Galvus Met in Diabetes

width = Galvus Met is an effective cure for type 2 diabetes, which is very popular, despite its high price.

It lowers blood sugar and rarely causes serious side effects. The active ingredients of the combined preparation are vildagliptin and metformin.

On this page you will find all information about the Galvus Met: full instructions for use on this medicinal medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Galvus Met. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Oral hypoglycemic drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Galvus Met cost? The average price in pharmacies is at the level of1 600 rubles.

Form of issue and composition

Dosage form Galvus Met - tablets coated with a film sheath: oval, with bevelled edges, on one side, the NVR marking; 50 + 500 mg - light yellow with a faint pinkish hue, marking on the other side of the LLO; 50 + 850 mg - yellow with a weak grayish tinge, marking on the other side - SEH; 50 + 1000 mg - dark yellow with a grayish tint, marking on the other side - FLO (in blisters for 6 or 10 pcs., In a cardboard bundle 1, 3, 5, 6, 12, 18 or 36 blisters).

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1 tablet of 50 mg / 850 mg contains 50 mg of vildagliptin and 850 mg of metformin hydrochloride;
1 tablet of 50 mg / 1000 mg contains 50 mg of vildagliptin and 1000 mg of metformin hydrochloride;

Excipients: hydroxypropylcellulose, magnesium stearate, hypromellose, titanium dioxide (E 171), polyethylene glycol, talc, iron oxide yellow (E 172).

Pharmacological effect

The composition of the drug Galvus Met includes 2 hypoglycemic agents with different mechanisms of action: vildagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4), and metformin (in the form of a hydrochloride), a representative of the class biguanides. The combination of these components makes it possible to more effectively control the concentration of blood glucose in patients with type 2 diabetes mellitus within 24 hours.

Indications for use

Reception Galvus Meta is shown in the following cases:

with type 2 diabetes, when other treatment options did not work;
in the case of ineffective therapy with metformin or vildagliptin as separate drugs;
when the patient had previously used drugs with similar components;
for the integrated treatment of diabetes in conjunction with other hypoglycemic drugs or insulin.

Contraindications

The drug was tested on conditionally healthy patients who do not have serious illnesses and serious health problems.

It is not recommended to take Galvus Met:

Persons who have intolerance to vildagliptin or to components that are part of the tablets.
To the teenagers who have not reached majority. Such a warning is caused by the fact that the effect of the drug on children has not been tested.
Patients with severe impairment of liver and kidney function. This is due to the fact that active components of the drug can lead to complete failure of these organs.
People who have reached advanced age. Their body is sufficiently worn out to expose it to additional loads, which create substances that are part of the galvus.
Pregnant women and nursing mothers. Recommendations are justified by the fact that the reaction of the organism of this category of patients to the drug was not investigated. There is a certain risk of impaired glucose metabolism, congenital anomalies and sudden death of newborns.

When exceeding the maximum allowable dose of taking medicine, there were no serious deviations in health in people.

Application in pregnancy and lactation

There is insufficient data on the use of Galvusmet in pregnant women. Studies of vildagliptin on animals have revealed reproductive toxicity in high doses. In studies of metformin on animals, this effect has not been shown. Studies of combined use in animals showed no teratogenicity, but fetotoxicity was detected at doses toxic to the female. The potential risk in humans is unknown. G alvusmeth should not be used during pregnancy.

It is not known whether vildagliptin and / or metformin penetrates human milk in human milk, therefore G alvusmet should not be given to women during breast-feeding.

Studies of vildagliptin in rats at doses equivalent to more than 200 times the dose in humans showed no impairment of fertility and early embryonic development. Studies of the influence of Galvusmet on fertility in humans have not been conducted.

Instructions for use

The instructions for use indicate that Galvus Met is used inside. The dosage regimen should be selected individually, depending on the effectiveness and tolerability of therapy. When using Galvus Met, do not exceed the recommended maximum daily dose of vildagliptin (100 mg).

The recommended initial dose of Galvus Meth should be selected, taking into account the duration of diabetes mellitus and the level of glycemia, the patient's condition and already used in the patient's regimens for treatment with vildagliptin and / or metformin. To reduce the severity of gastrointestinal side effects associated with metformin, Galvus Met is taken with meals.

The initial dose of Galvus Met with ineffectiveness of monotherapy with vildaglyptin:

Treatment with Galvus Met can be started with a single tablet with a dosage of 50 mg + 500 mg twice a day; After evaluating the therapeutic effect, the dose can be gradually increased.

Initial dose of Galvus Met with ineffective monotherapy with metformin:

Depending on the dose of metformin already taken, treatment with Galvus Met can be started with a single tablet with a dosage of 50 mg + 500 mg, 50 mg + 850 mg or 50 mg + 1000 mg 2 times / day.

The initial dose of Galvus Met in patients who previously received combination therapy with vildagliptin and metformin as separate tablets:

Depending on the doses of vildagliptin or metformin already taken, treatment with Galvus Meth should be started with a tablet, maximally close in dosage to existing treatment, 50 mg + 500 mg, 50 mg + 850 mg or 50 mg + 1000 mg, and adjust the dose depending on the effectiveness.

The starting dose of Galvus Met as an initial therapy in patients with type 2 diabetes mellitus with insufficient effectiveness of diet and exercise:

As a starting therapy, Galvus Met should be used in an initial dose of 50 mg + 500 mg 1 once / day and after evaluating the therapeutic effect, gradually increase the dose to 50 mg + 1000 mg 2 times / day.

Combination therapy with Galvus Meth and sulfonylureas or insulin derivatives:

The dose of Galvus Meth is calculated based on the dose of vildagliptin 50 mg x 2 times / day (100 mg / day) and metformin in a dose equal to that previously taken as a mono drug.

Metformin is excreted by the kidneys. Because patients with over 65 years of age are often noted to have impaired renal function, the dose of Galvus Meth in these patients should be adjusted based on the indicators of kidney function. When using the drug in patients older than 65 years, it is necessary to regularly monitor the kidney function.

Side effects

The use of drugs and Galvus Met can affect the work of internal organs and the state of the body as a whole. The most common side effects are:

aches and pains of an acute nature in the abdomen;
allergic skin rashes;
disorders, constipation and diarrhea;
edema;
dizziness and headaches;
trembling of limbs;
a feeling of chills;
nausea accompanied by vomiting;
liver and pancreas disease, for example, hepatitis and pancreatitis;
strong peeling of the skin;
gastroesophageal reflux;
low resistance of the body to infections and viruses;
low working capacity and fast fatigue;
occurrence of blisters.

Overdose

If the recommended therapeutic dose is significantly exceeded, nausea, vomiting, severe muscle pain, hypoglycemia and lactic acidosis (the result of metformin) may be observed. In such cases, the drug is stopped, gastric, intestinal and symptomatic washing is performed.

special instructions

Do not try to replace injections of insulin with Galvus or Galvus Met. It is advisable to pass blood tests that check the functioning of the kidneys and liver, before starting treatment with these drugs. Repeat the test once a year or more often. Metformin should be discontinued 48 hours before the forthcoming surgery or X-ray examination with the introduction of a contrast agent.

Drug Interactions

Vildagliptin rarely interacts with other drugs.

Metformin can interact with many popular medicines, in particular, with tablets from high blood pressure and thyroid hormones. Talk to your doctor! Tell him about all the drugs that you take before you are prescribed a diabetes treatment regimen.

Reviews

We picked up some feedback from people about the drug:

Natasha. I have an initial diabetes mellitus, the sugar stably kept at the mark,. Have registered to drink Galvus Met, Glukofazh and to observe special rules of a delivery. Honestly, since I was diagnosed with diabetes and I started taking pills and sticking to a diet, I began to feel much better. Already in the first month, as I began to drink Galvus Met, drowsiness and constant thirst had left. I became cheerful, more mobile. Then I started taking Glucophage, and now I feel like I'm a healthy normal person. Two months after the start of the Galvus Meta intake, she measured the sugar, the analysis showed 5 units. That is, it's almost normal for a healthy person!
Elena. Constantly I buy this drug for my mother. She has been suffering with diabetes for more than ten years. He suits her. With regular intake of this drug, she feels much better. It happens that he will forget to buy a new pack, and the old one is over, then her condition is just awful. Sugar in the blood rises, and it can not do anything, only lies, until it takes this pill. I buy all the medicines for parents, so I know that the price of this drug is acceptable, and this is a big plus.
Anna. I would like to talk about the preparation Galvus Met. Its distinctive feature is that it really helps, in contrast to cheaper analogues. I take it not for the first time and until I found nothing better. Do not forget about a strict diet and do not really get involved in physical exercises - there are people who after the physical exertion of sugar in the blood. The most important thing for me is that with the taking of pills I have more strength, I can do something and not feel limited. Many of my friends who accept it, have not switched to insulin, which is very cool.