How to take Biseptol 120 tablets and 480 mg

Biseptol is a fully synthesized combination that has an antimicrobial effect and contains co-trimoxazole in its composition.

The latter belongs to the group of sulfonamides, which are the first systemic antimicrobial agents.

On this page you will find all information about Biseptol: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Biseptol. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibacterial sulfanilamide preparation.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Biseptol cost? The average price in pharmacies is at the level of40 rubles.

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Form of issue and composition

Pharmacological effect

Biseptol (480, 120 and 240 mg) is a broad-spectrum antimicrobial drug that refers to sulfanilamide preparations. The combination of active substances interferes with the synthesis of folic acid, which is responsible for metabolic processes in microbial cells, as well as their division.

Co-trimoxazole does not kill pathogens of various diseases, but limits their reproduction, giving the immune system the ability to cope with pathogens. This explains the absence of a strong toxic effect during treatment with biseptol.

The drug is able to cope with approximately 40 types of pathogenic microorganisms, among which streptococcal and staphylococcal infections, cholera vibrio, toxoplasma, salmonella, chlamydia, E. coli and others. Anaerobic and mycobacteria, as well as viruses, the drug does not have an effect.

It is also used for primary and secondary prevention of pneumocystosis and toxoplasmosis in HIV carriers.

Indications for use

According to the manufacturer's instructions, Biseptol is prescribed in the treatment of infectious and inflammatory diseases, which are caused by microorganisms that are sensitive to the medicine, namely:

• Gonorrhea;
• Otitis, sinusitis;
• Infections of soft tissues and skin, including pyoderma, furunculosis;
• Infections of the genitourinary system, including urethritis, pyelonephritis, prostatitis, salpingitis;
• Various infections of the respiratory tract, including pneumonia, bronchitis, lung abscess, pleural empyema;
• Infections of the gastrointestinal tract, including abdominal paratyphoid, typhoid, bacterial cholera, dysentery, diarrhea.

Biseptol - an antibiotic or not?

According to the annotation, Biseptol is not an antibiotic. It is a bactericidal drug (it causes the death of a microbial cell), but it does not apply to antibiotics. The effect of the drug is due to the fact that it blocks the synthesis of folic acid, without which the microbial cell can not divide. Sulfamethoxazole and trimethoprim supplement and reinforce each other in this mechanism.

Contraindications

Absolute contraindications:

• severe renal dysfunction in the absence of the ability to monitor the concentration of the drug in the blood plasma;
• hyperbilirubinemia in children;
• severe blood diseases;
• deficiency of glucose-6-phosphate dehydrogenase;
• established damage to the liver parenchyma;
• severe renal failure;
• increased sensitivity to the components of the drug, as well as to sulfonamides.

Biseptol should not be taken to women during pregnancy and lactation.

Children do not prescribe the drug:

• tablets - up to 3 years;
• suspension - up to 2 months (or until, months, if the child is born from a mother with HIV infection).

Caution requires the use of Biseptolum in the presence of the following diseases:

• bronchial asthma;
• deficiency of folic acid in the body;
• thyroid disease.

Application in pregnancy and lactation

At pregnancy the preparation should be appointed or nominated only in the event that the expected advantage from its or his application surpasses possible risk for a fetus, because both trimethoprim and sulfamethoxazole penetrate the placental barrier and, thus, can affect the exchange of folic acid acid. In late pregnancy, the use of the drug should be avoided because of the possible risk of developing nuclear jaundice in newborns.

Due to the fact that trimethoprim and sulfamethoxazole penetrate into breast milk, the use of co-trimoxazole during the lactation period is contraindicated.

Instructions for use

The instructions for use indicate that the dosage of Biseptol is set individually depending on the disease. The drug is taken after a meal, squeezed with enough liquid.

1. Children aged 3 to 5 years, the drug is prescribed to 240 mg (2 tablets). on 120 mg) 2 times / day; Children aged 6 to 12 years - 480 mg (4 tablets). on 120 mg or 1 tab. on 480 mg) 2 times / day.
2. Adults and children over 12 years of age the drug is prescribed for 960 mg 2 times / day, with prolonged therapy - 480 mg 2 times / day.
3. The duration of the course of treatment is from 5 to 14 days. In severe disease and / or chronic infections, an increase in the single dose by 30-50% is possible.

If the duration of the course of therapy is more than 5 days and / or the dose is increased, it is necessary to control the picture peripheral blood; at occurrence of pathological changes it is necessary to appoint folic acid in a dose of 5-10 mg / day.

• With pneumonia, the drug is prescribed at the rate of 100 mg of sulfamethoxazole per 1 kg of body weight / day. The interval between meals is 6 hours, the duration of the reception is 14 days.
• With gonorrhea, the dose of the drug is 2 g (in terms of sulfamethoxazole) 2 times / day with an interval between doses of 12 hours.

In patients with renal insufficiency with QC 15-30 ml / min, the standard dose of Biseptol should be reduced by 50%.

Side effects

Patients may experience the following side effects with Biseptol:

1. Urinary tract: tubulointerstitial nephritis, increased level of creatinine, salt diathesis,
2. Metabolism: Biseptol should be taken with caution in violation of potassium metabolism;
3. Gastrointestinal tract: hepatitis, stool disorders (diarrhea), cholestatic syndrome, glossitis, increase in the level of liver enzymes, patients with severe chronic diseases and immune diseases, it is often diagnosed acute pancreatitis;
4. Skin Reactions, which often disappear after the drug is discontinued: an increase in the sensitivity of the body to ultraviolet radiation, polymorphic erythema, malignant exudative erythema, acute or toxic epidermal necrolysis, hemorrhagic vasculitis;
5. central nervous system: meningeal syndrome, impaired coordination of movements, hallucinatory conditions;
6. Musculoskeletal system: muscle and joint pain;
7. Changing the picture of blood: a decrease in the level of leukocytes in the total cellular composition of the blood, a decrease in the number of neutrophils, a lower content thrombocytes, neutropenia, folic acid deficiency, aplastic anemia, increased concentrations of methaemoglobin, disease Werlhof.

Patients who do not have diabetes mellitus in the first days of therapy observed a decrease in the concentration of glucose in the blood. Hypoglycemia also occurs in individuals with kidney and liver diseases. The cause of this pathological condition may be inadequate nutrition.

Overdose

special instructions

Regular monitoring of sulfamethoxazole concentration in the blood is necessary. If the index is greater than 150 μg / ml, then the treatment is stopped until it reaches 120 μg / ml and below. If the course of treatment is calculated for a month or more, then regular monitoring of the blood condition is required.

When appointingfolic acidhematologic changes are reversible. In AIDS patients, side effects occur more frequently and are more pronounced. Biseptol is not recommended whenpharyngitisand tonsilititis caused by beta-hemolytic streptococcus g. A.

Drug Interactions

1. Salicylic acid derivatives increase the effect of Biseptol.
2. Sulfamethoxazole and trimethoprim increase the anticoagulant activity of indirect anticoagulants, as well as the effect of hypoglycemic drugs and methotrexate.
3. In combination with thiazide diuretics, there is a risk of thrombocytopenia and bleeding.
4. In combination with diuretics, the risk of developing thrombocytopenia increases.
5. Biseptol reduces the intensity of hepatic metabolism of phenytoin and warfarin, enhancing their effect.
6. Phenytoin, barbiturates, PASC increase the manifestations of folic acid deficiency in combination with Biseptolum.
7. Benzocaine, procaine, procainamide (as well as other drugs that result in hydrolysis of PABA) reduce the effectiveness of Biseptol®.
8. Ascorbic acid, hexamethylenetetramine increases the risk of crystalluria when taking Biseptol.
9. Biseptol can increase the amount of digoxin in the blood plasma in some elderly patients.
10. In combination with drugs that inhibit bone marrow hematopoiesis, the risk of myelosuppression increases.
11. Biseptol reduces the effectiveness of oral contraceptives.

Reviews

We picked up some of the people's opinions about Biseptol:

1. Olga. "Biseptol" is considered to be an old, reliable, proven drug that helps in solving problems not only in patients with respiratory organs, but also with ulcers, barley, and diarrhea. Treated with success to themselves and their children. I know that it is bad for the liver, because it consumed it only after eating and squeezed milk. In the battle with bronchopulmonary diseases, it is necessary to take 4 tablets a day, 2 at the same time for 3-5 days, depending on the severity. It is enough for abscesses 1-2 single intake of 2 tablets, and from diarrhea it saves from one reception in the same quantity of tablets. Wonderful drug!
2. Tatyana. That's right, if dogs are treated, it means that the person will also be suitable. Biseptol is better to refrain from giving to children (up to 8 years) - boys. It acts on the testicles. This was told to me in 1982 by one of the most intelligent and competent therapists. And in the future it can be used in treatment. Bronchitis was treated earlier without the use of antibiotics. And they coped well And now they all put antibiotics on. Immediately allergy, hormones and the process is started.
3. Ruslan. Antibiotics kill micro-organisms, and antimicrobials are not directly lethal to them, but violate their metabolism, so they die. This drug, for example, disrupts the formation of folic acid and dihydrofolic acid among microorganisms. This distinguishes drugs of this group from antibiotics in that they do not destroy the useful microflora so much and have fewer side effects.
4. Irina. This is a very good medicine. The elder child often suffered from cough during the cold season, the throat began to ache almost every 2-3 weeks. The treatment took quite a long time. Very much helped or assisted these tablets. There are small tablets for children, but my child asked to pound them and take them as a powder. They are quite bitter, but here the effect of them is different when coughing. I know that even acquaintances who suffer from bronchitis respond very well to this medication. Itself took "Biseptol" for adults with a cough, too, helped. Only here the size of tablets for adults is very large.
5. Edwin. I used to use biseptol frequently, especially in the winter, when I'm freezing, before sleeping, two tablets and in the morning are bodrenky. But one day a good doctor after a surgery has jinxed and now I have blimps and itch. I do not use them for 17 years, but I would like to return to it, doxycycline as a dead poultice.

Analogues

Analogues are drugs:Bactisptol, Bactrim, Biseptazole, Biseptrim, Grosseptol, Ko-Trimoxazole, Oriprim, Raseptol, Solyseptol, Sumetrolim, Triseptol.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Biseptol refers to antibacterial medicines, leave of which pharmacies are allowed only for medical purposes. The shelf life of Biseptol in tablets and Biseptol 480 is 5 years when the storage conditions are met, and suspensions are 3 years.

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