Penzital

Penzital is an enzyme preparation with proteolytic, amylolytic and lipolytic action, which compensates for the lack of exocrine function of the pancreas.

The enzymes included in the pancreatin (alpha-amylase, lipase, trypsin, chymotrypsin) are involved in the breakdown of fats to glycerol and fatty acids, proteins - up to amino acids, starch - to dextrins and monosaccharides, and also contribute to the normalization of digestive processes and improve the functional state of the gastrointestinal tract.

The maximum enzymatic activity is observed 30-45 minutes after oral administration.

Clinical and pharmacological group

Enzyme means.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much is Penzital in pharmacies? The average price is at the level of80 rubles.

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Form of issue and composition

Penzital is released in the form of tablets coated with enteric coating: white, round, biconvex (10 pcs. in strips, 1-12 strips in a cardboard bundle).

The composition of 1 tablet includes:

• Active substance: pancreatin - 21, mg (has the following enzymatic activity: amylase - 4500 ED FIP, lipase - 6000 ED FIP, protease - 300 units FIP);
• Auxiliary components: lactose, microcrystalline cellulose, sodium starch glycolate, talc, diethyl phthalate, povidone, colloidal silicon dioxide, methacrylic acid copolymer, titanium dioxide.

Pharmacological effect

Penzital is an enzyme preparation that compensates for the inadequacy of pancreatic secretion.

This means that the drug is used as a symptomatic treatment of any conditions that are associated with incomplete digestion of food due to inadequate production of enzymes by pancreatic cells rights. Enzymes in the drug make up for the lack of their own enzymes, which must be produced by the pancreas.

Lipase, amylase and proteases (trypsin and chymotrypsin) help to break up the proteins from food to amino acids, fats - to fatty acids and starch - to dextrins, glucose, galactose and other monosaccharides. The main therapeutic effect of Penzital is the normalization of the digestive process and the improvement of the functional activity of the gastrointestinal tract. Thus, it can be simplified to say that Penzital is a tablet against indigestion caused by a deficiency of the digestive system (for example, pancreatitis) or overeating. As a result of the drug, nutrients from the eaten food are fully absorbed.

The maximum activity of the enzymes that make up the drug is observed 30 to 45 minutes after taking the pill through the mouth.

One of the Penzital proteases, trypsin, stimulates the activity of the pancreas, causing it to produce more enzymes necessary for digestion. In addition, trypsin has an analgesic effect.

Indications for use

What helps? Indications for the appointment of Penzital are:

1. Diarrhea of ​​non-infectious origin, flatulence.
2. Disturbance of assimilation of food (after excision of the small intestine and stomach).
3. Preparation for ultrasound and radiographic diagnosis of the abdominal cavity.
4. Substitution treatment for pancreatic insufficiency (eg, pancreatectomy, dyspepsia, condition after irradiation, chronic pancreatitis, cystic fibrosis, Remkheld syndrome).
5. To improve the digestion of food in individuals with normal function of the digestive tract in case of errors in nutrition (irregular meals, a large amount of food, eating fatty foods) and with prolonged immobilization, sedentary lifestyle, violations of chewing function.

Contraindications

Penzital is contraindicated for use in the presence of the following pathological or functional conditions in humans:

1. Exacerbation of chronic pancreatitis;
2. Acute pancreatitis;
3. Hypersensitivity to the components of the drug.

Use in pregnancy and lactation

There are no reliable data indicating the safety of pancreatin during pregnancy. Experimental studies have shown that pancreatin does not have a teratogenic effect.

Treatment of pregnant women Penzitalom under indications is possible only in those cases when the benefit for the mother exceeds the possible harm for the child.

Dosage and route of administration

The instructions for use indicate that the dose (in terms of lipase) depends on the age and extent of pancreatic function deficiency. The average dose for adults is 15, 00 units / day. With total insufficiency of the exocrine function of the pancreas - 400 000 units / day, which corresponds to the daily needs of an adult in lipase.

The maximum daily dose is 15 000 units / kg.

Children under the age of 1.5 years - 50 000 U / day; over 1.5 years - 100 000 units / day.

Duration of treatment can vary from several days (with digestion due to inaccuracies in the diet) up to several months and even years (if necessary, a constant replacement therapy).

Side effects

The drug is well tolerated by patients. With increased individual sensitivity in rare cases, the following side effects may develop on the background of therapy:

1. Change in indicators of urinalysis - hyperuricosuria, hyperuricemia.
2. Allergic reactions - rashes on the skin, hives, itching and flaky skin.
3. On the part of the digestive tract organs - constipation, heaviness in the stomach, rumbling in the abdomen, flatulence, nausea, sometimes vomiting, stomatitis, skin irritation in the area of ​​perianal folds.

These side effects are not dangerous and go away quickly after stopping the use of pills or reducing the dose.

Overdose

In children, overdose with tablets manifests itself in the form of constipation, and in adults - an increase in the concentration of uric acid in the blood and urine (hyperuricemia and hyperuricosuria).

When there are signs of excess dose, taking the drug is canceled, the level of uric acid decreases, symptomatic therapy of constipation is carried out. Additional measures for treatment, gastric lavage are not required.

special instructions

Before you start using the drug, read the special instructions:

1. It is not recommended to use chronic exacerbation of chronic pancreatitis in the phase.
2. In cystic fibrosis, the dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.
3. With a high activity of lipase contained in pancreatin, the probability of constipation in children increases. Increase in the dose of pancreatin in this category of patients should be carried out gradually.
4. Cystic fibrosis does not recommend the use of pancreatin in doses greater than 10 000 units / kg / day (in terms of lipase) due to an increased risk of developing strictures (fibrous colonopathy) in the ileocecal region and in the ascending colonic gut.
5. Disturbances from the digestive system can occur in patients with increased sensitivity to pancreatin, or in patients with meconium ileus or bowel resection in the anamnesis.

Drug Interactions

With simultaneous use with antacids, calcium-containing carbonate and / or magnesium hydroxide, a decrease in the effectiveness of pancreatin is possible.

With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.

With the simultaneous use of iron preparations, it is possible to reduce the absorption of iron.

Reviews

We picked up some reviews of people who used the drug Penzital:

1. Natalia. I often overeat, although I root myself for it. If I feel discomfort and heaviness in the stomach, I help to facilitate digestion of food with special enzyme preparations. I accept the cheapest Penzital. I like that he quickly eliminates the severity, normalizes the process of digestion. For two days the problem passes.
2. Igor. I have chronic pancreatitis, so I need a permanent enzymatic support for the pancreas. I used to drink Penzital, but from him I started to have pain in my stomach. I had to change the drug to a weaker one by the effect - I take Pancreatin. While I like it from the action, but let's see what happens next.
3. Nina. And after my trips to the guests I drink penzital. Sometimes I even take it with me if I know that there will be a lot of food. I ate, drank, and forgot that something might be sick somewhere. And I sit quietly communicate, but I do not sigh because of gravity.

Analogues

There are many analogues of the drug with the same composition and principle of operation. Popular substitutes for tablets are enzyme medicines.

1. According to the active substance: Biosim, Vestal, Gastenorm forte, Creon, Mezim, Mezim forte, Mikrazim, Pangrol, PanziKam, Panzim Fort, Panzinorm, Pancreasim, Pancreatin, Pancrenorm, Pancitrat, Penzital, Uni-Festal, Enzistal-P, Hermitage;
2. On the mechanism of action: Abomin, Biofestal, Nigedaza, Normoenzyme, Normoenzyme forte, Orazy, Pankreoflat, Pepsin K, Pepfiz, Ferestal, Festal, Unienzym with MPS, Enzistal, Enterosan.

Before using analogues, consult your doctor.

Penzital or Pancreatin - which is better?

The drugs are similar in terms of the active substance, but the activity of pancreatin enzymes in Penzital is higher, so its effectiveness is more obvious. Doctors use Pancreatin to prevent overeating to avoid the appearance of unpleasant symptoms.

The drug can be used as a maintenance therapy after a course of treatment with Penzitalom. The latter is prescribed for the treatment of digestive disorders as an active therapy for the normalization of the condition. After achieving the effect, you can switch to a weaker Pancreatin drug.

Storage conditions and shelf life

In accordance with the manufacturer's recommendations, the tablets should be stored in a dry place, the optimum temperature regime of storage - from 2 to 25 ºС. If these conditions are met, the shelf life is 3 years.

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