Sogniteff drops

Signitis is an antimicrobial solution for instillation into the eye and is used to prevent and eliminate infections of a bacterial nature.

The main component of Signtsef is the antibiotic levofloxacin, which is classified as a series of fluoroquinolines. The main advantage of the substance - the ability to stop the reproduction, growth and development of pathogenic bacteria, due to which it is actively used to treat a variety of pathologies of the organs of vision.

Penetrating and affecting the microbes, the drug concentrates in the tear fluid, gradually accumulating in it, as a result of which the number of procedures for instillation, as a rule, is small.

Clinical and pharmacological group

Antibacterial preparation of a group of fluoroquinolones for topical application in ophthalmology.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much do Signycephs cost in pharmacies? The average price is at the level of240 rubles.

Composition and form of release

Eye drops Signtsef are a clear solution, which has a light yellow color. The main active ingredient of the drug is levofloxacin, its content in 1 ml of the solution is 5 mg. Also in the composition of the preparation are auxiliary substances, which include:

• Hypromellose.
• Sodium hydroxide.
• Sodium chloride.
• Benzoalkonium chloride.
• Hydrochloric acid.
• Water for injections.

They are contained in a plastic bottle-dropper volume of 5 ml. Cardboard pack contains one plastic bottle-dropper and instructions to the drug.

pharmachologic effect

The active substance of this antibiotic is levofloxacin, one of the newest preparations of a number of fluoroquinolines. A distinctive feature of its action will be oppression of the growth of infection in the cells of the eye. This allows to stop their development in those cases when other drugs can not recognize the infection. Today SIGNITSEF has a lot of analogs based on levofloxacin.

In addition to hemygymhydrate levofloxacin (5 mg / ml) in the composition of drops are present: benzalkonium hydrochloride, hydrochloric acid, sodium chloride and hydrochloride, as well as water and hypromellose. Additional substances are needed as preservatives and antibiotic stabilizers. And they can cause side effects. So, levofloxacin penetrates into the cells of the anterior structures of the eye and stabilizes, and then depresses the infection. This antibiotic has the ability to accumulate and persists long enough in the lacrimal fluid. That allows to reduce the amount of instillations after relief of acute manifestations.

An insignificant amount of levofloxcin entering the systemic circulation and a short period of treatment does not cause the systemic actions characteristic of fluoroquinolines.

Indications for use

What helps? Significus works well against a number of microorganisms, among them chlamydia, brahmanella, staphylococcus and streptococci and many others.

Thanks to this, the facility effectively fights against:

1. Conjunctivitis (including viral form);
2. Keratitis;
3. Iridocyclitis;
4. Complications after operations;
5. Blepharitis;
6. Uveitis;
7. Barley of different stages of development;
8. Dacryocystitis.

Contraindications

Signitis is not allowed to be used in the following cases:

• epilepsy;
• period of pregnancy and breastfeeding;
• hypersensitivity to the constituents of this drug;
• children before the performance of one year;
• the presence of tendon lesions in quinolone therapy, which was performed earlier;
• use of soft contact lenses.

Dosage and route of administration

As indicated in the instructions for use, Signicef ​​eye drops are applied topically by instillation into the affected eye.

• Recommended dosing: the first two days of 1-2 drops every 2 hours during wakefulness, up to 8 times a day. From 3 to 5 days of instillation recommended to be conducted 4 times a day.

The duration of treatment is determined by the doctor and usually is 5 days.

Side effect

The incidence of side effects is approximately 1 in 10 cases of the drug. Among the undesirable symptoms of patients' reviews are:

• itching in the eye,
• redness of the conjunctiva and eyelids,
• hyperemia and puffiness of the eye structures,
• abundant lacrimation on the continuation of a long period,
• pain in the eye, sensation of foreign body,
• photophobia.

The system does not describe the systemic symptoms. Patients' responses are called headache and rhinitis. It is believed that because of small doses of levofloxacin, even with accidental ingestion of the contents of the vial, a concentration dangerous to health in the body is not achieved.

Overdose

Due to the small amount of levofloxacin that is present in this medicine, the probability of overdose is minimal, even if a person accidentally takes it inside.

If a large dose of the drug hits the eye, it should be rinsed with warm water.

special instructions

Before you start using the drug, read the special instructions:

1. Eye drops can not be administered subconjunctivally and into the anterior chamber of the eye.
2. To avoid contamination of the tip of the dropper and solution, do not touch the eye when digging.
3. With the simultaneous use of other ophthalmic agents, the interval between instillations should be at least 15 minutes.
4. Drops should not be used during the wearing of hydrophilic (soft) contact lenses, due to the presence in the drops of the preservative benzalkonium chloride, which can be absorbed by contact lenses and have an adverse effect on eye tissues, and also cause a change in the color of the contact lenses.

Interaction with other drugs

Special studies on the interaction of eye drops Signtsef was not conducted.

Since Cmax levofloxacin in plasma after instillation in the eye is at least 1000 times lower than after oral administration in standard doses, interaction with other drugs, characteristic of systemic use, is clinically insignificant. .

Reviews

Reviews of SIGNITSEF in the form of eye drops and a solution for infusions testify to the high effectiveness of the drug.

Among the negative moments, patients note the relatively high cost of both solution and drops, as well as the fact that the drug is contraindicated in pregnancy and lactation.

Analogues

Structural analogs for the active substance:

• Ashlyov;
• Glevo;
• Ivacin;
• L Optic Rompharm;
• Lebel;
• Levoxime;
• Levot P;
• Levostar;
• Levotech;
• Levoflox;
• Levofloxabol;
• Levofloxacin;
• Leobeg;
• Leflobact;
• Leflobact Forte;
• Lefokcin;
• Luffy;
• Matlevo;
• Oftakwix;
• Remedy;
• Roflox Scan;
• Tavanik;
• Tanflomed;
• Flexine;
• Floracid;
• Hayleflex;
• Ecology;
• Eleflox.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store the drops Signtsef is recommended in a dark place, protected from children. The ambient temperature should not exceed 30 degrees Celsius. Freeze the drops can not.

The shelf life of this medication is two years, but after otkuporki it should be used within thirty days.

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