Nolitsin

Nolitsin - an antibacterial drug, belongs to the group of fluoroquinolones. Used in nephrology and urology for the treatment of a number of infectious and inflammatory diseases. Active component - norfloxacin (in 1 tablet - 400 mg of substance).

High sensitivity to norfloxacin is shown by Klebsiella, Staphylococcus, Neisseria, Escherichia coli, legionella, chlamydia, shigella, salmonella, enterobacteria, dysentery sticks, hemophilic rods. Stability to Nolycin is manifested by streptococci and anaerobic bacteria.

After taking the main component is absorbed into the digestive tract, the maximum concentration in the plasma is achieved after 1-2 hours, the antimicrobial action lasts 12 hours. Eating a meal reduces the absorption of norfloxacin. 15% of the substance binds to plasma proteins, bioavailability is 30-40%.

Clinical and pharmacological group

Antibacterial drug of the group of fluoroquinolones.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Nolycin in pharmacies? The average price is at the level of250 rubles.

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Form of issue and composition

Medication Nolitsin 400 mg is available in tablet form in blisters of 10, 20 pieces. Photo of the packaging can be seen at the beginning of the article.

The composition of 1 tablet includes:

Active substance: norfloxacin - 400 mg;
Additional components: povidone, sodium carboxymethyl starch, microcrystalline cellulose, colloidal anhydrous silicon dioxide, magnesium stearate, purified water;
Sheath: hypromellose, talc, titanium dioxide, propylene glycol, yellow dye sunset (E110) (yellow disperse dye, E110).

Pharmacological effect

Nolitsin is an antimicrobial drug that creates high concentrations in the urine. Nolitsin contains the active ingredient norfloxacin, a substance of the quinolone group.

Norfloxacin is effective against gram-negative aerobic microorganisms, as well as against strains of some Gram-positive bacteria. The mechanism of action of norfloxacin is associated with the suppression of the DNA-gyrase enzyme in cells of microorganisms, as a result of which the synthesis of bacterial DNA is prevented. In addition, norfloxacin forms complexes with DNA fragments during the cleavage of the DNA chain, which prevents supercoiling and disrupts DNA synthesis.

It is possible to develop cross-resistance between quinolones.

Indications for use

According to the instructions to Nolitsin, the drug is intended for the treatment of infectious and inflammatory diseases caused by pathogens that are sensitive to norfloxacin. In particular, it is assigned when:

Uncomplicated gonorrhea of the lower part of the urogenital tract;
Flowing in acute or chronic form of infectious diseases of the kidneys and urinary tract (urethritis, cystitis, pyelonephritis);
Gastroenteritis (inflammation of the mucosa of the digestive tract) of bacterial genesis, including salmonellosis and shigellosis;
Infections of the genital and pelvic organs (chronic bacterial prostatitis, endometritis, cervicitis, epididymitis, orchitis, etc.).

In addition, Nolitsin can be prescribed for the prevention of travelers' diarrhea, sepsis in patients with agranulocytosis, relapse of infectious diseases of the urinary tract.

Contraindications

The drug can be taken only as prescribed by the doctor, self-medication can lead to serious negative consequences. Before starting treatment, read the attached instructions. Tablets are contraindicated in the presence of the following conditions:

Pregnancy and the period of breastfeeding;
Individual intolerance to norfloxacin or any of the constituent components;
Hepatic or renal insufficiency;
Age under 18, since clinical experience is not available, and the safety of the drug for children and adolescents is not proven.

Relative contraindications include:

Disorders of cerebral circulation;
Epilepsy;
Atherosclerotic deposits on the walls of the blood vessels of the brain;
Individual intolerance to acetylsalicylic acid.

Use in pregnancy and lactation

The effect of the drug in the period of fetal and lactation is not studied. It is known that norfloxacin rapidly penetrates the placental barrier. According to the instructions, Nolycin is administered during pregnancy if the intended benefit from its use is higher than the potential risk to the child.

If the medicine is prescribed during lactation, breastfeeding should be discontinued.

Dosage and route of administration

The instructions for use indicate that Nolicin is taken orally, on an empty stomach (at least 1 hour before or 2 hours after ingestion) and drink plenty of fluids.

The recommended dose is 400 mg 2 times a day. Duration of treatment is from 7 to 14 days, if necessary, spend a longer treatment.

With uncomplicated gonorrhea - once in a dose of 800-1200 mg or 400 mg 2 times / day for 3-7 days.
In chronic bacterial prostatitis - 400 mg 2 times / day for 4-6 weeks or more.
In bacterial gastroenteritis (shigellosis, salmonellosis) - 400 mg 2 times / day for 5 days.
In acute uncomplicated cystitis - 400 mg 2 times / day for 3-5 days.
For the prevention of sepsis in neutropenia - 400 mg 2 times / day for 8 weeks.
For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes a year or more 2 within six months) - 200 mg once a night for a long time (from 6 months to several years).
To prevent travel diarrhea, it is recommended to take 400 mg / day 1 day before departure, during the entire travel time and 2 days after the end (not more than 21 days).

Patients with renal dysfunction with QC greater than 20 ml / min dosage regimen correction is not required.

With SC less than 20 ml / min (or serum creatinine level> 5 mg / dl) and patients on hemodialysis, appoint half the therapeutic dose of Nolycin 2 times / day or a full dose 1 time / day.

Side effects

Adverse reactions in the treatment of Nolitocin may occur from various organs and systems:

Hematopoietic system: lowering of hematocrit, leukopenia, eosinophilia;
Cardiovascular system: vasculitis, arrhythmia, tachycardia, lowering blood pressure;
Musculoskeletal system: tendonitis, arthralgia, tendon ruptures (usually on the background of contributing factors);
Allergic reactions: skin itching, rash, swelling, urticaria, malignant exudative erythema (Stevens-Johnson syndrome);
Nervous system: hallucinations, headache, fainting, dizziness, insomnia; among the elderly patients - irritability, a sense of fear, fatigue, anxiety, drowsiness, tinnitus, depression;
Digestive system: vomiting, loss of appetite, nausea, bitterness in the mouth, abdominal pain, diarrhea, pseudomembranous enterocolitis (with prolonged therapy), increased activity of hepatic transaminases;
The urinary system: glomerulonephritis, albuminuria, crystalluria, polyuria, dysuria, urethral bleeding, increased creatinine and urea blood plasma;
Others: Candidiasis.

Overdose

It is manifested by intense vomiting, nausea, dizziness, drowsiness, "cold" sweat. Therapy includes hydration treatment with forced diuresis, gastric lavage. Specific antidote is not developed.

special instructions

Before you start using the drug, read the special instructions:

During treatment with norfloxacin, exposure to direct sunlight should be avoided. In addition, patients should receive a sufficient amount of fluid (under the control of diuresis).
When pain occurs in the tendons or at the first signs of tendovaginitis, it is necessary to cancel the drug. During therapy with norfloxacin it is recommended to avoid excessive physical exertion.
During the period of therapy, an increase in the prothrombin index is possible (during surgical interventions it is necessary to monitor the state of the blood coagulation system).
In the presence of an allergic reaction to acetylsalicylic acid, the azo dye E110 (dye yellow dispenser, E110), can cause a hypersensitivity reaction, up to the bronchospasm.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

Norfloxacin reduces the effect of nitrofurans.
Simultaneous use with drugs that reduce the convulsive threshold can lead to the development of epileptiform seizures.
Simultaneous use with GCS may increase the risk of tendonitis or cases of rupture of tendons.
Norfloxacin can enhance the therapeutic effect of hypoglycemic drugs (sulfonylurea derivatives).
Norfloxacin can enhance the therapeutic effects of cyclosporine and warfarin, in some cases with norfloxacin with cyclosporine an increase in the serum creatinine concentration was observed, therefore, in such patients monitoring of this index is necessary.
The simultaneous use of norfloxacin and antacid agents containing aluminum or magnesium hydroxide, as well as preparations containing iron, zinc, sucralfate, reduces the absorption of norfloxacin (the interval between their intake should be at least 2 hours).
With the simultaneous use of norfloxacin and theophylline should monitor the concentration of theophylline in the blood plasma and adjust it dose, tk. norfloxacin reduces the clearance of theophylline by 25%, and the development of corresponding undesirable side effects can occur.
Simultaneous reception of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in it. In this regard, in such cases, as well as with simultaneous administration with barbiturates and other drugs for general anesthesia, it is necessary to monitor heart rate, blood pressure and ECG parameters.

Reviews

We picked up some reviews of people who used the drug Nolitsin:

Hope. A good antibiotic, first met him, when my husband was prescribed for inflammation of the prostate. literally over a week the main symptoms came to naught, was able to continue to be treated with special drugs and a smart-prost. In comparison with other antibiotics, the treatment turned out to be quick, and effective, and harmless - even the intestines did not suffer.
Oksana. I drank a week course of nolycin and I will not return to it again. Cramps began, legs as if they were wooden, I can not bend and unbend. It seems like the second day the drug does not take, and these side effects do not pass. To see nolitsin has a long curative effect, and in my case a long side effect. Somehow it is necessary to withdraw the drug from the body. I do not advise everyone to take it.
Julia. In my student years, I got into trouble with cystitis. She ran to the doctor. After the urgent delivery of the necessary tests, the doctor, delicately inquiring about whether I intend to become pregnant in the near future and receiving a negative answer, appointed nolycin. Apparently, the drug is serious and somehow it may affect the course of pregnancy. After the first day of taking the drug, it became much easier. But I drank a lot how the doctor appointed.

Analogues

If necessary, Nolycin can be replaced with analogs containing the same active substance. In this list, such drugs as Norbaktin, Normaks, Norfloxacin, Sofazin, Renor, Utibid.

Before using analogues, consult your doctor.

Storage conditions and shelf life

According to the instructions Nolitsin can not be stored for more than 5 years from the date of release. Capsules should be kept in a dry place inaccessible to children and sun rays. The air temperature should not exceed 25 ° C.