How to take allopurinol for gout?

Allopurinol for gout - how to take it, compatibility with alcohol, side effects

In 1739 the Frenchman Mosheron wrote a treatise "On noble gout and its virtues but today there is hardly anyone who would wish to mark himself with such a "privilege". The absence of gout treatment can lead to disability.

Complex therapy for this disease differs in duration, but time will not be wasted if you drink Allopurinol with gout - An anti-inflammatory drug that has a huge amount of positive feedback from people who have been treated and who have observed the terms of the courses and dosage.

What is Allopurinol

The substance of allopurinol is an inhibitor of xanthine oxidase, a catalyst that facilitates the conversion of xanthine to uric acid.

The medicinal preparation begins to be applied at a stage when the tests indicate hyperuricemia, that is, an increase in the content of uric acid in the blood.

Systemic use of the drug becomes necessary if hyperuricemia has given such a complication as gout.

Allopurinol is available in the form of tablets and consists of 10 pieces per blister pack. The medicine is sold in cardboard packs, 3 or 5 blisters each.

The drug can be presented in vials of opaque color, with a content of 50 pieces (allopurinol 100 mg per tablet) or 30 pieces (300 mg of active substance per tablet).

The vials are placed in a cardboard box.

With a systematically increased level of uric acid in the body, a pathological condition (gout) develops in a person, due to the deposition of urate salts in the tissues.

According to the reviews, the drug is not intended for rapid relief of pain, but for the gradual elimination of the very cause of painful manifestations in gout.

Indications for use

Allopurinol is used to help patients who are diagnosed with hyperuricemia that can not be corrected by diet. The drug is used and for the following indications:

• urate stone disease;
• urate nephropathy;
• excretion of uric acid;
• treatment of primary or secondary hyperuricemia of various origin;
• congenital enzymatic insufficiency;
• urolithiasis disease;
• the effects of nephrolithiasis (in the form of stones);
• radiation, cytostatic therapy, as well as treatment with corticosteroids;
• prevention of hyperuricemia.

Composition

Widely presented in pharmacy chains,the preparation has a composition that depends on the content of the active substance.One tablet contains 100 mg of allopurinol, has a color ranging from greyish-white to white, a flat shape. Detailed composition:

• allopurinol g;
• lactose monohydrate - 50 mg;
• potato starch - 32 mg;
• Povidone K25 mg;
• talc - 6 mg;
• magnesium stearate - 3 mg;
• sodium carboxymethyl starch, mg.

Tablets with allopurinol in a volume of 300 mg have a color ranging from grayish white to white, a flat shape, on one side of the risk, on the other - the engraving "E352".In addition to the basic substance, one tablet contains such components:

• microcrystalline cellulose - 52 mg;
• sodium carboxymethyl starch - 20 mg;
• gelatin - 12 mg;
• silicon dioxide colloidal dehydrated - 3 mg;
• magnesium stearate - 3 mg.

pharmachologic effect

The drug helps to reduce the concentration in urine and blood levels of uric acid, which reduces the intensity of the processes of deposition of its crystals.

Under the influence of allopurinol, already deposited crystals undergo gradual dissolution.

The drug can upset the synthesis of uric acid (urostatic effect), which leads to a decrease in its level in the body.

Effectiveness of treatment

Before the start of therapy, it is necessary to carefully study the possible contraindications of the drug and compare them with the state of health. All doubts must be resolved, referring to a specialist.

With strict compliance with the prescriptions for taking the drug, relief should appear after a few months.The drug has a cumulative effect, so it is important to withstand all courses of use.

As a result, the number and brightness of attacks, the rate of urate deposition will noticeably decrease.

How to take Allopurinol for gout

Tablets from gout are taken orally, by oral method, washed down with water, without chewing and not grinding the dose.

In renal and hepatic insufficiency, the dosage of the drug decreases and depends on the patient's condition, the creatinine clearance in the blood serum.

During the treatment with tablets it is important to maintain adequate hydration, drink plenty of water,observe a certain diet to maintain a normal diuresis and increase the solubility of urates.

Reception of allopurinol for gout occurs after eating.Adults and children over 10 years of age are prescribed a daily dose of 100-300 mg / day.

The initial dosage is 100 mg once a day, gradually it increases every 1-3 weeks per 100 mg. The maintenance dose is 200-600 mg / day, in some cases, the doctors prescribe 600-800 mg / day.

If the daily dosage exceeds 300 mg, it is divided into 2-4 divided doses at regular intervals.

The maximum single dose is 300 mg, the maximum daily dose is 800 mg.Children aged 3-6 years receive a dose, based on body weight - 5 mg per kg of weight, 6-10 years - 10 mg. Multiplicity - three times / day, the maximum daily dosage should not exceed 400 mg.

In patients with impaired renal function or chronic renal insufficiency, dosage reduction in 100 mg every 1-2 days, with hemodialysis 300-400 mg after each session (2-3 times in week).

It is necessary to abolish the drug carefully, not abruptly, so that the remission lasts longer.

Course and duration of treatment

Normalization of uric acid levels in the blood with gout is achieved 4-6 months after the start of taking Allopurinol.

According to reviews, you can stop seizures in 6-12 months, the same time is needed to resolve gouty knots in the joints. Drink tablets can be 2-3 years with small interruptions.

An independent decision to stop taking can provoke an aggravation and destroy all the results of therapy.

Contraindications

There are a number of contraindications - factors in which tablets from gout Allopurinol are banned or not recommended by doctors because of dangerous consequences for the body:

• hypersensitivity to the components of the drug;
• severe violations of kidney function, liver disease, decreased creatinine clearance;
• acute pain and gout attacks;
• pregnancy;
• children's age to three years.

Side effects

Reception of Allopurinol may be accompanied by the appearance of rare side effects, which is due to the failure of the liver and kidneys.Undesirable consequences are as follows:

• furunculosis;
• disorders of the lymphatic and circulatory systems (anemia, agranulocytosis, thrombocytopenia, leukocytosis, leukopenia, eosinophilia and aplasia);
• immune system: hypersensitivity (arthralgia, fever, epidermal scaling, lymphadenopathy);
• metabolic processes (hyperlipidemia, diabetes mellitus);
• depression;
• drowsiness, headache, paresthesia, neuropathy, loss of mobility;
• vision (macular changes, deterioration of visual quality);
• symptoms of angina pectoris;
• increased blood pressure;
• diarrhea, nausea;
• from the bile duct and liver - hepatitis;
• rash, Stevenson-Johnson syndrome, epidermal necrolysis, loss of hair color;
• myalgia;
• hematuria, uremia, renal insufficiency;
• erectile dysfunction, gynecomastia.

Overdose

The intake of 20 g of allopurinol is tolerated by the body without adverse reactions.Sometimes a dose less than this can lead to an overdose, manifested by nausea, diarrhea, dizziness.

Prolonged intake of 200-400 mg tablets / day is marked by skin reactions of intoxication, fever, hepatitis. Symptomatic and supportive measures, adequate hydration, hemodialysis are taken to eliminate signs of poisoning.

There is no specific antidote for the excretion of allopurinol and metabolic products.

Compatibility of Allopurinol and Alcohol

Doctors do not recommend combining Allopurinol and alcohol, because any alcohol increases the level of uric acid in the body, which only exacerbates the disease.

Allopurinol and alcohol are antagonists. You can not drink tablets and ethanol at the same time, this leads to the risk of dizziness, diarrhea, vomiting, apathy, seizures.

Bleeding of the internal organs may begin.

Drug analogues

There are few known direct analogs of Allopurinol for the content of the active enzyme.Most drug substitute drugs have another active ingredient, but the principle of action remains the same. On the shelves of pharmacies you can find the following analogs of Allopurinol:

• Allogexal
• Adenurik;
• Phoebus-40;
• Allpol;
• Alopron;
• Purinol;
• Sanphipurol.

Price

The drug Allopurinol is sold through pharmacies on prescription, it can be ordered through the catalog or bought from the online store. The cost of the medicine is affected by the number of tablets in the package.Pharmacies in Moscow and St. Petersburg offer medicines at the following prices:

Number of tablets, concentration of active substance	Manufacturer	Approximate price, rubles
50 pcs., 100 mg	Russia	94
Hungary	106
30 pcs., 300 mg	140
Russia	97

A source: http://sovets.net/15037-allopurinol-pri-podagre.html

How to take Allopurinol tablets with gout?

With gout, Allopurinol is used to eliminate the cause of its occurrence. The components of the drug affect both the symptoms of the disease and the pathological changes caused by it in the body.

Treatment of gout Allopurinol helps reduce the level of uric acid, which in the body is converted into urate. Purines are colorless crystals that react with organic acids to form salts.

The catalyst is xanthine, which is present in some tissues of the body. Crystals dissolve in alkalis.

In the human body, an xanthine oxidase enzyme is produced that promotes the oxidation of hypoxanthine, a component of purines. The end product of these chemical reactions is uric acid.

An increase in its quantity is called hyperuricemia, and developing as a result of complication is gout. Salts in the region of the joints fall with a blood stream that delivers oxygen and nutrients to the tissues.

The deposition of urates contributes to the appearance of characteristic outgrowths and pronounced painful sensations.

Therapeutic effect of the drug

Allopurinol is incorporated into metabolic processes and under the influence of xanthine oxidase it is converted to oxypurinol. It is an analog of xanthine, not subject to oxidation.

Therapeutic effect occurs 2 hours after taking the pill.

Thus, Allopurinol can be considered an inhibitor of the enzyme, it prevents an increase in the level of uric acid in the body.

To eliminate the symptoms of gout, it is answered by oxypurinol. The active substance prevents the deposition of urate and dissolves the already existing ones. After elimination of hyperuricemia, the growth of tophi in the joint region stops.

Especially often, allopurinol is used for chronic forms of gouty arthritis.

After taking the tablets dissolve, the active substance is absorbed into the intestine. The maximum concentration in the blood is observed after, hours. Part of the drug is excreted in the small intestine.

A long period of decay provides an accumulation of the active substance. Oxipurinol is in the body for 20-70 hours. It is secreted by the kidneys, without being associated with protein compounds and enzymes-catalysts of chemical reactions.

With chronic renal failure, the time of excretion of oxypurinol increases.

Most patients note that Allopurinol does not reduce the intensity of the pain syndrome, but its reception during the remission prevents the occurrence of an attack. The therapeutic effect is directed to the cause of the disease.

The dosage of the drug is chosen by the attending physician, he must take into account the stage and severity of gout, the presence of concomitant pathologies. Incorrect intake of allopurinol can provoke an exacerbation.

The introduction of this drug should be combined:

• with the use of painkillers and anti-inflammatory drugs;
• physiotherapeutic procedures;
• preventive measures.

Basic therapy is prescribed in cases when exacerbations occur at least 4 times a year and are accompanied by the appearance of tophi. Prophylactic reception of allopurinol is indicated with persistent hyperuricemia and the appearance of the first signs of arthritis.

How is the drug taken?

It is necessary to start treatment with the introduction of minimal effective doses.

This will help evaluate the reaction of the body to the active substance and prevent the occurrence of acute gouty attacks, which may be accompanied by the beginning of the therapeutic course. This approach reduces the intensity of side effects.

The effectiveness of treatment is determined by analyzing the amount of uric acid. With the withdrawal of the drug, this indicator reaches its former values ​​after 3-4 days.

If discomforts appear against the background of already begun therapy, the dose of the drug is reduced. Completely to cancel it it is impossible, as any treatment at early stages promotes insignificant deterioration of a status. Only then you can see the first results of therapy.

In the beginning, Allopurinol is recommended in combination with NSAIDs or colchicine. After 3 days, the amount of uric acid in the blood will begin to decrease, on day 7 this figure will approach the norm.

After elimination of hyperuricemia, the dose of the drug is reduced. Strong remission comes in 4-6 months. After this, the patient will take maintenance amounts of the medication.

With long-term use of allopurinol, complete disposal of joint manifestations of gout is possible.

Contraindications and treatment recommendations

Allopurinol is not prescribed for children, pregnant and lactating women. Do not take the drug to patients planning to conceive. Allopurinol has a teratogenic effect, it can provoke congenital malformations:

• heart;
• excretory system;
• the fetal brain.

Do not use it for violations of the liver. Allopurinol can be used in the treatment of children with malignant forms of hyperuricemia.

During the treatment period, you must adhere to the principles of proper nutrition. To starve is strictly forbidden, this promotes the accelerated disintegration of purines with the formation of uric acid. From the diet it is necessary to exclude fatty, spicy and salty foods.

You need to eat small meals. Refuse from alcohol and smoking. You need to eat as many fresh fruits and vegetables as possible. Alkaline mineral waters are useful. It is allowed to use mors, green tea, diluted with water juices.

Citrus cleanse the body of urates.

Allopurinol is usually well tolerated by the body, however, allergic reactions and side effects such as leukocytosis, eosinophilia, thrombocytopenia can occur. The drug can interfere with the function of the liver and kidneys.

Long-term use of allopurinol by men contributes to a decrease in libido, the development of impotence and infertility. Taste and visual perception can change, blood pressure and heart rate may decrease.

When these symptoms appear, treatment should be stopped.

A source: https://OrtoCure.ru/kosti-i-sustavy/podagra/lechenie-allopurinolom.html

Allopurinol for gout

Allopurinol for gout- a drug from the group of uricosuric agents, which is recommended to be taken during remission to prevent the development of gouty attacks and prevent the onset of pain syndrome.

Characteristics of the disease

In the time of Hippocrates' life gout was considered a disease peculiar to aristocrats and representatives of high society who did not deny themselves food and refined drinks.

Today gout is known as a chronic relapsing disease caused by disturbed metabolic processes of the body.

That is, the frustrated synthesis of purine substances and the excretion of uric acid (urate) components from the body.

Of course, the development of this disease affects the habits of nutrition, but this is not the only reason for the formation of gout.

Causes of gout

Factors that trigger the development of the disease include the following:

• Disturbed metabolism of the human body;
• Genetic propensity (the presence of a specific X chromosome in the DNA);
• Excessive consumption of harmful foods and alcohol.

Gout is not completely eliminated, but is a lifelong disease, so to maintain health with this diagnosis must adhere to certain recommendations of the a rheumatologist.

Principles of gout treatment

Treatment of gout is based on the following principles of medical therapy:

• Urikozuricheskie means (drugs that remove excess uric acid from the body, for example, allopurinol)
• Urine depressants (drugs that block the production of urates);
• NPvs (non-steroidal anti-inflammatory drugs);
• Glucocorticosteroids (gk);
• Painkillers (during an attack of gout exacerbation);
• Means of local effects (ointments, gels, compresses).

1. Physiotherapy;
2. Treatment with folk methods (application of tinctures from medicinal herbs, decoctions, teas);
3. Dietary food.

Urikozuric means

For the treatment of gout during remission often used drugs to control the level of uric acid in the human body.

These drugs include uricosuric drugs and uricodepressants.

These medicines have an active effect on the body of a person suffering from gout, but during treatment it is necessary to adhere to some useful recommendations of specialists.

The main principles of treatment with drugs that control the level of urate in the blood:

• The use of uricodepressants and uricosuric drugs should begin during the initial stage of gout development (it is dangerous to start taking drugs during an acute gouty attack);
• The course of treatment is carried out only during the chronic course of the disease, that is, in interstep stages of remission;
• Treatment continues for life (after consulting with a doctor, you can take a short break for 14-28 days, after which the treatment continues);
• The prescription and appointment of a specific drug and daily dosage is determined by a rheumatologist (these parameters depend on the form and type of the disease development, as well as on the level of uric acid in the blood);
• When using the means regulating the level of MK it is necessary to adhere to daily diuresis (use of liquid from 2 to 3 liters of water, unsweetened tea, broth of dogrose, milk).

Treatment of gout with allopurinol

Let's consider in detail how to take allopurinol with gout, which is a means of long-term treatment for this disease.

Allopurinol does not have an effective analgesic effect on the body, so its use during an acute gouty attack is not effective. However, this drug acts because of its cumulative effect, after prolonged use by the patient.

Composition of the product

Pharmacological form of the drug has the following composition:

• Allopurinol - 100 mg;
• Starch - about 7, 7 mg;
• Sucrose - 20 mg;
• Magnesium stearate - 1 mg;
• Nutritional gelatin 3 mg.

Features of the drug

Allopurinol actively affects the body, controlling the production and excretion of uric acid components in the body.

The active substance of the drug inhibits the activity of the enzyme xanthine oxidase, which promotes the oxidation of hypoxanthine to xanthine and its further synthesis into fragments of urate.

This process also controls the level of uric acid in the human blood.

Reception of allopurinol is recommended in the following cases:

• Diagnosed hyperuricemia with gout (high urate content in the blood - over 500 μmol);
• Urinary nephropathy disease;
• Urolithiasis disease;
• Prevention of urate deposits in the blood in patients with cancer.

Mode of application

Allopurinol is available in tablets of 100 and 300 mg for oral use. The tablet should be swallowed and washed down with plenty of liquid. Take the medicine after eating.

What should be the daily dosage of allopurinol for gout, determines the attending physician rheumatologist.

We offer some options for taking the drug during the day:

• 200 mg of allopurinol (2 tablets per day, 1 tablet);
• 200-600 mg of the drug throughout the day (the dose is divided into 3 equal doses);
• 800 mg - the highest dose of taking allopurinol per day (the maximum dose of one-time intake is 300 mg of the drug).

Children under the age of 13 can also receive allopurinol, but in such cases, the daily dose is calculated by 10-20 mg of the drug per 1 kg of body weight.

components of uric acid in the blood decreases by 2-3 days after the application of allopurinol from gout, the level of urates is stabilized on the 7-10 day after the start of the course of therapy.

A persistent effect of normalizing the level of uric acid is achieved after 4-6 months.

If these indicators are within the normal range, the daily dosage of the drug is reduced to 100 mg (1 tablet per day).

Cost of allopurinol

The price of tablets from gout allopurinol is from 80 to 120 rubles, depending on the company and the country of the manufacturer. It seems the cost is very low, but given the fact that this drug a person needs to buy permanently and for life, the total amount will run round.

Adverse events from the drug

Since allopurinol is an active drug, it has a direct effect on the human body. As a rule, acute adverse events with the use of allurinolol is not observed, but there is a possibility of certain side effects.

The following side effects can be observed:

1. Malnutrition of the gastrointestinal tract (nausea, vomiting, diarrhea, spasms);
2. Allergic manifestations on the skin (reddening of some areas of the skin, itching, dermatitis, rash);
3. Violation of metabolic processes of the body (hyperglycemia, hyperlipidemia);
4. Emotional disorders (depression, drowsiness, irritability, nephropathy);
5. Sleep disorders (insomnia, amnesia, nightmares);
6. Violation of the hepatobiliary system (increased activity of kidney enzymes, xanthine stones, liver necrosis);
7. Disorder of the circulatory system (leukopenia, leukocytosis, agranulocytosis, thrombocytopenia).

Contraindications to use

Specialists determine the following contraindications to the use of the drug allopurinol:

1. Hypersensitivity to the components of the drug allopurinol;
2. Chronic renal failure;
3. The initial stage of hemochromatosis development;
4. Gouty condition (exacerbation of gout);
5. Pregnancy or breast-feeding;
6. Diabetes;
7. Acute liver disorders;
8. Children under 3 years;
9. Disorders of the cardiovascular system.

Patient Reviews

Reviews about the medicine for gout allopurinol are very different. Nevertheless, as a rule, there are very positive reviews of patients.

Of course, the positive effect of taking the drug is largely dependent on the correctly selected daily dosage, which is determined by the results of laboratory studies of the patient's analyzes.

"I was diagnosed with gout about 4 years ago. Since last year, I started taking allopurinol to reduce the level of uric acid in the blood.

Attacks of acute gout began to appear less often and intensity of pain syndrome decreased during exacerbation.

I realized that the treatment of gout without the use of allopurinol is not effective, "says Ilya, 42.

Alla, who is 53 years old: "After the start of taking allopurinol, I got an allergy on my skin, having consulted with the rheumatologist, I have lowered a daily dose of a preparation with 400 mg to 200, collateral the effects have disappeared. The level of uric acid salts also decreased noticeably. "

You can learn more about the methods of gout treatment from the video provided:

The use of this drug will help you maintain your condition during chronically occurring gout, and also reduce the severity of the pain syndrome during an attack. Take care of yourself and be well!

A source: http://travmapedia.ru/bolezni-sustavov/podagra/8654-allopurinol-pri-podagre/

Allopurinol: an effective drug for treating gout

Gout - a disease of aristocrats in the past - in the modern world is a consequence of disturbed metabolism (metabolism) in the human body. The treatment of gout is life-long, and with this, no matter how much you want, you have to accept it.

Drug therapy of gouty arthritis includes the use of non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticosteroids (GK) and antidotal drugs.

If NSAIDs and HA are used to stop acute attacks, then to prevent exacerbations, drugs with a good uricosuric effect are needed.

Allopurinol with gout is the most effective remedy for improving kidney secretion of uric acid.

Allopurinol (Milurit) has no direct analgesic effect, so when exacerbating gout for pain relief, it is useless. BUT: regular intake of this drug helps to eliminate pain in the future.

Indications for use

1. Primary and secondary gout.
2. Renal stone disease with the formation of urates.
3. Primary and secondary hyperuricemia.
4. Cytostatic and radiation therapy of neoplasms.
5. Psoriasis.
6. Massive therapy with corticosteroids.
7. In the complex treatment of epilepsy in children.

Detailed information on the mechanism of action of the drug and the indications can be found in the instructions for use or find out from your doctor.

Mode of application

Tablets are taken internally after eating. The daily dose of the medicine is calculated by the doctor taking into account the severity of the disease and the concentration of uric acid in the blood.

Begin treatment usually with minimal doses, gradually increasing them to the required level under control blood test: the amount of uric acid decreases already on the 2-3 day of taking Allopurinol, and by 7-10 days it reaches norms.

Upon achievement of a stable therapeutic effect, the doctor transfers the patient to maintenance doses of Allopurinol.

Efficiency from application

If you take Allopurinol, strictly following the recommendations of the doctor, then in six months or a year you can see significant progress: the intensity and frequency of attacks gouty arthritis becomes smaller and less frequent, tofus begin to resolve and soften (bound by connective tissue of the nodule - deposits of urinary salts acid).

Kidney stones (urates) are not formed during treatment with the drug.

Allopurinol is available in the form of tablets, and, gram. It is released in pharmacies according to the doctor's prescription.

Features of use and contraindications

Treatment with Allopurinol is a long and continuous process. It is possible, although not advisable, to take a break for 2-3 weeks, but with normal blood and urine indicators and only with the permission of the doctor.

Independently discontinue taking the medication is not recommended, since with the elimination of allopurinol, the level of uric acid begins to increase by 3-4 days.

This anti-gouty drug is not combined with some medications - this point must necessarily be taken into account by the attending physician.

The main requirement in the treatment of this drug is strict adherence to the diet.

The slightest error in nutrition reduces all efforts of the doctor and patient "to no."

Take alcohol during treatment with Allopurinol is prohibited, since it lowers the effectiveness of the drug.

The main contraindications include the following:

• kidney failure;
• pregnancy and the period of breastfeeding;
• idiopathic hemochromatosis;
• exacerbation of gouty arthritis;
• individual sensitivity to the drug.

Side effects and overdose

A pronounced side effect from taking the tablets was not observed, the medicine is usually well tolerated by the patients.

But there are possible reactions from the gastrointestinal tract - nausea, vomiting, diarrhea, abdominal pain; allergic manifestations - skin itching, burning, flushing, rash by type of urticaria, dermatitis; from the side of the nervous system - sleep disorders, depression, amnesia; from the hematopoietic system - leukopenia, leukocytosis, eosinophilia.

Another advise:Treatment of gout with iodine

At the initial stages of treatment from the affected joints, arthralgia (intensification of soreness) may appear, that is, exacerbation of the disease.

Overdose, symptoms: dizziness, gastrointestinal disorders, oliguria (little allocated in a day urine).

The patients' comments about this medicine are very diverse, from sharply negative to enthusiastic. The drug itself is good and effective, and those people who have correctly picked up the dosage will not boast of Allopurinol.

Dissatisfied or have become patients of unscrupulous doctors and they incorrectly selected a dose, or, after reading information about the pills, were engaged and took them incorrectly - although everyone already knows that the appointment of Allopurinol should be prescribed by a doctor and the dosage should be selected according to the results of laboratory research.

The price of allopurinol is relatively low (on average, 80-100 rubles), which is very important, because the medicine must be taken for life, which means that the financial expenses will be regular.

Analogues of the drug - Aloprone, Allupol, Sanipiprol, Purinol, Allopurinol-Aegis. In all of them, active ingredient is allopurinol.

Maybe in the future, because medicine and pharmaceuticals are developing swiftly, and a medicine will appear that will defeat the disease from just one pill. So far this is only a dream. To date, Allopurinol - the only and, in fact, an effective tool for the treatment of gouty arthritis.

A source: http://MoyaSpina.ru/medikamenty/allopurinol-terapii-podagricheskogo-artrita

Treatment of gout with Allopurinol

Gout is a disease characterized by the accumulation of a large amount of uric acid in the joints of the human body. Gout develops as a result of metabolic disorders, when excessive amounts of urate (uric acid salts) are released.

Another reason for the accumulation of sodium urate is the inability of the kidneys to excrete it from the body in time. As a result, uric acid salts accumulate in large and small bone joints, crystallize, which leads to gradual destruction of the affected joint.

The disease is chronic.

Gout is a disease of joints and tissues caused by a metabolic disorder in the body

If the rules of proper nutrition are not observed, the risk of a re-attack of gout accompanied by severe pain, swelling, swelling, and redness of the affected bone joint increases. Exacerbation of gout brings enormous discomfort to a person, markedly reduces the quality of life. The disease requires mandatory complex therapy aimed at eliminating the inflammatory process, relieving pain, hyperemia, redness, reducing the level of uric acid in the body. Allopurinol with gout is the most effective method of arresting inflammation, alleviating the patient's condition. How to take Allopurinol with gout, the features of the drug, side effects, analogs - later in this article.

Characteristics of the drug

Milurite (allopurinol) - a drug whose main effect is to reduce the concentration of uric acid in the human body.

The drug helps to reduce uricosuria, and therefore, prevents the formation of urate deposits in the urinary tract. By reducing the activity of xanthine oxidase, stops the formation of xanthine, which turns into uric acid.

As a result, the level of urate throughout the body decreases (in the blood, urine, lymph, muscles, joints, kidneys).

Milurite inhibits the growth of crystalline formations - tophi

The drug Allopurinol is indicated for the treatment of primary or secondary gout, hyperuricemic Nephropathy, including in patients with cancer, undergoing a course chemotherapy. Medication is also effective in combating urate stones in the kidneys, for treating gout with chronic arthropathy and massive nodes. It is used in the complex therapy of psoriasis, epilepsy in childhood, and also with corticosteroid therapy. Some doctors say that allopurinol is ineffective when exacerbated, since it does not reduce the soreness accompanying an acute attack of gout. the drug's task is to block the activity of xanthine oxidase, which contributes to the formation of uric acid.

Mode of application

The drug is available in tablets, and, for oral administration. Tablets are consumed whole, not chopping in the mouth. Wash down with the necessary amount of clean water.

According to the official instructions for use, it is better to use the medicine after eating. During treatment, it is recommended to drink plenty of fluids to maintain a full-fledged diuresis.

Dosage, duration of treatment is determined by the attending physician, taking into account the features of the course of the disease, the degree of development of the disease, the presence of concomitant pathologies, the general state of human health.

The daily dosage is, g. active substance. In neglected cases, therapy is performed with large doses of the drug before, per day. The intake of tablets is broken down into several receptions, if the amount of recommended allopurinol is greater, g.

Milurite is available only in the form of tablets

Treatment with allopurinol is continuous, continuous. According to the patients' reviews, only after six months of regular use of the medication comes a significant relief.

The number of seizures decreases many times, gouty sites gradually resolve. The suspension of taking the drug is allowed only after the approval of the doctor and does not exceed 14 days.

It is noticed that already 3 days after the unauthorized cancellation of the use of the drug, the level of uric acid returns to the previous level.

Special instructions:

• The drug is not suitable for use by people with impaired renal and hepatic function, as it enhances the evacuation of xanthine and hypoxanthine through the urinary tract;
• During therapy it is necessary to observe a strict diet, it is forbidden to consume alcohol-containing drinks;
• the drug is not compatible with certain medicines. Always tell your doctor about medication used at the time of allopurinol discharge;
• it is contraindicated to prescribe to pregnant and breastfeeding mothers;
• tablets are not prescribed for acute gouty arthritis, as well as individual intolerance to the components of the drug.

Nausea is one of the side effects of the drug Allopurinol

Adverse Events

As a rule, Allopurinol is well tolerated, however, some patients experience the following side effects on their side:

• the digestive system (stool disorder, vomiting, abdominal pain);
• nervous system (headache, depressive condition, paralysis, coma, increased drowsiness);
• cardiovascular (bradycardia, hypotension);
• reproductive (problems with erection, infertility);
• metabolism (increased blood sugar, hyperlipidemia).

Possible violation of visual acuity, hearing, taste sensations, the development of cataracts. Taking medication affects blood, increasing the risk of developing leukopenia, leukocytosis, aplastic anemia, eosinophilia, etc.

Patients hypersensitive to allopurinol face allergic reactions, accompanied by urticaria, dermatitis, Quinck edema, anaphylactic shock, vasculitis.

It is important to note, patients who use amoxicillin, ampicillin, suffering from renal or hepatic deficiency are at risk for developing side effects from facilities.

The presence of any side effects is an indication to abolish the use of allopurinol and seek medical help.

Analogues of allopurinol: Alopron, Purinol, Allpol. These medicines contain the active substance allopurinol, therefore fully comply with the requirements for treatment.

A source: https://osustave.ru/allopurinol-pri-podagre

How to take Allopurinol for gout: dosage, side effects, and treatment

Gout is a widespread disease, especially among middle-aged and elderly men. Currently, the number of cases of gout in women is increasing.

The disease is associated with a violation of metabolism and accumulation of uric acid salts in the joints of the human body.

The accumulation of urate, as the salts are called, in the joint - gradually contributes to the destruction of the cartilaginous surfaces of the bones rubbing against each other, which is accompanied by very severe pains.

The absence of cartilage leads to the destruction of bone tissue. Allopurinol with gout is one of the drugs that prevent the causes of the disease.

Intended use of the preparation

Allopurinol for elimination of urate crystals

The processes of deformation and destruction of the joints are accompanied by an inflammatory process. Launched forms of gout are difficult to treat.

This is associated with a constant demand of physicians to apply to doctors at the first suspicions of joint pathology and with the first pain syndromes accompanying them. By suppressing the activity of a number of enzymes, allopurinol helps reduce uric acid in the blood.

This, in turn, reduces the number of urates and the possibility of their deposition in the tissues of the body.

The use of allopurinol is usually combined with drugs that relieve severe pain. This is a necessary measure in gout attacks, the frequency and duration of which depends on the stage of the disease. In total, four stages of gout are distinguished.

At the first stage, the symptomatology of the disease manifests itself only in blood tests to the level of uric acid in it. Complaints from the sick do not come.

But, starting from the second stage, pain syndrome is more and more often, joint deformation occurs, cartilage and bone tissue are gradually destroyed.

The onset of gout

Most often gout develops as a result of malnutrition, especially when the excess in food substances, which are the starting compounds for the formation of uric acid. For example, purines.

Decomposing, with the formation of uric acid, which accumulates in the blood, they promote the formation of salts (urates). Crystals of these salts, settling on the joints, damage them.

The cause may be a complication after the transferred infectious diseases in the form of autoimmune pathology. Less often, the appearance of gout is associated with heredity or with the use of medications.

Such abnormalities as obesity, diabetes, hypertension and psoriasis can also cause gout.

From the point of view of dietetics, you should avoid excess foods such as red meat, liver, kidneys, as well as coffee and black tea, or completely eliminate them.

Under the restrictions should get and food such as fatty fish, mushrooms, caviar, eggplant, spinach and sorrel.

An obviously negative effect on the condition of patients taking medication for gout is alcohol, since it delays the excretion of uric acid from the body. Considering these recommendations, it is possible to considerably facilitate the course of the disease and reduce the painful sensations in the deformed joints. But without drug treatment, all the same, you can not do.

There is a large number of tips and medical prescriptions about how to take allopurinol with gout - one of the potent drugs that have a curative effect on the very cause of the disease.

Methods of treatment

Medication for gout

The drug in question is the most effective agent in the treatment of gout.

It suppresses the formation of the enzyme xanthine oxidase, which promotes the formation and accumulation of xanthine, the starting material for the formation of uric acid during its decomposition.

Correction of failures in the complex biochemical mechanism of uric acid formation, with the help of allopurinol, requires a certain time.

Treatment of gout with allopurinol simultaneously helps suppress the production of the enzyme xanthine oxidase, reduce urate concentration in the urine and accelerate the release of xanthine through the kidneys.

There are a number of contraindications that need to be considered when prescribing a course of treatment so as not to reduce the healing effect of the prescribed therapy.

First of all it concerns renal failure, pregnancy or hypersensibility to allopurinol. In rare cases, you may experience an allergic reaction, dyspepsia and vomiting, as well as a sleep disorder, a manifestation of amnesia.

Reception of allopurinol is undesirable also to persons connected with serious work or driving of transport when fast psychomotor reactions are necessary.

Dosage and side effects

Depending on the stage of development of the disease, the course of treatment for gout is usually prescribe allopurinol from 100 to 900 mg per day, the number of receptions from two to four times a day, after meal.

For children under the age of 15, the maximum daily dosage is reduced by half. It should be noted that the derivatives of salicylic acid - salicylates, significantly reduce the effectiveness of allopurinol.

It is desirable to provide a separate intake of allopurinol and cytostatics.

Since allopurinol inhibits the activity of certain enzymes, its action, in general, can affect the entire biochemical system of adjusting the functions of the human body. Consequently, there are rare occurrences of any deviations from different systems:

• digestive;
• cardiovascular;
• urinary;
• endocrine;
• central nervous system.

The most unexpected is an exacerbation of gout when taking allopurinol. But this happens only with the beginning of the course of treatment, since uric acid from the site of its concentration in the tissues is excreted into the blood. In the future, the soreness of gout attacks is significantly reduced.

As an anesthetic at the beginning of the course of treatment of this disease colchicine can be prescribed, which removes the acuteness of inflammation and reduces soreness in the affected parts of the body. It is recommended to observe the daily dose of drinking water at least 2 liters during the entire course of treatment, under the normal mode of urination.

Application features

According to the patients who used allopurinol for gout, the pain associated with bouts of gout goes quite quickly after the beginning of the course of treatment.

They also note the fact that proper nutrition helps to strengthen the therapeutic effect of the course of allopurinol.

During 2-3 weeks, many patients showed a decrease in edema of joints prone to gout, and pain was significantly reduced.

The success of treatment, basically, depends on at what point the patient drew attention to the onset of the disease and how quickly measures were taken to cure him.

The best result can be achieved with the individual appointment of a course of treatment, and this becomes possible only after careful examination of the patient and examination of the test results, which takes a certain amount time. According to statistical data, the guaranteed stabilization of the level of uric acid in the blood is achieved after 4-6 months of treatment with allopurinol.

A source: https://NogoStop.ru/stopa/zabolevaniya/allopurinol-pri-podagre.html