Neuromidine

Neuromidine has anticholinesterase action.

Has an effect on smooth muscles, improving contractility, normalizes the activity of the nervous system and stabilizes neuromuscular contacts, promotes better memorization and perception, and also slows the development of diseases with a violation of cognitive functions.

The drug is often used in the recovery period after a stroke of the brain, with various lesions of the roots of the spinal cord, muscle weakness, in violation of motor activity of varying severity, violation and absence of peristalsis and the main functions of the digestive system.

Clinical and pharmacological group

Cholinesterase inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Neuromidine cost in pharmacies? The average price is at the level of1 100 rubles.

Form of issue and composition

Neuromidine is manufactured in the following dosage forms:

Solution for intramuscular and subcutaneous administration: clear, colorless (1 ml in ampoules of neutral glass, 5 ampoules in contour cell packs, 2 packs in a cardboard bundle).
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Tablets: flat-cylindrical, white, round, with a facet (10 pcs. in contour cell packs of polyvinyl chloride film and aluminum foil, 5 packs per carton).

The composition of 1 ml of solution includes:

Active substance: ipidakrin hydrochloride - 5 or 15 mg (in the form of monohydrate ipidakrin hydrochloride);
Auxiliary components: concentrated hydrochloric acid - up to pH 3, water for injection - up to 1 ml.

The composition of 1 tablet includes:

Active ingredient: ipidakrin hydrochloride - 20 mg (as monohydrate of ipidacrine hydrochloride);
Auxiliary components: lactose monohydrate - 65 mg, potato starch - 14 mg, calcium stearate - 1 mg.

Pharmacological effect

Neuromidine, being an anticholinesterase drug, promotes the stimulation of neuromuscular transmission, strengthening the contractility of smooth muscle organs. The drug normalizes the conductivity of nerve impulses in the peripheral nervous system, and also stimulates the central nervous system with mildly expressed sedation.

Neuromidine has analgesic and antiarrhythmic effects, improves memory, increases learning ability.

The drug does not mutagenic, teratogenic, embryotoxic and carcinogenic effect, as well as immunotoxic and allergic actions. Thanks to rapid absorption, the maximum concentration of active substance in the blood is noted after an hour.

Indications for use

Indications for the use of Neuromidine in the form of tablets are such diseases or pathological conditions:

vestibular disorders;
cognitive impairment;
the recovery period after organic lesions of the CNS in the presence of motor disorders;
intestinal atony of different etiology;
diseases of the peripheral nervous system;
polyneuropathy and polyradiculopathy;
myasthenia gravis and myasthenic syndrome;
bulbar paralysis and paresis;
lag in the child's physical and mental development.

In addition to the above indications, the drug in the form of injections (injections) is used for such violations:

mononeuropathy;
diseases of the CNS (central nervous system);
weak labor activity.

Contraindications

Medication can not be administered in the following situations:

lactation period;
bradycardia;
pregnancy;
epilepsy;
bronchial asthma;
age to 18 years;
angina pectoris;
exacerbation of gastrointestinal ulcers;
obstruction of intestinal permeability and urinary tract;
disturbance of the vestibular apparatus;
increased susceptibility to the action of the components of the composition of the agent;
neuroleptic extrapyramidal pathologies;

With extreme caution:

hyperthyroidism;
lactose intolerance (for taking tablets);
diseases of the respiratory system.

Use in pregnancy and lactation

The drug should not be taken during pregnancy due to the fact that it enhances the tone of the uterus. When lactation, the drug is excreted with milk.

Dosage and route of administration

The instructions for use indicate that the doses and duration of treatment with Neuromidine are determined individually, depending on the severity of the disease.

Diseases of the peripheral nervous system:

With mono- and polyneuropathy, polyradiculopathy of different etiology - 10-20 mg (0.5-1 tab.) 1-3 times / day. The course of treatment is from 1 to 2 months. If necessary, the course of treatment can be repeated several times with a break between courses in 1-2 months.
To prevent myasthenic crises, with severe disorders of neuromuscular conduction, 1-2 ml (15-30 mg) of 1.5% solution Neuromidine for injection, then the treatment is continued, appointing Neuromidine inside in the form of tablets - the dose can be increased to 20-40 mg (1-2 tablets) 5 times / day.

Diseases of the central nervous system:

With bulbar paralysis and paresis, during the recovery period of organic lesions of the CNS (traumatic, vascular and other genesis), accompanied by motor and / or cognitive impairment - 10-20 mg (0.5-1 tab.) 2-3 times / day. The course of treatment is from 2 to 6 months. If necessary, repeat the treatment.
For treatment and prevention of intestinal atony - 20 mg (1 tab.) 2-3 times / day for 1-2 weeks.

If the next dose has not been taken on time, in addition it should not be taken.

The maximum daily dose is 200 mg.

Side effects

The use of a medicament may provoke the following undesirable manifestations:

Reactions associated with the activation of m-cholinergic receptors: increased secretion of bronchial secretion, bradycardia, diarrhea, palpitation, salivation, cramps, pain in the abdomen, jaundice, nausea, increased sweating.

When used in high dosage: drowsiness, vomiting, headache, allergic manifestations on the skin, weakness, painful sensations behind the sternum, dizziness.

Overdose

In case of an overdose, it is possible that not only secondary symptoms, but also various complications arise. If the fact of an overdose of a medicine is appropriate, then this condition will be accompanied by the appearance of a decrease in appetite, increased salivation, acceleration of intestinal motility, as well as the appearance of diarrhea and excessive urination.

A significant overdose of the drug can lead to a violation of the heart muscle, as well as the occurrence of arrhythmias, seizures, loss of coordination and consciousness. A person can fall into a coma, so it is very important to observe the dosage and the scheme of the drug.

To eliminate signs of overdose resort to the use of symptomatic drugs, presented in the form of Atropine or Metacin.

special instructions

During the period of treatment, the patient should exclude the use of alcohol. Alcohol increases the side effects of the drug.

During treatment the patient should refrain from driving motor vehicles, as well as practicing potentially dangerous Activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

The drug can be used in combination with nootropic drugs.
Neuromidine enhances sedation in combination with CNS depressants.
The risk of bradycardia increases if beta-blockers were used before the start of treatment with Neuromidine.
The effect of the drug and side effects are enhanced when combined with other cholinesterase inhibitors and m-cholinomimetic agents.
In patients with myasthenia gravis, the risk of developing a cholinergic crisis increases with the simultaneous use of Neuromidine with other cholinergic agents.
Neuromidine weakens the depressing effect on neuromuscular transmission and conduction of excitation along the peripheral nerves of local anesthetics, aminoglycosides, potassium chloride.

Reviews

We picked up some reviews of people who used the drug Neuromidine:

Vasilisa. During the sessions and examinations I drink the drug one tablet several times a day. It helps to memorize the necessary information and formulas. I order it through the online store, there it is cheaper than in the pharmacy. The only drawback of this medication is side effects, I often feel dizzy, nauseous.
Natasha. Accepted Neuromidine for the treatment of diabetic polyneuropathy. Constantly my legs hurt very much, the sensitivity on my fingers was lost. Month every day ate 2 tablets Neuromidine. A slight improvement came only now: the pains diminished slightly. Honestly, I would like a more vivid effect after a whole month of admission. There were no side effects.
Irina. Treated this drug my mom. After the transferred microstroke she had forgetfulness, confusion of consciousness. First, on the appointment of a doctor, they punctured 10 days of injection, and then took a pill for a month. The effect is good, my mother has improved memory, well-being. The only negative - if she took them before meals, complained of nausea.

Analogues

In case of patient intolerance of the components of the drug, it is recommended to select a therapeutic substitute. There are several analogues of the drug Neuromidine. Among the most popular means are:

Proserin;
Aksamon;
Kalimin 60-H;
Ipidacrin;
Amiridin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in a place inaccessible to children and protected from light. The temperature is 15-25 degrees Celsius.

Compliance with storage conditions, guarantees the safety of the properties of Neuromidine tablets for three years, and the solution for injections in ampoules - two years.