How to apply Domperidone: instructions and reviews

Domperidone is an anti-emetic. Has antiemetic effect, soothes hiccups and eliminates nausea in some cases.

The effect is due to blockade of central dopamine receptors. This eliminates the inhibitory effect of dopamine on the motor function of the gastrointestinal tract and increases the evacuation and motor activity of the stomach.

On this page you will find all information about Domperidon: full instructions for use with this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Domperidon. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiemetic drug of central action, blocking dopamine receptors.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Domperidone? The average price in pharmacies is at the level of120 rubles.

Form of issue and composition

The preparation is produced in a solid form, which is covered with a shell, round on both sides round white tablets. One pack can include 10 to 50 tablets. Other forms (capsules, suppositories, syrup, injections, etc.) have no such medication.

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One tablet contains the active component of domperidone - 10 mg + additional substances (microcellulose, colloidal silicon dioxide, macrogol, polyvinyl alcohol, talc, starch, magnesium stearate, polyethylene glycol, titanium dioxide).

Pharmacological effect

Has antiemetic effect, soothes hiccups and eliminates nausea in some cases. Has a regulating and normalizing effect on the motor activity of the gastrointestinal tract, which is associated with a blocking effect on the dopamine receptors (D2) of the gastrointestinal tract. By action is close to metoclopramide.

Unlike metoclopramide, it does not penetrate the blood-brain barrier (a barrier between blood and brain tissue) and does not cause extrapyramidal disorders (disorders of coordination of movements with a decrease in their volume and trembling).

Indications for use

When is he appointed? Domperidone is in demand:

With hiccups.
With esophagitis or esophageal reflux.
When atony of the digestive tract, including the postoperative state.
With flatulence, heartburn, a feeling of stomach overflow, bloating, abdominal pain or belching.
When radiocontrast studies of the digestive tract, if you want to strengthen peristalsis.
With dyspepsia, provoked by delayed evacuation of food from the stomach.
With nausea or vomiting caused by various causes, for example, taking medications, organic gastrointestinal pathology, eating disorders, infection, or endoscopic examination.

Contraindications

Bleeding from the gastrointestinal tract, mechanical intestinal obstruction, perforation (end-to-end defect) stomach or intestines, pregnancy, breast-feeding, hypersensitivity to the drug. Newborns, infants and children weighing up to 20 kg of the drug is not prescribed.

Do not prescribe domperidone with anticholinergics (atropine, spasmolytic, platyphylline, etc.) due to the fact that the latter depress intestinal tone.

Application in pregnancy and lactation

The use of the drug during pregnancy is prohibited.

Reception Domperidona during lactation involves a temporary interruption of breastfeeding.

Instructions for use

In the instructions for use indicated that Domperidon taken inside 15-20 minutes before meals.

Adults and children over 5 years with chronic dyspeptic symptoms - 10 mg 3-4 times / day, incl. and before bedtime if necessary.
With severe nausea and vomiting - 20 mg 3-4 times / day, the last reception - before bedtime.
The maximum daily dose is 80 mg.

For patients with renal insufficiency, dose adjustment is necessary, the frequency of administration should not exceed 1-2 times / day.

Side effects

The drug Domperidone usually has a good tolerance of patients. In single cases there are spasms of the intestine, which have a short-term manifestation and quickly disappear. Extrapyramidal manifestations sometimes appear in children even less often in adults and completely disappear if the medication is stopped. Sometimes Domperidone provokes an increased level of prolactin in the blood plasma, because the pituitary gland is outside the BBB area.

Rarely, but there are cases of galactorrhea and gynecomastia. When hypotension of GEB in patients with children or with its violation, side effects of a neuralgic nature may occur. Rashes on skin and itching are extremely rare.

Overdose

In reviews of Domperidone, it is noted that in case of an overdose, the drug may experience extrapyramidal disorders, disorientation and drowsiness.

special instructions

Domperidone and antacid preparations or drugs that reduce gastric secretion should not be taken together at the same time. When taking domperidone before meals, these medications should be taken after meals.

Drug Interactions

Cimetidine, sodium hydrogen carbonate reduce the bioavailability of domperidone.
With simultaneous admission with paracetamol and digoxin, the concentrations of these drugs in the blood do not change.
M-cholinoblockers and antacid drugs neutralize the action of domperidone.
Domperidone is compatible with antipsychotic drugs (neuroleptics) and with dopamine receptor agonists (bromocriptine, levodopa).
The concentration of domperidone in plasma increases with simultaneous use with inhibitors of the isoenzyme CYP3A4: antifungal azole agents, antibiotics of the macrolide group, HIV protease inhibitors, nefazodone (antidepressant). When co-administered with ketoconazole, approximately a threefold increase in Cmax domperidone in plasma is achieved.

Reviews

We picked up some feedback from people about the preparation of Domperidon:

Natalia. The gastroenterologist prescribed to drink the drug for 10 days + hetopa 40 with duodeno-gastral reflux. It really helped. Months five had no problems. Now the same symptoms of heartburn, nausea, belching with air. I'm thinking of going back to the doctor or taking the same course myself.... The FGD did one year ago, and duodenal-gastric reflux was detected there. again you do not want to go through this procedure ..
Julia. With this drug, I "met" thanks to my mother-in-law. Once, on one family feast, I felt unwell after a large amount of fatty food I had eaten, my mother-in-law saved me with Domperidon's pill. Relief came almost instantly, pain and abdominal pain disappeared. Ever since, in my ambulance kit, he always is. This drug is really effective, and besides, inexpensive compared to imported analogues.

Analogues

With the same active substance are produced drugs: Domet, Damelium, Domperidon Hexal, Domstal, Domperidon-Teva, Motigeckt, Motilium, Motilak, Motinorm, Nauzelin, Motionium, Peridal, Passagex, Euciton, Peridone and Cilroton.

Before using analogues, consult your doctor.