Tavegil

Tavegil (Tavegil) - antihistamine drug, characterized by a prolonged (prolonged) effect and not having a sedative (calming) effect.

The drug has a pronounced antihistamine effect, prevents the release from the mast cells of blood serotonin, histamine, bradykinin, which are responsible for the development of allergic reactions. Helps reduce vascular permeability, prevents the development of edema of tissues. Sedative (soothing) action in the treatment of Tavegil is not noted.

After taking the therapeutic effect begins after 30-40 minutes. The total duration of the action is 10-12 hours. It is excreted primarily through the kidneys.

Clinical and pharmacological group

The blocker of histamine H1 receptors. Anti-allergic drug.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Tavegil cost in pharmacies? The average price is at the level of225 rubles.

Composition and form of release

Dosage forms of Tavegil:

Tablets: flat, round, with bevelled edge, white or almost white, with engraving "FROM" on one side and risk on the other (5 pcs. Each). in blisters, in a cardboard bundle of 2, 3 or 6 blisters; 10 pieces each. in blisters, in a cardboard bundle of 1, 2, 3 or 6 blisters);
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Solution for intravenous and intramuscular administration: colorless or from light yellow to pale greenish yellow color, transparent (2 ml in ampoules, 5 ampoules in plastic pallets, in a cardboard box 1 pallet);
Syrup for oral administration (60 ml each in dark glass bottles, in a cardboard bundle 1 bottle complete with a dispensing cap).

Tablets composition (in 1 piece):

Active substance: klemastin (in the form of hydrofumarate) - 1 mg;
Auxiliary components: corn starch, lactose monohydrate, magnesium stearate, povidone and talc.

The composition of the solution (in 1 ml):

Active substance: klemastin (in the form of hydrofumarate) - 1 mg;
Auxiliary components: ethanol, sorbitol, sodium citrate dihydrate, propylene glycol, water for injection.

The composition of the syrup (in 5 ml):

Active substance: klemastin (in the form of hydrofumarate) - 0.5 mg;
Auxiliary components: methyl-p-hydroxybenzoate, propyl-p-hydroxybenzoate, disodium hydrogen phosphate, sorbitol 70%, potassium dihydrogen phosphate, sodium saccharin, propylene glycol, demineralized water, a mixture of fruit flavoring additives (ABRAC S-2718).

pharmachologic effect

An allergic reaction occurs when a foreign protein (allergen) enters the human body, to which the individual has increased sensitivity - it already has special cells of immune memory, capable of synthesizing antibodies.

It is at the contact of the antigen and the antibody, capable of neutralizing it, and an allergic reaction develops, which is accompanied by the release of biologically active substances - histamine, serotonin, bradykinin. It is their action on the body that explains the variety of reactions - the appearance of a sharp expansion of blood vessels, edema of the mucous membranes and subcutaneous fat, cough, a cold of various skin rashes, a sharp and uncontrolled lowering of blood pressure.

Introduction into the human body of the active substance of the drug Tavegil, klemastin, changes the mechanism of interaction histamine with specific cell receptors - they become insensitive to this substance. Accordingly, the intensity of immune hypersensitivity reactions decreases in the body, the allergy symptoms are eliminated, the itch and discomfort disappear.

Indications for use

Indications for use are allergic diseases:

Food allergy;
Dermatoses of allergic origin;
Angioedema angioedema Quincke;
Seasonal allergic rhinitis, conjunctivitis;
Acute and chronic urticaria;
In the complex therapy of internal diseases accompanied by allergic reactions (bronchial asthma, obstructive bronchitis, pneumonia, arthritis, nephritis).

Contraindications

simultaneous use of monoamine oxidase inhibitors (MAO);
diseases of the lower respiratory tract, including bronchial asthma;
the period of breastfeeding;
individual intolerance of Tavegil components.

In addition, it is contraindicated to prescribe a solution for IV and / or injection during pregnancy, with intolerance to fructose and for intra-arterial administration.

You can not take Tavegil tablets during pregnancy, as well as patients with glucose-galactose malabsorption syndrome, severe lactase deficiency, intolerance to galactose.

Age contraindications to Tavegil's appointment to children:

solution: up to 1 year;
pills: up to 6 years;
syrup: up to 1 year.

According to the instructions, Tavegil with caution is recommended to appoint with stenosing stomach ulcer, pyloroduodenal obstruction, prostatic hypertrophy complicated urinary retention, bladder neck obstruction, hyperthyroidism, increased intraocular pressure, arterial hypertension, and other cardiovascular diseases.

In addition, with extreme caution should be used syrup with stenosis of the pylorus, zakratougolnoy glaucoma.

Intended use for pregnancy and lactation

The use of Tavegil in the form of injections or tablets at any period of pregnancy is contraindicated, since the clinical experience of use is absent and it is not known how treatment can affect the fetal development of the fetus.

The active ingredients of the drug can be excreted in breast milk, so during breastfeeding therapy Tavegil is undesirable. If a woman needs treatment, the woman should stop breastfeeding.

Dosage and route of administration

As indicated in the instructions for use of the tablet, Tavegil should be taken before meals, washed down with water.

Children aged 6-12 years are prescribed 1 / 2-1 tab. before breakfast and at night.
Inside adults and children over 12 years of age appoint 1 tab. (1 mg) in the morning and evening. In cases that are difficult to treat, the daily dose can be up to 6 tab. (6 mg).

Syrup Tavegil is taken orally before breakfast and before bedtime, using the supplied measuring cup.

Adolescents from 12 years and adults are prescribed 10 ml 2 times a day, with severe forms of disease to achieve a clinical effect, the daily dose can be increased to 60 ml.

Recommended doses of Tavegil to children, depending on age:

6-12 years: 5-10 ml twice a day;
3-6 years: 5 ml 2 times a day;
1-3 years: 2-2.5 ml 2 times a day.

Side effect

If the prescribed dose is observed, side effects on the drug are rare. In individuals with increased individual sensitivity to the drug or in patients who use Tavegil for a long time, undesirable side effects may occur:

Rashes on the skin, anaphylactic shock in rare cases, swelling of the mucous membranes;
From the side of the cardiovascular system - lower blood pressure, tachycardia, heart rhythm disturbance;
From the nervous system - drowsiness, dizziness, lethargy, inhibition, apathy, asthenia, headaches;
From the respiratory system - violation of respiratory function, cough due to excessive dryness of mucous membranes;
On the part of the digestive system - dry mouth, thirst, stomatitis, abdominal pain, nausea, vomiting, diarrhea, increased activity of liver transaminases;
Local reactions when injected - infiltrate at the injection site, pain, hematoma.

If you experience any of these side effects, stop treatment and consult a doctor.

Overdose

Overdose of antihistamine drugs can lead to both depressing and stimulating effects on the central nervous system. Also, manifestations of anticholinergic action may develop: blood rushes to the upper half of the trunk, dry mouth, abnormalities of the gastrointestinal tract, fixed dilatation of the pupils.

special instructions

Before starting treatment, read the special instructions:

Tavegil in the form of tablets is contraindicated in children under the age of 6 years. For treatment of children aged 1 year, Tavegil can be used in the form of a solution for intravenous and / or intravenous administration.
To prevent distortion of skin scarification test results for allergens, the drug should be discontinued 72 hours before the allergy testing.
The tablets contain lactose, so the drug is not recommended for patients suffering from rare congenital diseases, associated with galactose intolerance, severe lactase deficiency and impaired glucose-galactose absorption.

Clemastin has a minor sedative effect (from mild to moderate in intensity), so patients who are taking Tavegil are advised to abstain from driving vehicles, working with mechanisms, as well as from other activities requiring increased attention and speed of psychomotor reactions.

Interaction with other drugs

Incompatible with simultaneous administration of MAO inhibitors.

Tavegil potentiates the effect of drugs that depress the central nervous system (hypnotics, sedatives, tranquilizers), m-holinoblokatorov, as well as ethanol.

Reviews

We offer you to read reviews of people who used Tavegil:

Novel. I feel that it helps, but I also fall asleep at the same time in the daytime, even if I drank one pill at night, stuffy nose, desire only bed rest, good luck in recovery!
A fox. 30 years ago, a dermatologist recommended Tavegil. I was rescued by tavegil and ointment by fluorocort. For a decade, I was "forgetting" the allergy. Then she could "remember" again. And again I was saved by Tavegil. Less is drowsiness! But when you suffer from itching, redness, you do not sleep at night, you can forget about drowsiness for a while.
Zoya. I finished taking Tavegil tablets literally two days ago, and I was treating allergic rhinitis. It occurs to me every spring. I'm allergic to something, but to be honest, for about six years I have not been able to figure out what it is. Sometimes it seems to me that the whole thing is in flowering trees, and sometimes it seems that all the blame is ordinary dust. I do not know what the problem is, but it is still necessary to solve it. That's why I've been taking Tavegil every spring for spring.