Sulfadimethoxin

Sulfadimethoxin is a chemical analogue of paraaminobenzoic acid, a substance vital to bacteria and some protozoa (toxoplasm) for the synthesis of its DNA.

Sulfadimethoxin is absorbed by bacteria, disrupts the formation of nucleic acids, as a result, the cell of the pathogen can not reproduce and function normally.

The drug is active against gram-positive and gram-negative microorganisms: streptococci, staphylococci, protea, E. coli, Klebsiella, Shigella and Salmonella, cholera vibrio, gonococcus, toxoplasm, causative agent of trachoma.

Clinical and pharmacological group

Antibacterial agent, a sulfonamide derivative.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Sulfadimethoxin cost in pharmacies? The average price is at the level of35 rubles.

Composition and form of release

Dosage form Sulfadimetoksina - tablets: white or white with a cream shade, flat-cylindrical shape, with a risk and chamfer (in contour mesh or cell-free packages of 10 pcs., in a carton pack of 1 or 2 packs; in polymer banks of 10 pcs., in a cardboard bundle of 1 can; in a polyethylene pencil case for 15 pcs.; in dark glass jars of 20 pcs., in a cardboard bundle of 1 can).

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Composition of 1 tablet:

active substance: sulfadimethoxin - 0.2 or 0.5 g;
auxiliary components (0.2 / 0.5 g of active ingredient): aerosil (colloidal silicon dioxide) - 0.000 44 / 0.001 1 g; potato starch grade "Extra" - 0.016 92 / 0.042 3 g; calcium stearate - 0.002 2 / 0.005 5 g; medical gelatin - 0.000 44 / 0.001 1 g.

pharmachologic effect

The drug is effective against bacterial infections. The mechanism of its action is the inhibition of the enzyme glucose-6-dehydrogenase, responsible for the synthesis of dihydrofolic acid (a variety of folic). It is necessary for bacteria to produce purines and pyrimidines, which are part of the DNA of the cell. The active substance of the drug stops the reproduction, and does not kill the encapsulated bacteria, which are at rest in the body, does not cause resistance.

The active ingredient is an analog of para-aminobenzoic acid, it breaks the metabolism of bacteria and produces enzymes of phosphatases. Sulfadimethoxin inhibits the multiplication of gram-positive staphylococci, streptococci, gram-negative intestinal sticks, Friedlander sticks, Klebsiella, pneumococci, causative agents of dysentery and other shigellosis infections. The drug depresses the growth of chlamydia, weakly affects the proteas.

The drug is found in the blood half an hour after intake, reaches a maximum concentration after 8-12 hours, poorly penetrates through the blood-brain barrier, therefore is ineffective against meningitis (caused by meningococcus) and inflammatory processes of the brain. The active substance of the composition soon after absorption in the gastrointestinal tract is found in the joint and peritoneal fluid, pleural effusion, exudate of the middle ear. Metabolism of the component occurs in the liver, it is excreted in the urine and bile.

Indications for use

What helps? Sulfadimethoxin is used for the treatment of infectious inflammatory diseases (caused by microorganism-sensitive microorganisms sensitive to sulfadimethoxin), such as:

pneumonia,
erysipelas,
pyoderma,
trachoma,
angina,
otitis,
sinusitis,
acute respiratory infections,
bronchitis,
inflammatory diseases of the urinary and bile ducts,
dysentery,
drug-resistant forms of malaria (in combination with antimalarial drugs),
inflammatory lesions of the central nervous system, wound infections.

Contraindications

According to the instructions, Sulfadimethoxin is contraindicated in the following cases:

azotemia;
porphyria;
pregnancy and lactation period (the appointment of Sulfadimethoxin is possible only in cases of excess of the expected benefit over possible harm);
age up to 3 months;
thyroid disease;
oppression of bone marrow hematopoiesis;
congenital deficiency of glucose-6-phosphate dehydrogenase;
hepatic / renal insufficiency;
chronic heart failure;
individual intolerance of the drug components.

Caution in the use of Sulfadimethoxin (relative contraindications) is required in the presence of the following diseases / conditions:

anemia with a reduced color index;
functional disorders of the liver / kidney;
deficiency of folic acid.

Intended use for pregnancy and lactation

Sulfadimethoxin is highly undesirable for use in pregnancy and during breastfeeding, as it penetrates well through the placenta and into breast milk, and can cause a child to have dyspepsia, liver and kidney damage, nuclear jaundice or hemolytic anemia.

Dosage and route of administration

As indicated in the instructions for use before starting the test, it is necessary to check the sensitivity to this medicine of pathogenic microflora. The use of sulfadimethoxin in the absence of sensitivity does not make sense, since the harm caused by the active substance to the body exceeds the benefit of fighting with pathogenic bacteria.

Adults on the first day are prescribed a dose of 1000 mg, then - 500 mg per day. In the case of a severe course of infection, it is possible to increase the starting dose to 2 mg, and daily - up to 1 mg. Take the medicine once a day, after eating. Duration of treatment is 7-10 days.
Children prescribe medication at a dose of 25 mg / kg of weight on the first day, and 12.5 mg / kg per day on subsequent days.
Reception of the drug should necessarily take another 2-3 days after lowering body temperature. During the application of the drug, it is necessary to limit the patient's exposure to the sun, or getting it under the influence of ultraviolet irradiation.

It is necessary to strictly observe the time interval for taking tablets. Do not take a double dose, if the drug was not taken on time. In this case, you should drink it as soon as possible, and do not shift the intake too close to the next to avoid an overdose.

In veterinary medicine of small domestic animals, children's dosages of the drug are used.

Side effect

The use of Sulfadimethoxin can cause the following side effects:

Central nervous system: a headache is possible.
The system of hematopoiesis: rarely - agranulocytosis, leukopenia.
Digestive system: cholestatic hepatitis, nausea, dyspeptic symptoms, vomiting.
Allergic manifestations: drug fever, skin rashes

Overdose

The state of supersaturation of the body with the drug is clinically manifested in intense thirst, severe dryness in the mouth, a small amount saturated yellow-brown urine, pain in the right hypochondrium (projection of the liver) and lower back (renal localization). Biochemical analysis will reveal a significant increase in such enzymes as AST, ALT and acid phosphatase.

Therapeutic measures for overdose:

Reflexogenic initiation of vomiting.
Gastric lavage or high cleansing enema.
Astringent and absorbent preparations orally.
Saline laxatives.
Forced diuresis, if the drug has fully absorbed from the gastrointestinal tract.

special instructions

It is applied externally as a part of combined preparations.

During treatment, an abundant alkaline drink is recommended, monitoring the blood and urine.

Interaction with other drugs

Sulfadimethoxin reduces the effectiveness of bactericidal antibiotics acting only on fissile microorganisms (including penicillins, cephalosporins).

Reviews

We offer you to familiarize yourself with the opinions of people who used the drug Sulfadimethoxin:

Lilya. An excellent product, quickly puts on its feet. We forgot about him, but in vain. The husband only escapes them from any colds and inflammations. And recently my mother, 75, was cured of otitis for 3 days by sulfadimethoxin. I advise everyone.
Olga. I have chronic bronchitis with an asthmatic component, very long time doctors did not prescribe antibiotics, namely sulfadimethoxin + euphyllin = the effect is very good and inexpensive. But very individual, especially with heart failure.
Sasha. Sulfadimethoxin in tablets, a couple of years ago, helped me a lot during a flu or cold. I drank these pills constantly, as I started to get sick, three tablets at a time on the first day, the next day 2 tablets and for 3 days 1 tablet, but I had enough and one day to feel good. Now, though I will drink a pack of these pills and no result. Maybe it's my body accustomed to them, or the pharmacists began to make a poor-quality medicine.

Reviews of doctors about the drug confirm the effectiveness of the drug in the fight against coccal infection internal organs and skin, if fully consistent with the conservative course of treatment. Otherwise, pathogenic microorganisms develop resistance to a whole group of drugs, since all sulfonamides have a typical chemical structure.

Analogues

Structural analogues of the active substance of the drug Sulfadimetoksin does not.

Similar to the action of drugs:

Sulfamonomethoxin, Sulfamethoxypyrazine (Sulfalen), Sulfadiazine (Sulfazin), Sulfamethoxazole.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The drug should be stored away from light sources, in a dark place. It is also recommended to hide the tablets out of the reach of children. The medicine can be stored for up to 5 years. It is not recommended to apply the drug after the expiration of this period. The date of manufacture should be looked at the package of the preparation.