Senadexin

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Senadexin is a laxative plant-based drug, which, due to its low cost, is one of the most common drugs to fight constipation.

One of the significant disadvantages of this medication is that with prolonged use the intestine ceases to work independently. The composition of Senadixin includes a sheet of hay, which has a positive effect on intestinal motility.

Antraglikozidy (organic compounds), pass, not sucked through the stomach and small intestine, and getting into the large intestine, I begin to act. Under the influence of intestinal bacteria, they are split into substances that irritate the receptors of the large intestine.

Clinical and pharmacological group

Laxative means of plant origin.

Terms of sale from pharmacies

You can buy without a doctor's prescription.

Price

How much does Senadexin cost in pharmacies? The average price is at the level of25 rubles.

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Composition and form of release

Medicinal form of Senadexin - tablets (10 or 20 pcs. Each). packaged).

  • The active substance of the drug is senna leaf extract (7 g in 1 tablet) containing 20% ​​calcium salts of sennosides A and B.
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Auxiliary components: methylparaben, vanillin, magnesium stearate, corn starch, stearic acid, lactose monohydrate, croscarmellose sodium, microcrystalline cellulose.

pharmachologic effect

Pharmacological action of the drug is provided by substances called anthraglycosides, mainly group A and B coenzymes.

When using the drug inside, its active components pass through the intestinal tract, bypassing the stomach and small intestine in unchanged form. In the area of ​​the large intestine, they under the influence of intestinal bacteria acquire other therapeutically significant forms.

  • Glycosides break down into anthranol and antrones, which in this form can become irritating factors for receptors of the intestinal mucosa. Thus, peristalsis in the intestinal region is activated, and the process of defecation is accelerated.
  • Antrons and anthranols prevent the absorption of water and electrolytes, and also affect the diffusion of water into the lumen of the intestine. And due to the osmotic effect, the feces increase in volume, they soften - and this all contributes to the acceleration of peristalsis and activates the process of the release of the intestine from content.

The therapeutic effect occurs in the intervalfrom 6 to 12 hours after admission.

With prolonged useThe effectiveness of the drug is reduced due to a decrease in potassium in the body.

Indications for use

What helps? Senadexin is used in the following cases:

  1. With acute or chronic constipation with intestinal atony;
  2. In preparation for surgical interventions and diagnostic procedures;
  3. For the regulation of stool with hemorrhoids and anal fissures.
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Contraindications

Absolute:

  • Strangulated hernia;
  • Spastic constipation;
  • Abdominal pain of unknown origin;
  • Violations of water-electrolyte metabolism;
  • Cystitis;
  • Uterine and gastrointestinal bleeding;
  • Peritonitis;
  • Acute inflammatory diseases of the abdominal cavity;
  • Intestinal obstruction;
  • Children under 6 years;
  • Hypersensitivity to the components of the drug.

Relative (should be used with caution, since the likelihood of complications is high):

  • Diseases of the liver and / or kidney;
  • Pregnancy;
  • Breastfeeding period.

Intended use for pregnancy and lactation

It is recommended to refrain from accepting funds in specified periods.

Dosage and route of administration

As indicated in the instructions for use of the tablet, Senadixin is taken at night, with plenty of water. In accordance with the instructions, Senadexin is taken as needed, 1-2 tablets once, or courses of 2-3 weeks. After three weeks of taking a long break, not less than 2 weeks.

Dosage:

  • For children over 12 years and adults 1-2 tablets 1 time per day, before bedtime.
  • Children from 6 to 12 years are prescribed for ½-1 tablet once a day, children from one to six years for 1/3 tablets. Children under the age of one year are not prescribed Senadexin.
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Side effect

In some cases, with the use of Senadexin, the following side effects are noted: colicky pain in the abdomen, flatulence, digestive disorders, intestinal atony, dehydration, anorexia, allergic reaction.

With prolonged use of the drug, especially in high doses, hypokalemia, albuminuria, pseudomelanosis intestines, hematuria, nausea, vomiting, urine discoloration, diarrhea, convulsions, confusion, vascular collapse.

Overdose

If there is a significant excess of the recommended therapeutic dosage of Senadexin tablets, severe diarrhea develops with rapid loss of mineral salts and fluid from the body. In this case, pathogenetic therapy with intravenous administration of solutions of electrolytes is carried out.

special instructions

Senadecin is not recommended for more than 14 days.

After taking the drug, urine can be painted red-brown or yellow-brown in color.

Use with caution in diseases of the liver and / or kidney. Can be used for preoperative preparation of patients.

Interaction with other drugs

With the simultaneous use of Senadixin: with antibiotics of the tetracycline series - their absorption is disturbed; from licorice root preparations, glucocorticosteroids, thiazide diuretics - the risk of developing hypokalemia.

With prolonged use of the drug in high doses, it is possible to influence the action antiarrhythmic drugs (increases the likelihood of hypokalemia) and increased action cardiac glycosides.

Reviews

The patients' opinion about "Senadexin" was divided. Some consider it an excellent remedy for constipation, which brought them the long-awaited relief. Others, on the contrary, talk about its weak therapeutic effect. However, most of the reviews about this laxative are positive.

Despite the fact that it has a vegetable origin and the instructions indicate a rather large list of side manifestations, many patients did not feel the negative effects of the drug in the form of allergies or problems with digestion. Those who have been helped by the medicine are told that the painful sensations after taking in the intestines pass, and the positive result comes rather soon and does not cause excessive discomfort.

Analogues

Structural analogs for the active substance:

  • Bekunis dragees;
  • Herbion Laxana;
  • Glaxen;
  • Iksprep;
  • Pursennid;
  • Regulax;
  • Senadé;
  • Senales;
  • Senna;
  • Sennalax;
  • Senna leaf extract (Sennosides A and B calcium salts);
  • Thyssen;
  • ExLax.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store at temperatures up to 25 ° C in the original packaging. Keep away from children.

Shelf life - 3 years.


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