Ranitidine

width = Ranitidine - a medicine without which the treatment of peptic ulcer of the stomach or duodenum is not complete.

Being both the most accessible and effective enough, it gained popularity both among family doctors and among specialists of a narrow profile (the drug is often used in surgery before surgery to prevent the transfer of gastric contents into respiratory ways).

The mechanism of action of Ranitidine is directly related to the blocking of histamine receptors that are in the stomach. This leads to a significant decrease in the secretion of hydrochloric acid and prevention of further destruction of the mucosa. This property allows you to take it for medical purposes, and for the prevention.

Clinical and pharmacological group

The blocker of histamine H2 receptors. Antiulcer drug.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much is ranitidine in pharmacies? The average price is at the level of45 rubles.

Composition and form of release

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Dosage form - tablets covered with a film membrane: round, biconvex, light orange (in blisters 10 tab., 2 blisters in a cardboard box).

Active ingredient: ranitidine (in the form of hydrochloride) - 150 or 300 mg in 1 tablet.

Auxiliary components: Kollidon VA-64, corn starch, silicon colloidal dioxide, propylene glycol, polyethylene glycol 6000, sodium lauryl sulfate, hypromellose, magnesium stearate, ethyl cellulose, microcrystalline cellulose, titanium dioxide, dye sunset sunset yellow.

pharmachologic effect

The main drug effect of the drug is due to the blockage of ranitidine hydrochloride H2-histamine receptors of the lining of the gastric mucosa. Also, the substance significantly reduces the stimulated and basal production of hydrochloric acid, provoked by food loads, stimulation of pressoreceptors, exposure to biogenic stimulants and hormones (eg, histamine, gastrin or pentagastrin). When using the product

Ranitidine there is a marked decrease in the amount of hydrochloric acid and the total volume of gastric juice, increase in the pH of the stomach environment, which causes a decrease in the activity and action of the enzyme pepsin. If the therapeutic dosages prescribed by the doctor are observed, the medication does not directly affect the concentration of prolactin. The drug has an inhibitory effect on microsomal oxygenases.

The intake of food does not affect the rate of absorption of ranitidine hydrochloride from the gastrointestinal tract. Biological availability is approximately 50%. The ability to build connections with serum proteins is no more than 15%. The maximum concentration in plasma is achieved on average 3 hours after oral administration. The duration of therapeutic action is 12 hours.

It is subjected to primary metabolism in the liver. The half-life is between 3 and 9 hours. Excretion occurs mainly with urine (70%, of which 35% unchanged) and feces (30%).

The substance can penetrate through the placental barrier and stand out with breast milk.

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Indications for use

What helps? Indications for Ranitidine are the following:

Zollinger-Ellison syndrome.
Erosive esophagitis, reflux esophagitis.
"Stress" and postoperative ulcers of the upper gastrointestinal tract - for the purpose of treatment and prevention.
Ulcers of the duodenum and stomach, caused by the intake of NSAIDs - for the purpose of treatment and prevention.
Aspiration of gastric juice in surgical interventions under general anesthesia (Mendelssohn syndrome) - for the prevention.
Bleeding from the upper gastrointestinal tract - to prevent relapses.

Contraindications

Absolute:

Children up to 12 years;
Pregnancy and lactation;
Individual hypersensitivity to the components of Ranitidine.

Relative:

Cirrhosis of the liver with portosystemic encephalopathy in history;
Hepatic and / or renal insufficiency;
Acute porphyria, in history including.

Intended use for pregnancy and lactation

Controlled and adequate studies proving the safety of Ranitidine in pregnancy are not available, which makes it impossible to assign it to this category of patients. Lactation is stopped for the period of treatment for the health of the child.

Dosage and route of administration

As indicated in the instructions for use Ranitidine is taken regardless of food intake, without chewing, squeezed with a small amount of liquid. Assign only adults and children over 12 years.

Averaged Dosages:

Prevention of recurrent bleeding. For 150 mg 2 times / day.
Postoperative and "stressful" ulcers. Assign 150 mg 2 times / day for 4-8 weeks.
Ulcers associated with taking NSAIDs. Assign 150 mg 2 times / day or 300 mg per night for 8-12 weeks. Prevention of ulceration when taking NSAIDs - 150 mg 2 times / day.
Stomach ulcer and duodenal ulcer. For treatment of exacerbations appoint 150 mg 2 times / day (morning and evening) or 300 mg at night. If necessary, 300 mg twice a day. The duration of the course of treatment is 4-8 weeks. To prevent exacerbations appoint 150 mg at night, for smokers - 300 mg at night.
Zollinger-Ellison syndrome. The initial dose is 150 mg 3 times / day, if necessary, the dose can be increased.
Erosive reflux esophagitis. Assign 150 mg 2 times / day or 300 mg at night. If necessary, the dose may be increased to 150 mg 4 times / day. The course of treatment is 8-12 weeks. Prolonged preventive therapy - 150 mg 2 times / day.
Prevention of the development of Mendelssohn syndrome. Assign a dose of 150 mg for 2 hours before anesthesia, and preferably 150 mg the night before.

If there is a concomitant liver function disorder, a dose reduction may be required.

Patients with renal insufficiency with CC less than 50 ml / min the recommended dose is 150 mg / day.

Side effect

Side effects with Ranitidine are rare. It can be the phenomena connected with the cardiovascular and nervous systems, the digestive tract.

Adverse reactions associated with the cardiovascular system:

bradycardia;
lowering blood pressure;
atrioventricular blockade, mainly with parenteral administration;
arrhythmias.

Adverse reactions associated with the nervous system:

dizziness,
headache,
increased fatigue,
drowsiness,
noise in ears,
decreased clearness of vision.

In seriously ill patients, confusion, hallucinations are possible.

Adverse reactions associated with the gastrointestinal tract:

nausea,
vomiting,
constipation,
diarrhea,
abdominal pain.

Also, allergic reactions of the following type are not excluded:

hives,
rash,
angioedema.

Possible changes in the composition of the blood (thrombocytopenia, leukopenia, agranulocytosis), hepatitis, decreased potency or libido, gynecomastia, dry mouth, arthralgia and myalgia, bronchospasm, hair loss.

Overdose

Symptoms of overdose: bradycardia, convulsions, ventricular arrhythmias.

As a treatment, symptomatic therapy is used. When there is a spasm, Diazepam is prescribed. With ventricular arrhythmias and bradycardia, the administration of Lidocaine and Atropine is indicated.

special instructions

Before you start using the drug, read the special instructions:

Safety and efficacy of ranitidine in children younger than 12 years of age have not been established.
There is evidence that ranitidine can cause acute attacks of porphyria.
Ranitidine, like all H2-histaminoblockers, is undesirable to abruptly cancel ("ricochet" syndrome).
It can be the cause of a false positive response to a sample of protein in the urine.
With long-term treatment of weakened patients under stress, bacterial lesions of the stomach are possible with the subsequent spread of infection.
Treatment with ranitidine may mask the symptoms associated with carcinoma of the stomach, so before starting treatment it is necessary to exclude the presence of cancer-ulcers.
Blockers of H2-histamine receptors should be taken 2 hours after taking itraconazole or ketoconazole in order to avoid a significant decrease in their absorption.
May increase the activity of glutamate transpeptidase.
The blockers of H2-histamine receptors can counteract the effects of pentagastrin and histamine on the acid-forming function of the stomach, therefore, within 24 hours preceding the test, use of blockers H2-histamine-receptors is not recommended.
During treatment, avoid eating foods, beverages and other medications that can cause irritation of the gastric mucosa.
Blockers of H2-histamine receptors can suppress the skin reaction to histamine, thus leading to false positive results (before carrying out diagnostic skin tests for the detection of an allergic skin reaction of an immediate type, the use of H2-histamine receptor blockers is recommended to cease).

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

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Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Smoking reduces the effectiveness of ranitidine.
Drugs that depress the bone marrow increase the risk of neutropenia.
Increases the concentration of metoprolol in the blood serum (by 80% and 50%, respectively), while the half-life of metoprolol increases from 4.4 to 6.5 h.
Due to the increase in the pH of the contents of the stomach with simultaneous intake may decrease the absorption of itraconazole and ketoconazole.
Inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propracolol, diazepam, lidocaine, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformin, metronidazole, antagonists calcium.
When used simultaneously with antacids, sucralfate in high doses, it is possible to slow the absorption of ranitidine, so a break between taking these drugs should be at least 2 hours.

Reviews

We offer to read reviews of people who used the drug Ranitidine:

Lyudmila. I "killed" the stomach in my student years. Ate, that's horrible: instant noodles, sandwiches, fried potatoes. In general, something that is fast, since there was not much time to cook. A couple of years later, pain began. Every day by the evening the stomach made itself felt. Mom advised ranitidine. Tablets are really good. Really helped with pain. I have been saving them for more than 10 years, if the pain makes itself felt.
Tatyana. About 25 years ago, I had an ulcer of the duodenal ulcer and after a hospital treatment ranitidine was prescribed to me for prevention, averno, to fix the treatment of one pill at night. I took this medicine also in the following year, already at that time, when pains appeared in the stomach. I can tell you, it helped me a lot, I can say, it saved me. But still take without a doctor's recommendation, you can not cover up the more dangerous diseases, which is written in the instructions.
Diana. This is probably the ideal remedy for the stomach, which is struck. I somehow had severe heartburn and eructations about and without reason, it was very strange. I used to eat bad food earlier and ate only fried, never ate soups and stuff. Now my diet is completely different and I eat in a normal way, so then ranitidine saved me. I slammed the tube and found the initial signs of gastritis, sat on a diet and drank every day two tablets ranitidine. It was very helpful, the only side effect was bitterness in the mouth. The gastritis has passed, and now I am healthy, and the stomach in general does not hurt, watch or keep up the delivery.

Analogues

Structural analogs for the active substance:

Acidex;
Acyl;
Gertokalm;
Gistak;
Zantak;
Zantyn;
Zoran;
Raniberle 150;
Ranigast;
Ranisan;
Ranital;
Ranitidin Sediko;
Ranitidin Sopharma;
Ranitidine Akos;
Ranitidine Acry;
Ranitidine-LekT;
Ranitidine-Ferein;
Ranitidine hydrochloride;
Ranitin;
Rantak;
Ranks;
Ulkodin;
Ulkosan;
Ullran.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The shelf life of Ranitidine tablets is 3 years from the date of manufacture. They should be stored in original original packaging, dry and out of reach of children at an air temperature of + 15 to + 30 ° C.