A solution of aminocaproic acid is referred to as haemostatic and antihemorrhagic agents.
The use of aminocaproic acid is recommended for stopping bleeding, with increased fibrolysis (the process of liquefaction of blood clots).
On this page you will find all information about Aminocaproic Acid: the full instructions for use for this medicated medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Aminocaproic acid. Want to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Conditions of leave from pharmacies
It is released on prescription.
Price list
How much is Aminocaproic acid? The average price in pharmacies is at the level of190 rubles.
.Form of issue and composition
Aminocaproic acid is a drug haemostatic drug that inhibits the conversion of profibrinolysin into fibrinolysin.
Issued by:
- Powder for the preparation of solution for intravenous use;
- Granules (Aminocaproic acid for children);
- 5% solution of the agent in isotonic sodium chloride solution.
Aminocaproic acid can be used:
- For intravenous injection. This method is most in demand with acute bleeding, as well as during surgical treatment.
- For oral administration. This use of the drug is indicated not only for bleeding, but also for rotovirus.
- For instillation in the nose. It is used as a ready-mixed solution or powdered or granulated aminocaproic acid mixed with unsweetened water (a 5% solution is also prepared from this form of the drug).
- For inhalations. The procedures are performed by a nebulizer with adenoids, with coughing, as well as with a prolonged runny nose or with sinusitis.
- For washing the nose. This manipulation is sometimes prescribed to remove yellow or green dense nasal discharge. In this case, the rinsing must necessarily be performed by a doctor, since an incorrect procedure can cause increased edema and irritation of the mucosa.
Pharmacological effect
Aminocaproic acid is an antihemorrhagic and haemostatic drug that has a specific haemostatic effect in bleeding related to an increase in fibrinolysis (the process of dissolution of clots blood).
This drug helps to reduce the permeability of capillaries, as well as the inhibition of fibrinolysis in general. Aminocaproic acid increases the antitoxic ability of the liver, exhibits moderate anti-shock and anti-allergic activity. The drug is able to improve some indicators of specific and nonspecific protection in ARVI.
After application, the maximum concentration of aminocaproic acid in the blood is observed after 2-3 hours. There is practically no binding to plasma proteins. The main part of the drug is excreted by the kidneys in an unchanged form, and 10-15% is biotransformed in the liver. Accumulation of aminocaproic acid occurs only if there are violations of the urinary function.
Indications for use
According to the instructions, Aminocaproic acid is prescribed for the prevention and control of bleeding, which associated with increased fibrinolytic activity, or a state of hypofibrinogenemia and afibrinogenemii.
Indications for the use of the drug are:
- Complicated abortion and uterine bleeding;
- Premature detachment of the placenta;
- Operations in the field of ENT organs and nasal bleeding;
- Surgical operations on organs that are rich in fibrinolysis activators (brain, lungs, adrenal glands, uterus, pancreas, thyroid and prostate gland);
- Extracorporeal circulation;
- Postoperative recovery period (for vascular and heart surgery);
- Burn disease;
- Diseases of internal organs complicated by hemorrhagic syndrome (bleeding from the bladder, gastrointestinal bleeding).
Old-school doctors are often prescribed for ENT pathologies. In such cases, it is used to:
- elimination of edema of the mucous membrane and a feeling of nasal congestion;
- reduce the amount of mucus produced;
- decrease in the severity of the inflammatory process, in particular, with allergic rhinitis;
- stopping nasal bleeding.
Since ACC is a compound that is close to the human body, in many cases it is prescribed even for the prevention of complications in the mild forms of rhinitis. But such a preventive measure is shown only in the presence of a tendency in the child to nosebleeds or diseases accompanied by increased fragility of the capillaries.
Thus, the medicine is indicated when:
- rhinitis of any etiology, including allergic;
- all kinds of sinusitis;
- adenoid;
- nasal bleeding;
- flu and ARI.
Also, aminocaproic acid is often buried in the nose of a child to prevent the development of SARS in the so-called cold season.
Contraindications
The drug is contraindicated in:
- Individual intolerance;
- Propensities to thrombosis and thromboembolic diseases;
- Diseases of the kidneys with a violation of their function;
- Coagulopathies based on diffuse intravascular coagulation;
- DIC-syndrome;
- Pregnancy and lactation;
- Violations of cerebral circulation;
- Bleeding from the upper respiratory tract of unknown origin.
Application in pregnancy and lactation
The drug is not prescribed for pregnant and lactating women. This remedy is inappropriate in those cases when there is a possibility of increased blood loss during childbirth, because in the postpartum period thromboembolic complications may develop.
Instructions for use
The instructions for use indicate that Aminocaproic acid is applied IV, drip.
If it is necessary to achieve a rapid effect (acute hypofibrinogenemia), inject up to 100 ml of 50 mg / ml solution at a rate of 50-60 drops per minute for 15-30 minutes. During the first hour, 4-5 g (80-100 ml) is administered and then, if necessary, 1 g (20 ml) every hour for about 8 hours or until the bleeding is completely stopped.
In the case of ongoing or repeated bleeding infusion, 50 mg / ml aminocaproic acid solution is repeated every 4 hours.
Children, at the rate of 100 mg / kg - in 1 hour, then 33 mg / kg / h; the maximum daily dose is -18 g / m 2. The daily intake for adults is 5-30 g. Daily intake for children under 1 year - 3 g; 2-6 years - 3-6 g; 7-10 years - 6-9 g, from 10 years - as for adults. In acute blood loss: children under 1 year - 6 g, 2-4 years - 6-9 g, 5-8 years - 9-12 g, 9-10 years - 18 g. Duration of treatment is 3-14 days.
Aminocaproic acid in the nose: Instruction
It is also recommended to use the drug Aminocaproic acid in the nose (child or adult), locally. By laying for 10 minutes in the nasal passage of cotton turundum every three hours, pre-moistened solution of 5% aminocaproic acid, or by observing the specified multiplicity, instill 4-5 drops of the solution in nasal passages. The drug can be used for inhalations for children and adults. In such cases, a nebulizer may be used for inhalations to the child.
- In case of severe hypertoxic types of influenza or acute respiratory viral infection, the dosage of the drug is allowed to be raised to the maximum recommended at this age with a moderate increase in fibrinolytic activity.
- Aminocaproic acid, if necessary, can be used in combination with other antiviral drugs, interferon-containing agents and interferon inducers.
- Intranasal instillation of aminocaproic acid up to four times a day is advisable during the epidemic period for prevention.
The duration of therapy depends on the severity of the disease and is determined by the individual doctor.
Side effects
Aminocaproic acid is usually well tolerated, but the following adverse reactions may occur.
- From the nervous system: headache, dizziness, tinnitus, convulsions.
- From the cardiovascular system: orthostatic hypotension, subendocardial hemorrhage, bradycardia, arrhythmia.
- From the side of the digestive tract: nausea, vomiting, diarrhea.
- From the coagulation system: a blood clotting disorder.
- Other: possible hypersensitivity reactions (incl. Catarrhal phenomena of the upper respiratory tract), skin rash, myoglobinuria, rhabdomyolysis, acute renal failure.
Adverse events are rare and dose-dependent; when the dose is reduced, they usually disappear.
With topical application of ACC, it is quite safe and very rarely causes the development of undesirable effects and side effects.
Overdose
Symptoms of an overdose of aminocaproic acid:increased side effects, the formation of thrombi, embolism. With prolonged use (more than 6 days) of high doses (for adults - more than 24 grams per day) - hemorrhages.
Treatment:withdrawal of the drug, symptomatic therapy.
special instructions
Before you start using the drug, you should carefully read the instructions for its use. It is worth paying attention to the features of its use:
- Long-term administration of aminocaproic acid or its intravenous administration as a solution should be accompanied by laboratory monitoring of the functional state of the blood coagulation system.
- During the period of drug use, it is necessary to refuse to take fatty foods, which can provoke thrombus formation in vessels with subsequent thromboembolism.
- Do not take Aminocaproic acid with oral contraceptives, as this can increase blood clotting.
- During the treatment period, it is impossible to perform work related to the need for increased concentration of attention and speed of psychomotor reactions.
Drug Interactions
Can be combined with the introduction of hydrolysates, glucose solutions (dextrose solutions), anti-shock solutions. In acute fibrinolysis, the administration of aminocaproic acid with a fibrinogen content of 2-4 g (maximal 8 g) must be supplemented with a subsequent infusion.
Do not add any medications to the aminocaproic acid solution.
Antiaggregate decrease with simultaneous reception of anticoagulants of direct and indirect action.
Reviews
ENT doctors speak about aminocaproic acid well and have been using such a medicament for treating various ENT pathologies for years. They note the effectiveness of this remedy in viral rhinitis, inflammation of the nasal mucosa, sinusitis, and nosebleeds. They are attracted by the fact that, compared with other drugs from the cold, aminocaproic acid does not dry the mucous membrane and does not provoke a narrowing of the vessels.
Most mothers who used aminocaproic acid in rhinitis for treatment or for prophylactic purposes, too, leaves positive feedback. They note a fairly rapid action in rhinitis, affordable cost of the medicine, as well as safety for the child. Minuses of use in the common cold are called complications with the administration of the drug in the nose, since aminocaproic acid is sold without a pipette, and the bottle opens uncomfortably.
Analogues
The same active substance has a preparation Polikapran.
Before using analogues, consult your doctor.
Storage conditions and shelf life
Shelf life is 3 years. Store in a dark place inaccessible to children, with a temperature not exceeding + 25 ° C.
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