Amlodipine tablets: instructions for use

Amlodipine refers to blockers of slow calcium channels, that is, it disrupts the transfer of calcium into cellular structures.

In general, the effect is on the smooth muscles of the vascular walls. In addition, with admission manifested and antianginal effect - there is an increase in the lumen of the vessels of both the coronary and peripheral channel. An additional drop in blood pressure. The main reason for the appointment of this remedy is hypertension and angina pectoris.

On this page you will find all information about Amlodipine: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Amlodipine. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The calcium channel blocker.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Amlodipine? The average price in pharmacies is at this level:

• Tablets 5 mg, 20 pieces - 51 - 109 rubles;
• Tablets 5 mg, 30 pieces - 34 - 209 rubles;
• Tablets 5 mg, 60 pieces - 83 - 124 rubles;
• Tablets 5 mg, 90 pieces - 113 - 174 rubles;
• Tablets 10 mg, 20 pieces - 71 - 167 rubles;
• Tablets 10 mg, 30 pieces - 60 - 281 rubles;
• Tablets 10 mg, 60 pieces - 113 - 128 rubles;
• Tablets 10 mg, 90 pieces - 184 - 226 rubles.

The cost of amlodipine may vary considerably depending on the manufacturer of the drug. So, the preparations of the Israeli corporation Teva or the Swiss Sandoz are quite expensive, and Amlodipine, produced by Russian pharmaceutical plants, on the contrary, is quite cheap. Unfortunately, the quality and effectiveness of Amlodipine from different manufacturers is also very different. Therefore, if Amlodipine of any producer is ineffective or provoked by-products effects, it makes sense to purchase a drug from another company, because it can be excellent medicine.

Form of issue and composition

Produced in the form of tablets of 10, 20, 30, 40, 50 or 100 pieces. The active ingredient is 5 or 10 mg per tablet.

• Contains in its compositionamlodipine besylate, in the equivalent of pure amlodipine at 5 and 10 mg.
• Additional substances are: crospovidone, lactose monohydrate, calcium stearate, povidone.

Pharmacological effect

Amlodipine helps with abnormalities in the work of the heart, blocks the calcium channels of the walls of blood vessels and cardiac muscle cells. As a result, calcium intake through cell membranes is prevented, which leads to relaxation of the myocardium and muscle tone of the vessels. Thus, the vessels expand, blood flow is facilitated, and as a result, blood pressure is lowered.

Since the relaxed state of the heart muscle requires less oxygen for normal operation, it acquires the ability to function under similar conditions. This allows the patient suffering from angina better to tolerate the load, less likely to experience attacks of the disease. In the reduced need of the heart in oxygen is the antianginal effect of the drug.

Antihypertensive properties are manifested by lowering blood pressure. These effects, as well as high safety, cause the popularity of the drug. Due to the lack of action aimed at rapid reduction of pressure, prevention of reflex heart beat, tablets "Amlodipine" are prescribed for patients with diabetes, asthma, gout.

Indications for use

In what cases can the medication be prescribed to the patient? Indications for receiving this remedy are the following conditions:

• Stenocardia is stable;
• vasoconstriction or vasospasm;
• angina pectoris;
• hypertension arterial (as a monotherapy and in combination with other medicines);
• cardiomyopathy dilated non-ischemic.

In what other cases can the drug "Amlodipine" be recommended? What helps this medicine? It is often prescribed together with antianginal medicines, including patients who are immune to treatment with beta-blockers or nitrates.

Contraindications

Amlodipine is not used for individual drug intolerance, cardiogenic shock, during pregnancy, breastfeeding, with arterial hypotension and collapse.

The drug is administered with caution in chronic heart failure, diabetes, lipid abnormalities exchange, liver function, after a heart attack (especially in the first month), as well as patients in the elderly and patients before 18 years.

Application in pregnancy and lactation

There have been no studies showing that Amlodipine has a negative effect on the mother and child. Amlodipine is used only in very extreme cases, when its beneficial effect from treatment far exceeds the possible harm. In cases when Amlodipine is used during lactation, breastfeeding is stopped throughout the treatment, up to the complete removal of the drug and its components from the body.

Instructions for use Amlodipine

The instructions for use indicate that Amlodipine is taken orally, regardless of food intake.

Side effects

When using the drug, the following side effects are possible:

From the system of blood vessels, heart and hematopoiesis	swelling of the extremities (especially the feet and ankles), dyspnea, chest pain, migraine, hypotension, hyperemia of the face and body, heart rhythm disturbances, extrasystole, leukopenia, thrombocytopenia, hyperglycemia.
From the side of the central nervous system (nervous system)	over fatigability, dizziness, disturbance of wakefulness and sleep, headache, tremor, convulsions, asthenia, paresthesia, loss of consciousness, depressive state, nervousness, amnesia, apathy, anxiety.
From the digestive tract (digestive system)	nausea, pulling pain in the epigastric region, increased bilirubin levels, stools, flatulence, dry mouth, increased appetite or anorexia, pancreatitis, gastritis.
Are common	violation of sexual function, violation of urination, myasthenia gravis, development of joint pathologies, pruritus, erythematous rash, alopecia, urticaria, violation functions of vision (most often a violation of accommodation), ringing in the ears, possible profuse nasal bleeding, changes in body temperature, hyperhidrosis (increased sweating).

Overdose

The maximum allowable dose for treatment is 10 mg per day. As a rule, the patient is prescribed 5 mg per day, and if necessary, the dose is corrected by the attending physician. In case of non-compliance, an unauthorized increase in dosage may result in an overdose resulting in the following symptoms:

• tachycardia;
• deterioration of perfusion of internal organs;
• hypotension.

With an overdose of amlodipine, dialysis is not effective. The patient should immediately rinse the stomach, give an activated carbon (or other adsorbent) to drink. The victim should be laid on a hard surface, make sure that his legs are slightly raised. Continuous control of the function of the respiratory and cardiovascular systems, the general circulation of blood, as well as diuresis. As a rule, treatment is symptomatic. The doctor can prescribe and supportive treatment - the introduction of mezatone, dopamine intravenously.

special instructions

Before completely canceling the drug, experts recommend gradually reduce the dosage, that is, a sharp drug cancellation is not welcome.

Pharmacological drug does not have a negative effect on blood plasma lipids, as well as metabolism. Taking the medicine does not affect the central nervous system - it does not cause drowsiness, dizziness.

It is necessary to keep blood pressure under control from the first days - in case of its sharp decrease, such complications as weakness, dizziness and fatigue are possible. The drug can be used for people whose work requires increased concentration. If the patient notes a significant deterioration after the start of the drug, in this case contact your doctor - to set the optimal dose of medication. facilities.

Drug Interactions

1. With the simultaneous use of inhibitors of microsomal oxidation, the concentration of amlodipine increases, and when microsomal enzymes are taken, the concentration decreases.
2. NSAIDs, alpha-adrenostimulators, sympathomimetics and estrogens weaken the hypotensive effect of the drug. Beta-adrenoblockers, diuretics, nitrates, antipsychotic drugs, slow calcium channel blockers and ATP inhibitors increase the vasodilator and hypotensive effect.
3. The pharmacokinetics of amlodipine are not affected by warfarin, digoxin, cimetidine.
4. With simultaneous use with lithium drugs, nausea, vomiting, stool disorder, tinnitus, tremor, and ataxia are possible.
5. The drug effect of amlodipine may decrease potassium preparations.
6. Drugs that extend the QT interval can enhance the negative ionotropic effect.

Reviews

Most of the reviews on Amlodipine (from 80% to 90%) are positive, due to a marked positive effect on the course of the existing heart disease or hypertension. In most cases, people take amlodipine for hypertension in order to reduce and maintain pressure within normal limits.

The reviews indicate that the drug gently and effectively lowers blood pressure, eliminates noise in the head, is well tolerated and allows you to maintain efficiency and well-being. The advantages that distinguish Amlodipine from other antihypertensive drugs, people consider several characteristics of the drug - Firstly, it is an opportunity to use the elderly, secondly, the convenience of taking (once a day) and the duration of the therapeutic effect.

Negative responses about Amlodipine are few and are due to two main factors - Inefficiency in this particular case and poor tolerance in connection with strong severity side effects. Most often in negative reviews, it is noted that amlodipine causes drowsiness, lethargy and apathy, which are very poorly tolerated, since they do not allow a person to lead a normal image life.

Analogues

Than it is possible to replace a medicine? Of course, any drug is synonymous with the word "amlodipine" in its name.

• Analogues of the drug are also medicines: Agen, Azomex, Aladin, Amlo, Amlovas, Amlovel, Amlodak, Amlodex, Amlodin, Amlocor, Amlong, Amlopril, Vasodipine, Vasotal, Vascopin, Norvadin, Norvasc, Normodipin, Semlopin, Stamlo, Tenox, Tenigal, Emlodin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

How to choose probiotics for the intestine: a list of drugs.

Effective and inexpensive cough syrups for children and adults.

Modern non-steroidal anti-inflammatory drugs.

Review of tablets from the increased pressure of the new generation.

Antiviral drugs are inexpensive and effective.