Bicillin 3

Bicillin-3 is an antibiotic from the penicillin group, which is destroyed by the enzyme penicillinase.

Has a bactericidal effect, inhibiting the synthesis of peptidoglycan cell walls of microorganisms.

On this page you will find all information about Bicillin 3: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Bicillin 3. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic group of penicillins, destroyed penicillinase.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Bicillin 3? The average price in pharmacies is at the level of530 rubles.

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Form of issue and composition

Bicillin-3 is available in powder form for the preparation of a suspension for intramuscular injection, which is white or white with a light yellowish hue, prone to clumping and forming a stable suspension with the addition of water (60, 00 units or , 0, 00 units in 10 ml vials, in a carton of 1, 5 or 10 bottles).

Composition per 1 bottle 1 200 000 units:

• benzylpenicillin potassium salt (benzylpenicillin potassium) or benzylpenicillin sodium salt (benzylpenicillin sodium) - 40, 00 units;
• benzathine benzylpenicillin - 400 000 units;
• benzylpenicillin novocaine salt (benzylpenicillin procaine) - 400 000 units.

Composition per 1 bottle 600 000 units:

• benzylpenicillin potassium salt (benzylpenicillin potassium) or benzylpenicillin sodium salt (benzylpenicillin sodium) - 20, 00 units;
• benzathine benzylpenicillin - 200 000 units;
• benzylpenicillin novocaine salt (benzylpenicillin procaine) - 200 000 units.

Pharmacological effect

Complex bactericidal preparation, which includes 3 salts of benzylpenicillin.

Oppresses the synthesis of the bacterial cell membrane, shows activity against gram-positive microorganisms: Streptococcus spp., Streptococcus pneumoniae., Staphylococcus spp., Clostridium spp., Actinomyces israelii., Bacillus anthracis; as well as against gram-negative pathogens: Neisseria meningitidis, Treponema spp., Neisseria gonorrhoeae. Staphylococcus spp strains synthesizing penicillinase are relatively resistant to the drug.

Indications for use

Indications for use Bicillin-3 is an infection caused by bacteria that are sensitive to penicillin, especially when taking long-term treatment:

• yaws (syphilis tropical);
• tonsillitis, lacunar angina, catarrhal angina;
• scarlet fever;
• erysipelatous lesion;
• syphilis primary, secondary, unknown genesis;
• Rheumatism, rheumatoid arthritis, rheumatic carditis, rheumatoid diseases;
• wound infection: infected wounds, burns, purulent wounds, wound botulism.

Contraindications

The drug is not prescribed if there is an allergy to penicillin group drugs, as well as excessive sensitivity to novocaine.

The drug is contraindicated in children.

With caution should be used antibacterial agent with a propensity for development:

• Hives
• Exacerbations of asthma attacks
• Hay fever.

Application in pregnancy and lactation

The use of the drug during pregnancy is possible in the presence of indications for admission, when the expected therapeutic effectiveness for the mother significantly exceeds the possible threat to the health of the fetus. How long will the treatment continue, please check with your doctor.

If it is necessary to carry out therapeutic therapy with "Bicillin-3" during lactation it is necessary to stop breastfeeding.

Instructions for use

The instructions for use indicate that the suspension of Bicillin-3 is prepared immediately before use. In the bottle with the drug injected with 2-3 ml of sterile water for injection or isotonic sodium chloride solution. The mixture in the vial is shaken for 30 seconds (in the direction of the longitudinal axis) to form a homogeneous suspension (or suspension) that is injected deeply into the upper outer quadrant of the buttocks. Rubbing the buttocks after the injection is not recommended.

• Bicillin-3 is injected deep into the upper outer quadrant of the buttocks at a dose of no more than 1.2 million units. If necessary, 2 injections are done in different buttocks. Repeated injections are carried out for 4 days after the previous injection.
• The drug in a dose of 600 000 units is administered once every 6 days.
• In the treatment of primary and secondary syphilis, a single dose of the drug is 1.8 million. ED. The course of treatment - 7 injections. The first injection is carried out at a dose of 30, 00 units, the second injection at 1 day in a full dose (1.8 million units, ED). Subsequent injections are carried out 2 times a week.
• In the treatment of secondary recurrent and latent early syphilis, a dose of 30, 00 units is used for the first injection, 1.8 million for the subsequent injection ED. Injections are carried out 2 times a week.
• The course of treatment - 14 injections.

It is forbidden to / in the introduction of the drug.

Side effects

The drug can cause the following side effects: laboratory evidence of leukopenia, anemia, thrombocytopenia joins, hypocoagulation is also possible. In addition, allergic reactions may develop on Bicillin-3: Quincke's edema, skin rash, hives, arthritis, eosinophilia, erythema multiforme, joins dermatitis of exfoliative nature, anaphylactic shock is not excluded, it should immediately be given to the patient appropriate therapeutic Events.

Other manifestations of side effects on intramuscular injection of the drug will be: headache, arthralgia, body temperature rises, stomatitis, glossitis may occur. In addition, there is local tenderness at the injection site. With prolonged treatment, the occurrence of superinfection is not ruled out.

Overdose

To date, there has been no report of an overdose.

special instructions

1. Intravenous and endolumbral administration is not allowed, because development of Ouenier's syndrome (depression, anxiety, paresthesia, impaired vision) is possible.
2. When developing allergic reactions should immediately stop the treatment. With the development of anaphylactic shock, an anti-shock therapy (norepinephrine, GCS, ventilator) is indicated.
3. It should be taken into account that the use of the drug in insufficient doses or early cessation of treatment leads to the emergence of resistant strains of excipients.
4. Features of the influence of the drug on the ability to drive vehicles or potentially dangerous mechanisms.
5. When treating venereal diseases, in cases of suspected syphilis before treatment and then for 4 months, serological / microscopic examinations should be performed.

Given the side effects of the drug, care should be taken when driving vehicles and moving machinery

Drug Interactions

Bactericidal antibiotics (aminoglycosides, cephalosporins, vancomycin, rifampicin) intensify the action Bicillin-3; bacteriostatic (tetracyclines, lincosamides, macrolides, chloramphenicol) weaken the action preparation. Allopurinol increases the risk of allergic reactions.

Reviews

We picked up some feedback from people about the Bicillin 3 drug:

1. Katerina. At a daughter from the very early childhood chronic tonsillitis, a sore throat with a sore throat, cones began to appear in a throat. Constantly at the LOR and she, after all, said to put this shot with a prophylactic goal - from complications that can go to the heart and to the joints. We initially refused, but after reading the annotation, we decided - it is still possible for the children, so the drug is not so terrible. Now kolem every six months and live without angina at all!
2. Julia. First, she refused this drug for her son, the antibiotic is still a nasty prick, but when in the winter we hit four times with the strongest sore throat, there are no options, serious heart and joint problems may occur, and bicillin excludes complications. The injection was carried easily, the angina was no more, a year had already passed, the state of health and tests were normal, there were no deviations in the development, pah-pah-pah.

There are testimonials indicating the development of allergic reactions, which in some cases requires the abolition of therapy.

Analogues

Preparations similar to Bicillin-3 are represented by various salts of benzylpenicillin of domestic production.

Other drugs, based on penicillins, are semisynthetic analogues that are resistant to the action of penicillinase and have a broad spectrum of antibacterial action. These drugs are based on ampicillin, amoxicillin, carbenicillin and others, available in the form of tablets, capsules and parenteral forms.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in a place protected from moisture, at a temperature of 8-15 ° C. Keep away from children.

Shelf life - 3 years.

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