Motilac

Motilac is a medicinal product from a group of drugs designed to combat various disorders of gastrointestinal processes.

The components of the drug increase the time of contractions of the stomach and intestinal tract, accelerate the process of defecation, eliminate the causes of nausea, vomiting. This drug is recommended for use in the vomiting of any etiology, nausea, hiccough, various degrees of heartburn, flatulence.

The drug does not have a pharmacological effect on gastric secretion.

Clinical and pharmacological group

Antiemetic drug of central action, blocking dopamine receptors.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much does Motilac cost? The average price in pharmacies is at the level of255 rubles.

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Form of issue and composition

Motilac is made in the tablet form of two types:

• Round, biconcave, white or almost white, used for resorption of tablets, with a content of domperidone in each of them in a dosage of 10 mg. Auxiliary components are: primogel, dextrose, magnesium stearate, FS-95 adjuvant, sucrose, crospovidone, peppermint oil.
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• Biconvex, covered with white or yellowish-white shell tablets for oral administration. 1 tablet contains 10 mg of domperidone, the active ingredient, the remaining components are: povidone, sodium carboxymethyl starch, silicon dioxide with colloid, lactose, potato starch, magnesium stearate, polyethylene glycol 4000, titanium dioxide, hydroxypropylcellulose, talc;

Realized Motilak 10 tablets, which are in blisters, which are 1 or 3 pieces are enclosed in boxes of cardboard.

Pharmacological effect

Active substance Motilac has antiemetic and prokinetic effect, accelerating if necessary gastric emptying, increasing duration of peristaltic contractions of the stomach and duodenum, eliminating the development of nausea and vomiting and increasing the tone of the lower esophageal sphincter.

Motilak reviews the effect on gastric secretion does not.

Indications for use

What helps? Motilac is prescribed for a complex of dyspeptic manifestations, often associated with esophagitis, slow emptying of the stomach, gastroesophageal reflux:

1. Flatulence, belching.
2. Heartburn with throwing the contents of the stomach into the mouth (or without it).
3. The feeling of bloating and overflow in the epigastrium, pain in the upper abdomen.
4. Nausea and vomiting of any origin (organic, functional, infectious), as well as provoked by drug therapy, radiotherapy, non-diet, intoxication, the use of dopamine agonists in Parkinson's disease (eg, bromocriptine and Levodopa).

Contraindications

Most contraindications refer to the pathology of the organs of the digestive system. Basic:

• through hole in the wall of the stomach (perforation);
• hormonally active tumor of the pituitary gland (prolactinoma);
• intestinal obstruction mechanical (intestinal obstruction);
• complication of chronic gastrointestinal diseases with marked bleeding into the lumen of the small or large intestine.

Use in pregnancy and lactation

In pregnancy, especially in the first trimester, and also during lactation, Motilac is prescribed only on strict indications.

Dosage and route of administration

The instructions for use indicate that, depending on the age and indications, Motilak is prescribed:

• For chronic dyspeptic symptoms, adults are prescribed 10 mg (1 tab.) 3 times a day and, if necessary, additionally before bedtime. In case of insufficient effect, this dose is doubled.

Children over 5 yearsappoint 2.5 mg / 10 kg of body weight 3 times during the day and, if necessary, additionally before bedtime.

• In acute and subacute conditions, especially with nausea and vomiting, adults are prescribed 20 mg (2 tablets) 3-4 times during the day and, if necessary, additionally before bedtime.

Children over 5 yearsprescribe 5 mg per 10 kg of body weight 3-4 times during the day and, if necessary, additionally before bedtime.

When taking the drug after a meal, absorption is somewhat slowed down.

With continued use (for chronic symptoms), it is preferable to take the drug inside 15-30 minutes before meals.

Whenrenal failuredepending on the degree of severity, it is recommended to reduce the frequency of taking the drug to 1-2 times / day.

Side effects

Undesirable effects from taking the drug, most often occur when the recommended dose is not observed, or as an allergic reaction to the components of the drug. Possible manifestations:

1. Digestive system: in some cases - transient spasms of the intestine.
2. Allergic reactions: rarely - urticaria, rash.
3. Endocrine system: rarely - dysmenorrhea due to hyperprolactinaemia, gynecomastia, galactorrhea.
4. Central nervous system: rarely - extrapyramidal symptoms in children and with increased permeability of the blood-brain barrier (completely reversible and spontaneously disappear after drug withdrawal).

Overdose

If you accidentally take too many "Motilak" tablets, this will cause drowsiness, disorientation and other reactions from the nervous system. To eliminate them, the child is given a sorbent and keeps track of his condition.

If worsened, they immediately go to a doctor who usually prescribes antihistamines and anticholinergics.

special instructions

Since domperidone is metabolized in the liver, caution should be given to patients with hepatic insufficiency.

Because a very small amount of the drug is excreted by the kidneys unchanged, patients with renal insufficiency do not practically need a single dose adjustment. However, with a repeated appointment, the frequency of taking the drug should be reduced depending on the severity of renal failure, and a dose reduction may also be required. With prolonged therapy, patients with impaired renal function require regular monitoring.

When appointing Motilac with antacid or antisecretory drugs, they should not be taken simultaneously with Motilac.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Domperidone does not affect the level of paracetamol and digoxin in the blood.
2. With simultaneous use of anticholinergic drugs can neutralize the effect of Motilac.
3. With simultaneous use of antacids and inhibitors of gastric secretion reduce the bioavailability of Motilac.
4. It is possible that Motilac may affect the absorption of concomitantly administered drugs with sustained release of the active substance or coated with an enteric coating.
5. On the basis of in vitro studies, it is assumed that, when used simultaneously with Motilac, drugs that significantly inhibit the isoenzyme CYP3A4 (antifungal agents of the azole group, macrolide antibiotics, HIV protease inhibitors, nefazodone antidepressant), there may be an increase in domperidone level in the plasma.

Reviews

We picked up some reviews of people who took the drug Motilac:

1. Alexander. Motilac was my salvation when the doctors put reflux esophagitis. Who faced, knows what kind of anguish. A little that I eat, immediately belching, heartburn, flatulence, heaviness... Belching pulled me the hardest. Sometimes it seemed that the gastric juice splashed into the lungs. It may be nonsense, but when one day after day you suffer in this misfortune, you start to think about anything. Tried many different drugs. Some helped better, some worse. Money for it went nemereno. Motilac also promotes rapid digestion, food quickly "falls through" in the stomach, which makes it possible to enjoy rest in a horizontal position. No heartburn, no cursing belch. Yes, and it is inexpensive, unlike foreign preparations of a similar action.
2. Alexey. With chronic gastritis, you must follow a diet that almost every patient, from time to time, violates. I'm not an exception. It is necessary to admit the error in nutrition, heartburn and nausea are guaranteed. To get rid of these unpleasant symptoms I use Motilak. It works very well. But I do not advise you.
3. Julia. My seven-year-old child often gets sick. Complains of a sensation of a coma in the throat, dull pain in the upper abdomen, heartburn. The doctor constantly appoints either Motilium, which is expensive, or Domstal, which is not always on the shelves of pharmacies. Yesterday decided to try Motilak with a similar action and low price. To the child helps or assists perfectly!

Analogues

Structural analogs for the active substance:

• Damelyum;
• Domet;
• Domperidone;
• Domstal;
• Motigect;
• Motilium;
• The monotonous;
• Motion;
• The passenger.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Storage temperature of the Motilac should not exceed 25 ° C, the product must be protected from exposure to light and moisture. The shelf life of both forms of tablets is not more than 24 months.

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