At what pressure to take Lercamen: instruction and feedback

Lercamen is a drug that blocks the slow calcium channels.

This drug is used in the therapy of diseases of the cardiovascular system. The persistent hypotensive effect of the drug lasts 24 hours, that is, it should be taken once a day in the morning. Lercamen does not affect the level of glucose and the total cholesterol in the blood.

The main active ingredient of the drug, lercanidipine, is a substance from the group of Ca2 + antagonists, which is characterized by its ability to inhibit the transmembrane rush of calcium into the smooth muscle musculature. As a result, the lumen of the vessels gradually widens, in the shortest possible time reducing the overall peripheral resistance of the vessels, which prevents the development of tachycardia and hypertension, that is, a persistent increase in blood pressure.

Clinical and pharmacological group

Selective calcium channel blocker with a predominant effect on blood vessels.

Conditions of leave from pharmacies

It is released on prescription.

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Price list

How much is Lercamen? The average price in pharmacies is at the level of350 rubles.

Form of issue and composition

Lercamen is produced in the form of biconvex, round, film-coated pale yellow or light yellow color tablets, with a risk on one side, a light yellow color on the break, in blisters, in packs of cardboard.

In one tablet, "Lercamen" is:

Lercanidipine - 10 mg or 20 mg;
Excipients and lactose monohydrate.

The composition of the film shell of Lercamena includes opadrai 02F25077, titanium dioxide, macrogol 6000, iron oxide, talc and hypromellose.

Pharmacological effect

The main active substance of Lercamena (lercanidipine hydrochloride) inhibits the cells of the smooth muscles of the vessels and stops the transmembrane flow of calcium into the cardiomyocytes.

The drug produces a direct relaxing effect on the smooth muscles of the vessels, exerting an antihypertensive effect. Also, the drug has a prolonged antihypertensive property.

Indications for use

At what pressure do you designate? Direct indications for the use of the drug Lercamena - essential arterial hypertension of mild and moderate severity. The drug is taken only with these conditions.

Do not take with hypertensive crises or for preventive purposes. Admission is possible only after consultation of a cardiologist and by direct indications.

Contraindications

Absolute:

Obstruction of vessels emanating from the left ventricle of the heart;
Pregnancy;
Lack of reliable methods of contraception;
Lactation period;
Age to 18 years;
Untreated heart failure;
Severe renal insufficiency (creatinine clearance less than 30 ml / min);
Severe hepatic impairment;
Unstable angina;
Period 1 month after myocardial infarction;
Lactose intolerance, glucose-galactose malabsorption syndrome, lactase deficiency;
Simultaneous use of cyclosporine or inhibitors of CYP3A4 (itraconazole, ketoconazole, ritonavir, erythromycin, trolleandomycin);
Simultaneous reception with grapefruit juice;
Hypersensitivity to the drug components or other dihydropyridine derivatives.

Relative:

Cardiac ischemia;
Left ventricular dysfunction;
Elderly age;
Renal failure (creatinine clearance more than 30 ml / minute);
Hepatic insufficiency of mild and moderate severity;
Syndrome of weakness of the sinus node.

Use in pregnancy and lactation

The use of Lercamen in pregnancy and during breastfeeding, as well as in women of childbearing age in the absence of reliable contraception is contraindicated.

Pre-clinical studies showed no teratogenic effect of lercanidipine in rats and rabbits, and the reproductive function of rats was unchanged.

In view of the lack of clinical experience with lercanidipine during pregnancy and during breastfeeding, and since it is known that other dihydropyridine derivatives were teratogenic effect in animals, lercanidipine is not recommended for use in pregnancy and in women of childbearing age who do not use reliable methods of contraception.

Due to the high lipophilicity of lercanidipine, it can be assumed that it penetrates into breast milk, so the drug is not recommended for use during breastfeeding

Dosage and route of administration

The instructions for use indicate: Lercamen is taken orally, at least 15 minutes before meals, preferably in the morning, without chewing, squeezed with enough water.

Assign 10 mg once a day. Depending on the individual tolerance of the drug to the patient, the dose can be increased to 20 mg.

Therapeutic dose is selected gradually, tk. the maximum antihypertensive effect develops approximately 2 weeks after the start of the drug. It is unlikely that the effectiveness of the drug will increase with a dose increase of more than 20 mg / day, while the risk of side effects increases.

Care should be taken when using Lercamen in patients with mild and moderate renal and hepatic insufficiency.
In case of renal insufficiency (CC less than 30 ml / min) and liver failure of a severe degree of fatigue, the use of Lercamen is contraindicated.
In renal failure (QC more than 30 ml / min) or liver failure of mild to moderate severity, the initial dose is 10 mg, then with caution increase the dose to 20 mg / day. Antihypertensive effect can be increased in patients with mild or moderate hepatic insufficiency and dose correction may be required.

Clinical studies show that in elderly patients, dose adjustment of Lercamen is not required. However, care should be taken at the initial stage of treatment with Lercamen in this group of patients.

Side effects

The use of Lercamena, according to reviews, causes side effects from various body systems, namely:

Dyspepsia, vomiting, reversible increase in hepatic enzyme activity, epigastric pain, nausea, diarrhea and gingival hyperplasia (digestive system).
Peripheral edema, palpitation, tachycardia, lowering blood pressure, chest pain, angina pectoris, asthenia, myocardial infarction, fatigue, headache and dizziness (cardiovascular system).

Also, Lercamen, according to reviews, sometimes causes polyuria, skin rash, myalgia and drowsiness.

Overdose

For all time of a finding of a preparation in the market it was observed only three cases of an overdosage at doses 150, 280 and 800 milligrams:

an overdose of 150 mg marked drowsiness;
at 280 mg - severe myocardial ischemia, mild renal failure;
at 800 milligrams - nausea, arterial hypotension.

special instructions

Against the background of treatment with this drug may cause asthenia, dizziness, fatigue and drowsiness, namely so when treating Lercamen, patients need to drive the car with extreme caution.

It is not possible to combine the drug with alcohol, as this can lead to severe drowsiness.

Drug Interactions

The drug can interact with a large number of drugs from other clinico-pharmacological groups, so in case of their admission, it is necessary to warn the attending physician.

Reviews

We picked up some reviews of people who took the drug Lercamen:

Lyudmila. At the beginning (10-20 mg) of the reception, the pulse, heart rate, heat, and diuretic was increased, and the dose was reduced to 5 mg. The body is used to, I drink 5-10 mg in the evening. All is normal only it is hot from a tablet then all passes or takes place. In the morning I drink 80 msg, which began to hold pressure only after accumulation-for 8 weeks, I thought already to change.
Tamara. From constantly leaping pressure to 180-200 / 120 the doctor wrote out three preparations, including. and lercamen 10, began to take 1/2 tablet at night, the pulse became more frequent, but bisoprolol 5 mg in the morning, it quenches well and reduces pressure, from the third drug from the pressure will have to be abandoned, since the pressure is kept within 130/80 pulses to 80. Very good drug. I hope these endless pressure rises will go away.
Stas. I took 5 mg first, then 10, then 20. In the afternoon the pressure is normal, in the evening it starts to rise to 160-180, in the morning the same picture. Before that, I took amlodipine, the pressure was normal within a day, but the ankles and legs at the bottom generally swelled.