Nicergoline

width = Nicergoline - a drug that has a vasodilating effect. He is included in the group of alpha-andrenoblokatorov and stimulates blood circulation of the brain and peripheral organs.

The drug after ingestion or injection begins to act on the arteries of the brain. It improves blood circulation and helps reduce vascular resistance, increasing arterial blood flow and consuming oxygen and glucose by brain tissues.

The vessels of the lungs also expand and the blood supply of the extremities improves. In some cases there is a decrease and normalization of blood pressure. The vascular tone is reduced as a result of the use of the drug.

Clinical and pharmacological group

Alpha-blocker.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Nicergoline in pharmacies? The average price is at the level of400 rubles.

Form of issue and composition

The drug Nicergoline is available in tablets and injection solutions. The injections of Nicergoline are a lyophilizate for the preparation of a solution for injection. It goes in ampoules of 4 mg immediately complete with a solvent. Solvent is a solution of sodium chloride,% in ampoules of 5 ml.

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Pharmacological effect

The drug has a vasodilating effect, affects the arteries of the brain. Nicergoline is included in the group of alpha-blockers. It is a synthetic ergot alkaloid derived from an alpha-adrenoblocker having traces of bromosubstituted nicotinic acid in the chemical formula. The combined action of the main active substance and the ergoline derivative allows the drug to have a beneficial effect on the metabolic and hemodynamic processes of the brain.

Produced medicine effect:

Improve blood circulation in the brain.
Reduction of aggregation (adhesion) of platelets.
Decrease in the level of systemic arterial pressure.
Increasing the resistance of neurocytes (cells of the nervous system) to insufficient intake of oxygen and nutrients.
Increase the intensity of metabolism (metabolism) in the neurocytes, which leads to a better release of energy.
Reduction of the resistance of the vessels of the lungs, upper and lower extremities.

Among the advantages of Nicergoline - a beneficial effect on blood pressure, which leads to its normalization in those suffering from hypertension. The drug reduces the aggregation of platelets, improves blood flow in arteriopathy. The bioavailability of Nicergoline is 60%. The maximum concentration of the drug in the blood is noted in an hour and a half after administration.

Indications for use

The preparation "Nicergolin" itself, analogues and synonyms of this drug adrenoblocker should be taken only after detailed consultation and according to the doctor's prescription.

These drugs are prescribed for complex vascular pathologies.

In the complex treatment of hypertensive crises.
With diabetic retinopathy and optic nerve neuropathy.
With violations of the circulation of peripheral parts of the brain.
With complex manifestations of migraine.
With acute violations of the blood supply of the extremities.
In pathological processes in the cornea of the eye.
With stable violations of the functions of cerebral metabolic vessels. This pathology can be diagnosed in a patient in both acute and chronic forms and develops against a background of hypertension, atherosclerosis, embolism, thrombosis, ischemic and vascular problems.

A wide range of indications for use makes this drug a group of blockers universal agent in the treatment of central and peripheral circulatory disorders. In addition, the effect of taking "Nicergoline" is observed quickly, since the maximum concentration of active substance is diagnosed in the body within an hour after taking.

Contraindications

Nicergoline in all dosage forms is contraindicated in the presence of hypersensitivity to the components of the drug.

Tablets are administered with caution to patients with hyperuricemia or gout in the anamnesis and / or together with drugs that lead to a disruption of the metabolism or excretion of uric acid.

Injection solution

Stenocardia of tension;
Organic heart damage;
Myocardial infarction;
Arterial hypotension;
Pronounced atherosclerosis of peripheral vessels;
Pregnancy and the period of breastfeeding.

Pills

Lack of isomaltase / sucrose and lactase, glucose-galactose malabsorption, intolerance to lactose and fructose;
Disorders of orthostatic regulation;
Myocardial infarction, suffered in recent times;
Pronounced bradycardia;
Acute bleeding;
Age to 18 years.

Use in pregnancy and lactation

Lactation and pregnancy are absolute contraindications to the use of the drug.

Dosage and route of administration

The instructions for use indicate that at the beginning of treatment may be prescribed intramuscular or intravenous administration of the agent with a further transition to oral administration as a supportive therapy.

Lyophilizate for solution for injection

Before administration, the lyophilizate is diluted with the applied sodium chloride solution,%. The resulting solution is administered intramuscularly, intravenously and intraarterially.

With intramuscular injections, the recommended single dose is 2-4 mg, administered 2 times a day.

The intravenous solution is driped in a single dose of 4-8 mg, diluted in 100 ml of physiological sodium chloride solution (in some cases, intravenous infusion is possible 2 times a day).

With intra-arterial administration, the dose is 4 mg per 10 ml of the solvent, the duration of the injection is 2 minutes.

Dragee

Dragee is taken before or during meals, without chewing, squeezed enough water, 10 mg (1 dragee) 2-3 times a day. The course of treatment is 2-3 months. When observing the improvement of the condition or with functional disorders of the kidneys, the recommended daily dose is reduced by 2 times - up to 10-15 mg taken in 2-3 doses.

The therapeutic effect of all forms of the drug develops gradually. The course of therapy is long - at least 2 months.

Film-coated tablets

Nicergoline in tablets are taken orally.

The dose and duration of the course are determined by the nature, severity of the disease and the effectiveness of the therapy. Sometimes it is preferable to start the treatment with parenteral administration, after which it is necessary to switch to the intake of Nicergoline for supporting treatment.

The average single dose is 10 mg, the frequency of reception is 3 times a day, with the same intervals between doses. Usually, the therapy is long (up to several months).

In the treatment of vascular dementia, usually prescribed 30 mg 2 times a day, with 1 time in 6 months is recommended to consult with a doctor to confirm the appropriateness of continuing therapy.

For functional disorders of the kidneys (with serum creatinine ≥ 2 mg / dl), a therapeutic dose of Nicergoline is recommended to be reduced.

Side effects

During treatment with Nicergoline, in some patients, the following side effects may occur: low blood pressure, nausea and stomach pain, dizziness, problems with gastrointestinal path.

A rise in body temperature, drowsiness, various allergic reactions, which usually manifest as a rash, sleep disturbance, an increase in the level of uric acid.

If one or more effects are detected, you should consult your doctor.

Overdose

The main symptom of an overdose of Nicergoline is a significant decrease in blood pressure. In this case, the patient should be given a horizontal position.

In exceptional cases, if necessary, sympathomimetics are prescribed, but regular monitoring of blood pressure is required.

special instructions

Before you start using the drug, read the special instructions:

After intravenous or intravenous injection of nicergoline, the patient should be in a horizontal position for several minutes.
Patients with renal insufficiency and elderly patients with a serum creatinine level greater than 2 mg / dl require a correction of the dosing regimen.
With prolonged therapy, patients should be examined at least once every 6 months, with a view to possibly reducing the dose or abolishing nicergoline.

Drug Interactions

Nicergoline is not recommended for use in combination with drugs that promote the development of violations of excretion of uric acid. The drug enhances the effect of antihypertensive drugs, indirect anticoagulants and antiaggregants.

Reviews

We picked up some reviews of people who used the drug Nicergoline:

Svetlana. As for me, so "Nicergolin" is a terrible drug, there is no benefit from it, only very often the pressure falls below the skirting. It seems to me that everything from a very rapid introduction, try to enter as slowly as possible. And in general, better buy another, more powerful drug.
Alla. I took nicergoline 5 mg 3 times. Side effect at once: there were strong pains behind a breast bone and strong pains in a back, has understood the reason not at once. Has made an electrocardiogram - have shown changes (one month prior to reception was normal). After reading about the side effects of alpha blockers, I realized that it was from nicergoline.