Tablets Groprinosin 500mg: manual, reviews of people

Groprinosin works simultaneously as both an immunostimulant and an antiviral agent.

It blocks the multiplication of the virus and gives impetus to the activation of the immune system. The medication helps to significantly reduce the manifestations of the disease and increases the resistance (resistance) of the body to a harmful virus.

On this page you will find all information about Groprinosin: full instructions for use for this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Groprinosin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Immunostimulating drug with antiviral activity.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Groprinosin? The average price in pharmacies is at the level of600 rubles.

Form of issue and composition

Groprinosin produced in a single form - in the form of white, oblong, biconvex tablets, having a risk on one side. The composition of 1 tablet includes inosine pranobeks (500 mg) + auxiliary components (magnesium stearate, povidone, starch).

Tablets Groprinosin 10 pieces are packed in blisters. The cardboard pack can contain 2, 3 or 5 blisters with tablets.

Pharmacological effect

Groprinosin is an immunostimulant with antiviral effect. The drug is a complex of the salt of 4-acetamidobenzoic acid and inosine with N, N-dimethylamino-2-propanol.

Increases the resistance of the body, reduces the manifestation of viral diseases and accelerates the process of reconvalescence. The use of Groprinosin as an adjuvant for skin and mucous membrane damage caused by the Herpes simplex virus, contributes to the acceleration of healing of affected areas. In this case, edema, new vesicles, erosion and recurrence of the disease manifest themselves much less often. The drug blocks the multiplication of viruses due to damage to their genetic apparatus, activates the activity of macrophages, the proliferation of lymphocytes and the production of cytokines.

Timely use of this drug leads to a decrease in the frequency of viral infections, a reduction in duration and a decrease in the severity of the course of the disease.

Indications for use

Groprinosin, according to the instructions, is used to treat:

1. Viral hepatitis B (in acute or chronic form);
2. Diseases provoked by the activity of herpesviruses such as HSV-1 or HSV-2 (including herpes of the lips, ophthalmoherpes, herpes mucosa oral cavity, skin of the face and hands), genital herpes, leukoencephalitis Van-Bogart (subacute sclerosing encephalitis);
3. Viral infections in patients with normal and decreased immune status, including acute respiratory viral infection, influenza, parainfluenza, viral bronchitis, epidemic parotitis, rhino- and adenovirus infections, measles (including if the disease occurs in a complicated or severe form);
4. Diseases caused by herpesvirus type HHV-4 (Epstein-Barr virus), including mononucleosis;
5. Diseases that are caused by the activity of herpesvirus type HHV-3 - chicken pox and herpes zoster, including recurrent disease and in people with immunodeficiency;
6. Diseases associated with cytomegalovirus (herpes virus type 5) and human papillomavirus;
7. Chronic recurrent infections of the respiratory and urogenital tract in patients with impaired immunity (including diseases caused by intracellular pathogens, for example, chlamydia).

Contraindications

Despite the fact that the medication is well tolerated by patients, there are a number of limitations to its use. Groprinosin contraindicated in the following conditions:.

1. Chronic failure of the functional activity of the kidneys.
2. Arrhythmias of any type and origin (violation of the frequency and rhythm of contractions of the heart).
3. Pregnancy at any time of the course and the period of breastfeeding.
4. Children up to 3 years.
5. Individual intolerance, hypersensitivity to inosine pranobex or auxiliary components of the drug.
6. Urolithiasis is a pathology in which insoluble calculi form in the kidneys, ureters, or bladder.
7. Gout - an exchange pathology, characterized by an increase in the level of uric acid in the body and the deposition of its salts in the tissues of the joints.

Before you start using the drug, you need to make sure there are no contraindications.

Application in pregnancy and lactation

Given the complete lack of clinical trials aimed at identifying the safety of the drug on the body of nursing mothers and pregnant women (data on whether the active substance to penetrate into the placenta and is able to act on the body of the infant, breast-feeding, are completely absent), it is forbidden to apply it for the treatment of patients of this category.

Instructions for use

The instructions for use indicate that Groprinosin is taken inside after eating, at regular intervals (8 or 6 hours) 3-4 times / day. Tablets are taken with a small amount of water.

• Adults prescribe from 6 to 8 tablets / day in 3-4 reception.
• Children aged 3 to 12 years are prescribed a dose of 50 mg / kg / day, divided into 3-4 doses.

In both adults and children, in severe infectious diseases, the dose can be individually increased to 100 mg / kg of body weight / day, divided into 4-6 receptions. The maximum daily dose in adults is 3-4 g, the maximum daily dose in children is 50 mg / kg.

In acute diseases, treatment usually lasts from 5 to 14 days. After the disappearance of symptoms, treatment should be continued for 1-2 days or more, depending on the indications.

In chronic relapsing diseases, treatment in adults and children is conducted with courses lasting 5-10 days at intervals of 8 days.

Treatment of infections caused by the herpes virus in adults and children: should take several courses, lasting 5-10 days before the disappearance of symptoms. To reduce the number of relapses it is recommended to carry out maintenance treatment for 1 tab. 2 times / day for 30 days.

Against the background of treatment with Groprinosin, patients with hepatic insufficiency should be monitored every 2 weeks for uric acid in the serum and urine. It is recommended to monitor the activity of hepatic enzymes every 4 weeks with prolonged courses of treatment with the drug.

Side effects

The drug Grosrinumine can cause a number of side effects:

• Skin, subcutaneous fat: itching and rash.
• Kidneys and urinary tract: polyuria, but rarely.
• Allergic reaction: rash, hives, angioedema.
• Musculoskeletal system: pain in the joints, gout.
• Nervous system: headaches, dizziness, fatigue, less nervous state, drowsiness and insomnia.
• Gastrointestinal tract: poor appetite, nausea, vomiting, pain in the abdomen, less often diarrhea or constipation.
• Hepatobiliary system: activity of hepatic enzymes, AF.
• High concentration of blood urea nitrogen.

Overdose

When the drug is overdosed, an emergency gastric lavage is performed, and then symptomatic treatment is started.

special instructions

1. With extreme caution, Groprinosin is prescribed to patients with acute renal failure. In this case, a reduction in the therapeutic dose is required, taking into account the fact that the process of inosine metabolism occurs in the liver.
2. If it is necessary to use the drug in patients with hyperuricemia, it is necessary to control the level of uric acid in urine and serum. If the content of uric acid is significantly exceeded, drugs are prescribed to reduce its level.
3. Groprinosin does not affect the ability to drive vehicles and does not reduce the speed of reactions and concentration of attention when working with dangerous mechanisms.
4. During treatment, alcoholic beverages are prohibited, since the drug increases the toxic effect of alcohol on the liver, which can lead to the development of severe complications.

Drug Interactions

1. Immunosuppressants weaken the immunostimulating effect of Groprinosin.
2. Joint use with zidovudine leads to an increase in the concentration of the latter in blood plasma and lengthens its half-life. Zidovudine dose adjustment is required.
3. Grogrinosin with caution is prescribed to patients taking xanthine oxidase (allopurinol) inhibitors, or "loop" diuretics (furosemide, torasemide, ethacrynic acid), as this can lead to an increase in the concentration of uric acid in the blood serum.

Reviews

We picked up some feedback from people about the Groprinosin drug:

1. Anya. At the child the virus EP, for 2 months had been ill with a terrible angina 3 times!!!! Prescribed 3 different aniabiotics, it helped, but a week later it all started again. 90-year-old infectiologist prescribed "Groprinosin" -10 days. The child at that time was 2 years old. But the weight We have more than 15kg))))) Thank God!! We have half a year do not remember anything about tonsils. The maximum-cold in easy form!
2. Lyudmila. I started to drink the drug, Coincidence or not, I do not know. The day later, the temperature rose 38.5, vomiting, nausea, today is the third day, the temperature and nausea disappeared, I do not know what it was, but indigestion remained. Just now, I ate and my stomach swelled, as if what I ate during the day and sits in the stomach, I'll look at the hour in 4, if not, I'll have to induce vomiting.
3. Sasha. With angina and cold very quickly helped, now the doctor prescribed for a viral infection, I am treated for 3 days, on the first day in general t from 38.5 to 36.6 killed and felt like a cucumber, on day 3 woke up with t 38, drank, fell to 37 below does not fall. A man weighs 90 years 28, a course 4 times a day for 2 tablets (500 mg).
4. Marina. I was diagnosed with HPV. I learned about this disease quite by accident. And all because of the fact that my gynecologist insisted that I pass the tests for HPV. As a result, I already had types that can cause cancer. Therefore, the doctor, without slowing down, appointed me a drug called Groprinosin. Duration of admission was 10 days. All these 10 days I drank 2 tablets 3 times a day. Thank God that there were no side effects after using the remedy. I can say with certainty that Groprinosin helps with HPV. After repeated analyzes, everything returned to normal.

Analogues

Currently, in the Russian pharmaceutical market, Groprinosin has only one drug-synonym: tablets Isoprinosin.

The analogues of Groprinosin are the following medicines :);

• Kagocel (tablets);
• Lavomax (tablets);
• Oxolin (ointment for topical application);
• Panavir (gel, suppositories and injection solution);
• Proteflazide (extract for oral and topical application);
• Tilaxin (tablets);
• Tyloron (capsules and tablets);
• Ferrovir (injection solution);
• Allokin-alpha (lyophilizate for solution for injection);
• Alpisarin (tablets);
• Amiksin (tablets);
• Arbidol and Arbidolum Maximum (tablets);
• Hyporamin (tablets and lyophilizate for the preparation of a solution for inhalation and administration to the nasal passages;
• Ergoferon (tablets and solution for oral administration).

Before using analogues, consult your doctor.

Storage conditions and shelf life

Gropronosin tablets do not require special storage conditions - they should lie in a dry and dark place, the air temperature is desirable 25 degrees and below.

It is stored for three years from the date of manufacture.

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