive-mnestic functions of the brain.

Intravenous application contributes to the restoration of impaired consciousness. Has an awakening effect in the suppression of consciousness after anesthesia. Reception in the first 12 hours. after the development of stroke contributes to a favorable course of ischemic and necrotic processes in the affected area, reduces foci of lesion, restores neurological status, reduces the level of disability in a remote period.

The bioavailability of the drug is high. Active components are absorbed from the digestive tract (by oral intake), distributed in tissues, participate in the reactions of energy metabolism. The maximum percentage of blood is reached within 4-6 hours after ingestion. Nicotinamide and riboflavin have the ability to penetrate the placental barrier and into breast milk. The drug is metabolized in the liver, excreted by the kidneys.

Indications for use

Cytoflavin tablets are recommended for admission to adult patients for the complex treatment of the following conditions / diseases:

• consequences of cerebral infarction;
• Other cerebrovascular diseases (DVB), incl. hypertensive encephalopathy, cerebral atherosclerosis;
• neurasthenia, the symptoms of which include fatigue, increased irritability, loss of ability to long-term mental and physical stress.

Cytoflavin solution is used to treat children from the moment of birth, including premature (with a gestation period of 28-36 weeks), as part of a comprehensive therapy for cerebral ischemia.

In adult patients, the solution is used in the treatment of the following conditions / diseases:

• cerebral infarction;
• the effects of DVB (cerebral infarction, cerebral atherosclerosis);
• toxic and hypoxic encephalopathy due to acute and chronic poisoning, endotoxicosis; oppression of consciousness after anesthesia;
• hypoxic encephalopathy in cardiac surgery with the use of artificial circulation (therapy and prevention).

Contraindications

Cytoflavin is contraindicated in the following cases:

• hypersensitivity to active substances and auxiliary components of the drug;
• lactation;
• connection to the ventilator (with a low partial pressure of oxygen in the arterial blood).

With special care, this medication is prescribed for persons suffering from nephrolithiasis, hyperuricemia and gout.

Intended use for pregnancy and lactation

According to the instructions, taking Cytoflavin tablets is not advisable during the period of gestation, as well as breastfeeding. If the doctor decides that the benefits of the application will exceed the risk, then the administration of the drug is permissible in strictly defined frames and under the supervision of a specialist. An important condition is the absence of allergic reactions to the drug components.

When breastfeeding, the use of cytoflavin is prohibited.

Dosage and route of administration

As indicated in the instructions for use, the tablets should be taken at least 30 minutes before meals, without chewing, washing with water (100 ml).

• Cytoflavin appoint 2 tab. 2 times / day with an interval of 8-10 hours. It is recommended to take the drug in the morning and in the afternoon, not later than 18 hours.

The duration of treatment is 25 days. The appointment of a second course is possible with an interval of at least 1 month.

Cytoflavin solution - instruction

Adults injected only intravenously drip in the dilution of 100-200 ml of a 5-10% glucose solution or 0.9% sodium chloride solution. The drug is administered at a rate of 3-4 ml per minute.

With a cerebral infarction, the drug is administered as early as possible in a volume of 10 ml (with a heavy flow of 20 ml) for administration at an interval of 8-12 hours. Course - 10 days.

In cerebrovascular diseases, 10 ml of the drug is given for administration once a day for 10 days.

With toxic and hypoxic encephalopathy, 10 ml is given for administration twice a day after 8-12 hours. Course - 5 days. In a coma, 20 ml is administered per dilution in 200 ml of a dextrose solution. When oppression of consciousness after anesthesia, the same dose is prescribed, but only once.

At a hypoxic encephalopathy at cardiosurgical operations with use of an artificial circulation it is shown on 20 ml of a preparation in cultivation on 200 ml of 5% of a solution of a dextrose. The drug is administered 3 days before and after the operation and also on the day of the operation.

In children with cerebral ischemia (including newborns), the daily dose is calculated based on the weight - 2 ml per 1 kg of body weight. This amount is administered intravenously drip after dilution in a 5% or 10% solution of dextrose. For the first time the drug is administered within the first 12 hours after birth. The optimal time to start therapy is the first 2 hours of life.

The prepared solution is recommended to be administered by means of an infusion pump at a rate of 1 to 4 ml / h. The drug should be delivered evenly throughout the day, depending on the estimated daily volume solutions for basic therapy, the patient's hemodynamic state and acid-base state. The course lasts 5 days.

Adverse Reactions

Are rare. Possible: headache, tachycardia and arrhythmia, changes in blood pressure and ECG, nausea and vomiting, allergic reactions, urine can turn yellow, general weakness, impairment thermoregulation.

Overdose Symptoms

During the entire period of observation of the clinical use of the drug, no cases of overdose with tablets or Cytoflavin solution were recorded. However, theoretically, if an overdose occurs, symptomatic therapy should be used to maintain the normal functioning of vital organs and systems.

special instructions

Before you start using the drug, read the special instructions:

1. During the treatment, intensive staining of urine in yellow color is possible.
2. With arterial hypertension, it may be necessary to adjust the doses of antihypertensive drugs.
3. In patients with diabetes, treatment should be controlled by the concentration of glucose in the blood.

Cytoflavin does not affect the ability to drive vehicles, to work with moving mechanisms; on the work of dispatchers and operators.

Compatibility with other drugs

Succinic acid, inosine and nicotinamide, which are part of the drug Cytoflavin, are compatible with other medicines.

Riboflavin, which is part of the drug Cytoflavin, reduces the activity of certain antibiotics (tetracyclines, erythromycin, lincomycin), is incompatible with streptomycin. Ethanol, tricyclic antidepressants, tubular secretion blockers reduce the absorption of riboflavin, and thyroid hormones accelerate its metabolism.

Patient Reviews

We offer you to read reviews of people who used Cytoflavin:

1. Nastya. Dripped during pregnancy first and last time. An hour after the administration of the dropper, pains in the stomach, nausea began. The manager said: "You come up, keep dripping!". As a result, when the dropper ended, rose from the couch and collapsed, the pressure dropped to 40 by 60. Doll brought in feelings, the child did not move for two days, his pulse slowed very much. And the headmistress with huge eyes persuaded to drip more and said that I would crush the child... That's the story. With the baby, thank God, everything is fine.
2. Sergei. Neuropathologist appointed this drug in the treatment of posttraumatic epilepsy. I accept courses, one month after a three-month break. During the course I feel more active, the brain works better, the lethargy and apathy disappear. There are no seizures for a year and a half already. There are no side effects.
3. Oleg. It was restored after a stroke. I read positive reviews about the drug Cytoflavin, consulted my doctor, drank a monthly course. It is believed that the drug has a positive effect on blood circulation and stimulates the respiration of cells, which helps to reduce lesions, but I did not notice any positive changes.

Analogues

Structural analogues of the active ingredient do not have a cytoflavin drug.

Analogues on the therapeutic effect (preparations for the treatment of cerebral atherosclerosis):

• Aminalon;
• Antisclerin;
• Vero Simvastatin;
• Vestibo;
• Vee Mineral;
• Vinpoton;
• Vinpocetine;
• Gamalon;
• Dimephosphone;
• Zocor;
• Zokor forte;
• Instenon;
• Cavinton;
• Cavinton forte;
• Combbitropyl;
• Xantinol nicotinate;
• Mexidol;
• Memorial;
• Neurox;
• Nicergoline;
• Nootebril;
• Nootropil;
• Omaron;
• Pantogam;
• Pentoxifylline;
• Placenta compositum;
• Ralofect;
• Sermion;
• Simlo;
• Stugeron;
• Trental;
• Fezam;
• Cinnarizine;
• Cinnaron;
• Eikonol;
• Eikonol;
• Eifitol;

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Shelf life of Cytoflavin tablets is 2 years. They should be stored in the original factory packaging, dark, dry and inaccessible to children at an air temperature of no more than + 25 ° C.

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